{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T23:32:56Z","timestamp":1771457576013,"version":"3.50.1"},"reference-count":91,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2017.00390","type":"journal-article","created":{"date-parts":[[2017,4,10]],"date-time":"2017-04-10T23:42:50Z","timestamp":1491867770000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":32,"title":["Disarming Cellular Alarm Systems\u2014Manipulation of Stress-Induced NKG2D Ligands by Human Herpesviruses"],"prefix":"10.3389","volume":"8","author":[{"given":"Dominik","family":"Schmiedel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ofer","family":"Mandelboim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2017,4,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2356","DOI":"10.1093\/molbev\/msu185","article-title":"Evolutionary origins of human herpes simplex viruses 1 and 2","volume":"31","author":"Wertheim","year":"2014","journal-title":"Mol Biol Evol"},{"key":"B2","doi-asserted-by":"crossref","DOI":"10.1017\/CBO9780511545313","volume-title":"Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis","author":"Arvin","year":"2007"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3402\/jom.v5i0.22766","article-title":"Herpesviruses: latency and reactivation \u2013 viral strategies and host response","volume":"5","author":"Grinde","year":"2013","journal-title":"J Oral Microbiol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1056\/NEJM200008173430707","article-title":"Epstein-Barr virus infection","volume":"343","author":"Cohen","year":"2000","journal-title":"N Engl J Med"},{"issue":"Suppl 4","key":"B5","first-page":"S7","article-title":"The prevalence of varicella-zoster virus infection in normal healthy individuals aged above 6 months","volume":"88","author":"Kowitdamrong","year":"2005","journal-title":"J Med Assoc Thai"},{"key":"B6","doi-asserted-by":"crossref","DOI":"10.1017\/CBO9780511545313.037","article-title":"Persistence in the population: epidemiology, transmission","volume-title":"Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis","author":"Wald","year":"2007"},{"key":"B7","doi-asserted-by":"crossref","DOI":"10.1017\/CBO9780511545313.054","article-title":"The epidemiology of EBV and its association with malignant disease","volume-title":"Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis","author":"Hjalgrim","year":"2007"},{"key":"B8","doi-asserted-by":"crossref","DOI":"10.1017\/CBO9780511545313.050","article-title":"HHV-6A, 6B, and 7: persistence in the population, epidemiology and transmission","volume-title":"Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis","author":"Emery","year":"2007"},{"key":"B9","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1046\/j.1365-3156.1998.00316.x","article-title":"Review of varicella zoster seroepidemiology in India and Southeast Asia","volume":"3","author":"Lee","year":"1998","journal-title":"Trop Med Int Health"},{"key":"B10","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/S0264-410X(01)00276-6","article-title":"Seroprevalence of varicella-zoster virus in the German population","volume":"20","author":"Wutzler","year":"2001","journal-title":"Vaccine"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.1038\/modpathol.2011.62","article-title":"Geographic variation in the prevalence of Epstein-Barr virus-positive diffuse large B-cell lymphoma of the elderly: a comparative analysis of a Mexican and a German population","volume":"24","author":"Hofscheier","year":"2011","journal-title":"Mod Pathol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1286","DOI":"10.1093\/infdis\/jit321","article-title":"Age-specific prevalence of Epstein-Barr virus infection among individuals aged 6-19 years in the United States and factors affecting its acquisition","volume":"208","author":"Balfour","year":"2013","journal-title":"J Infect Dis"},{"key":"B13","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1128\/CMR.00062-12","article-title":"The \u201csilent\u201d global burden of congenital cytomegalovirus","volume":"26","author":"Manicklal","year":"2013","journal-title":"Clin Microbiol Rev"},{"key":"B14","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1111\/j.1365-2796.2010.02220.x","article-title":"Modulation of host innate and adaptive immune defenses by cytomegalovirus: timing is