{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:05:06Z","timestamp":1790661906258,"version":"4.1.0"},"reference-count":69,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2013\/08216-2"],"award-info":[{"award-number":["2013\/08216-2"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005639","name":"Universidade de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["11.1.21625.01.0"],"award-info":[{"award-number":["11.1.21625.01.0"]}],"id":[{"id":"10.13039\/501100005639","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2017.00949","type":"journal-article","created":{"date-parts":[[2017,8,21]],"date-time":"2017-08-21T03:41:28Z","timestamp":1503286888000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":62,"title":["Th17-Inducing Cytokines IL-6 and IL-23 Are Crucial for Granuloma Formation during Experimental Paracoccidioidomycosis"],"prefix":"10.3389","volume":"8","author":[{"given":"Fabrine Sales Massafera","family":"Trist\u00e3o","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda Agostini","family":"Rocha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Carlos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nat\u00e1lia","family":"Ketelut-Carneiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila Oliveira Silva","family":"Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiane Maria","family":"Milanezi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Santana","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2017,8,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"509","DOI":"10.3389\/fphar.2016.00509","article-title":"Peptides derived from a phage display library inhibit adhesion and protect the host against infection by Paracoccidioides brasiliensis and Paracoccidioides lutzii","volume":"7","author":"de Oliveira","year":"2016","journal-title":"Front Pharmacol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.1590\/S0102-311X2002000500037","article-title":"Paracoccidioidomycosis mortality in Brazil (1980\u20131995)","volume":"18","author":"Coutinho","year":"2002","journal-title":"Cad Saude Publica"},{"key":"B3","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1016\/j.clindermatol.2012.01.006","article-title":"Paracoccidioidomycosis","volume":"30","author":"Marques","year":"2012","journal-title":"Clin Dermatol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1080\/02681218780000231","article-title":"Experimental murine paracoccidiodomycosis induced by the inhalation of conidia","volume":"25","author":"McEwen","year":"1987","journal-title":"J Med Vet Mycol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/S0923-2494(98)80764-5","article-title":"Immunity to Paracoccidioides brasiliensis infection","volume":"149","author":"Calich","year":"1998","journal-title":"Res Immunol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1007\/s11046-007-9048-1","article-title":"Innate immunity to Paracoccidioides brasiliensis infection","volume":"165","author":"Calich","year":"2008","journal-title":"Mycopathologia"},{"key":"B7","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1080\/mmy.40.2.153.159","article-title":"Enhanced production of specific IgG4, IgE, IgA and TGF-beta in sera from patients with the juvenile form of paracoccidioidomycosis","volume":"40","author":"Mamoni","year":"2002","journal-title":"Med Mycol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"2271","DOI":"10.1084\/jem.20061308","article-title":"Interleukin (IL)-22 and IL-17 are coexpressed by Th17\u2009cells and cooperatively enhance expression of antimicrobial peptides","volume":"203","author":"Liang","year":"2006","journal-title":"J Exp Med"},{"key":"B9","doi-asserted-by":"publisher","first-page":"651503","DOI":"10.1155\/2014\/651503","article-title":"Th17\u2009cells in autoimmune and infectious diseases","volume":"2014","author":"Zambrano-Zaragoza","year":"2014","journal-title":"Int J Inflam"},{"key":"B10","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1007\/s12026-007-8014-9","article-title":"Th17\u2009cells: a new fate for differentiating helper T cells","volume":"41","author":"Chen","year":"2008","journal-title":"Immunol Res"},{"key":"B11","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1016\/j.immuni.2009.02.007","article-title":"Critical