{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:45:51Z","timestamp":1790959551530,"version":"4.1.0"},"reference-count":58,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["92661"],"award-info":[{"award-number":["92661"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["U19-AI082655, U19-AI109776"],"award-info":[{"award-number":["U19-AI082655, U19-AI109776"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01-AI036525"],"award-info":[{"award-number":["R01-AI036525"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2017.00208","type":"journal-article","created":{"date-parts":[[2017,3,27]],"date-time":"2017-03-27T06:11:55Z","timestamp":1490595115000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":32,"title":["Importance of Salmonella Typhi-Responsive CD8+ T Cell Immunity in a Human Typhoid Fever Challenge Model"],"prefix":"10.3389","volume":"8","author":[{"given":"Stephanie","family":"Fresnay","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica A.","family":"McArthur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence S.","family":"Magder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas C.","family":"Darton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire S.","family":"Waddington","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph J.","family":"Blohmke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Angus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myron M.","family":"Levine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Pollard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo B.","family":"Sztein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2017,3,2]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1086\/649541","article-title":"Global trends in typhoid and paratyphoid fever","volume":"50","author":"Crump","year":"2010","journal-title":"Clin Infect Dis"},{"key":"B2","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1146\/annurev-micro-091313-103739","article-title":"Salmonella enterica serovar Typhi and the pathogenesis of typhoid fever","volume":"68","author":"Dougan","year":"2014","journal-title":"Annu Rev Microbiol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1111\/j.1600-065X.2010.00999.x","article-title":"Immunity to salmonellosis","volume":"240","author":"Dougan","year":"2011","journal-title":"Immunol Rev"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1016\/S1286-4579(01)01487-3","article-title":"Host-Salmonella interaction: human trials","volume":"3","author":"Levine","year":"2001","journal-title":"Microbes Infect"},{"key":"B5","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1056\/NEJM197010012831406","article-title":"Typhoid fever: pathogenesis and immunologic control","volume":"283","author":"Hornick","year":"1970","journal-title":"N Engl J Med"},{"key":"B6","first-page":"70","article-title":"Appraisal of typhoid vaccine in experimentally infected human subjects","volume":"78","author":"Hornick","year":"1967","journal-title":"Trans Am Clin Climatol Assoc"},{"key":"B7","doi-asserted-by":"publisher","first-page":"516","DOI":"10.3389\/fimmu.2014.00516","article-title":"Complex adaptive immunity to enteric fevers in humans: lessons learned and the path forward","volume":"5","author":"Sztein","year":"2014","journal-title":"Front Immunol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1230","DOI":"10.1093\/cid\/ciu078","article-title":"An outpatient, ambulant-design, controlled human infection model using escalating doses of Salmonella Typhi challenge delivered in sodium bicarbonate solution","volume":"58","author":"Waddington","year":"2014","journal-title":"Clin Infect Dis"},{"key":"B9","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1097\/MOG.0000000000000021","article-title":"Typhoid epidemiology, diagnostics and the human challenge model","volume":"30","author":"Darton","year":"2014","journal-title":"Curr Opin Gastroenterol"},{"issue":"8","key":"B10","doi-asserted-by":"publisher","first-page":"e0004926","DOI":"10.1371\/journal.pntd.0004926","article-title":"Using a human challenge model of infection to measure vaccine efficacy: a randomised, controlled trial comparing the typhoid vaccines M01ZH09 with placebo and Ty21a","volume":"10","author":"Darton","year":"2016","journal-title":"PLoS Negl Trop Dis"},{"key":"B11","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1186\/s12967-016-0819-7","article-title":"Salmonella Typhi-specific multifunctional CD8+ T cells play a dominant role in protection from typhoid fever in humans","volume":"14","author":"Fresnay","year":"2016","journal-title":"J Transl Med"},{"issue":"2002","key":"B12","doi-asserted-by":"publisher","first-page":"2196","DOI":"10.4049\/jimmunol.169.4.2196","article-title":"Characterization