everything","volume":"267","author":"Loewendorf","year":"2010","journal-title":"J Intern Med"},{"key":"B15","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/2042-4280-3-5","article-title":"Herpes simplex virus and varicella zoster virus, the house guests who never leave","volume":"3","author":"Kinchington","year":"2012","journal-title":"Herpesviridae"},{"key":"B16","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1002\/rmv.1791","article-title":"Immune escape of gamma-herpesviruses from adaptive immunity","volume":"24","author":"Hu","year":"2014","journal-title":"Rev Med Virol"},{"key":"B17","doi-asserted-by":"crossref","DOI":"10.1017\/CBO9780511545313.049","article-title":"HHV-6A, 6B, and 7: immunobiology and host response","volume-title":"Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis","author":"Wang","year":"2007"},{"key":"B18","doi-asserted-by":"publisher","first-page":"e26097","DOI":"10.4161\/onci.26097","article-title":"New prospects on the NKG2D\/NKG2DL system for oncology","volume":"2","author":"Ullrich","year":"2013","journal-title":"Oncoimmunology"},{"key":"B19","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1016\/j.immuni.2008.02.016","article-title":"NKG2D-deficient mice are defective in tumor surveillance in models of spontaneous malignancy","volume":"28","author":"Guerra","year":"2008","journal-title":"Immunity"},{"key":"B20","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1016\/j.clim.2013.09.003","article-title":"A selective role of NKG2D in inflammatory and autoimmune diseases","volume":"149","author":"Guerra","year":"2013","journal-title":"Clin Immunol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"1545","DOI":"10.1016\/S1286-4579(02)00038-2","article-title":"Human natural killer cell deficiencies and susceptibility to infection","volume":"4","author":"Orange","year":"2002","journal-title":"Microbes Infect"},{"key":"B22","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1016\/j.jaci.2013.07.020","article-title":"Natural killer cell deficiency","volume":"132","author":"Orange","year":"2013","journal-title":"J Allergy Clin Immunol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1038\/nri1199","article-title":"Roles of the NKG2D immunoreceptor and its ligands","volume":"3","author":"Raulet","year":"2003","journal-title":"Nat Rev Immunol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"5944","DOI":"10.1038\/onc.2008.272","article-title":"NKG2D ligands in tumor immunity","volume":"27","author":"Nausch","year":"2008","journal-title":"Oncogene"},{"key":"B25","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/j.it.2008.04.007","article-title":"NKG2D ligands: key targets of the immune response","volume":"29","author":"Gonzalez","year":"2008","journal-title":"Trends Immunol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"12445","DOI":"10.1073\/pnas.93.22.12445","article-title":"Cell stress-regulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium","volume":"93","author":"Groh","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B27","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1146\/annurev.immunol.16.1.359","article-title":"NK cell receptors","volume":"16","author":"Lanier","year":"1998","journal-title":"Annu Rev Immunol"},{"key":"B28","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.immuni.2006.06.013","article-title":"Human NK cell education by inhibitory receptors for MHC class I","volume":"25","author":"Anfossi","year":"2006","journal-title":"Immunity"},{"key":"B29","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1038\/nri2144","article-title":"Promiscuity and the single receptor: NKG2D","volume":"7","author":"Eagle","year":"2007","journal-title":"Nat Rev Immunol"},{"key":"B30","doi-asserted-by":"publisher","first-page":"299","DOI":"10.3389\/fimmu.2012.00299","article-title":"Human NKG2D-ligands: cell biology strategies to ensure immune recognition","volume":"3","author":"Fernandez-Messina","year":"2012","journal-title":"Front Immunol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.molmed.2010.01.002","article-title":"MICA polymorphism: biology and importance in immunity and disease","volume":"16","author":"Choy","year":"2010","journal-title":"Trends Mol