{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:31:00Z","timestamp":1790271060324,"version":"4.1.0"},"reference-count":51,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006492","name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2017.01065","type":"journal-article","created":{"date-parts":[[2017,8,31]],"date-time":"2017-08-31T03:45:15Z","timestamp":1504151115000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":22,"title":["The Sand Fly Salivary Protein Lufaxin Inhibits the Early Steps of the Alternative Pathway of Complement by Direct Binding to the Proconvertase C3b-B"],"prefix":"10.3389","volume":"8","author":[{"given":"Antonio F.","family":"Mendes-Sousa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir Fazito do","family":"Vale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naylene C. S.","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anderson B.","family":"Guimaraes-Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos H.","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauricio R. V.","family":"Sant\u2019Anna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiano","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaden","family":"Kamhawi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 M. C.","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John F.","family":"Andersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesus G.","family":"Valenzuela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo N.","family":"Araujo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2017,8,31]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1146\/annurev.ento.48.060402.102812","article-title":"Role of arthropod saliva in blood feeding: sialome and post-sialome perspectives","volume":"48","author":"Ribeiro","year":"2003","journal-title":"Annu Rev Entomol"},{"key":"B2","doi-asserted-by":"crossref","first-page":"11234","DOI":"10.1016\/S0021-9258(18)99153-2","article-title":"Isolation of maxadilan, a potent vasodilatory peptide from the salivary glands of the sand fly Lutzomyia longipalpis","volume":"266","author":"Lerner","year":"1991","journal-title":"J Biol Chem"},{"key":"B3","doi-asserted-by":"publisher","first-page":"5226","DOI":"10.4049\/jimmunol.167.9.5226","article-title":"Sandfly maxadilan exacerbates infection with Leishmania major and vaccinating against it protects against L. major infection","volume":"167","author":"Morris","year":"2001","journal-title":"J Immunol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"2185","DOI":"10.1161\/ATVBAHA.112.253906","article-title":"Lufaxin, a novel factor Xa inhibitor from the salivary gland of the sand fly Lutzomyia longipalpis blocks protease-activated receptor 2 activation and inhibits inflammation and thrombosis in vivo","volume":"32","author":"Collin","year":"2012","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"e1003923","DOI":"10.1371\/journal.ppat.1003923","article-title":"Lundep, a sand fly salivary endonuclease increases Leishmania parasite survival in neutrophils and inhibits XIIa contact activation in human plasma","volume":"10","author":"Chagas","year":"2014","journal-title":"PLoS Pathog"},{"key":"B6","doi-asserted-by":"publisher","first-page":"19300","DOI":"10.1038\/srep19300","article-title":"SALO, a novel classical pathway complement inhibitor from saliva of the sand fly Lutzomyia longipalpis","volume":"6","author":"Ferreira","year":"2016","journal-title":"Sci Rep"},{"key":"B7","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1038\/cr.2009.139","article-title":"Complement and its role in innate and adaptive immune responses","volume":"20","author":"Dunkelberger","year":"2010","journal-title":"Cell Res"},{"key":"B8","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1038\/nri3761","article-title":"Complement \u2013 tapping into new sites and effector systems","volume":"14","author":"Kolev","year":"2014","journal-title":"Nat Rev Immunol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1126\/science.272.5258.50","article-title":"The instructive role of innate immunity in the acquired immune response","volume":"272","author":"Fearon","year":"1996","journal-title":"Science"},{"key":"B10","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1038\/ni.1923","article-title":"Complement: a key system for immune surveillance and homeostasis","volume":"11","author":"Ricklin","year":"2010","journal-title":"Nat Immunol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1042\/CS20020362","article-title":"Beyond lysis: how complement influences cell fate","volume":"104","author":"Cole","year":"2003","journal-title":"Clin Sci (Lond)"},{"key":"B12","doi-asserted-by":"publisher","first-page":"2701","DOI":"10.1073\/pnas.74.7.2701","article-title":"Interaction