{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T21:16:55Z","timestamp":1793740615523,"version":"4.6.1"},"reference-count":50,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81471983, 81572801, 81572022"],"award-info":[{"award-number":["81471983, 81572801, 81572022"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2017.00137","type":"journal-article","created":{"date-parts":[[2017,2,12]],"date-time":"2017-02-12T22:37:02Z","timestamp":1486939022000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":14,"title":["Macrophages Polarized by Expression of ToxoGRA15II Inhibit Growth of Hepatic Carcinoma"],"prefix":"10.3389","volume":"8","author":[{"given":"Yuanling","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faustina","family":"Poppoe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingli","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanhong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihong","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jilong","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2017,2,13]]},"reference":[{"issue":"2","key":"B1","doi-asserted-by":"publisher","first-page":"69","DOI":"10.3322\/caac.20107","article-title":"Global cancer statistics","volume":"61","author":"Jemal","year":"2011","journal-title":"CA Cancer J Clin"},{"issue":"12","key":"B2","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1056\/NEJMra1001683","article-title":"Hepatocellular carcinoma","volume":"365","author":"El-Serag","year":"2011","journal-title":"N Engl J Med"},{"issue":"23","key":"B3","doi-asserted-by":"publisher","first-page":"2207","DOI":"10.1056\/NEJMra1204479","article-title":"Two hundred years of cancer research","volume":"366","author":"DeVita","year":"2012","journal-title":"N Engl J Med"},{"issue":"1","key":"B4","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1038\/nn.4185","article-title":"The role of microglia and macrophages in glioma maintenance and progression","volume":"19","author":"Hambardzumyan","year":"2016","journal-title":"Nat Neurosci"},{"issue":"10","key":"B5","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1038\/ni.1937","article-title":"Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm","volume":"11","author":"Biswas","year":"2010","journal-title":"Nat Immunol"},{"issue":"11","key":"B6","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1016\/S1471-4906(02)02302-5","article-title":"Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes","volume":"23","author":"Mantovani","year":"2002","journal-title":"Trends Immunol"},{"issue":"1","key":"B7","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.immuni.2014.09.021","article-title":"Tumor-associated macrophages: from mechanisms to therapy","volume":"41","author":"Noy","year":"2014","journal-title":"Immunity"},{"issue":"1","key":"B8","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/2045-824X-5-20","article-title":"The role of tumor-associated macrophages in tumor vascularization","volume":"5","author":"Guo","year":"2013","journal-title":"Vasc Cell"},{"issue":"5","key":"B9","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1172\/JCI31422","article-title":"Altered macrophage differentiation and immune dysfunction in tumor development","volume":"117","author":"Sica","year":"2007","journal-title":"J Clin Invest"},{"issue":"9","key":"B10","doi-asserted-by":"publisher","first-page":"e24407","DOI":"10.1371\/journal.pone.0024407","article-title":"Antitumor effect of malaria parasite infection in a murine Lewis lung cancer model through induction of innate and adaptive immunity","volume":"6","author":"Chen","year":"2011","journal-title":"PLoS One"},{"issue":"Suppl","key":"B11","doi-asserted-by":"publisher","first-page":"S38","DOI":"10.3346\/jkms.2007.22.S.S38","article-title":"Inhibition of Lewis lung carcinoma growth by Toxoplasma gondii through induction of Th1 immune responses and inhibition of angiogenesis","volume":"22","author":"Kim","year":"2007","journal-title":"J Korean Med Sci"},{"issue":"8","key":"B12","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1016\/j.ijpara.2009.02.004","article-title":"Toxoplasmosis: a history of clinical observations","volume":"39","author":"Weiss","year":"2009","journal-title":"Int J Parasitol"},{"issue":"4","key":"B13","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1128\/MMBR.00027-15","article-title":"Long-term relationships: the complicated interplay between the host and the developmental stages of Toxoplasma gondii during acute and chronic infections","volume":"79","author":"Pittman","year":"2015","journal-title":"Microbiol Mol Biol Rev"},{"issue":"2","key":"B14","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1038\/nri3598","article-title":"Innate immunity to Toxoplasma gondii infection","volume":"14","author":"Yarovinsky","year":"2014","journal-title":"Nat Rev Immunol"},{"issue":"5806","key":"B15","doi-asserted-by":"publisher","first-page":"1780","DOI":"10.1126\/science.1133690","article-title":"Polymorphic secreted kinases are key virulence factors in toxoplasmosis","volume":"314","author":"Saeij","year":"2006","journal-title":"Science"},{"issue":"7125","key":"B16","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1038\/nature05395","article-title":"Toxoplasma