Med"},{"key":"B32","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/S1074-7613(01)00095-4","article-title":"ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor","volume":"14","author":"Cosman","year":"2001","journal-title":"Immunity"},{"key":"B33","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1038\/87757","article-title":"Complex structure of the activating immunoreceptor NKG2D and its MHC class I-like ligand MICA","volume":"2","author":"Li","year":"2001","journal-title":"Nat Immunol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.4049\/jimmunol.169.3.1395","article-title":"Structural studies of allelic diversity of the MHC class I homolog MIC-B, a stress-inducible ligand for the activating immunoreceptor NKG2D","volume":"169","author":"Holmes","year":"2002","journal-title":"J Immunol"},{"key":"B35","doi-asserted-by":"publisher","first-page":"4186","DOI":"10.1038\/ncomms5186","article-title":"RNA-binding proteins regulate the expression of the immune activating ligand MICB","volume":"5","author":"Nachmani","year":"2014","journal-title":"Nat Commun"},{"key":"B36","doi-asserted-by":"publisher","first-page":"e08474","DOI":"10.7554\/eLife.08474","article-title":"A forward genetic screen reveals novel independent regulators of ULBP1, an activating ligand for natural killer cells","volume":"4","author":"Gowen","year":"2015","journal-title":"Elife"},{"key":"B37","doi-asserted-by":"publisher","first-page":"e13426","DOI":"10.7554\/eLife.13426","article-title":"The RNA binding protein IMP3 facilitates tumor immune escape by downregulating the stress-induced ligands ULPB2 and MICB","volume":"5","author":"Schmiedel","year":"2016","journal-title":"Elife"},{"key":"B38","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1038\/ni.1642","article-title":"Human microRNAs regulate stress-induced immune responses mediated by the receptor NKG2D","volume":"9","author":"Stern-Ginossar","year":"2008","journal-title":"Nat Immunol"},{"key":"B39","doi-asserted-by":"publisher","first-page":"5463","DOI":"10.1158\/0008-5472.CAN-11-2671","article-title":"miR-10b downregulates the stress-induced cell surface molecule MICB, a critical ligand for cancer cell recognition by natural killer cells","volume":"72","author":"Tsukerman","year":"2012","journal-title":"Cancer Res"},{"key":"B40","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.1016\/S0140-6736(00)04638-9","article-title":"Herpes simplex virus infections","volume":"357","author":"Whitley","year":"2001","journal-title":"Lancet"},{"key":"B41","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.14219\/jada.archive.2002.0366","article-title":"Diagnosis and management of recurrent herpes simplex infections","volume":"133","author":"Siegel","year":"2002","journal-title":"J Am Dent Assoc"},{"key":"B42","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1111\/j.1365-3083.2009.02241.x","article-title":"Herpes simplex virus infection downmodulates NKG2D ligand expression","volume":"69","author":"Schepis","year":"2009","journal-title":"Scand J Immunol"},{"key":"B43","doi-asserted-by":"publisher","first-page":"7932","DOI":"10.1128\/JVI.00292-15","article-title":"Varicella-zoster virus and herpes simplex virus 1 differentially modulate NKG2D ligand expression during productive infection","volume":"89","author":"Campbell","year":"2015","journal-title":"J Virol"},{"key":"B44","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1016\/j.celrep.2016.09.077","article-title":"HSV1 microRNA modulation of GPI anchoring and downstream immune evasion","volume":"17","author":"Enk","year":"2016","journal-title":"Cell Rep"},{"key":"B45","doi-asserted-by":"publisher","first-page":"4088","DOI":"10.1093\/emboj\/20.15.4088","article-title":"PIG-S and PIG-T, essential for GPI anchor attachment to proteins, form a complex with GAA1 and GPI8","volume":"20","author":"Ohishi","year":"2001","journal-title":"EMBO J"},{"key":"B46","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1093\/jb\/mvn090","article-title":"Biosynthesis, remodelling and functions of mammalian GPI-anchored proteins: recent progress","volume":"144","author":"Kinoshita","year":"2008","journal-title":"J Biochem"},{"key":"B47","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1016\/S1474-4422(09)70134-6","article-title":"Varicella zoster virus vasculopathies: diverse clinical manifestations, laboratory features, pathogenesis, and treatment","volume":"8","author":"Gilden","year":"2009","journal-title":"Lancet