{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T15:43:01Z","timestamp":1771515781992,"version":"3.50.1"},"reference-count":67,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/501100001321","name":"National Research Foundation","doi-asserted-by":"publisher","award":["SOUTH AFRICA"],"award-info":[{"award-number":["SOUTH AFRICA"]}],"id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001322","name":"South African Medical Research Council","doi-asserted-by":"publisher","award":["SOUTH AFRICA"],"award-info":[{"award-number":["SOUTH AFRICA"]}],"id":[{"id":"10.13039\/501100001322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007112","name":"University of Cape Town","doi-asserted-by":"publisher","award":["SOUTH AFRICA"],"award-info":[{"award-number":["SOUTH AFRICA"]}],"id":[{"id":"10.13039\/501100007112","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2017.00180","type":"journal-article","created":{"date-parts":[[2017,3,14]],"date-time":"2017-03-14T06:38:18Z","timestamp":1489473498000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Myeloid and T Cell-Derived TNF Protects against Central Nervous System Tuberculosis"],"prefix":"10.3389","volume":"8","author":[{"given":"Nai-Jen","family":"Hsu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ngiambudulu M.","family":"Francisco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roanne","family":"Keeton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nasiema","family":"Allie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val\u00e9rie F. J.","family":"Quesniaux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernhard","family":"Ryffel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muazzam","family":"Jacobs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2017,2,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1016\/1074-7613(95)90001-2","article-title":"Tumor necrosis factor-alpha is required in the protective immune response against Mycobacterium tuberculosis in mice","volume":"2","author":"Flynn","year":"1995","journal-title":"Immunity"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1909","DOI":"10.1371\/journal.pcbi.0030194","article-title":"Differences in reactivation of tuberculosis induced from anti-TNF treatments are based on bioavailability in granulomatous tissue","volume":"3","author":"Marino","year":"2007","journal-title":"PLoS Comput Biol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1002\/art.27271","article-title":"Tumor necrosis factor neutralization results in disseminated disease in acute and latent Mycobacterium tuberculosis infection with normal granuloma structure in a cynomolgus macaque model","volume":"62","author":"Lin","year":"2010","journal-title":"Arthritis Rheum"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1809","DOI":"10.1038\/srep01809","article-title":"Prominent role for T cell-derived tumour necrosis factor for sustained control of Mycobacterium tuberculosis infection","volume":"3","author":"Allie","year":"2013","journal-title":"Sci Rep"},{"key":"B5","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1016\/j.cell.2010.02.013","article-title":"The lta4h locus modulates susceptibility to mycobacterial infection in zebrafish and humans","volume":"140","author":"Tobin","year":"2010","journal-title":"Cell"},{"key":"B6","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1016\/j.cell.2011.12.023","article-title":"Host genotype-specific therapies can optimize the inflammatory response to mycobacterial infections","volume":"148","author":"Tobin","year":"2012","journal-title":"Cell"},{"key":"B7","doi-asserted-by":"publisher","first-page":"94","DOI":"10.2174\/156652409787581655","article-title":"Pathogenesis of central nervous system tuberculosis","volume":"9","author":"Be","year":"2009","journal-title":"Curr Mol Med"},{"key":"B8","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1016\/j.tube.2010.05.002","article-title":"Specific bacterial genotypes of Mycobacterium tuberculosis cause extensive dissemination and brain infection in an experimental model","volume":"90","author":"Hernandez Pando","year":"2010","journal-title":"Tuberculosis (Edinb)"},{"key":"B9","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1086\/430614","article-title":"Virulence of selected Mycobacterium tuberculosis clinical isolates in the rabbit model of meningitis is dependent on phenolic glycolipid produced