co-opts host gene expression by injection of a polymorphic kinase homologue","volume":"445","author":"Saeij","year":"2007","journal-title":"Nature"},{"issue":"6","key":"B17","doi-asserted-by":"publisher","first-page":"1561","DOI":"10.1093\/infdis\/172.6.1561","article-title":"Toxoplasma gondii comprises three clonal lineages: correlation of parasite genotype with human disease","volume":"172","author":"Howe","year":"1995","journal-title":"J Infect Dis"},{"issue":"6","key":"B18","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1016\/j.chom.2011.04.015","article-title":"Toxoplasma polymorphic effectors determine macrophage polarization and intestinal inflammation","volume":"9","author":"Jensen","year":"2011","journal-title":"Cell Host Microbe"},{"issue":"1","key":"B19","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1084\/jem.20100717","article-title":"Strain-specific activation of the NF-kappaB pathway by GRA15, a novel Toxoplasma gondii dense granule protein","volume":"208","author":"Rosowski","year":"2011","journal-title":"J Exp Med"},{"issue":"11","key":"B20","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1038\/nrmicro2858","article-title":"Modulation of innate immunity by Toxoplasma gondii virulence effectors","volume":"10","author":"Hunter","year":"2012","journal-title":"Nat Rev Microbiol"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2016.21","article-title":"Toxoplasma gondii GRA15II effector-induced M1 cells ameliorate liver fibrosis in mice infected with Schistosomiasis japonica","author":"Xie","year":"2016","journal-title":"Cell Mol Immunol"},{"issue":"1","key":"B22","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1186\/s13045-016-0359-x","article-title":"Nickel pyrithione induces apoptosis in chronic myeloid leukemia cells resistant to imatinib via both Bcr\/Abl-dependent and Bcr\/Abl-independent mechanisms","volume":"9","author":"Lan","year":"2016","journal-title":"J Hematol Oncol"},{"issue":"6","key":"B23","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/j.chom.2011.05.010","article-title":"Macrophages as a battleground for toxoplasma pathogenesis","volume":"9","author":"Murray","year":"2011","journal-title":"Cell Host Microbe"},{"issue":"9","key":"B24","doi-asserted-by":"publisher","first-page":"5336","DOI":"10.1073\/pnas.0931259100","article-title":"PD-L1 and PD-L2 are differentially regulated by Th1 and Th2 cells","volume":"100","author":"Loke","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"7203","key":"B25","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1038\/nature07205","article-title":"Cancer-related inflammation","volume":"454","author":"Mantovani","year":"2008","journal-title":"Nature"},{"issue":"1","key":"B26","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.gde.2008.01.003","article-title":"Pathways connecting inflammation and cancer","volume":"18","author":"Allavena","year":"2008","journal-title":"Curr Opin Genet Dev"},{"issue":"5","key":"B27","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/j.semcancer.2008.03.004","article-title":"Macrophage polarization in tumour progression","volume":"18","author":"Sica","year":"2008","journal-title":"Semin Cancer Biol"},{"issue":"11","key":"B28","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.1038\/nm.3394","article-title":"Microenvironmental regulation of tumor progression and metastasis","volume":"19","author":"Quail","year":"2013","journal-title":"Nat Med"},{"issue":"1","key":"B29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.critrevonc.2007.07.004","article-title":"The inflammatory micro-environment in tumor progression: the role of tumor-associated macrophages","volume":"66","author":"Allavena","year":"2008","journal-title":"Crit Rev Oncol Hematol"},{"issue":"7525","key":"B30","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1038\/nature13931","article-title":"Cancer: metastasis risk after anti-macrophage therapy","volume":"515","author":"Keklikoglou","year":"2014","journal-title":"Nature"},{"issue":"4","key":"B31","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1016\/j.ccell.2015.02.015","article-title":"Macrophages and therapeutic resistance in cancer","volume":"27","author":"Ruffell","year":"2015","journal-title":"Cancer Cell"},{"key":"B32","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1146\/annurev.immunol.021908.132532","article-title":"Alternative activation of macrophages: an immunologic functional perspective","volume":"27","author":"Martinez","year":"2009","journal-title":"Annu Rev Immunol"},{"issue":"12","key":"B33","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1016\/j.it.2004.09.015","article-title":"The chemokine system in diverse forms of macrophage activation and polarization","volume":"25","author":"Mantovani","year":"2004","journal-title":"Trends Immunol"},{"issue":"13","key":"B34","doi-asserted-by":"publisher","first-page":"5103","DOI":"10.1073\/pnas.1219920110","article-title":"Reversible epigenetic down-regulation of MHC molecules by devil facial tumour disease illustrates immune escape by