regulation of early Th17\u2009cell differentiation by interleukin-1 signaling","volume":"30","author":"Chung","year":"2009","journal-title":"Immunity"},{"key":"B12","doi-asserted-by":"publisher","first-page":"13463","DOI":"10.1073\/pnas.0906988106","article-title":"IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1\u2009cells","volume":"106","author":"Guo","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B13","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1016\/j.coi.2007.07.020","article-title":"Th17: the third member of the effector T cell trilogy","volume":"19","author":"Bettelli","year":"2007","journal-title":"Curr Opin Immunol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.coi.2007.04.005","article-title":"Differentiation and function of Th17 T cells","volume":"19","author":"Stockinger","year":"2007","journal-title":"Curr Opin Immunol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1038\/ni1497","article-title":"Development, cytokine profile and function of human interleukin 17-producing helper T cells","volume":"8","author":"Wilson","year":"2007","journal-title":"Nat Immunol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1084\/jem.20041257","article-title":"IL-23 drives a pathogenic T cell population that induces autoimmune inflammation","volume":"201","author":"Langrish","year":"2005","journal-title":"J Exp Med"},{"key":"B17","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1007\/s00011-011-0419-1","article-title":"Th17\u2009cell cytokine secretion profile in host defense and autoimmunity","volume":"61","author":"Graeber","year":"2012","journal-title":"Inflamm Res"},{"key":"B18","doi-asserted-by":"publisher","first-page":"4947","DOI":"10.4049\/jimmunol.0803282","article-title":"Lipocalin 2 is required for pulmonary host defense against Klebsiella infection","volume":"182","author":"Chan","year":"2009","journal-title":"J Immunol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.1128\/IAI.01389-13","article-title":"Interleukin-17-induced protein lipocalin 2 is dispensable for immunity to oral candidiasis","volume":"82","author":"Ferreira","year":"2014","journal-title":"Infect Immun"},{"key":"B20","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.4049\/jimmunol.162.4.2347","article-title":"Neutrophil recruitment by human IL-17 via C-X-C chemokine release in the airways","volume":"162","author":"Laan","year":"1999","journal-title":"J Immunol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/S0091-6749(00)90189-1","article-title":"Increased elastase and myeloperoxidase activity associated with neutrophil recruitment by IL-17 in airways in vivo","volume":"105","author":"Hoshino","year":"2000","journal-title":"J Allergy Clin Immunol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1084\/jem.194.4.519","article-title":"Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defense","volume":"194","author":"Ye","year":"2001","journal-title":"J Exp Med"},{"key":"B23","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1038\/nri2939","article-title":"Immunity to fungal infections","volume":"11","author":"Romani","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/j.chom.2012.04.008","article-title":"Th17\u2009cells in immunity to Candida albicans","volume":"11","author":"Hernandez-Santos","year":"2012","journal-title":"Cell Host Microbe"},{"key":"B25","doi-asserted-by":"publisher","first-page":"4720","DOI":"10.4049\/jimmunol.1301679","article-title":"Selective ablation of lung epithelial IKK2 impairs pulmonary Th17 responses and delays the clearance of Pneumocystis","volume":"191","author":"Perez-Nazario","year":"2013","journal-title":"J Immunol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"3055","DOI":"10.1128\/IAI.01329-06","article-title":"Interleukin-23 (IL-23)-IL-17 cytokine axis in murine Pneumocystis carinii infection","volume":"75","author":"Rudner","year":"2007","journal-title":"Infect Immun"},{"key":"B27","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1038\/nrmicro1815","article-title":"An integrated model of the recognition of Candida albicans by the innate immune system","volume":"6","author":"Netea","year":"2008","journal-title":"Nat Rev