Neurol"},{"key":"B48","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/j.ncl.2008.03.011","article-title":"Varicella zoster virus infection: clinical features, molecular pathogenesis of disease, and latency","volume":"26","author":"Mueller","year":"2008","journal-title":"Neurol Clin"},{"key":"B49","doi-asserted-by":"publisher","first-page":"45","DOI":"10.7326\/0003-4819-118-1-199301010-00009","article-title":"NIH conference. Epstein-Barr virus infections: biology, pathogenesis, and management","volume":"118","author":"Straus","year":"1993","journal-title":"Ann Intern Med"},{"key":"B50","first-page":"108","article-title":"Epstein-Barr virus-associated diseases in humans","volume":"71","author":"Kawa","year":"2000","journal-title":"Int J Hematol"},{"key":"B51","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1017\/S1462399407000312","article-title":"Nasopharyngeal carcinoma: molecular pathogenesis and therapeutic developments","volume":"9","author":"Tao","year":"2007","journal-title":"Expert Rev Mol Med"},{"key":"B52","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1128\/JVI.01777-06","article-title":"The switch from latent to productive infection in Epstein-Barr virus-infected B cells is associated with sensitization to NK cell killing","volume":"81","author":"Pappworth","year":"2007","journal-title":"J Virol"},{"key":"B53","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1016\/j.chom.2009.03.003","article-title":"Diverse herpesvirus microRNAs target the stress-induced immune ligand MICB to escape recognition by natural killer cells","volume":"5","author":"Nachmani","year":"2009","journal-title":"Cell Host Microbe"},{"key":"B54","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.imlet.2011.01.009","article-title":"IDO metabolite produced by EBV-transformed B cells inhibits surface expression of NKG2D in NK cells via the c-Jun N-terminal kinase (JNK) pathway","volume":"136","author":"Song","year":"2011","journal-title":"Immunol Lett"},{"key":"B55","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1002\/path.4437","article-title":"The pathogenesis of human cytomegalovirus","volume":"235","author":"Griffiths","year":"2015","journal-title":"J Pathol"},{"key":"B56","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1126\/science.1140956","article-title":"Host immune system gene targeting by a viral miRNA","volume":"317","author":"Stern-Ginossar","year":"2007","journal-title":"Science"},{"key":"B57","doi-asserted-by":"publisher","first-page":"1428","DOI":"10.1002\/1521-4141(200105)31:51428:AID-IMMU14283.0.CO;2-4","article-title":"ULBP1, 2, 3: novel MHC class I-related molecules that bind to human cytomegalovirus glycoprotein UL16, activate NK cells","volume":"31","author":"Kubin","year":"2001","journal-title":"Eur J Immunol"},{"key":"B58","doi-asserted-by":"publisher","first-page":"902","DOI":"10.4049\/jimmunol.171.2.902","article-title":"Effects of human cytomegalovirus infection on ligands for the activating NKG2D receptor of NK cells: up-regulation of UL16-binding protein (ULBP)1 and ULBP2 is counteracted by the viral UL16 protein","volume":"171","author":"Rolle","year":"2003","journal-title":"J Immunol"},{"key":"B59","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.1084\/jem.20022059","article-title":"Human cytomegalovirus glycoprotein UL16 causes intracellular sequestration of NKG2D ligands, protecting against natural killer cell cytotoxicity","volume":"197","author":"Dunn","year":"2003","journal-title":"J Exp Med"},{"key":"B60","doi-asserted-by":"publisher","first-page":"4196","DOI":"10.4049\/jimmunol.170.8.4196","article-title":"Intracellular retention of the MHC class I-related chain B ligand of NKG2D by the human cytomegalovirus UL16 glycoprotein","volume":"170","author":"Wu","year":"2003","journal-title":"J Immunol"},{"key":"B61","doi-asserted-by":"publisher","first-page":"3207","DOI":"10.1002\/eji.200939502","article-title":"ULBP6\/RAET1L is an additional human NKG2D ligand","volume":"39","author":"Eagle","year":"2009","journal-title":"Eur J Immunol"},{"key":"B62","doi-asserted-by":"publisher","first-page":"12345","DOI":"10.1128\/JVI.01175-09","article-title":"NKG2D ligand MICA is retained in the cis-Golgi apparatus by human cytomegalovirus protein UL142","volume":"83","author":"Ashiru","year":"2009","journal-title":"J