{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:45:12Z","timestamp":1790646312370,"version":"4.1.0"},"reference-count":85,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/100007637","name":"Departamento Administrativo de Ciencia, Tecnolog\u00eda e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["Grant # 111571249846"],"award-info":[{"award-number":["Grant # 111571249846"]}],"id":[{"id":"10.13039\/100007637","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005278","name":"Universidad de Antioquia","doi-asserted-by":"publisher","award":["CODI-Grant 91515"],"award-info":[{"award-number":["CODI-Grant 91515"]}],"id":[{"id":"10.13039\/501100005278","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2017.00261","type":"journal-article","created":{"date-parts":[[2017,3,14]],"date-time":"2017-03-14T23:42:31Z","timestamp":1489534951000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":109,"title":["Aspirin: The Mechanism of Action Revisited in the Context of Pregnancy Complications"],"prefix":"10.3389","volume":"8","author":[{"given":"Angela P.","family":"Cadavid","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2017,3,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"CD004659","DOI":"10.1002\/14651858.CD004659.pub2","article-title":"Antiplatelet agents for preventing pre-eclampsia and its complications","volume":"2","author":"Duley","year":"2007","journal-title":"Cochrane Database Syst Rev"},{"issue":"3","key":"B2","doi-asserted-by":"publisher","first-page":"e0116296","DOI":"10.1371\/journal.pone.0116296","article-title":"Risk threshold for starting low dose aspirin in pregnancy to prevent preeclampsia: an opportunity at a low cost","volume":"10","author":"Bartsch","year":"2015","journal-title":"PLoS One"},{"issue":"2","key":"B3","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.ajog.2016.09.076","article-title":"The role of aspirin dose on the prevention of preeclampsia and fetal growth restriction: systematic review and meta-analysis","volume":"216","author":"Roberge","year":"2017","journal-title":"Am J Obstet Gynecol"},{"issue":"4","key":"B4","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1067\/mob.2000.106754","article-title":"Does aspirin have a role in improving pregnancy outcome for women with the antiphospholipid syndrome? A randomized controlled trial","volume":"183","author":"Pattison","year":"2000","journal-title":"Am J Obstet Gynecol"},{"issue":"6","key":"B5","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1097\/00006250-200306000-00031","article-title":"Antiphospholipid syndrome: obstetric diagnosis, management, and controversies","volume":"101","author":"Branch","year":"2003","journal-title":"Obstet Gynecol"},{"key":"B6","first-page":"A90","article-title":"Potential use of aspirin triggered lipoxins in alterations of the gestation. Placenta","volume-title":"Abstracts for the V Latin American Symposium on Maternal-Fetal Interaction and Placenta and IV Latin American Symposium on Reproductive Immunology Meeting 2013","author":"Cadavid","year":"2013"},{"key":"B7","doi-asserted-by":"publisher","first-page":"89","DOI":"10.3389\/conf.fimmu.2015.05.00089","article-title":"Aspirin: the mechanism of action revisited in the context of pregnancy complications","volume":"5","author":"Cadavid","year":"2015","journal-title":"Front Immunol"},{"issue":"8 Suppl","key":"B8","doi-asserted-by":"publisher","first-page":"1520","DOI":"10.1902\/jop.2008.080231","article-title":"Controlling the resolution of acute inflammation: a new genus of dual anti-inflammatory and proresolving mediators","volume":"79","author":"Serhan","year":"2008","journal-title":"J Periodontol"},{"issue":"8","key":"B9","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1084\/jem.192.8.1197","article-title":"Novel functional sets of lipid-derived mediators with antiinflammatory actions generated from omega-3 fatty acids via cyclooxygenase 2-nonsteroidal antiinflammatory drugs and transcellular processing","volume":"192","author":"Serhan","year":"2000","journal-title":"J Exp Med"},{"key":"B10","volume-title":"Molecules that Changed the World","author":"Nicolaou","year":"2008"},{"key":"B11","volume-title":"Acetylsalicylic Acid","author":"Schr\u00f6r","year":"2010"},{"issue":"25","key":"B12","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1038\/newbio231232a0","article-title":"Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs","volume":"231","author":"Vane","year":"1971","journal-title":"Nat New