{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T13:39:09Z","timestamp":1784036349152,"version":"3.55.0"},"reference-count":47,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DE 023207"],"award-info":[{"award-number":["DE 023207"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["DE 022597"],"award-info":[{"award-number":["DE 022597"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["FP7-HEALTH-F3-2012-306029"],"award-info":[{"award-number":["FP7-HEALTH-F3-2012-306029"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["2014\/12\/W\/NZ6\/00454, 2012\/04\/A\/NZ1\/00051"],"award-info":[{"award-number":["2014\/12\/W\/NZ6\/00454, 2012\/04\/A\/NZ1\/00051"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004569","name":"Ministerstwo Nauki i Szkolnictwa Wy\u017cszego","doi-asserted-by":"publisher","award":["2975\/7.PR\/13\/2014\/2"],"award-info":[{"award-number":["2975\/7.PR\/13\/2014\/2"]}],"id":[{"id":"10.13039\/501100004569","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2017.00353","type":"journal-article","created":{"date-parts":[[2017,3,29]],"date-time":"2017-03-29T03:34:33Z","timestamp":1490758473000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":16,"title":["Antimicrobial and Attractant Roles for Chemerin in the Oral Cavity during Inflammatory Gum Disease"],"prefix":"10.3389","volume":"8","author":[{"given":"Urszula","family":"Godlewska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Brzoza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aneta","family":"Sroka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawel","family":"Majewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Jentsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Eckert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigrun","family":"Eick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Potempa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian A.","family":"Zabel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Cichy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2017,3,29]]},"reference":[{"key":"B1","first-page":"1","article-title":"Chemerin regulation and role in host defense","volume":"3","author":"Zabel","year":"2014","journal-title":"Am J Clin Exp Immunol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1084\/jem.20030382","article-title":"Specific recruitment of antigen-presenting cells by chemerin, a novel processed ligand from human inflammatory fluids","volume":"198","author":"Wittamer","year":"2003","journal-title":"J Exp Med"},{"key":"B3","doi-asserted-by":"publisher","first-page":"244","DOI":"10.4049\/jimmunol.174.1.244","article-title":"Chemokine-like receptor 1 expression and chemerin-directed chemotaxis distinguish plasmacytoid from myeloid dendritic cells in human blood","volume":"174","author":"Zabel","year":"2005","journal-title":"J Immunol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"34661","DOI":"10.1074\/jbc.M504868200","article-title":"Chemerin activation by serine proteases of the coagulation, fibrinolytic, and inflammatory cascades","volume":"280","author":"Zabel","year":"2005","journal-title":"J Biol Chem"},{"key":"B5","doi-asserted-by":"publisher","first-page":"3713","DOI":"10.4049\/jimmunol.178.6.3713","article-title":"Staphylococcus aureus-derived staphopain B, a potent cysteine protease activator of plasma chemerin","volume":"178","author":"Kulig","year":"2007","journal-title":"J Immunol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.4049\/jimmunol.1002352","article-title":"Regulation of chemerin chemoattractant and antibacterial activity by human cysteine cathepsins","volume":"187","author":"Kulig","year":"2011","journal-title":"J Immunol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1084\/jem.20080129","article-title":"Chemerin expression marks early psoriatic skin lesions and correlates with plasmacytoid dendritic cell recruitment","volume":"206","author":"Albanesi","year":"2009","journal-title":"J Exp Med"},{"key":"B8","doi-asserted-by":"publisher","first-page":"6489","DOI":"10.4049\/jimmunol.0901037","article-title":"Mouse ChemR23 is expressed in dendritic cell subsets and macrophages, and mediates an anti-inflammatory activity of chemerin in a lung disease model","volume":"183","author":"Luangsay","year":"2009","journal-title":"J Immunol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"e58709","DOI":"10.1371\/journal.pone.0058709","article-title":"Chemerin is an antimicrobial agent in human epidermis","volume":"8","author":"Banas","year":"2013","journal-title":"PLoS One"},{"key":"B10","doi-asserted-by":"publisher","first-page":"e0117830","DOI":"10.1371\/journal.pone.0117830","article-title":"The expression and regulation of chemerin in the epidermis","volume":"10","author":"Banas","year":"2015","journal-title":"PLoS One"},{"key":"B11","doi-asserted-by":"publisher","first-page":"G1","DOI":"10.1152\/ajpgi.90730.2008","article-title":"Epithelial cells in fetal intestine produce chemerin to recruit macrophages","volume":"297","author":"Maheshwari","year":"2009","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"5457","DOI":"10.4049\/jimmunol.1003862","article-title":"The