Virol"},{"key":"B63","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.4049\/jimmunol.1000789","article-title":"Intracellular sequestration of the NKG2D ligand ULBP3 by human cytomegalovirus","volume":"185","author":"Bennett","year":"2010","journal-title":"J Immunol"},{"key":"B64","doi-asserted-by":"publisher","first-page":"e1004058","DOI":"10.1371\/journal.ppat.1004058","article-title":"Two novel human cytomegalovirus NK cell evasion functions target MICA for lysosomal degradation","volume":"10","author":"Fielding","year":"2014","journal-title":"PLoS Pathog"},{"key":"B65","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1016\/S0198-8859(01)00241-5","article-title":"Typing for all known MICA alleles by group-specific PCR and SSOP","volume":"62","author":"Zhang","year":"2001","journal-title":"Hum Immunol"},{"key":"B66","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1007\/s002510050655","article-title":"Population study of allelic diversity in the human MHC class I-related MIC-A gene","volume":"49","author":"Petersdorf","year":"1999","journal-title":"Immunogenetics"},{"key":"B67","doi-asserted-by":"publisher","first-page":"193","DOI":"10.3389\/fimmu.2015.00193","article-title":"The impact of glycosyl-phosphatidyl-inositol anchored MICA alleles on novel NKG2D-based therapies","volume":"6","author":"Vales-Gomez","year":"2015","journal-title":"Front Immunol"},{"key":"B68","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1016\/j.celrep.2015.01.029","article-title":"Dynamic co-evolution of host and pathogen: HCMV downregulates the prevalent allele MICA *008 to escape elimination by NK cells","volume":"10","author":"Seidel","year":"2015","journal-title":"Cell Rep"},{"key":"B69","doi-asserted-by":"crossref","DOI":"10.1017\/CBO9780511545313.048","article-title":"HHV-6A, 6B, and 7: molecular basis of latency and reactivation","volume-title":"Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis","author":"Kondo","year":"2007"},{"issue":"1","key":"B70","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s13365-016-0473-0","article-title":"Roseolovirus-associated encephalitis in immunocompetent and immunocompromised individuals","volume":"23","author":"Ongradi","year":"2017","journal-title":"J Neurovirol"},{"key":"B71","doi-asserted-by":"publisher","first-page":"9608","DOI":"10.1128\/JVI.01164-16","article-title":"Human herpesvirus 6B downregulates expression of activating ligands during lytic infection to escape elimination by natural killer cells","volume":"90","author":"Schmiedel","year":"2016","journal-title":"J Virol"},{"key":"B72","doi-asserted-by":"publisher","first-page":"e1002362","DOI":"10.1371\/journal.ppat.1002362","article-title":"The human herpesvirus-7 (HHV-7) U21 immunoevasin subverts NK-mediated cytoxicity through modulation of MICA and MICB","volume":"7","author":"Schneider","year":"2011","journal-title":"PLoS Pathog"},{"key":"B73","first-page":"222","article-title":"Kaposi\u2019s sarcoma-associated herpesvirus (KSHV\/HHV8): key aspects of epidemiology and pathogenesis","volume":"5","author":"Viejo-Borbolla","year":"2003","journal-title":"AIDS Rev"},{"key":"B74","doi-asserted-by":"publisher","first-page":"1186","DOI":"10.1056\/NEJM199505043321802","article-title":"Kaposi\u2019s sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas","volume":"332","author":"Cesarman","year":"1995","journal-title":"N Engl J Med"},{"key":"B75","doi-asserted-by":"publisher","first-page":"1656","DOI":"10.1073\/pnas.0707883105","article-title":"Down-regulation of NKG2D and NKp80 ligands by Kaposi\u2019s sarcoma-associated herpesvirus K5 protects against NK cell cytotoxicity","volume":"105","author":"Thomas","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B76","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1126\/science.1227919","article-title":"Decoding human cytomegalovirus","volume":"338","author":"Stern-Ginossar","year":"2012","journal-title":"Science"},{"key":"B77","doi-asserted-by":"publisher","first-page":"e1003847","DOI":"10.1371\/journal.ppat.1003847","article-title":"KSHV 2.0: a comprehensive annotation of the Kaposi\u2019s sarcoma-associated herpesvirus genome using next-generation sequencing reveals novel genomic and functional features","volume":"10","author":"Arias","year":"2014","journal-title":"PLoS