Microbiol"},{"key":"B28","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1016\/j.micinf.2010.03.013","article-title":"Host responses to Candida albicans: Th17\u2009cells and mucosal candidiasis","volume":"12","author":"Conti","year":"2010","journal-title":"Microbes Infect"},{"key":"B29","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1016\/j.immuni.2011.03.002","article-title":"CD4(+)CD25(+)Foxp3(+) regulatory T cells promote Th17\u2009cells in vitro and enhance host resistance in mouse Candida albicans Th17\u2009cell infection model","volume":"34","author":"Pandiyan","year":"2011","journal-title":"Immunity"},{"key":"B30","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1093\/infdis\/jiu136","article-title":"Dectin-1 induces M1 macrophages and prominent expansion of CD8+IL-17+ cells in pulmonary paracoccidioidomycosis","volume":"210","author":"Loures","year":"2014","journal-title":"J Infect Dis"},{"key":"B31","doi-asserted-by":"publisher","first-page":"261","DOI":"10.3389\/fmicb.2015.00261","article-title":"TLR-4 cooperates with Dectin-1 and mannose receptor to expand Th17 and Tc17 cells induced by Paracoccidioides brasiliensis stimulated dendritic cells","volume":"6","author":"Loures","year":"2015","journal-title":"Front Microbiol"},{"key":"B32","doi-asserted-by":"publisher","first-page":"5986","DOI":"10.1073\/pnas.1035999100","article-title":"IL-17 production from activated T cells is required for the spontaneous development of destructive arthritis in mice deficient in IL-1 receptor antagonist","volume":"100","author":"Nakae","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B33","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1002\/art.20885","article-title":"Induction of cartilage damage by overexpression of T cell interleukin-17A in experimental arthritis in mice deficient in interleukin-1","volume":"52","author":"Koenders","year":"2005","journal-title":"Arthritis Rheum"},{"key":"B34","doi-asserted-by":"publisher","first-page":"e1000159","DOI":"10.1371\/journal.ppat.1000159","article-title":"Interleukin-17A mediates acquired immunity to pneumococcal colonization","volume":"4","author":"Lu","year":"2008","journal-title":"PLoS Pathog"},{"key":"B35","doi-asserted-by":"publisher","first-page":"4414","DOI":"10.4049\/jimmunol.0903332","article-title":"Essential role of IL-17A in the formation of a mycobacterial infection-induced granuloma in the lung","volume":"184","author":"Okamoto Yoshida","year":"2010","journal-title":"J Immunol"},{"key":"B36","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.immuni.2007.12.010","article-title":"Macrophage and T cell dynamics during the development and disintegration of mycobacterial granulomas","volume":"28","author":"Egen","year":"2008","journal-title":"Immunity"},{"key":"B37","doi-asserted-by":"publisher","first-page":"1811","DOI":"10.1016\/S0002-9440(10)65053-5","article-title":"Interferon-gamma and tumor necrosis factor-alpha determine resistance to Paracoccidioides brasiliensis infection in mice","volume":"156","author":"Souto","year":"2000","journal-title":"Am J Pathol"},{"key":"B38","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.micpath.2010.12.008","article-title":"Paracoccidioidomycosis: cells expressing IL17 and Foxp3 in cutaneous and mucosal lesions","volume":"50","author":"Pagliari","year":"2011","journal-title":"Microb Pathog"},{"key":"B39","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1007\/BF00683967","article-title":"A new fluorescent viability test for fungi cells","volume":"66","author":"Calich","year":"1979","journal-title":"Mycopathologia"},{"key":"B40","doi-asserted-by":"publisher","first-page":"3049","DOI":"10.4049\/jimmunol.180.5.3049","article-title":"CCR5-dependent regulatory T cell migration mediates fungal survival and severe immunosuppression","volume":"180","author":"Moreira","year":"2008","journal-title":"J Immunol"},{"key":"B41","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.1128\/IAI.01209-12","article-title":"5-lipoxygenase activity increases susceptibility to Paracoccidioides brasiliensis experimental infection","volume":"81","author":"Tristao","year":"2013","journal-title":"Infect Immun"},{"key":"B42","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1590\/1414-431X20133140","article-title":"The