of CD8(+) effector T cell responses in volunteers immunized with Salmonella enterica serovar Typhi strain Ty21a typhoid vaccine","volume":"169","author":"Salerno-Goncalves","year":"1950","journal-title":"J Immunol"},{"key":"B13","doi-asserted-by":"crossref","first-page":"3987","DOI":"10.4049\/jimmunol.155.8.3987","article-title":"Cytotoxic T lymphocytes after oral immunization with attenuated vaccine strains of Salmonella typhi in humans","volume":"155","author":"Sztein","year":"1995","journal-title":"J Immunol"},{"issue":"2003","key":"B14","doi-asserted-by":"publisher","first-page":"2734","DOI":"10.4049\/jimmunol.170.5.2734","article-title":"Concomitant induction of CD4+ and CD8+ T cell responses in volunteers immunized with Salmonella enterica serovar Typhi strain CVD 908-htrA","volume":"170","author":"Salerno-Goncalves","year":"1950","journal-title":"J Immunol"},{"issue":"2004","key":"B15","doi-asserted-by":"publisher","first-page":"5852","DOI":"10.4049\/jimmunol.173.9.5852","article-title":"Identification of a human HLA-E-restricted CD8+ T cell subset in volunteers immunized with Salmonella enterica serovar Typhi strain Ty21a typhoid vaccine","volume":"173","author":"Salerno-Goncalves","year":"1950","journal-title":"J Immunol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"3521","DOI":"10.1128\/IAI.73.6.3521-3530.2005","article-title":"Immunization of volunteers with Salmonella enterica serovar Typhi strain Ty21a elicits the oligoclonal expansion of CD8+ T cells with predominant Vbeta repertoires","volume":"73","author":"Salerno-Goncalves","year":"2005","journal-title":"Infect Immun"},{"key":"B17","doi-asserted-by":"publisher","first-page":"1416","DOI":"10.1016\/j.vaccine.2006.10.040","article-title":"Cell-mediated immune responses in humans after immunization with one or two doses of oral live attenuated typhoid vaccine CVD 909","volume":"25","author":"Wahid","year":"2007","journal-title":"Vaccine"},{"issue":"Suppl 1","key":"B18","doi-asserted-by":"publisher","first-page":"S15","DOI":"10.1086\/518140","article-title":"Cell-mediated immunity and antibody responses elicited by attenuated Salmonella enterica serovar Typhi strains used as live oral vaccines in humans","volume":"45","author":"Sztein","year":"2007","journal-title":"Clin Infect Dis"},{"key":"B19","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1038\/mi.2008.30","article-title":"Generation of specific effector and memory T cells with gut- and secondary lymphoid tissue-homing potential by oral attenuated CVD 909 typhoid vaccine in humans","volume":"1","author":"Wahid","year":"2008","journal-title":"Mucosal Immunol"},{"key":"B20","doi-asserted-by":"publisher","first-page":"e5879","DOI":"10.1371\/journal.pone.0005879","article-title":"Priming of Salmonella enterica serovar Typhi-specific CD8(+) T cells by suicide dendritic cell cross-presentation in humans","volume":"4","author":"Salerno-Goncalves","year":"2009","journal-title":"PLoS One"},{"key":"B21","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1128\/CVI.00234-10","article-title":"Ex vivo kinetics of early and long-term multifunctional human leukocyte antigen E-specific CD8+ cells in volunteers immunized with the Ty21a typhoid vaccine","volume":"17","author":"Salerno-Goncalves","year":"2010","journal-title":"Clin Vaccine Immunol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"e38408","DOI":"10.1371\/journal.pone.0038408","article-title":"Heterogeneity of multifunctional IL-17A producing S. Typhi-specific CD8+ T cells in volunteers following Ty21a typhoid immunization","volume":"7","author":"McArthur","year":"2012","journal-title":"PLoS One"},{"key":"B23","doi-asserted-by":"publisher","first-page":"1508","DOI":"10.1093\/infdis\/170.6.1508","article-title":"Cytokine production patterns and lymphoproliferative responses in volunteers orally immunized with attenuated vaccine strains of Salmonella Typhi","volume":"170","author":"Sztein","year":"1994","journal-title":"J Infect Dis"},{"key":"B24","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/S0022-1759(03)00265-5","article-title":"Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation","volume":"281","author":"Betts","year":"2003","journal-title":"J Immunol Methods"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1568","DOI":"10.1002\/eji.201243262","article-title":"Mycobacterium tuberculosis-specific CD8+ T cells are functionally and phenotypically different between latent infection and active disease","volume":"43","author":"Rozot","year":"2013","journal-title":"Eur J Immunol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1038\/nri2274","article-title":"T-cell quality in