{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T21:11:45Z","timestamp":1785445905524,"version":"3.56.0"},"reference-count":45,"publisher":"Frontiers Media SA","content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2017.00154","type":"journal-article","created":{"date-parts":[[2017,2,16]],"date-time":"2017-02-16T03:32:17Z","timestamp":1487215937000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":54,"title":["\u03b22\u21921-Fructans Modulate the Immune System In Vivo in a Microbiota-Dependent and\u2009-Independent Fashion"],"prefix":"10.3389","volume":"8","author":[{"given":"Floris","family":"Fransen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neha M.","family":"Sahasrabudhe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlies","family":"Elderman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Bosveld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahar","family":"El Aidy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Floor","family":"Hugenholtz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theo","family":"Borghuis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Kousemaker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Winkel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christa","family":"van der Gaast-de Jongh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marien I.","family":"de Jonge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark V.","family":"Boekschoten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hauke","family":"Smidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henk A.","family":"Schols","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"de Vos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2017,2,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1038\/nri3738","article-title":"Regional specialization within the intestinal immune system","volume":"14","author":"Mowat","year":"2014","journal-title":"Nat Rev Immunol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1038\/nrg3182","article-title":"The human microbiome: at the interface of health and disease","volume":"13","author":"Cho","year":"2012","journal-title":"Nat Rev Genet"},{"key":"B3","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1038\/nri3312","article-title":"The impact of probiotics and prebiotics on the immune system","volume":"12","author":"Klaenhammer","year":"2012","journal-title":"Nat Rev Immunol"},{"key":"B4","doi-asserted-by":"crossref","first-page":"2493S","DOI":"10.1093\/jn\/137.11.2493S","article-title":"Inulin-type fructans: functional food ingredients","volume":"137","author":"Roberfroid","year":"2007","journal-title":"J Nutr"},{"key":"B5","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1079\/NRR200479","article-title":"Dietary modulation of the human colonic microbiota: updating the concept of prebiotics","volume":"17","author":"Gibson","year":"2004","journal-title":"Nutr Res Rev"},{"key":"B6","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1080\/10408398.2012.656772","article-title":"Immunological properties of inulin-type fructans","volume":"55","author":"Vogt","year":"2015","journal-title":"Crit Rev Food Sci Nutr"},{"key":"B7","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1111\/j.1365-2249.2004.02487.x","article-title":"Dietary fructooligosaccharides up-regulate immunoglobulin A response and polymeric immunoglobulin receptor expression in intestines of infant mice","volume":"137","author":"Nakamura","year":"2004","journal-title":"Clin Exp Immunol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1271\/bbb.67.758","article-title":"Dietary fructooligosaccharides induce immunoregulation of intestinal IgA secretion by murine Peyer\u2019s patch cells","volume":"67","author":"Hosono","year":"2003","journal-title":"Biosci Biotechnol Biochem"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1653","DOI":"10.1017\/S000711450812342X","article-title":"Long-chain inulin increases dendritic cells in the Peyer\u2019s patches and increases ex vivo cytokine secretion in the spleen and mesenteric lymph nodes of growing female rats, independent of zinc status","volume":"101","author":"Ryz","year":"2009","journal-title":"Br J Nutr"},{"issue":"Suppl","key":"B10","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1017\/S0007114510003363","article-title":"Prebiotic effects: metabolic and health benefits","volume":"104","author":"Roberfroid","year":"2010","journal-title":"Br J Nutr"},{"key":"B11","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1038\/nri3830","article-title":"The impact of diet on asthma and allergic diseases","volume":"15","author":"Julia","year":"2015","journal-title":"Nat Rev Immunol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1097\/MCO.0b013e32833eebe5","article-title":"Butyrate and other short-chain fatty acids as modulators of immunity: what relevance for health?","volume":"13","author":"Meijer","year":"2010","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"B13","doi-asserted-by":"publisher","first-page":"6734","DOI":"10.1038\/ncomms7734","article-title":"Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome","volume":"6","author":"Macia","year":"2015","journal-title":"Nat Commun"},{"key":"B14","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1126\/science.1241165","article-title":"The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis","volume":"341","author":"Smith","year":"2013","journal-title":"Science"},{"key":"B15","doi-asserted-by":"publisher","first-page":"e68367","DOI":"10.1371\/journal.pone.0068367","article-title":"Immune modulation by different types of \u03b22\u21921-fructans is toll-like receptor dependent","volume":"8","author":"Vogt","year":"2013","journal-title":"PLoS One"},{"key":"B16","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1016\/j.cmet.2014.07.003","article-title":"Starving our microbial self: the deleterious consequences of a diet deficient in microbiota-accessible carbohydrates","volume":"20","author":"Sonnenburg","year":"2014","journal-title":"Cell Metab"},{"key":"B17","doi-asserted-by":"publisher","first-page":"R80","DOI":"10.1186\/gb-2004-5-10-r80","article-title":"Bioconductor: open software development for computational biology and bioinformatics","volume":"5","author":"Gentleman","year":"2004","journal-title":"Genome Biol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"160","DOI":"10.2390\/biecoll-jib-2011-160","article-title":"MADMAX \u2013 management and analysis database for multiple ~omics experiments","volume":"8","author":"Lin","year":"2011","journal-title":"J Integr Bioinform"},{"key":"B19","doi-asserted-by":"publisher","first-page":"e175","DOI":"10.1093\/nar\/gni179","article-title":"Evolving gene\/transcript definitions significantly alter the interpretation of GeneChip data","volume":"33","author":"Dai","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"B20","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/S0074-7742(04)60002-X","article-title":"Experimental design and low-level analysis of microarray data","volume":"60","author":"Bolstad","year":"2004","journal-title":"Int Rev Neurobiol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"7846","DOI":"10.1128\/AEM.05220-11","article-title":"Barcoded primers used in multiplex amplicon pyrosequencing bias amplification","volume":"77","author":"Berry","year":"2011","journal-title":"Appl Environ Microbiol"},{"key":"B22","doi-asserted-by":"crossref","first-page":"808","DOI":"10.2144\/04365ST04","article-title":"Improved extraction of PCR-quality community DNA from digesta and fecal samples","volume":"36","author":"Yu","year":"2004","journal-title":"Biotechniques"},{"key":"B23","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1111\/1574-6941.12127","article-title":"Diversity of human small intestinal Streptococcus and Veillonella populations","volume":"85","author":"Van den Bogert","year":"2013","journal-title":"FEMS Microbiol Ecol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"2071","DOI":"10.1128\/AEM.02477-10","article-title":"Microarray analysis and barcoded pyrosequencing provide consistent microbial profiles depending on the source of human intestinal samples","volume":"77","author":"Van den Bogert","year":"2011","journal-title":"Appl Environ Microbiol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"D590","DOI":"10.1093\/nar\/gks1219","article-title":"The SILVA ribosomal RNA gene database project: improved data processing and web-based tools","volume":"41","author":"Quast","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"B26","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1038\/nmeth.f.303","article-title":"QIIME allows analysis of high-throughput community sequencing data","volume":"7","author":"Caporaso","year":"2010","journal-title":"Nat Methods"},{"key":"B27","doi-asserted-by":"publisher","first-page":"9440","DOI":"10.1073\/pnas.1530509100","article-title":"Statistical significance for genomewide studies","volume":"100","author":"Storey","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B28","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1186\/1471-2105-7-538","article-title":"Intensity-based hierarchical Bayes method improves testing for differentially expressed genes in microarray experiments","volume":"7","author":"Sartor","year":"2006","journal-title":"BMC Bioinformatics"},{"key":"B29","doi-asserted-by":"publisher","first-page":"2261","DOI":"10.1038\/ismej.2015.39","article-title":"The coral core microbiome identifies rare bacterial taxa as ubiquitous endosymbionts","volume":"9","author":"Ainsworth","year":"2015","journal-title":"ISME J"},{"key":"B30","doi-asserted-by":"publisher","first-page":"1254009","DOI":"10.1126\/science.1254009","article-title":"Innate