{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T15:26:04Z","timestamp":1775661964193,"version":"3.50.1"},"reference-count":73,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["280469"],"award-info":[{"award-number":["280469"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["AGL2014-54456-JIN"],"award-info":[{"award-number":["AGL2014-54456-JIN"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2017.00295","type":"journal-article","created":{"date-parts":[[2017,3,15]],"date-time":"2017-03-15T03:56:14Z","timestamp":1489550174000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":38,"title":["B Cell-Activating Factor Regulates Different Aspects of B Cell Functionality and Is Produced by a Subset of Splenic B Cells in Teleost Fish"],"prefix":"10.3389","volume":"8","author":[{"given":"Carolina","family":"Tafalla","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosario","family":"Castro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aitor G.","family":"Granja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2017,3,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.it.2011.02.004","article-title":"Innate control of B cell responses","volume":"32","author":"Cerutti","year":"2011","journal-title":"Trends Immunol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1038\/embor.2012.111","article-title":"Activation of B cells by non-canonical helper signals","volume":"13","author":"Cerutti","year":"2012","journal-title":"EMBO Rep"},{"key":"B3","doi-asserted-by":"publisher","first-page":"4464","DOI":"10.1182\/blood-2002-10-3123","article-title":"Macrophage- and dendritic cell-dependent regulation of human B-cell proliferation requires the TNF family ligand BAFF","volume":"101","author":"Craxton","year":"2003","journal-title":"Blood"},{"key":"B4","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1182\/blood-2004-02-0564","article-title":"Proinflammatory mediators elicit secretion of the intracellular B-lymphocyte stimulator pool (BLyS) that is stored in activated neutrophils: implications for inflammatory diseases","volume":"105","author":"Scapini","year":"2005","journal-title":"Blood"},{"key":"B5","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/S1074-7613(02)00398-9","article-title":"Dendritic cells, BAFF, and APRIL: innate players in adaptive antibody responses","volume":"17","author":"MacLennan","year":"2002","journal-title":"Immunity"},{"key":"B6","doi-asserted-by":"publisher","first-page":"547","DOI":"10.4049\/jimmunol.171.2.547","article-title":"Cutting edge: germinal centers formed in the absence of B cell-activating factor belonging to the TNF family exhibit impaired maturation and function","volume":"171","author":"Vora","year":"2003","journal-title":"J Immunol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1016\/j.coi.2005.04.005","article-title":"The role of APRIL and BAFF in lymphocyte activation","volume":"17","author":"Schneider","year":"2005","journal-title":"Curr Opin Immunol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1182\/blood.V97.1.198","article-title":"Synthesis and release of B-lymphocyte stimulator from myeloid cells","volume":"97","author":"Nardelli","year":"2001","journal-title":"Blood"},{"key":"B9","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1038\/35010115","article-title":"TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease","volume":"404","author":"Gross","year":"2000","journal-title":"Nature"},{"key":"B10","doi-asserted-by":"publisher","first-page":"2108","DOI":"10.1126\/science.1061965","article-title":"BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF","volume":"293","author":"Thompson","year":"2001","journal-title":"Science"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1747","DOI":"10.1084\/jem.189.11.1747","article-title":"BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth","volume":"189","author":"Schneider","year":"1999","journal-title":"J Exp Med"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1084\/jem.192.10.1453","article-title":"BAFF mediates survival of peripheral immature B lymphocytes","volume":"192","author":"Batten","year":"2000","journal-title":"J Exp Med"},{"key":"B13","doi-asserted-by":"publisher","first-page":"2331","DOI":"10.4049\/jimmunol.173.4.2331","article-title":"B cell-activating factor belonging to the TNF