memory and protection: implications for vaccine design","volume":"8","author":"Seder","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"5622","DOI":"10.1128\/IAI.70.10.5622-5627.2002","article-title":"Oral immunization with a Salmonella enterica serovar Typhi vaccine induces specific circulating mucosa-homing CD4(+) and CD8(+) T cells in humans","volume":"70","author":"Lundin","year":"2002","journal-title":"Infect Immun"},{"key":"B28","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1111\/j.1600-065X.2010.00970.x","article-title":"Immunology of gut mucosal vaccines","volume":"239","author":"Pasetti","year":"2011","journal-title":"Immunol Rev"},{"key":"B29","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1016\/j.it.2008.08.003","article-title":"T-cell recruitment to the intestinal mucosa","volume":"29","author":"Agace","year":"2008","journal-title":"Trends Immunol"},{"key":"B30","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.it.2006.03.007","article-title":"T-cell homing specificity and plasticity: new concepts and future challenges","volume":"27","author":"Mora","year":"2006","journal-title":"Trends Immunol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.mib.2010.10.003","article-title":"Mechanisms controlling pathogen colonization of the gut","volume":"14","author":"Stecher","year":"2011","journal-title":"Curr Opin Microbiol"},{"key":"B32","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1128\/IAI.01432-07","article-title":"Enteric salmonellosis disrupts the microbial ecology of the murine gastrointestinal tract","volume":"76","author":"Barman","year":"2008","journal-title":"Infect Immun"},{"key":"B33","doi-asserted-by":"publisher","first-page":"e1001043","DOI":"10.1371\/journal.ppat.1001043","article-title":"Regulatory T cell suppressive potency dictates the balance between bacterial proliferation and clearance during persistent Salmonella infection","volume":"6","author":"Johanns","year":"2010","journal-title":"PLoS Pathog"},{"key":"B34","doi-asserted-by":"publisher","first-page":"e1004914","DOI":"10.1371\/journal.ppat.1004914","article-title":"Activation of Salmonella Typhi-specific regulatory T cells in typhoid disease in a wild-type S. Typhi challenge model","volume":"11","author":"McArthur","year":"2015","journal-title":"PLoS Pathog"},{"key":"B35","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1038\/nature05115","article-title":"PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression","volume":"443","author":"Day","year":"2006","journal-title":"Nature"},{"key":"B36","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.1016\/j.celrep.2013.11.002","article-title":"PD-1 dependent exhaustion of CD8+ T cells drives chronic malaria","volume":"5","author":"Horne-Debets","year":"2013","journal-title":"Cell Rep"},{"key":"B37","doi-asserted-by":"publisher","first-page":"4911","DOI":"10.1128\/JVI.77.8.4911-4927.2003","article-title":"Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment","volume":"77","author":"Wherry","year":"2003","journal-title":"J Virol"},{"key":"B38","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1182\/blood-2009-12-255125","article-title":"Interferon-gamma and tumor necrosis factor-alpha induce an immunoinhibitory molecule, B7-H1, via nuclear factor-kappaB activation in blasts in myelodysplastic syndromes","volume":"116","author":"Kondo","year":"2010","journal-title":"Blood"},{"key":"B39","doi-asserted-by":"publisher","first-page":"e1004207","DOI":"10.1371\/journal.ppat.1004207","article-title":"Salmonella enterica serovar Typhi conceals the invasion-associated type three secretion system from the innate immune system by gene regulation","volume":"10","author":"Winter","year":"2014","journal-title":"PLoS Pathog"},{"key":"B40","doi-asserted-by":"publisher","first-page":"e1004306","DOI":"10.1371\/journal.ppat.1004306","article-title":"The Vi capsular polysaccharide enables Salmonella enterica serovar Typhi to evade microbe-guided neutrophil chemotaxis","volume":"10","author":"Wangdi","year":"2014","journal-title":"PLoS Pathog"},{"key":"B41","doi-asserted-by":"publisher","first-page":"660","DOI":"10.4161\/viru.22761","article-title":"Interactions of Salmonella enterica with dendritic cells","volume":"3","author":"Swart","year":"2012","journal-title":"Virulence"},{"key":"B42","doi-asserted-by":"publisher","first-page":"17769","DOI":"10.1073\/pnas.0504382102","article-title":"Salmonella inhibit T cell proliferation by a direct, contact-dependent immunosuppressive effect","volume":"102","author":"van der Velden","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B43","doi-asserted-by":"publisher","first-page":"2247","DOI":"10.1128\/IAI.00020-14","article-title":"Salmonella