lymphoid cells regulate intestinal epithelial cell glycosylation","volume":"345","author":"Goto","year":"2014","journal-title":"Science"},{"key":"B31","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1016\/j.chom.2014.08.017","article-title":"Epithelial IL-22RA1-mediated fucosylation promotes intestinal colonization resistance to an opportunistic pathogen","volume":"16","author":"Pham","year":"2014","journal-title":"Cell Host Microbe"},{"key":"B32","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1016\/j.cell.2009.09.033","article-title":"Induction of intestinal Th17 cells by segmented filamentous bacteria","volume":"139","author":"Ivanov","year":"2009","journal-title":"Cell"},{"key":"B33","doi-asserted-by":"publisher","first-page":"445","DOI":"10.3389\/fimmu.2013.00445","article-title":"The role of probiotics and prebiotics in inducing gut immunity","volume":"4","author":"Vieira","year":"2013","journal-title":"Front Immunol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"277","DOI":"10.4110\/in.2014.14.6.277","article-title":"Gut microbiota-derived short-chain fatty acids, T cells, and inflammation","volume":"14","author":"Kim","year":"2014","journal-title":"Immune Netw"},{"key":"B35","doi-asserted-by":"publisher","first-page":"5771","DOI":"10.1021\/jf200859z","article-title":"Degree of polymerization of inulin-type fructans differentially affects number of lactic acid bacteria, intestinal immune functions, and immunoglobulin A secretion in the rat cecum","volume":"59","author":"Ito","year":"2011","journal-title":"J Agric Food Chem"},{"key":"B36","doi-asserted-by":"publisher","first-page":"H36","DOI":"10.1111\/j.1750-3841.2008.00686.x","article-title":"The degree of polymerization of inulin-like fructans affects cecal mucin and immunoglobulin A in rats","volume":"73","author":"Ito","year":"2008","journal-title":"J Food Sci"},{"key":"B37","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.copbio.2014.09.005","article-title":"The small intestine microbiota, nutritional modulation and relevance for health","volume":"32","author":"Aidy","year":"2015","journal-title":"Curr Opin Biotechnol"},{"key":"B38","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1038\/nature04267","article-title":"Control of B-cell responses by toll-like receptors","volume":"438","author":"Pasare","year":"2005","journal-title":"Nature"},{"key":"B39","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1038\/nature13823","article-title":"Rapid fucosylation of intestinal epithelium sustains host-commensal symbiosis in sickness","volume":"514","author":"Pickard","year":"2014","journal-title":"Nature"},{"key":"B40","doi-asserted-by":"publisher","first-page":"9833","DOI":"10.1073\/pnas.96.17.9833","article-title":"A molecular sensor that allows a gut commensal to control its nutrient foundation in a competitive ecosystem","volume":"96","author":"Hooper","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B41","doi-asserted-by":"publisher","first-page":"1778","DOI":"10.1126\/science.1106469","article-title":"Human symbionts use a host-like pathway for surface fucosylation","volume":"307","author":"Coyne","year":"2005","journal-title":"Science"},{"key":"B42","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1093\/genetics\/158.2.747","article-title":"Contrasting patterns of polymorphisms at the ABO-secretor gene (FUT2) and plasma {{alpha}}(1,3)fucosyltransferase gene (FUT6) in human populations","volume":"158","author":"Koda","year":"2001","journal-title":"Genetics"},{"key":"B43","doi-asserted-by":"publisher","first-page":"e20113","DOI":"10.1371\/journal.pone.0020113","article-title":"Secretor genotype (FUT2 gene) is strongly associated with the composition of Bifidobacteria in the human intestine","volume":"6","author":"Wacklin","year":"2011","journal-title":"PLoS One"},{"issue":"1","key":"B44","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1093\/cid\/civ873","article-title":"Host genetic susceptibility to enteric viruses: a systematic review and metaanalysis","volume":"62","author":"Kambhampati","year":"2016","journal-title":"Clin Infect Dis"},{"key":"B45","doi-asserted-by":"publisher","first-page":"3468","DOI":"10.1093\/hmg\/ddq248","article-title":"Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn\u2019s disease","volume":"19","author":"McGovern","year":"2010","journal-title":"Hum Mol Genet"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2017.00154\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,24]],"date-time":"2022-07-24T06:35:01Z","timestamp":1658644501000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2017.00154\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,16]]},"references-count":45,"URL":"https:\/\/doi.org\/10.3389\/fimmu.2017.00154","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,16]]}}}