by the bacilli","volume":"192","author":"Tsenova","year":"2005","journal-title":"J Infect Dis"},{"key":"B10","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1086\/511273","article-title":"A new murine model to study the pathogenesis of tuberculous meningitis","volume":"195","author":"Van Well","year":"2007","journal-title":"J Infect Dis"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1242\/dmm.015453","article-title":"Modeling tuberculous meningitis in zebrafish using Mycobacterium marinum","volume":"7","author":"Van Leeuwen","year":"2014","journal-title":"Dis Model Mech"},{"key":"B12","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1006\/clin.1997.4367","article-title":"Cerebrospinal fluid cytokines in patients with tuberculous meningitis","volume":"84","author":"Mastroianni","year":"1997","journal-title":"Clin Immunol Immunopathol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.neulet.2010.07.029","article-title":"A study of cytokines in tuberculous meningitis: clinical and MRI correlation","volume":"483","author":"Misra","year":"2010","journal-title":"Neurosci Lett"},{"key":"B14","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1086\/591097","article-title":"Role of nitric oxide in defense of the central nervous system against Mycobacterium tuberculosis","volume":"198","author":"Olin","year":"2008","journal-title":"J Infect Dis"},{"key":"B15","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1186\/s12974-015-0345-1","article-title":"TNF-dependent regulation and activation of innate immune cells are essential for host protection against cerebral tuberculosis","volume":"12","author":"Francisco","year":"2015","journal-title":"J Neuroinflammation"},{"key":"B16","doi-asserted-by":"publisher","first-page":"11393","DOI":"10.1073\/pnas.91.24.11393","article-title":"Regional induction of tumor necrosis factor alpha expression in the mouse brain after systemic lipopolysaccharide administration","volume":"91","author":"Breder","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B17","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/S0301-0082(98)00045-8","article-title":"The role of tumour necrosis factor, interleukin 6, interferon-gamma and inducible nitric oxide synthase in the development and pathology of the nervous system","volume":"56","author":"Munoz-Fernandez","year":"1998","journal-title":"Prog Neurobiol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.jneuroim.2009.05.008","article-title":"Intracerebral Mycobacterium bovis bacilli Calmette-Guerin infection-induced immune responses in the CNS","volume":"213","author":"Lee","year":"2009","journal-title":"J Neuroimmunol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"5660","DOI":"10.4049\/jimmunol.1100663","article-title":"Pathogenic and protective functions of TNF in neuroinflammation are defined by its expression in T lymphocytes and myeloid cells","volume":"187","author":"Kruglov","year":"2011","journal-title":"J Immunol"},{"key":"B20","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.neuroscience.2015.06.038","article-title":"TNF and its receptors in the CNS: the essential, the desirable and the deleterious effects","volume":"302","author":"Probert","year":"2015","journal-title":"Neuroscience"},{"key":"B21","doi-asserted-by":"publisher","first-page":"5657","DOI":"10.1073\/pnas.96.10.5657","article-title":"Tumor necrosis factor alpha is a determinant of pathogenesis and disease progression in mycobacterial infection in the central nervous system","volume":"96","author":"Tsenova","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B22","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/j.neuint.2003.08.012","article-title":"Inhibition of cytokines expression in human microglia infected by virulent and non-virulent mycobacteria","volume":"44","author":"Curto","year":"2004","journal-title":"Neurochem Int"},{"key":"B23","doi-asserted-by":"publisher","first-page":"2054","DOI":"10.1086\/498165","article-title":"Mycobacterium tuberculosis-induced cytokine and chemokine expression by human microglia and astrocytes: effects of dexamethasone","volume":"192","author":"Rock","year":"2005","journal-title":"J Infect Dis"},{"key":"B24","doi-asserted-by":"publisher","first-page":"182","DOI":"10.3389\/fncel.2015.00182","article-title":"Microglia are crucial regulators of neuro-immunity during central nervous system