enterica serovar Typhi impairs CD4 T cell responses by reducing antigen availability","volume":"82","author":"Atif","year":"2014","journal-title":"Infect Immun"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1410863","article-title":"Chimpanzee adenovirus vector Ebola vaccine \u2013 preliminary report","author":"Ledgerwood","year":"2014","journal-title":"N Engl J Med"},{"key":"B45","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1038\/nm1592","article-title":"Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major","volume":"13","author":"Darrah","year":"2007","journal-title":"Nat Med"},{"key":"B46","doi-asserted-by":"publisher","first-page":"4781","DOI":"10.1182\/blood-2005-12-4818","article-title":"HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells","volume":"107","author":"Betts","year":"2006","journal-title":"Blood"},{"key":"B47","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.1096\/fasebj.3.14.2687068","article-title":"Macrophage inflammatory proteins 1 and 2: members of a novel superfamily of cytokines","volume":"3","author":"Wolpe","year":"1989","journal-title":"FASEB J"},{"issue":"6","key":"B48","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.1038\/mi.2015.24","article-title":"Immunization with Ty21a live oral typhoid vaccine elicits crossreactive multifunctional CD8+ T-cell responses against Salmonella enterica serovar Typhi, S. Paratyphi A, and S. Paratyphi B in humans","volume":"8","author":"Wahid","year":"2015","journal-title":"Mucosal Immunol"},{"key":"B49","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.4269\/ajtmh.13-0261","article-title":"Cellular and cytokine responses to Salmonella enterica serotype Typhi proteins in patients with typhoid fever in Bangladesh","volume":"90","author":"Bhuiyan","year":"2014","journal-title":"Am J Trop Med Hyg"},{"key":"B50","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1038\/ni.1890","article-title":"Antimicrobial activity of mucosal-associated invariant T cells","volume":"11","author":"Le Bourhis","year":"2010","journal-title":"Nat Immunol"},{"key":"B51","doi-asserted-by":"publisher","first-page":"511","DOI":"10.3389\/fimmu.2013.00511","article-title":"B cells modulate mucosal associated invariant T cell immune responses","volume":"4","author":"Salerno-Goncalves","year":"2014","journal-title":"Front Immunol"},{"key":"B52","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1016\/j.immuni.2014.12.007","article-title":"Tissue-resident memory T cells","volume":"41","author":"Schenkel","year":"2014","journal-title":"Immunity"},{"key":"B53","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1038\/35101614","article-title":"Complete genome sequence of Salmonella enterica serovar Typhimurium LT2","volume":"413","author":"McClelland","year":"2001","journal-title":"Nature"},{"key":"B54","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1128\/CVI.00058-12","article-title":"Live oral typhoid vaccine Ty21a induces cross-reactive humoral immune responses against Salmonella enterica serovar Paratyphi A and S. Paratyphi B in humans","volume":"19","author":"Wahid","year":"2012","journal-title":"Clin Vaccine Immunol"},{"key":"B55","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.cell.2014.03.011","article-title":"Role of the microbiota in immunity and inflammation","volume":"157","author":"Belkaid","year":"2014","journal-title":"Cell"},{"key":"B56","doi-asserted-by":"publisher","first-page":"e62026","DOI":"10.1371\/journal.pone.0062026","article-title":"Impact of oral typhoid vaccination on the human gut microbiota and correlations with S. Typhi-specific immunological responses","volume":"8","author":"Eloe-Fadrosh","year":"2013","journal-title":"PLoS One"},{"key":"B57","doi-asserted-by":"publisher","first-page":"e1001190","DOI":"10.1371\/journal.ppat.1001190","article-title":"Should the human microbiome be considered when developing vaccines?","volume":"6","author":"Ferreira","year":"2010","journal-title":"PLoS Pathog"},{"issue":"12","key":"B58","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1038\/ng.3143","article-title":"Variation at HLA-DRB1 is associated with resistance to enteric fever","volume":"46","author":"Dunstan","year":"2014","journal-title":"Nat Genet"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2017.00208\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,23]],"date-time":"2024-06-23T07:18:24Z","timestamp":1719127104000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2017.00208\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,2]]},"references-count":58,"URL":"https:\/\/doi.org\/10.3389\/fimmu.2017.00208","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,2]]}}}