Biol"},{"issue":"25","key":"B13","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1038\/newbio231235a0","article-title":"Aspirin selectively inhibits prostaglandin production in human platelets","volume":"231","author":"Smith","year":"1971","journal-title":"Nat New Biol"},{"issue":"15","key":"B14","doi-asserted-by":"publisher","first-page":"4399","DOI":"10.1093\/ije\/dym193","article-title":"Colorectal cancer risk, chronic illnesses, operations, and medications: case control results from the Melbourne Colorectal Cancer Study","volume":"48","author":"Kune","year":"1988","journal-title":"Cancer Res"},{"issue":"6618","key":"B15","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1136\/bmj.296.6618.320","article-title":"Secondary prevention of vascular disease by prolonged antiplatelet treatment. Antiplatelet Trialists\u2019 Collaboration","volume":"296","author":"Acheson","year":"1988","journal-title":"Br Med J (Clin Res Ed)"},{"issue":"6 Suppl A","key":"B16","first-page":"3A","article-title":"Randomized trial of intravenous streptokinase, oral aspirin, both, or neither among 17,187 cases of suspected acute myocardial infarction: ISIS-2. ISIS-2 (Second International Study of Infarct Survival) Collaborative Group","volume":"12","author":"Hunt","year":"1988","journal-title":"J Am Coll Cardiol"},{"issue":"8130","key":"B17","doi-asserted-by":"publisher","first-page":"1356","DOI":"10.1016\/S0140-6736(79)91996-2","article-title":"Effect of aspirin on incidence of pre-eclampsia","volume":"1","author":"Crandon","year":"1979","journal-title":"Lancet"},{"issue":"21","key":"B18","doi-asserted-by":"publisher","first-page":"9475","DOI":"10.1073\/pnas.92.21.9475","article-title":"Aspirin triggers previously undescribed bioactive eicosanoids by human endothelial cell-leukocyte interactions","volume":"92","author":"Claria","year":"1995","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"22","key":"B19","doi-asserted-by":"publisher","first-page":"18897","DOI":"10.1074\/jbc.M011147200","article-title":"Selective suppression of CCAAT\/enhancer-binding protein beta binding and cyclooxygenase-2 promoter activity by sodium salicylate in quiescent human fibroblasts","volume":"276","author":"Saunders","year":"2001","journal-title":"J Biol Chem"},{"issue":"4","key":"B20","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1016\/j.plipres.2013.08.003","article-title":"Interaction of nonsteroidal anti-inflammatory drugs with membranes: in vitro assessment and relevance for their biological actions","volume":"52","author":"Pereira-Leite","year":"2013","journal-title":"Prog Lipid Res"},{"key":"B21","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.taap.2015.12.005","article-title":"Small structural changes on a hydroquinone scaffold determine the complex I inhibition or uncoupling of tumoral oxidative phosphorylation","volume":"291","author":"Urra","year":"2016","journal-title":"Toxicol Appl Pharmacol"},{"issue":"6706","key":"B22","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1038\/23948","article-title":"The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta","volume":"396","author":"Yin","year":"1998","journal-title":"Nature"},{"issue":"1\u20132","key":"B23","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1023\/A:1006934612368","article-title":"Antioxidant properties of aspirin: characterization of the ability of aspirin to inhibit silica-induced lipid peroxidation, DNA damage, NF-kappaB activation, and TNF-alpha production","volume":"199","author":"Shi","year":"1999","journal-title":"Mol Cell Biochem"},{"issue":"8","key":"B24","doi-asserted-by":"publisher","first-page":"3073","DOI":"10.1073\/pnas.72.8.3073","article-title":"Acetylation of prostaglandin synthase by aspirin","volume":"72","author":"Roth","year":"1975","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"B25","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1038\/sj.bjp.0705907","article-title":"Aspirin induces nitric oxide release from vascular endothelium: a novel mechanism of action","volume":"143","author":"Taubert","year":"2004","journal-title":"Br J Pharmacol"},{"issue":"4","key":"B26","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1016\/S0006-291X(03)01504-3","article-title":"Heme oxygenase-1 induction may explain the antioxidant profile of aspirin","volume":"308","author":"Grosser","year":"2003","journal-title":"Biochem Biophys Res Commun"},{"issue":"3","key":"B27","doi-asserted-by":"publisher","first-page":"C507","DOI":"10.1152\/ajpcell.00230.2005","article-title":"New signaling routes for an old drug: lipoxin A4 might mediate heme oxygenase-1 