left lung is preferentially targeted during experimental paracoccidioidomycosis in C57BL\/6 mice","volume":"46","author":"Tristao","year":"2013","journal-title":"Braz J Med Biol Res"},{"key":"B43","first-page":"131","article-title":"Pathology","volume-title":"Paracoccidioidomycosis","author":"Montenegro","year":"1994"},{"key":"B44","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1590\/S0036-46651995000200012","article-title":"The experimental granuloma. A hypothesis to explain the persistence of the lesion","volume":"37","author":"Mariano","year":"1995","journal-title":"Rev Inst Med Trop Sao Paulo"},{"key":"B45","doi-asserted-by":"publisher","first-page":"e60","DOI":"10.14440\/jbm.2016.152","article-title":"Quantitative histological image analyses of reticulin fibers in a myelofibrotic mouse","volume":"3","author":"Lucero","year":"2016","journal-title":"J Biol Methods"},{"key":"B46","doi-asserted-by":"publisher","first-page":"e15263","DOI":"10.1371\/journal.pone.0015263","article-title":"A method for generation of bone marrow-derived macrophages from cryopreserved mouse bone marrow cells","volume":"5","author":"Marim","year":"2010","journal-title":"PLoS One"},{"key":"B47","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1038\/nri2800","article-title":"Innate IL-17-producing cells: the sentinels of the immune system","volume":"10","author":"Cua","year":"2010","journal-title":"Nat Rev Immunol"},{"key":"B48","doi-asserted-by":"publisher","first-page":"1541","DOI":"10.1038\/labinvest.2012.125","article-title":"Heme oxygenase-1 promotes granuloma development and protects against dissemination of mycobacteria","volume":"92","author":"Regev","year":"2012","journal-title":"Lab Invest"},{"key":"B49","doi-asserted-by":"publisher","first-page":"e2788","DOI":"10.1371\/journal.pntd.0002788","article-title":"Recombinant paracoccin reproduces the biological properties of the native protein and induces protective Th1 immunity against Paracoccidioides brasiliensis infection","volume":"8","author":"Alegre","year":"2014","journal-title":"PLoS Negl Trop Dis"},{"key":"B50","doi-asserted-by":"publisher","first-page":"2546","DOI":"10.1128\/IAI.68.5.2546-2552.2000","article-title":"Nitric oxide participation in the fungicidal mechanism of gamma interferon-activated murine macrophages against Paracoccidioides brasiliensis conidia","volume":"68","author":"Gonzalez","year":"2000","journal-title":"Infect Immun"},{"key":"B51","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1007\/s00430-009-0113-x","article-title":"Nitric oxide participation in granulomatous response induced by Paracoccidioides brasiliensis infection in mice","volume":"198","author":"Nishikaku","year":"2009","journal-title":"Med Microbiol Immunol"},{"key":"B52","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1590\/S0365-05962011000300014","article-title":"Immunology of paracoccidioidomycosis","volume":"86","author":"Fortes","year":"2011","journal-title":"An Bras Dermatol"},{"key":"B53","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1097\/00000372-200304000-00003","article-title":"Dendritic cells and pattern of cytokines in paracoccidioidomycosis skin lesions","volume":"25","author":"Pagliari","year":"2003","journal-title":"Am J Dermatopathol"},{"key":"B54","doi-asserted-by":"publisher","first-page":"2695","DOI":"10.1002\/eji.200737409","article-title":"IL-23 and the Th17 pathway promote inflammation and impair antifungal immune resistance","volume":"37","author":"Zelante","year":"2007","journal-title":"Eur J Immunol"},{"key":"B55","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1016\/j.jinf.2013.07.019","article-title":"Characterization of the immune response in human paracoccidioidomycosis","volume":"67","author":"de Castro","year":"2013","journal-title":"J Infect"},{"key":"B56","doi-asserted-by":"publisher","first-page":"3966","DOI":"10.1128\/IAI.05493-11","article-title":"Neutrophils produce interleukin 17A (IL-17A) in a dectin-1- and IL-23-dependent manner during invasive fungal infection","volume":"79","author":"Werner","year":"2011","journal-title":"Infect Immun"},{"key":"B57","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.1128\/IAI.00736-12","article-title":"Myeloid