family acts through separate receptors to support B cell survival and T cell-independent antibody formation","volume":"173","author":"Shulga-Morskaya","year":"2004","journal-title":"J Immunol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.cytogfr.2008.04.006","article-title":"TACI, an enigmatic BAFF\/APRIL receptor, with new unappreciated biochemical and biological properties","volume":"19","author":"Mackay","year":"2008","journal-title":"Cytokine Growth Factor Rev"},{"key":"B15","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1016\/S1074-7613(01)00130-3","article-title":"Regulation of the T-independent humoral response by TACI","volume":"14","author":"von Bulow","year":"2001","journal-title":"Immunity"},{"key":"B16","doi-asserted-by":"publisher","first-page":"2282","DOI":"10.4049\/jimmunol.179.4.2282","article-title":"TACI is required for efficient plasma cell differentiation in response to T-independent type 2 antigens","volume":"179","author":"Mantchev","year":"2007","journal-title":"J Immunol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1084\/jem.20031330","article-title":"BCMA is essential for the survival of long-lived bone marrow plasma cells","volume":"199","author":"O\u2019Connor","year":"2004","journal-title":"J Exp Med"},{"key":"B18","doi-asserted-by":"publisher","first-page":"2814","DOI":"10.4049\/jimmunol.175.5.2814","article-title":"B cell maturation antigen, the receptor for a proliferation-inducing ligand and B cell-activating factor of the TNF family, induces antigen presentation in B cells","volume":"175","author":"Yang","year":"2005","journal-title":"J Immunol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1182\/blood-2007-09-110874","article-title":"TACI, unlike BAFF-R, is solely activated by oligomeric BAFF and APRIL to support survival of activated B cells and plasmabflasts","volume":"111","author":"Bossen","year":"2008","journal-title":"Blood"},{"key":"B20","doi-asserted-by":"publisher","first-page":"7955","DOI":"10.4049\/jimmunol.178.12.7955","article-title":"Early diversification of the TNF superfamily in teleosts: genomic characterization and expression analysis","volume":"178","author":"Glenney","year":"2007","journal-title":"J Immunol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.fsi.2010.03.006","article-title":"Molecular cloning, functional characterization and phylogenetic analysis of B-cell activating factor in zebrafish (Danio rerio)","volume":"29","author":"Liang","year":"2010","journal-title":"Fish Shellfish Immunol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1016\/j.fsi.2011.03.020","article-title":"Molecular structure, expression and bioactivity characterization of TNF13B (BAFF) gene in mefugu, Takifugu obscurus","volume":"30","author":"Ai","year":"2011","journal-title":"Fish Shellfish Immunol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.intimp.2011.10.009","article-title":"Molecular cloning, expression and functional analysis of TNF13b (BAFF) in Japanese sea perch, Lateolabrax japonicus","volume":"12","author":"Cui","year":"2012","journal-title":"Int Immunopharmacol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1016\/j.dci.2013.01.004","article-title":"Identification of TNF13b (BAFF) gene from grass carp (Ctenopharyngodon idella) and its immune response to bacteria and virus","volume":"39","author":"Pandit","year":"2013","journal-title":"Dev Comp Immunol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.molimm.2014.01.005","article-title":"Molecular cloning, expression and functional analysis of B-cell activating factor (BAFF) in yellow grouper, Epinephelus awoara","volume":"59","author":"Xiao","year":"2014","journal-title":"Mol Immunol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.fsi.2014.12.022","article-title":"Comparative genomic of the BAFF and BAFF-like genes and immune response to bacteria of miiuy croaker (Miichthys miiuy)","volume":"43","author":"Meng","year":"2015","journal-title":"Fish Shellfish Immunol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"e0136015","DOI":"10.1371\/journal.pone.0136015","article-title":"CsBAFF, a teleost B cell activating factor, promotes pathogen-induced innate immunity and vaccine-induced adaptive immunity","volume":"10","author":"Sun","year":"2015","journal-title":"PLoS