tuberculosis","volume":"9","author":"Spanos","year":"2015","journal-title":"Front Cell Neurosci"},{"key":"B25","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1128\/IAI.61.1.197-203.1993","article-title":"Patterns of cytokine production by Mycobacterium-reactive human T-cell clones","volume":"61","author":"Barnes","year":"1993","journal-title":"Infect Immun"},{"key":"B26","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1111\/j.1365-2249.2004.02518.x","article-title":"T cell-derived tumour necrosis factor is essential, but not sufficient, for protection against Mycobacterium tuberculosis infection","volume":"137","author":"Saunders","year":"2004","journal-title":"Clin Exp Immunol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1038\/nm.2299","article-title":"Dominant TNF-alpha+ Mycobacterium tuberculosis-specific CD4+ T cell responses discriminate between latent infection and active disease","volume":"17","author":"Harari","year":"2011","journal-title":"Nat Med"},{"key":"B28","doi-asserted-by":"publisher","first-page":"6201","DOI":"10.4049\/jimmunol.181.9.6201","article-title":"Mycobacterium bovis bacille Calmette-Guerin infection in the CNS suppresses experimental autoimmune encephalomyelitis and Th17 responses in an IFN-gamma-independent manner","volume":"181","author":"Lee","year":"2008","journal-title":"J Immunol"},{"key":"B29","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.immuni.2004.11.016","article-title":"Distinct and nonredundant in vivo functions of TNF produced by t cells and macrophages\/neutrophils: protective and deleterious effects","volume":"22","author":"Grivennikov","year":"2005","journal-title":"Immunity"},{"key":"B30","doi-asserted-by":"publisher","first-page":"22454","DOI":"10.1038\/srep22454","article-title":"Innate myeloid cell TNFR1 mediates first line defence against primary Mycobacterium tuberculosis infection","volume":"6","author":"Segueni","year":"2016","journal-title":"Sci Rep"},{"key":"B31","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1038\/icb.2015.43","article-title":"Mycobacterium tuberculosis infection of the \u201cnon-classical immune cell\u201d","volume":"93","author":"Randall","year":"2015","journal-title":"Immunol Cell Biol"},{"key":"B32","doi-asserted-by":"publisher","first-page":"434","DOI":"10.3389\/fimmu.2016.00434","article-title":"Granulomas and inflammation: host-directed therapies for tuberculosis","volume":"7","author":"Ndlovu","year":"2016","journal-title":"Front Immunol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"1537","DOI":"10.1172\/JCI45005","article-title":"Soluble TNFRp75 regulates host protective immunity against Mycobacterium tuberculosis","volume":"124","author":"Keeton","year":"2014","journal-title":"J Clin Invest"},{"key":"B34","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1002\/glia.22393","article-title":"Development and homeostasis of \u201cresident\u201d myeloid cells: the case of the microglia","volume":"61","author":"Gomez Perdiguero","year":"2013","journal-title":"Glia"},{"key":"B35","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1038\/nrn3722","article-title":"Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease","volume":"15","author":"Prinz","year":"2014","journal-title":"Nat Rev Neurosci"},{"key":"B36","doi-asserted-by":"publisher","first-page":"6632","DOI":"10.1073\/pnas.1017820108","article-title":"Microglial glucocorticoid receptors play a pivotal role in regulating dopaminergic neurodegeneration in parkinsonism","volume":"108","author":"Ros-Bernal","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B37","doi-asserted-by":"publisher","first-page":"1618","DOI":"10.1038\/nn.3531","article-title":"A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation","volume":"16","author":"Goldmann","year":"2013","journal-title":"Nat Neurosci"},{"key":"B38","doi-asserted-by":"publisher","first-page":"673","DOI":"10.18632\/aging.100805","article-title":"Deletion of caspase-8 in mouse myeloid cells blocks microglia pro-inflammatory activation and confers protection in MPTP neurodegeneration model","volume":"7","author":"Kavanagh","year":"2015","journal-title":"Aging (Albany NY)"},{"key":"B39","doi-asserted-by":"publisher","first-page":"6348","DOI":"10.1073\/pnas.86.16.6348","article-title":"Production of tumor necrosis factor and other cytokines by astrocytes stimulated with lipopolysaccharide or a neurotropic