Pathog"},{"key":"B78","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1101\/gad.259077.115","article-title":"Viral noncoding RNAs: more surprises","volume":"29","author":"Tycowski","year":"2015","journal-title":"Genes Dev"},{"key":"B79","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.biomed.2013.01.001","article-title":"Long non-coding RNAs (lncRNAs) and viral infections","volume":"3","author":"Zhang","year":"2013","journal-title":"Biomed Pharmacother"},{"key":"B80","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1016\/j.molimm.2008.09.035","article-title":"Murine NKG2D ligands: \u201cdouble, double toil and trouble\u201d","volume":"46","author":"Samarakoon","year":"2009","journal-title":"Mol Immunol"},{"key":"B81","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1007\/s00251-014-0791-4","article-title":"High diversity of MIC genes in non-human primates","volume":"66","author":"Meyer","year":"2014","journal-title":"Immunogenetics"},{"key":"B82","doi-asserted-by":"publisher","first-page":"7708","DOI":"10.1073\/pnas.1230533100","article-title":"Comparative sequencing of human and chimpanzee MHC class I regions unveils insertions\/deletions as the major path to genomic divergence","volume":"100","author":"Anzai","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B83","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1093\/molbev\/msi127","article-title":"Reduced MIC gene repertoire variation in West African chimpanzees as compared to humans","volume":"22","author":"de Groot","year":"2005","journal-title":"Mol Biol Evol"},{"key":"B84","doi-asserted-by":"publisher","first-page":"3143","DOI":"10.4049\/jimmunol.177.5.3143","article-title":"Human cytomegalovirus-encoded UL16 discriminates MIC molecules by their alpha2 domains","volume":"177","author":"Spreu","year":"2006","journal-title":"J Immunol"},{"key":"B85","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1007\/s12275-013-2514-1","article-title":"Allelic MHC class I chain related B (MICB) molecules affect the binding to the human cytomegalovirus (HCMV) unique long 16 (UL16) protein: implications for immune surveillance","volume":"51","author":"Klumkrathok","year":"2013","journal-title":"J Microbiol"},{"key":"B86","doi-asserted-by":"publisher","first-page":"E4120","DOI":"10.1073\/pnas.1501880112","article-title":"Limits and patterns of cytomegalovirus genomic diversity in humans","volume":"112","author":"Renzette","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B87","doi-asserted-by":"publisher","first-page":"7673","DOI":"10.1128\/JVI.00578-15","article-title":"High-throughput analysis of human cytomegalovirus genome diversity highlights the widespread occurrence of gene-disrupting mutations and pervasive recombination","volume":"89","author":"Sijmons","year":"2015","journal-title":"J Virol"},{"key":"B88","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1007\/s002510050658","article-title":"MIC-A polymorphism in Japanese and a MIC-A-MIC-B null haplotype","volume":"49","author":"Komatsu-Wakui","year":"1999","journal-title":"Immunogenetics"},{"key":"B89","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1034\/j.1399-0039.2000.560309.x","article-title":"On the MICA deleted-MICB null, HLA-B*4801 haplotype","volume":"56","author":"Ota","year":"2000","journal-title":"Tissue Antigens"},{"key":"B90","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1034\/j.1399-0039.2001.057001001.x","article-title":"Wide distribution of the MICA-MICB null haplotype in East Asians","volume":"57","author":"Komatsu-Wakui","year":"2001","journal-title":"Tissue Antigens"},{"key":"B91","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1007\/s00251-002-0485-1","article-title":"High frequency of MIC null haplotype (HLA-B48-MICA-del-MICB*0107 N) in the Angaite Amerindian community in Paraguay","volume":"54","author":"Aida","year":"2002","journal-title":"Immunogenetics"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2017.00390\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,25]],"date-time":"2017-06-25T10:36:49Z","timestamp":1498387009000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2017.00390\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,11]]},"references-count":91,"URL":"https:\/\/doi.org\/10.3389\/fimmu.2017.00390","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,11]]}}}