One"},{"key":"B28","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/j.fsi.2016.02.026","article-title":"Molecular structure, distribution, and immunology function of TNFSF13B (BAFF) in Nile tilapia (Oreochromis niloticus)","volume":"51","author":"Liu","year":"2016","journal-title":"Fish Shellfish Immunol"},{"key":"B29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.dci.2015.10.004","article-title":"Molecular characterization and expression analysis of B cell activating factor from rock bream (Oplegnathus fasciatus)","volume":"55","author":"Godahewa","year":"2016","journal-title":"Dev Comp Immunol"},{"key":"B30","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1016\/j.fsi.2011.09.013","article-title":"The first BAFF gene cloned from the cartilaginous fish","volume":"31","author":"Ren","year":"2011","journal-title":"Fish Shellfish Immunol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1016\/j.dci.2011.11.010","article-title":"Characterisation and expression analysis of B-cell activating factor (BAFF) in spiny dogfish (Squalus acanthias): cartilaginous fish BAFF has a unique extra exon that may impact receptor binding","volume":"36","author":"Li","year":"2012","journal-title":"Dev Comp Immunol"},{"key":"B32","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/j.fsi.2015.09.033","article-title":"Characterisation of the TNF superfamily members CD40L and BAFF in the small-spotted catshark (Scyliorhinus canicula)","volume":"47","author":"Li","year":"2015","journal-title":"Fish Shellfish Immunol"},{"key":"B33","first-page":"761","article-title":"The relevance of cell microenvironments for the appearance of lympho-haemopoietic tissues in primitive vertebrates","volume":"10","author":"Zapata","year":"1995","journal-title":"Histol Histopathol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"1346","DOI":"10.1016\/j.dci.2011.11.009","article-title":"Mucosal immunoglobulins and B cells of teleost fish","volume":"35","author":"Salinas","year":"2011","journal-title":"Dev Comp Immunol"},{"key":"B35","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1038\/ni.1913","article-title":"IgT, a primitive immunoglobulin class specialized in mucosal immunity","volume":"11","author":"Zhang","year":"2010","journal-title":"Nat Immunol"},{"key":"B36","doi-asserted-by":"publisher","first-page":"13097","DOI":"10.1073\/pnas.1304319110","article-title":"Teleost skin, an ancient mucosal surface that elicits gut-like immune responses","volume":"110","author":"Xu","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B37","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1038\/ni1389","article-title":"B lymphocytes from early vertebrates have potent phagocytic and microbicidal abilities","volume":"7","author":"Li","year":"2006","journal-title":"Nat Immunol"},{"key":"B38","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1189\/jlb.0711372","article-title":"Pivotal advance: peritoneal cavity B-1 B cells have phagocytic and microbicidal capacities and present phagocytosed antigen to CD4+ T cells","volume":"91","author":"Parra","year":"2012","journal-title":"J Leukoc Biol"},{"key":"B39","doi-asserted-by":"publisher","first-page":"e82737","DOI":"10.1371\/journal.pone.0082737","article-title":"Transcriptional heterogeneity of IgM+ cells in rainbow trout (Oncorhynchus mykiss) tissues","volume":"8","author":"Abos","year":"2013","journal-title":"PLoS One"},{"key":"B40","doi-asserted-by":"publisher","first-page":"1768","DOI":"10.1128\/JVI.03080-14","article-title":"Early activation of teleost B cells in response to rhabdovirus infection","volume":"89","author":"Abos","year":"2015","journal-title":"J Virol"},{"key":"B41","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.dci.2015.03.002","article-title":"Molecular characterization of CD9 and CD63, two tetraspanin family members expressed in trout B lymphocytes","volume":"51","author":"Castro","year":"2015","journal-title":"Dev Comp Immunol"},{"key":"B42","doi-asserted-by":"publisher","first-page":"Unit 1016","DOI":"10.1002\/0471142727.mb1016s48","article-title":"Immunoprecipitation","volume":"10","author":"Bonifacino","year":"2001","journal-title":"Curr Protoc Mol Biol"},{"key":"B43","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.4049\/jimmunol.1302471","article-title":"CCR7 is mainly expressed in teleost gills, where it defines