induction by aspirin. Focus on \u201cNovel lipid mediator aspirin-triggered lipoxin A4 induces heme oxygenase-1 in endothelial cells\u201d","volume":"289","author":"Schroder","year":"2005","journal-title":"Am J Physiol Cell Physiol"},{"issue":"5149","key":"B28","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1038\/219068a0","article-title":"In vitro acetylation of plasma proteins, enzymes and DNA by aspirin","volume":"219","author":"Pinckard","year":"1968","journal-title":"Nature"},{"issue":"4","key":"B29","doi-asserted-by":"publisher","first-page":"533","DOI":"10.3892\/mmr_00000132","article-title":"Does aspirin acetylate multiple cellular proteins? (Review)","volume":"2","author":"Alfonso","year":"2009","journal-title":"Mol Med Rep"},{"issue":"10","key":"B30","doi-asserted-by":"publisher","first-page":"1400","DOI":"10.1161\/01.STR.23.10.1400","article-title":"Effects of low-to-high doses of aspirin on platelet aggregability and metabolites of thromboxane A2 and prostacyclin","volume":"23","author":"Tohgi","year":"1992","journal-title":"Stroke"},{"issue":"5","key":"B31","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.1097\/01.AOG.0000437382.03963.88","article-title":"Task force on hypertension in P. hypertension in pregnancy. Report of the American College of Obstetricians and Gynecologists\u2019 task force on hypertension in pregnancy","volume":"122","author":"American College of Obstetricians and Gynecologists","year":"2013","journal-title":"Obstet Gynecol"},{"issue":"5728","key":"B32","doi-asserted-by":"publisher","first-page":"1592","DOI":"10.1126\/science.1111726","article-title":"Latest advances in understanding preeclampsia","volume":"308","author":"Redman","year":"2005","journal-title":"Science"},{"issue":"4","key":"B33","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/0143-4004(91)90339-H","article-title":"Pre-eclampsia and the placenta","volume":"12","author":"Redman","year":"1991","journal-title":"Placenta"},{"key":"B34","doi-asserted-by":"publisher","first-page":"372","DOI":"10.3389\/fphys.2014.00372","article-title":"Endothelial dysfunction and preeclampsia: role of oxidative stress","volume":"5","author":"Sanchez-Aranguren","year":"2014","journal-title":"Front Physiol"},{"issue":"17","key":"B35","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1056\/NEJM199310213291701","article-title":"Prevention of preeclampsia with low-dose aspirin in healthy, nulliparous pregnant women","volume":"329","author":"Sibai","year":"1993","journal-title":"N Engl J Med"},{"issue":"8607","key":"B36","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/S0140-6736(88)92833-4","article-title":"Randomised trial of intravenous streptokinase, oral aspirin, both, or neither among 17,187 cases of suspected acute myocardial infarction: ISIS-2. ISIS-2 (Second International Study of Infarct Survival) Collaborative Group","volume":"2","author":"Beroyz","year":"1988","journal-title":"Lancet"},{"issue":"1","key":"B37","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1111\/j.1471-0528.2012.03493.x","article-title":"Aspirin in the prevention of pre-eclampsia in high-risk women: a randomised placebo-controlled PREDO Trial and a meta-analysis of randomised trials","volume":"120","author":"Villa","year":"2013","journal-title":"BJOG"},{"issue":"2","key":"B38","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.ajog.2016.10.016","article-title":"Antiplatelet therapy before or after 16 weeks\u2019 gestation for preventing preeclampsia: an individual participant data meta-analysis","volume":"216","author":"Meher","year":"2017","journal-title":"Am J Obstet Gynecol"},{"issue":"3","key":"B39","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1016\/j.ajog.2004.10.598","article-title":"Aspirin use during early pregnancy and the risk of congenital abnormalities: a population-based case-control study","volume":"192","author":"Norgard","year":"2005","journal-title":"Am J Obstet Gynecol"},{"issue":"2 Pt 1","key":"B40","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1097\/AOG.0b013e3181e9322a","article-title":"Prevention of preeclampsia and intrauterine growth restriction with aspirin started in early pregnancy: a meta-analysis","volume":"116","author":"Bujold","year":"2010","journal-title":"Obstet Gynecol"},{"issue":"9937","key":"B41","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/S0140-6736(14)60157-4","article-title":"Preconception low-dose aspirin and pregnancy outcomes: results from the EAGeR randomised