dendritic cells (DCs) of mice susceptible to paracoccidioidomycosis suppress T cell responses whereas myeloid and plasmacytoid DCs from resistant mice induce effector and regulatory T cells","volume":"81","author":"Pina","year":"2013","journal-title":"Infect Immun"},{"key":"B58","doi-asserted-by":"publisher","first-page":"4507","DOI":"10.4049\/jimmunol.1402321","article-title":"IL-18 triggered by the Nlrp3 inflammasome induces host innate resistance in a pulmonary model of fungal infection","volume":"194","author":"Ketelut-Carneiro","year":"2015","journal-title":"J Immunol"},{"key":"B59","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1016\/j.cytogfr.2010.10.004","article-title":"IL-17 and Th17\u2009cells in tuberculosis","volume":"21","author":"Torrado","year":"2010","journal-title":"Cytokine Growth Factor Rev"},{"key":"B60","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1172\/JCI37865","article-title":"Highly purified Th17\u2009cells from BDC2.5NOD mice convert into Th1-like cells in NOD\/SCID recipient mice","volume":"119","author":"Bending","year":"2009","journal-title":"J Clin Invest"},{"key":"B61","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.immuni.2008.11.005","article-title":"Late developmental plasticity in the T helper 17 lineage","volume":"30","author":"Lee","year":"2009","journal-title":"Immunity"},{"key":"B62","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1111\/j.1365-2249.2011.04543.x","article-title":"Excessive CD4+ T cells co-expressing interleukin-17 and interferon-gamma in patients with Behcet\u2019s disease","volume":"168","author":"Shimizu","year":"2012","journal-title":"Clin Exp Immunol"},{"key":"B63","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1111\/j.1365-2249.1993.tb07964.x","article-title":"Tumour necrosis factor production in vivo and in vitro in response to Paracoccidioides brasiliensis and the cell wall fractions thereof","volume":"93","author":"Figueiredo","year":"1993","journal-title":"Clin Exp Immunol"},{"key":"B64","doi-asserted-by":"publisher","first-page":"4593","DOI":"10.4049\/jimmunol.168.9.4593","article-title":"Dual role for nitric oxide in paracoccidioidomycosis: essential for resistance, but overproduction associated with susceptibility","volume":"168","author":"Nascimento","year":"2002","journal-title":"J Immunol"},{"key":"B65","doi-asserted-by":"publisher","first-page":"689","DOI":"10.4049\/jimmunol.168.2.689","article-title":"Myeloid suppressor lines inhibit T cell responses by an NO-dependent mechanism","volume":"168","author":"Mazzoni","year":"2002","journal-title":"J Immunol"},{"key":"B66","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.cytogfr.2003.10.003","article-title":"Inducible nitric oxide synthase activation by interleukin-17","volume":"15","author":"Miljkovic","year":"2004","journal-title":"Cytokine Growth Factor Rev"},{"key":"B67","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1165\/rcmb.2004-0213OC","article-title":"Interleukin-17 as a recruitment and survival factor for airway macrophages in allergic airway inflammation","volume":"33","author":"Sergejeva","year":"2005","journal-title":"Am J Respir Cell Mol Biol"},{"key":"B68","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1002\/eji.201141737","article-title":"Macrophages participate in IL-17-mediated inflammation","volume":"42","author":"Barin","year":"2012","journal-title":"Eur J Immunol"},{"key":"B69","doi-asserted-by":"publisher","first-page":"4146","DOI":"10.1038\/srep04146","article-title":"Unique macrophages different from M1\/M2 macrophages inhibit T cell mitogenesis while upregulating Th17 polarization","volume":"4","author":"Tatano","year":"2014","journal-title":"Sci Rep"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2017.00949\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T04:47:54Z","timestamp":1692938874000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2017.00949\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,21]]},"references-count":69,"alternative-id":["10.3389\/fimmu.2017.00949"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2017.00949","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,21]]},"article-number":"949"}}