role of ChemR23 in the induction and resolution of cigarette smoke-induced inflammation","volume":"186","author":"Demoor","year":"2011","journal-title":"J Immunol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1007\/s00784-014-1308-0","article-title":"Evaluation of the salivary levels of visfatin, chemerin, and progranulin in periodontal inflammation","volume":"19","author":"Ozcan","year":"2015","journal-title":"Clin Oral Investig"},{"key":"B14","doi-asserted-by":"publisher","first-page":"e12181","DOI":"10.1111\/jicd.12181","article-title":"Human chemerin correlation in gingival crevicular fluid and tear fluid as markers of inflammation in chronic periodontitis and type-2 diabetes mellitus","volume":"8","author":"Patnaik","year":"2017","journal-title":"J Investig Clin Dent"},{"key":"B15","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1111\/j.2041-1014.2012.00663.x","article-title":"Beyond the red complex and into more complexity: the polymicrobial synergy and dysbiosis (PSD) model of periodontal disease etiology","volume":"27","author":"Hajishengallis","year":"2012","journal-title":"Mol Oral Microbiol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1177\/0022034514528212","article-title":"The role of oral pathobionts in dysbiosis during periodontitis development","volume":"93","author":"Jiao","year":"2014","journal-title":"J Dent Res"},{"key":"B17","doi-asserted-by":"publisher","first-page":"5002","DOI":"10.1128\/JB.00542-10","article-title":"The human oral microbiome","volume":"192","author":"Dewhirst","year":"2010","journal-title":"J Bacteriol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"3077","DOI":"10.1111\/j.1462-2920.2011.02573.x","article-title":"Beyond the oral microbiome","volume":"13","author":"Jenkinson","year":"2011","journal-title":"Environ Microbiol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1111\/j.1600-051X.1998.tb02419.x","article-title":"Microbial complexes in subgingival plaque","volume":"25","author":"Socransky","year":"1998","journal-title":"J Clin Periodontol"},{"key":"B20","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1128\/MMBR.66.3.486-505.2002","article-title":"Communication among oral bacteria","volume":"66","author":"Kolenbrander","year":"2002","journal-title":"Microbiol Mol Biol Rev"},{"key":"B21","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1111\/j.1399-302X.2004.00175.x","article-title":"Synergy between Tannerella forsythia and Fusobacterium nucleatum in biofilm formation","volume":"20","author":"Sharma","year":"2005","journal-title":"Oral Microbiol Immunol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1177\/0022034511399096","article-title":"Stick to your gums: mechanisms of oral microbial adherence","volume":"90","author":"Nobbs","year":"2011","journal-title":"J Dent Res"},{"key":"B23","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1093\/jac\/dki103","article-title":"Antimicrobial peptides in the oral environment: expression and function in health and disease","volume":"7","author":"Dale","year":"2005","journal-title":"Curr Issues Mol Biol"},{"issue":"Suppl 11","key":"B24","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1111\/j.1600-051X.2010.01664.x","article-title":"Antimicrobial peptides and periodontal disease","volume":"38","author":"Gorr","year":"2011","journal-title":"J Clin Periodontol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1159\/000329673","article-title":"Antimicrobial peptides in periodontal innate defense","volume":"15","author":"Gorr","year":"2012","journal-title":"Front Oral Biol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.cytogfr.2015.12.001","article-title":"Secretory leukocyte protease inhibitor (SLPI), a multifunctional protein in the host defense response","volume":"28","author":"Majchrzak-Gorecka","year":"2016","journal-title":"Cytokine Growth Factor Rev"},{"key":"B27","doi-asserted-by":"publisher","first-page":"261","DOI":"10.3389\/fimmu.2016.00261","article-title":"Inhibitors of serine proteases in regulating the production and function of neutrophil extracellular traps","volume":"7","author":"Majewski","year":"2016","journal-title":"Front Immunol"},{"key":"B28","doi-asserted-by":"publisher","first-page":"463","DOI":"10.2144\/000113418","article-title":"Overlap extension PCR cloning: a simple and reliable way to create recombinant plasmids","volume":"48","author":"Bryksin","year":"2010","journal-title":"Biotechniques"},{"key":"B29","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1189\/jlb.4AB1114-543R","article-title":"The inhibitory effect of secretory leukocyte protease inhibitor (SLPI) on formation of neutrophil extracellular traps","volume":"98","author":"Zabieglo","year":"2015","journal-title":"J Leukoc Biol"},{"key":"B30","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1902\/jop.2011.100565","article-title":"Comparison of gingival crevicular fluid sampling methods in patients with severe chronic periodontitis","volume":"82","author":"Guentsch","year":"2011","journal-title":"J