trial","volume":"384","author":"Schisterman","year":"2014","journal-title":"Lancet"},{"issue":"2","key":"B42","doi-asserted-by":"publisher","first-page":"141.e1","DOI":"10.1016\/j.ajog.2016.09.086","article-title":"Should we recommend universal aspirin for all pregnant women?","volume":"216","author":"Mone","year":"2017","journal-title":"Am J Obstet Gynecol"},{"issue":"2","key":"B43","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1111\/j.1538-7836.2006.01753.x","article-title":"International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS)","volume":"4","author":"Miyakis","year":"2006","journal-title":"J Thromb Haemost"},{"issue":"9","key":"B44","first-page":"1684","article-title":"Beta 2 glycoprotein I and placental anticoagulant protein I in placentae from patients with antiphospholipid syndrome","volume":"21","author":"La Rosa","year":"1994","journal-title":"J Rheumatol"},{"issue":"11","key":"B45","doi-asserted-by":"publisher","first-page":"1644","DOI":"10.1172\/JCI18817","article-title":"Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome","volume":"112","author":"Girardi","year":"2003","journal-title":"J Clin Invest"},{"issue":"1","key":"B46","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1080\/0891693031000067322","article-title":"The role of complement in pregnancy and fetal loss","volume":"36","author":"Girardi","year":"2003","journal-title":"Autoimmunity"},{"issue":"9","key":"B47","doi-asserted-by":"publisher","first-page":"2061","DOI":"10.1093\/humrep\/12.9.2061","article-title":"Heparin and low-dose aspirin restore placental human chorionic gonadotrophin secretion abolished by antiphospholipid antibody-containing sera","volume":"12","author":"Di Simone","year":"1997","journal-title":"Hum Reprod"},{"issue":"6","key":"B48","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1038\/nrrheum.2011.52","article-title":"Pathogenesis of antiphospholipid syndrome: understanding the antibodies","volume":"7","author":"Meroni","year":"2011","journal-title":"Nat Rev Rheumatol"},{"issue":"2","key":"B49","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1111\/j.1600-0897.2009.00717.x","article-title":"Antiphospholipid antibodies induce a pro-inflammatory response in first trimester trophoblast via the TLR4\/MyD88 pathway","volume":"62","author":"Mulla","year":"2009","journal-title":"Am J Reprod Immunol"},{"issue":"2","key":"B50","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1093\/humrep\/14.2.489","article-title":"Low-molecular weight heparin restores in-vitro trophoblast invasiveness and differentiation in presence of immunoglobulin G fractions obtained from patients with antiphospholipid syndrome","volume":"14","author":"Di Simone","year":"1999","journal-title":"Hum Reprod"},{"issue":"5","key":"B51","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1111\/j.1600-0897.2009.00805.x","article-title":"Antiphospholipid antibodies limit trophoblast migration by reducing IL-6 production and STAT3 activity","volume":"63","author":"Mulla","year":"2010","journal-title":"Am J Reprod Immunol"},{"issue":"9133","key":"B52","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1016\/S0140-6736(05)60080-3","article-title":"Action of anticardiolipin and antibodies to beta2-glycoprotein-I on trophoblast proliferation as a mechanism for fetal death","volume":"352","author":"Chamley","year":"1998","journal-title":"Lancet"},{"issue":"1","key":"B53","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.acthis.2008.07.001","article-title":"Effects of anti-phospholipid antibodies on a human trophoblast cell line (HTR-8\/SVneo)","volume":"112","author":"Jovanovic","year":"2010","journal-title":"Acta Histochem"},{"issue":"4","key":"B54","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1095\/biolreprod53.4.905","article-title":"Monoclonal antiphosphatidylserine antibody inhibits intercellular fusion of the choriocarcinoma line, JAR","volume":"53","author":"Adler","year":"1995","journal-title":"Biol Reprod"},{"issue":"8","key":"B55","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1016\/j.placenta.2005.09.007","article-title":"Aberrations of early trophoblast differentiation predispose to pregnancy failure: lessons from the anti-phospholipid syndrome","volume":"27","author":"Bose","year":"2006","journal-title":"Placenta"},{"issue":"1","key":"B56","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1095\/biolreprod56.1.50","article-title":"Monoclonal antibody against phosphatidylserine inhibits in vitro human trophoblastic hormone production and invasion","volume":"56","author":"Katsuragawa","year":"1997","journal-title":"Biol