virus","volume":"86","author":"Lieberman","year":"1989","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B40","doi-asserted-by":"crossref","first-page":"2999","DOI":"10.4049\/jimmunol.144.8.2999","article-title":"Tumor necrosis factor-alpha production by astrocytes. Induction by lipopolysaccharide, IFN-gamma, and IL-1 beta","volume":"144","author":"Chung","year":"1990","journal-title":"J Immunol"},{"key":"B41","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1084\/jem.173.4.801","article-title":"Differential tumor necrosis factor alpha expression by astrocytes from experimental allergic encephalomyelitis-susceptible and -resistant rat strains","volume":"173","author":"Chung","year":"1991","journal-title":"J Exp Med"},{"key":"B42","doi-asserted-by":"publisher","first-page":"3110","DOI":"10.4049\/jimmunol.171.6.3110","article-title":"Reactivation of latent tuberculosis infection in TNF-deficient mice","volume":"171","author":"Botha","year":"2003","journal-title":"J Immunol"},{"key":"B43","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1016\/j.micinf.2007.02.002","article-title":"Tumor necrosis factor is critical to control tuberculosis infection","volume":"9","author":"Jacobs","year":"2007","journal-title":"Microbes Infect"},{"key":"B44","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/S1359-6101(03)00054-6","article-title":"Chemokines and tuberculosis","volume":"14","author":"Algood","year":"2003","journal-title":"Cytokine Growth Factor Rev"},{"key":"B45","doi-asserted-by":"publisher","first-page":"6846","DOI":"10.3389\/fmicb.2011.00002","article-title":"TNF influences chemokine expression of macrophages in vitro and that of CD11b+ cells in vivo during Mycobacterium tuberculosis infection","volume":"172","author":"Algood","year":"2004","journal-title":"J Immunol"},{"key":"B46","doi-asserted-by":"publisher","first-page":"7576","DOI":"10.4049\/jimmunol.176.12.7576","article-title":"A novel functional T cell hybridoma recognizes macrophage cell death induced by bacteria: a possible role for innate lymphocytes in bacterial infection","volume":"176","author":"Kubota","year":"2006","journal-title":"J Immunol"},{"key":"B47","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1111\/j.1365-3083.2009.02366.x","article-title":"Innate IFN-gamma production by subsets of natural killer cells, natural killer T cells and gammadelta T cells in response to dying bacterial-infected macrophages","volume":"71","author":"Kubota","year":"2010","journal-title":"Scand J Immunol"},{"key":"B48","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1006\/mcne.1996.0026","article-title":"Targeted CNS expression of interferon-gamma in transgenic mice leads to hypomyelination, reactive gliosis, and abnormal cerebellar development","volume":"7","author":"Corbin","year":"1996","journal-title":"Mol Cell Neurosci"},{"key":"B49","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1006\/mcne.1998.0725","article-title":"Interferon-gamma in progression to chronic demyelination and neurological deficit following acute EAE","volume":"12","author":"Renno","year":"1998","journal-title":"Mol Cell Neurosci"},{"key":"B50","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.neulet.2009.07.013","article-title":"Interleukin-2 deficiency-induced T cell autoimmunity in the mouse brain","volume":"463","author":"Huang","year":"2009","journal-title":"Neurosci Lett"},{"key":"B51","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.neulet.2011.05.230","article-title":"Loss of CNS IL-2 gene expression modifies brain T lymphocyte trafficking: response of normal versus autoreactive Treg-deficient T cells","volume":"499","author":"Huang","year":"2011","journal-title":"Neurosci Lett"},{"key":"B52","doi-asserted-by":"publisher","first-page":"196","DOI":"10.4172\/2329-6895.1000196","article-title":"Effects of brain-derived IL-2 deficiency and the development of autoimmunity on spatial learning and fear conditioning","volume":"3","author":"Petitto","year":"2015","journal-title":"J Neurol Disord"},{"key":"B53","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.4049\/jimmunol.162.5.2606","article-title":"IL-15 induces the expression of chemokines and their receptors in T lymphocytes","volume":"162","author":"Perera","year":"1999","journal-title":"J Immunol"},{"key":"B54","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.brainres.2005.02.010","article-title":"Changes in