Periodontol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.diagmicrobio.2010.08.017","article-title":"Comparison of real-time polymerase chain reaction and DNA-strip technology in microbiological evaluation of periodontitis treatment","volume":"69","author":"Eick","year":"2011","journal-title":"Diagn Microbiol Infect Dis"},{"key":"B32","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1111\/omi.12015","article-title":"Benzamidine derivatives inhibit the virulence of Porphyromonas gingivalis","volume":"28","author":"Frohlich","year":"2013","journal-title":"Mol Oral Microbiol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/j.ab.2010.06.029","article-title":"Identification of suitable reference genes for measurement of gene expression in human cervical tissues","volume":"405","author":"Shen","year":"2010","journal-title":"Anal Biochem"},{"key":"B34","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"B35","doi-asserted-by":"publisher","first-page":"888","DOI":"10.1093\/jac\/dki103","article-title":"Susceptibilities of periodontopathogenic and cariogenic bacteria to antibacterial peptides, {beta}-defensins and LL37, produced by human epithelial cells","volume":"55","author":"Ouhara","year":"2005","journal-title":"J Antimicrob Chemother"},{"key":"B36","doi-asserted-by":"publisher","first-page":"1599","DOI":"10.1124\/mol.104.004366","article-title":"Suppression of pathogenicity of Porphyromonas gingivalis by newly developed gingipain inhibitors","volume":"66","author":"Kadowaki","year":"2004","journal-title":"Mol Pharmacol"},{"key":"B37","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1034\/j.1600-0765.2001.360205.x","article-title":"Costimulatory molecules in human periodontal disease tissues","volume":"36","author":"Gemmell","year":"2001","journal-title":"J Periodontal Res"},{"issue":"Suppl 6","key":"B38","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1111\/j.1600-051X.2005.00820.x","article-title":"Aspects of adaptive host response in periodontitis","volume":"32","author":"Berglundh","year":"2005","journal-title":"J Clin Periodontol"},{"issue":"64","key":"B39","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1111\/prd.12002","article-title":"Inflammatory and immune pathways in the pathogenesis of periodontal disease","volume":"2000","author":"Cekici","year":"2014","journal-title":"Periodontol"},{"issue":"69","key":"B40","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1111\/prd.12092","article-title":"The role of natural killer cells in periodontitis","volume":"2000","author":"Wilensky","year":"2015","journal-title":"Periodontol"},{"key":"B41","doi-asserted-by":"publisher","first-page":"e0158629","DOI":"10.1371\/journal.pone.0158629","article-title":"Unprimed, M1 and M2 macrophages differentially interact with Porphyromonas gingivalis","volume":"11","author":"Lam","year":"2016","journal-title":"PLoS One"},{"key":"B42","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1111\/j.1348-0421.2007.tb03936.x","article-title":"Identification of a Porphyromonas gingivalis novel protein sov required for the secretion of gingipains","volume":"51","author":"Saiki","year":"2007","journal-title":"Microbiol Immunol"},{"key":"B43","doi-asserted-by":"publisher","first-page":"1176","DOI":"10.1038\/ismej.2011.191","article-title":"Distinct and complex bacterial profiles in human periodontitis and health revealed by 16S pyrosequencing","volume":"6","author":"Griffen","year":"2012","journal-title":"ISME J"},{"key":"B44","doi-asserted-by":"publisher","first-page":"1843","DOI":"10.1038\/srep01843","article-title":"Metagenomic sequencing reveals microbiota and its functional potential associated with periodontal disease","volume":"3","author":"Wang","year":"2013","journal-title":"Sci Rep"},{"key":"B45","doi-asserted-by":"crossref","first-page":"2664","DOI":"10.1182\/blood.V96.8.2664","article-title":"Antimicrobial proteins and peptides of blood: templates for novel antimicrobial agents","volume":"96","author":"Levy","year":"2000","journal-title":"Blood"},{"key":"B46","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1359\/jbmr.091106","article-title":"Role of chemerin\/CMKLR1 signaling in adipogenesis and osteoblastogenesis of bone marrow stem cells","volume":"25","author":"Muruganandan","year":"2010","journal-title":"J Bone Miner Res"},{"issue":"52","key":"B47","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1111\/j.1600-0757.2009.00321.x","article-title":"Cytokine responses against periodontal infection: protective and destructive roles","volume":"2000","author":"Liu","year":"2010","journal-title":"Periodontol"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2017.00353\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,4]],"date-time":"2020-10-04T15:12:46Z","timestamp":1601824366000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2017.00353\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,29]]},"references-count":47,"URL":"https:\/\/doi.org\/10.3389\/fimmu.2017.00353","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,29]]}}}