Reprod"},{"key":"B57","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1196\/annals.1422.054","article-title":"Pregnancies complicated with antiphospholipid syndrome: the pathogenic mechanism of antiphospholipid antibodies: a review of the literature","volume":"1108","author":"Di Simone","year":"2007","journal-title":"Ann N Y Acad Sci"},{"issue":"1\u20132","key":"B58","doi-asserted-by":"publisher","first-page":"e47","DOI":"10.1016\/j.ddmec.2011.12.002","article-title":"New insights into the molecular basis of the antiphospholipid syndrome","volume":"8","author":"Mineo","year":"2011","journal-title":"Drug Discov Today Dis Mech"},{"issue":"2","key":"B59","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1002\/art.38934","article-title":"Aspirin-triggered lipoxin prevents antiphospholipid antibody effects on human trophoblast migration and endothelial cell interactions","volume":"67","author":"Alvarez","year":"2015","journal-title":"Arthritis Rheumatol"},{"issue":"2","key":"B60","doi-asserted-by":"publisher","first-page":"279","DOI":"10.3899\/jrheum.080763","article-title":"Low molecular weight heparin and aspirin for recurrent pregnancy loss: results from the randomized, controlled HepASA Trial","volume":"36","author":"Laskin","year":"2009","journal-title":"J Rheumatol"},{"key":"B61","doi-asserted-by":"publisher","first-page":"CD002859","DOI":"10.1002\/14651858.CD002859.pub2","article-title":"Prevention of recurrent miscarriage for women with antiphospholipid antibody or lupus anticoagulant","volume":"2","author":"Empson","year":"2005","journal-title":"Cochrane Database Syst Rev"},{"issue":"4","key":"B62","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1007\/s11926-016-0566-z","article-title":"Emerging therapies in antiphospholipid syndrome","volume":"18","author":"Andrade","year":"2016","journal-title":"Curr Rheumatol Rep"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-016-8571-6","article-title":"Additional treatments for high-risk obstetric antiphospholipid syndrome: a comprehensive review","author":"Ruffatti","year":"2016","journal-title":"Clin Rev Allergy Immunol"},{"issue":"3","key":"B64","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1111\/j.1600-0897.1993.tb00581.x","article-title":"The effect of aspirin on recurrent fetal loss in experimental antiphospholipid syndrome","volume":"29","author":"Krause","year":"1993","journal-title":"Am J Reprod Immunol"},{"key":"B65","first-page":"465","article-title":"Coadjuvant effect of aspirin in the treatment of recurrent spontaneous abortion","volume":"35","author":"Cadavid","year":"1996","journal-title":"Am J Reprod Immunol"},{"issue":"4","key":"B66","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1111\/j.1600-0897.1999.tb00438.x","article-title":"Heparin plus aspirin as a \u201csingle\u201d therapy for recurrent spontaneous abortion associated with both allo- and autoimmunity","volume":"41","author":"Cadavid","year":"1999","journal-title":"Am J Reprod Immunol"},{"issue":"2","key":"B67","doi-asserted-by":"publisher","first-page":"91","DOI":"10.2174\/187152806776383125","article-title":"Lipoxin and synthetic lipoxin analogs: an overview of anti-inflammatory functions and new concepts in immunomodulation","volume":"5","author":"Parkinson","year":"2006","journal-title":"Inflamm Allergy Drug Targets"},{"issue":"4","key":"B68","doi-asserted-by":"publisher","first-page":"1663","DOI":"10.4049\/jimmunol.164.4.1663","article-title":"Cutting edge: lipoxins rapidly stimulate nonphlogistic phagocytosis of apoptotic neutrophils by monocyte-derived macrophages","volume":"164","author":"Godson","year":"2000","journal-title":"J Immunol"},{"issue":"1","key":"B69","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1160\/TH06-06-0315","article-title":"Aspirin-triggered lipoxin A4 blocks reactive oxygen species generation in endothelial cells: a novel antioxidative mechanism","volume":"97","author":"Nascimento-Silva","year":"2007","journal-title":"Thromb Haemost"},{"issue":"5","key":"B70","doi-asserted-by":"publisher","first-page":"2267","DOI":"10.4049\/jimmunol.164.5.2267","article-title":"Cutting edge: lipoxin (LX) A4 and aspirin-triggered 15-epi-LXA4 block allergen-induced eosinophil trafficking","volume":"164","author":"Bandeira-Melo","year":"2000","journal-title":"J Immunol"},{"issue":"3","key":"B71","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1124\/pr.58.3.4","article-title":"The lipoxin receptor ALX: potent ligand-specific and stereoselective actions in