a contagious cancer","volume":"110","author":"Siddle","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"9","key":"B35","doi-asserted-by":"publisher","first-page":"3413","DOI":"10.1172\/JCI80008","article-title":"Tumor neoantigens: building a framework for personalized cancer immunotherapy","volume":"125","author":"Gubin","year":"2015","journal-title":"J Clin Invest"},{"key":"B36","doi-asserted-by":"publisher","first-page":"187204","DOI":"10.1155\/2013\/187204","article-title":"The inflammatory microenvironment in hepatocellular carcinoma: a pivotal role for tumor-associated macrophages","volume":"2013","author":"Capece","year":"2013","journal-title":"Biomed Res Int"},{"issue":"4","key":"B37","doi-asserted-by":"publisher","first-page":"2011","DOI":"10.4049\/jimmunol.180.4.2011","article-title":"Plasticity of macrophage function during tumor progression: regulation by distinct molecular mechanisms","volume":"180","author":"Biswas","year":"2008","journal-title":"J Immunol"},{"issue":"9","key":"B38","doi-asserted-by":"publisher","first-page":"11553","DOI":"10.1007\/s13277-016-5098-7","article-title":"Role of interleukin-6 in cancer progression and therapeutic resistance","volume":"37","author":"Kumari","year":"2016","journal-title":"Tumour Biol"},{"key":"B39","doi-asserted-by":"publisher","first-page":"21260","DOI":"10.1038\/srep21260","article-title":"Interleukin-6-stimulated progranulin expression contributes to the malignancy of hepatocellular carcinoma cells by activating mTOR signaling","volume":"6","author":"Liu","year":"2016","journal-title":"Sci Rep"},{"issue":"328","key":"B40","doi-asserted-by":"publisher","first-page":"328rv4","DOI":"10.1126\/scitranslmed.aad7118","article-title":"PD-L1 (B7-H1) and PD-1 pathway blockade for cancer therapy: mechanisms, response biomarkers, and combinations","volume":"8","author":"Zou","year":"2016","journal-title":"Sci Transl Med"},{"issue":"3","key":"B41","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1128\/IAI.01049-09","article-title":"Cryptococcus neoformans variants generated by phenotypic switching differ in virulence through effects on macrophage activation","volume":"78","author":"Guerrero","year":"2010","journal-title":"Infect Immun"},{"issue":"3","key":"B42","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1038\/85330","article-title":"PD-L2 is a second ligand for PD-1 and inhibits T cell activation","volume":"2","author":"Latchman","year":"2001","journal-title":"Nat Immunol"},{"issue":"12","key":"B43","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.1038\/70932","article-title":"B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion","volume":"5","author":"Dong","year":"1999","journal-title":"Nat Med"},{"issue":"1","key":"B44","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1084\/jem.185.1.177","article-title":"CD80 costimulation is essential for the induction of airway eosinophilia","volume":"185","author":"Harris","year":"1997","journal-title":"J Exp Med"},{"issue":"3","key":"B45","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1038\/nrc745","article-title":"New functions for the matrix metalloproteinases in cancer progression","volume":"2","author":"Egeblad","year":"2002","journal-title":"Nat Rev Cancer"},{"issue":"8","key":"B46","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1096\/fasebj.13.8.781","article-title":"Regulation of matrix metalloproteinase expression in tumor invasion","volume":"13","author":"Westermarck","year":"1999","journal-title":"FASEB J"},{"issue":"3","key":"B47","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1002\/ijc.22594","article-title":"Resident stromal cell-derived MMP-9 promotes the growth of colorectal metastases in the liver microenvironment","volume":"121","author":"Gorden","year":"2007","journal-title":"Int J Cancer"},{"issue":"1","key":"B48","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1007\/s12035-013-8538-z","article-title":"Mmp-9 inhibition: a therapeutic strategy in ischemic stroke","volume":"49","author":"Chaturvedi","year":"2014","journal-title":"Mol Neurobiol"},{"issue":"9","key":"B49","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1038\/nri3499","article-title":"Metalloproteinases and their natural inhibitors in inflammation and immunity","volume":"13","author":"Khokha","year":"2013","journal-title":"Nat Rev Immunol"},{"issue":"7","key":"B50","doi-asserted-by":"publisher","first-page":"e1006189","DOI":"10.1371\/journal.pgen.1006189","article-title":"Secretion of rhoptry and dense granule effector proteins by nonreplicating Toxoplasma gondii uracil auxotrophs controls the development of antitumor immunity","volume":"12","author":"Fox","year":"2016","journal-title":"PLoS Genet"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2017.00137\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,18]],"date-time":"2019-09-18T11:56:30Z","timestamp":1568807790000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2017.00137\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,13]]},"references-count":50,"URL":"https:\/\/doi.org\/10.3389\/fimmu.2017.00137","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,13]]}}}