hippocampal IL-15, related cytokines, and neurogenesis in IL-2 deficient mice","volume":"1041","author":"Beck","year":"2005","journal-title":"Brain Res"},{"key":"B55","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.neulet.2007.01.086","article-title":"IL-15 and IL-15R alpha gene deletion: effects on T lymphocyte trafficking and the microglial and neuronal responses to facial nerve axotomy","volume":"417","author":"Huang","year":"2007","journal-title":"Neurosci Lett"},{"key":"B56","doi-asserted-by":"publisher","first-page":"3058","DOI":"10.1073\/pnas.0812851107","article-title":"Competing feedback loops shape IL-2 signaling between helper and regulatory T lymphocytes in cellular microenvironments","volume":"107","author":"Busse","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B57","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1038\/msb.2010.90","article-title":"Single-cell quantification of IL-2 response by effector and regulatory T cells reveals critical plasticity in immune response","volume":"6","author":"Feinerman","year":"2010","journal-title":"Mol Syst Biol"},{"key":"B58","doi-asserted-by":"publisher","first-page":"268","DOI":"10.3389\/fimmu.2012.00268","article-title":"Competition for IL-2 between regulatory and effector T cells to chisel immune responses","volume":"3","author":"Hofer","year":"2012","journal-title":"Front Immunol"},{"key":"B59","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1084\/jem.20040165","article-title":"Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFalpha therapy","volume":"200","author":"Ehrenstein","year":"2004","journal-title":"J Exp Med"},{"key":"B60","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.molmed.2009.12.003","article-title":"Disturbed regulatory T cell homeostasis in multiple sclerosis","volume":"16","author":"Venken","year":"2010","journal-title":"Trends Mol Med"},{"key":"B61","doi-asserted-by":"publisher","first-page":"154","DOI":"10.4049\/jimmunol.179.1.154","article-title":"Interaction of TNF with TNF receptor type 2 promotes expansion and function of mouse CD4+CD25+ T regulatory cells","volume":"179","author":"Chen","year":"2007","journal-title":"J Immunol"},{"key":"B62","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1038\/icb.2012.65","article-title":"TNFRp55 controls regulatory T cell responses in Yersinia-induced reactive arthritis","volume":"91","author":"Cargnelutti","year":"2013","journal-title":"Immunol Cell Biol"},{"key":"B63","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.clim.2006.11.009","article-title":"CD4(+)CD25(+)FoxP3(+) regulatory T cells suppress Mycobacterium tuberculosis immunity in patients with active disease","volume":"123","author":"Chen","year":"2007","journal-title":"Clin Immunol"},{"key":"B64","doi-asserted-by":"publisher","first-page":"2159","DOI":"10.1084\/jem.20062105","article-title":"Expansion and function of Foxp3-expressing T regulatory cells during tuberculosis","volume":"204","author":"Scott-Browne","year":"2007","journal-title":"J Exp Med"},{"key":"B65","doi-asserted-by":"publisher","first-page":"3678","DOI":"10.4049\/jimmunol.1102422","article-title":"Regulatory T cells selectively preserve immune privilege of self-antigens during viral central nervous system infection","volume":"188","author":"Cervantes-Barragan","year":"2012","journal-title":"J Immunol"},{"key":"B66","doi-asserted-by":"publisher","first-page":"1412","DOI":"10.4049\/jimmunol.1000560","article-title":"Critical role for TNF in the induction of human antigen-specific regulatory T cells by tolerogenic dendritic cells","volume":"185","author":"Kleijwegt","year":"2010","journal-title":"J Immunol"},{"key":"B67","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.4049\/jimmunol.1202659","article-title":"TNFR2 is critical for the stabilization of the CD4+Foxp3+ regulatory T cell phenotype in the inflammatory environment","volume":"190","author":"Chen","year":"2013","journal-title":"J Immunol"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2017.00180\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,22]],"date-time":"2024-06-22T23:31:53Z","timestamp":1719099113000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2017.00180\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,23]]},"references-count":67,"URL":"https:\/\/doi.org\/10.3389\/fimmu.2017.00180","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,23]]}}}