vivo","volume":"58","author":"Chiang","year":"2006","journal-title":"Pharmacol Rev"},{"issue":"14","key":"B72","doi-asserted-by":"publisher","first-page":"3877","DOI":"10.1096\/fj.07-8653com","article-title":"Lipoxin A4 stable analogs reduce allergic airway responses via mechanisms distinct from CysLT1 receptor antagonism","volume":"21","author":"Levy","year":"2007","journal-title":"FASEB J"},{"issue":"3\u20134","key":"B73","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.plefa.2005.05.007","article-title":"The role of aspirin-triggered lipoxins in the mechanism of action of aspirin","volume":"73","author":"Gilroy","year":"2005","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"issue":"3","key":"B74","doi-asserted-by":"publisher","first-page":"C557","DOI":"10.1152\/ajpcell.00045.2005","article-title":"Novel lipid mediator aspirin-triggered lipoxin A4 induces heme oxygenase-1 in endothelial cells","volume":"289","author":"Nascimento-Silva","year":"2005","journal-title":"Am J Physiol Cell Physiol"},{"issue":"1","key":"B75","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1097\/MJT.0b013e318164bd60","article-title":"Nitric oxide and aspirin: a new mediator for an old drug","volume":"16","author":"Schroder","year":"2009","journal-title":"Am J Ther"},{"issue":"2","key":"B76","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1530\/REP-11-0021","article-title":"A role for lipoxin A(4) as an anti-inflammatory mediator in the human endometrium","volume":"142","author":"Macdonald","year":"2011","journal-title":"Reproduction"},{"issue":"4\u20135","key":"B77","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.plefa.2012.08.003","article-title":"Aspirin triggered-lipoxin A4 reduces the adhesion of human polymorphonuclear neutrophils to endothelial cells initiated by preeclamptic plasma","volume":"87","author":"Gil-Villa","year":"2012","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"issue":"4","key":"B78","first-page":"162","article-title":"Omega-3 fatty acid supplementation during pregnancy","volume":"1","author":"Greenberg","year":"2008","journal-title":"Rev Obstet Gynecol"},{"issue":"2","key":"B79","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1530\/REP-14-0549","article-title":"Effects of maternal n-3 fatty acid supplementation on placental cytokines, pro-resolving lipid mediators and their precursors","volume":"149","author":"Keelan","year":"2015","journal-title":"Reproduction"},{"issue":"4","key":"B80","first-page":"163","article-title":"Omega-3 Fatty acids and pregnancy","volume":"3","author":"Coletta","year":"2010","journal-title":"Rev Obstet Gynecol"},{"key":"B81","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/1476-511X-12-16","article-title":"Modulating the inflammatory properties of activated microglia with docosahexaenoic acid and aspirin","volume":"12","author":"Pettit","year":"2013","journal-title":"Lipids Health Dis"},{"issue":"18","key":"B82","doi-asserted-by":"publisher","first-page":"2377","DOI":"10.2169\/internalmedicine.54.4623","article-title":"Aspirin and eicosapentaenoic acid may arrest progressive IgA nephropathy: a potential alternative to immunosuppression","volume":"54","author":"Hirahashi","year":"2015","journal-title":"Intern Med"},{"key":"B83","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.jnutbio.2016.05.012","article-title":"Addition of aspirin to a fish oil-rich diet decreases inflammation and atherosclerosis in ApoE-null mice","volume":"35","author":"Sorokin","year":"2016","journal-title":"J Nutr Biochem"},{"issue":"11","key":"B84","doi-asserted-by":"publisher","first-page":"2401","DOI":"10.1194\/jlr.M045583","article-title":"Short-term n-3 fatty acid supplementation but not aspirin increases plasma proresolving mediators of inflammation","volume":"55","author":"Barden","year":"2014","journal-title":"J Lipid Res"},{"issue":"1","key":"B85","doi-asserted-by":"publisher","first-page":"14","DOI":"10.4236\/wjcd.2012.21003","article-title":"The effects of EPA+DHA and aspirin on inflammatory cytokines and angiogenesis factors","volume":"2","author":"Block","year":"2012","journal-title":"World J Cardiovasc Dis"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2017.00261\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,25]],"date-time":"2017-06-25T08:37:58Z","timestamp":1498379878000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2017.00261\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,15]]},"references-count":85,"URL":"https:\/\/doi.org\/10.3389\/fimmu.2017.00261","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,15]]}}}