an IgD+IgM- B lymphocyte subset","volume":"192","author":"Castro","year":"2014","journal-title":"J Immunol"},{"key":"B44","doi-asserted-by":"publisher","first-page":"1825","DOI":"10.4049\/jimmunol.1500322","article-title":"Identification of teleost skin CD8alpha+ dendritic-like cells, representing a potential common ancestor for mammalian cross-presenting dendritic cells","volume":"195","author":"Granja","year":"2015","journal-title":"J Immunol"},{"key":"B45","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1242\/jeb.107.1.415","article-title":"Cardiac performance in the in situ perfused fish heart during extracellular acidosis: interactive effects of adrenaline","volume":"107","author":"Farrell","year":"1983","journal-title":"J Exp Biol"},{"key":"B46","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1007\/s11626-999-0005-9","article-title":"A stromal cell line from rainbow trout spleen, RTS34ST, that supports the growth of rainbow trout macrophages and produces conditioned medium with mitogenic effects on leukocytes","volume":"35","author":"Ganassin","year":"1999","journal-title":"In Vitro Cell Dev Biol Anim"},{"key":"B47","doi-asserted-by":"publisher","first-page":"962","DOI":"10.4049\/jimmunol.0802953","article-title":"Identification of a novel IL-1 cytokine family member in teleost fish","volume":"183","author":"Wang","year":"2009","journal-title":"J Immunol"},{"key":"B48","doi-asserted-by":"publisher","first-page":"5959","DOI":"10.4049\/jimmunol.1301584","article-title":"Two types of TNF-alpha exist in teleost fish: phylogeny, expression, and bioactivity analysis of type-II TNF-alpha3 in rainbow trout Oncorhynchus mykiss","volume":"191","author":"Hong","year":"2013","journal-title":"J Immunol"},{"key":"B49","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1038\/sj.emboj.7601556","article-title":"Novel regulation of MHC class II function in B cells","volume":"26","author":"Matsuki","year":"2007","journal-title":"EMBO J"},{"key":"B50","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1038\/nri844","article-title":"BAFF: a fundamental survival factor for B cells","volume":"2","author":"Mackay","year":"2002","journal-title":"Nat Rev Immunol"},{"key":"B51","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/S1359-6101(01)00025-9","article-title":"Mechanism of BLyS action in B cell immunity","volume":"13","author":"Do","year":"2002","journal-title":"Cytokine Growth Factor Rev"},{"key":"B52","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1084\/jem.20040973","article-title":"Plasma cell ontogeny defined by quantitative changes in blimp-1 expression","volume":"200","author":"Kallies","year":"2004","journal-title":"J Exp Med"},{"key":"B53","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1172\/JCI18025","article-title":"BAFF selectively enhances the survival of plasmablasts generated from human memory B cells","volume":"112","author":"Avery","year":"2003","journal-title":"J Clin Invest"},{"key":"B54","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1146\/annurev-immunol-020711-075032","article-title":"Germinal centers","volume":"30","author":"Victora","year":"2012","journal-title":"Annu Rev Immunol"},{"key":"B55","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1111\/j.1600-065X.2010.00940.x","article-title":"Plasma cell development and survival","volume":"237","author":"Oracki","year":"2010","journal-title":"Immunol Rev"},{"key":"B56","doi-asserted-by":"publisher","first-page":"7276","DOI":"10.4049\/jimmunol.179.11.7276","article-title":"Regulated expression of BAFF-binding receptors during human B cell differentiation","volume":"179","author":"Darce","year":"2007","journal-title":"J Immunol"},{"key":"B57","doi-asserted-by":"publisher","first-page":"4110","DOI":"10.1182\/blood-2012-09-459289","article-title":"A functional BCR in human IgA and IgM plasma cells","volume":"121","author":"Pinto","year":"2013","journal-title":"Blood"},{"key":"B58","doi-asserted-by":"publisher","first-page":"30004","DOI":"10.1038\/srep30004","article-title":"Distinct differentiation programs triggered by IL-6 and LPS in teleost IgM(+) B cells in the absence of germinal centers","volume":"6","author":"Abos","year":"2016","journal-title":"Sci