{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T01:23:36Z","timestamp":1792286616679,"version":"4.4.0"},"reference-count":20,"publisher":"Frontiers Media SA","content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2017.00343","type":"journal-article","created":{"date-parts":[[2017,3,23]],"date-time":"2017-03-23T00:11:19Z","timestamp":1490227879000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":13,"title":["Unexpected Cartilage Phenotype in CD4-Cre-Conditional SOS-Deficient Mice"],"prefix":"10.3389","volume":"8","author":[{"given":"Geoffrey","family":"Guittard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devorah L.","family":"Gallardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenmei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Melis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian C.","family":"Lui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert L.","family":"Kortum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas G.","family":"Shakarishvili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunmee","family":"Huh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Baron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Weigert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua A.","family":"Kramer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence E.","family":"Samelson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connie L.","family":"Sommers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2017,3,23]]},"reference":[{"issue":"3","key":"B1","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1177\/1947601911411084","article-title":"Ras in cancer and developmental diseases","volume":"2","author":"Fernandez-Medarde","year":"2011","journal-title":"Genes Cancer"},{"key":"B2","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.semcdb.2016.06.012","article-title":"The value of genomics in dissecting the RAS-network and in guiding therapeutics for RAS-driven cancers","volume":"58","author":"Shrestha","year":"2016","journal-title":"Semin Cell Dev Biol"},{"issue":"6","key":"B3","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.it.2013.02.004","article-title":"Ras and extracellular signal-regulated kinase signaling in thymocytes and T cells","volume":"34","author":"Kortum","year":"2013","journal-title":"Trends Immunol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"239","DOI":"10.3389\/fimmu.2013.00239","article-title":"Regulation of ras exchange factors and cellular localization of ras activation by lipid messengers in T cells","volume":"4","author":"Jun","year":"2013","journal-title":"Front Immunol"},{"issue":"3","key":"B5","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1101\/gad.11.3.309","article-title":"Mutation in Sos1 dominantly enhances a weak allele of the EGFR, demonstrating a requirement for Sos1 in EGFR signaling and development","volume":"11","author":"Wang","year":"1997","journal-title":"Genes Dev"},{"issue":"30","key":"B6","doi-asserted-by":"publisher","first-page":"12407","DOI":"10.1073\/pnas.1104295108","article-title":"Targeted Sos1 deletion reveals its critical role in early T-cell development","volume":"108","author":"Kortum","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"301","key":"B7","doi-asserted-by":"publisher","first-page":"ra99","DOI":"10.1126\/scisignal.2004494","article-title":"The ability of Sos1 to oligomerize the adaptor protein LAT is separable from its guanine nucleotide exchange activity in vivo","volume":"6","author":"Kortum","year":"2013","journal-title":"Sci Signal"},{"issue":"8","key":"B8","doi-asserted-by":"publisher","first-page":"2389","DOI":"10.1002\/eji.201445226","article-title":"Absence of both Sos-1 and Sos-2 in peripheral CD4(+) T cells leads to PI3K pathway activation and defects in migration","volume":"45","author":"Guittard","year":"2015","journal-title":"Eur J Immunol"},{"issue":"17","key":"B9","doi-asserted-by":"publisher","first-page":"6410","DOI":"10.1128\/MCB.20.17.6410-6413.2000","article-title":"Ras-guanine nucleotide exchange factor sos2 is dispensable for mouse growth and development","volume":"20","author":"Esteban","year":"2000","journal-title":"Mol Cell Biol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/978-1-4939-2809-5_3","article-title":"Genetic tools to study T cell development","volume":"1323","author":"Ciucci","year":"2016","journal-title":"Methods Mol Biol"},{"issue":"5","key":"B11","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1016\/S1074-7613(01)00227-8","article-title":"A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival","volume":"15","author":"Lee","year":"2001","journal-title":"Immunity"},{"key":"B12","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.jim.2016.06.005","article-title":"Chromosomal localisation of the CD4cre transgene in B6.Cg-Tg(Cd4-cre)1Cwi mice","volume":"436","author":"Westendorf","year":"2016","journal-title":"J Immunol Methods"},{"issue":"11","key":"B13","doi-asserted-by":"publisher","first-page":"1356","DOI":"10.1038\/nbt894","article-title":"Second-harmonic imaging microscopy for visualizing biomolecular arrays in cells, tissues and organisms","volume":"21","author":"Campagnola","year":"2003","journal-title":"Nat Biotechnol"},{"issue":"1","key":"B14","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1002\/humu.21636","article-title":"Sixteen years and counting: the current understanding of fibroblast growth factor receptor 3 (FGFR3) signaling in skeletal dysplasias","volume":"33","author":"Foldynova-Trantirkova","year":"2012","journal-title":"Hum Mutat"},{"issue":"6","key":"B15","doi-asserted-by":"publisher","first-page":"e1005214","DOI":"10.1371\/journal.pgen.1005214","article-title":"FGFR3 deficiency causes multiple chondroma-like lesions by upregulating hedgehog signaling","volume":"11","author":"Zhou","year":"2015","journal-title":"PLoS Genet"},{"issue":"3","key":"B16","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1101\/gad.1179104","article-title":"Constitutive activation of MEK1 in chondrocytes causes Stat1-independent achondroplasia-like dwarfism and rescues the Fgfr3-deficient mouse phenotype","volume":"18","author":"Murakami","year":"2004","journal-title":"Genes Dev"},{"issue":"3","key":"B17","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1002\/jor.21262","article-title":"Genetic inactivation of ERK1 and ERK2 in chondrocytes promotes bone growth and enlarges the spinal canal","volume":"29","author":"Sebastian","year":"2011","journal-title":"J Orthop Res"},{"issue":"3","key":"B18","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.gde.2009.04.001","article-title":"The RASopathies: developmental syndromes of Ras\/MAPK pathway dysregulation","volume":"19","author":"Tidyman","year":"2009","journal-title":"Curr Opin Genet Dev"},{"issue":"8","key":"B19","doi-asserted-by":"publisher","first-page":"992","DOI":"10.1002\/humu.20748","article-title":"The RAS\/MAPK syndromes: novel roles of the RAS pathway in human genetic disorders","volume":"29","author":"Aoki","year":"2008","journal-title":"Hum Mutat"},{"issue":"9863","key":"B20","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/S0140-6736(12)61023-X","article-title":"Noonan syndrome","volume":"381","author":"Roberts","year":"2013","journal-title":"Lancet"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2017.00343\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,3,23]],"date-time":"2017-03-23T00:11:19Z","timestamp":1490227879000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2017.00343\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,23]]},"references-count":20,"URL":"https:\/\/doi.org\/10.3389\/fimmu.2017.00343","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,23]]}}}