Rep"},{"key":"B59","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1126\/science.285.5425.260","article-title":"BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator","volume":"285","author":"Moore","year":"1999","journal-title":"Science"},{"key":"B60","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1084\/jem.20021343","article-title":"G-CSF-stimulated neutrophils are a prominent source of functional BLyS","volume":"197","author":"Scapini","year":"2003","journal-title":"J Exp Med"},{"key":"B61","doi-asserted-by":"publisher","first-page":"3482","DOI":"10.4049\/jimmunol.0802317","article-title":"T-independent antibody responses to T-dependent antigens: a novel follicular dendritic cell-dependent activity","volume":"182","author":"El Shikh","year":"2009","journal-title":"J Immunol"},{"key":"B62","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.it.2010.03.002","article-title":"Activation of B cells by antigens on follicular dendritic cells","volume":"31","author":"El Shikh","year":"2010","journal-title":"Trends Immunol"},{"key":"B63","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1182\/blood-2003-02-0540","article-title":"Involvement of BAFF and APRIL in the resistance to apoptosis of B-CLL through an autocrine pathway","volume":"103","author":"Kern","year":"2004","journal-title":"Blood"},{"key":"B64","doi-asserted-by":"publisher","first-page":"3268","DOI":"10.4049\/jimmunol.172.8.5128-c","article-title":"Lymphoma B cells evade apoptosis through the TNF family members BAFF\/BLyS and APRIL","volume":"172","author":"He","year":"2004","journal-title":"J Immunol"},{"key":"B65","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1080\/03009740701286615","article-title":"Expression of BAFF and BAFF-R in the synovial tissue of patients with rheumatoid arthritis","volume":"36","author":"Nakajima","year":"2007","journal-title":"Scand J Rheumatol"},{"key":"B66","doi-asserted-by":"publisher","first-page":"2083","DOI":"10.1002\/art.24628","article-title":"Systemic activation of the immune system induces aberrant BAFF and APRIL expression in B cells in patients with systemic lupus erythematosus","volume":"60","author":"Chu","year":"2009","journal-title":"Arthritis Rheum"},{"key":"B67","doi-asserted-by":"publisher","first-page":"1134","DOI":"10.1002\/art.22458","article-title":"Aberrant expression of BAFF by B lymphocytes infiltrating the salivary glands of patients with primary Sjogren\u2019s syndrome","volume":"56","author":"Daridon","year":"2007","journal-title":"Arthritis Rheum"},{"key":"B68","doi-asserted-by":"publisher","first-page":"5947","DOI":"10.4049\/jimmunol.179.9.5947","article-title":"In vitro and in vivo activation induces BAFF and APRIL expression in B cells","volume":"179","author":"Chu","year":"2007","journal-title":"J Immunol"},{"key":"B69","doi-asserted-by":"publisher","first-page":"5527","DOI":"10.4049\/jimmunol.1000146","article-title":"Requirement for BAFF and APRIL during B cell development in GALT","volume":"184","author":"Yeramilli","year":"2010","journal-title":"J Immunol"},{"key":"B70","doi-asserted-by":"publisher","first-page":"2111","DOI":"10.1126\/science.1061964","article-title":"An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway","volume":"293","author":"Schiemann","year":"2001","journal-title":"Science"},{"key":"B71","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.cellimm.2006.02.005","article-title":"B cells as antigen presenting cells","volume":"238","author":"Rodriguez-Pinto","year":"2005","journal-title":"Cell Immunol"},{"key":"B72","doi-asserted-by":"publisher","first-page":"1697","DOI":"10.1084\/jem.190.11.1697","article-title":"Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations","volume":"190","author":"Mackay","year":"1999","journal-title":"J Exp Med"},{"key":"B73","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1038\/nri2572","article-title":"Cracking the BAFF code","volume":"9","author":"Mackay","year":"2009","journal-title":"Nat Rev Immunol"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2017.00295\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T05:37:30Z","timestamp":1658813850000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2017.00295\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,15]]},"references-count":73,"URL":"https:\/\/doi.org\/10.3389\/fimmu.2017.00295","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,15]]}}}