between the third complement protein and cell surface macromolecules","volume":"74","author":"Law","year":"1977","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B13","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.4049\/jimmunol.123.3.1388","article-title":"Evidence for an ester linkage between the labile binding site of C3b and receptive surfaces","volume":"123","author":"Law","year":"1979","journal-title":"J Immunol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1084\/jem.142.4.856","article-title":"Properdin: binding to C3b and stabilization of the C3b-dependent C3 convertase","volume":"142","author":"Fearon","year":"1975","journal-title":"J Exp Med"},{"key":"B15","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1111\/j.1365-2249.2004.02627.x","article-title":"The quantitative role of alternative pathway amplification in classical pathway induced terminal complement activation","volume":"138","author":"Harboe","year":"2004","journal-title":"Clin Exp Immunol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1017\/S0031182003003329","article-title":"Anti-complement activity in the saliva of phlebotomine sand flies and other haematophagous insects","volume":"127","author":"Cavalcante","year":"2003","journal-title":"Parasitology"},{"key":"B17","doi-asserted-by":"publisher","first-page":"e79787","DOI":"10.1371\/journal.pone.0079787","article-title":"Different host complement systems and their interactions with saliva from Lutzomyia longipalpis (Diptera, Psychodidae) and Leishmania infantum promastigotes","volume":"8","author":"Mendes-Sousa","year":"2013","journal-title":"PLoS One"},{"key":"B18","doi-asserted-by":"publisher","first-page":"e6047","DOI":"10.1371\/journal.pone.0006047","article-title":"The role of salivary and intestinal complement system inhibitors in the midgut protection of triatomines and mosquitoes","volume":"4","author":"Barros","year":"2009","journal-title":"PLoS One"},{"key":"B19","doi-asserted-by":"publisher","first-page":"e0003513","DOI":"10.1371\/journal.pntd.0003513","article-title":"Anopheles midgut epithelium evades human complement activity by capturing factor H from the blood meal","volume":"9","author":"Khattab","year":"2015","journal-title":"PLoS Negl Trop Dis"},{"key":"B20","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.dci.2008.07.010","article-title":"Subversion of complement by hematophagous parasites","volume":"33","author":"Schroeder","year":"2009","journal-title":"Dev Comp Immunol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"e1000441","DOI":"10.1371\/journal.ppat.1000441","article-title":"Sand fly salivary proteins induce strong cellular immunity in a natural reservoir of visceral leishmaniasis with adverse consequences for Leishmania","volume":"5","author":"Collin","year":"2009","journal-title":"PLoS Pathog"},{"key":"B22","doi-asserted-by":"publisher","first-page":"e638","DOI":"10.1371\/journal.pntd.0000638","article-title":"Discovery of markers of exposure specific to bites of Lutzomyia longipalpis, the vector of Leishmania infantum chagasi in Latin America","volume":"4","author":"Teixeira","year":"2010","journal-title":"PLoS Negl Trop Dis"},{"key":"B23","doi-asserted-by":"publisher","first-page":"599","DOI":"10.4049\/jimmunol.1600020","article-title":"An inhibitor of the alternative pathway of complement in saliva of new world anopheline mosquitoes","volume":"197","author":"Mendes-Sousa","year":"2016","journal-title":"J Immunol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"2792","DOI":"10.1242\/jeb.019836","article-title":"The physiology of the midgut of Lutzomyia longipalpis (Lutz and Neiva 1912): pH in different physiological conditions and mechanisms involved in its control","volume":"211","author":"Santos","year":"2008","journal-title":"J Exp Biol"},{"key":"B25","doi-asserted-by":"crossref","first-page":"3444","DOI":"10.1016\/S0021-9258(18)61371-7","article-title":"Human complement proteins D, C2, and B. Active site mapping with peptide thioester substrates","volume":"262","author":"Kam","year":"1987","journal-title":"J Biol Chem"},{"key":"B26","doi-asserted-by":"publisher","first-page":"3717","DOI":"10.1242\/jeb.01185","article-title":"Identification of the most abundant secreted proteins from the salivary glands of the sand fly Lutzomyia longipalpis, vector of Leishmania chagasi","volume":"207","author":"Valenzuela","year":"2004","journal-title":"J Exp Biol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1038\/nsmb1210","article-title":"Factor B structure provides insights into activation of the central protease of the complement system","volume":"14","author":"Milder","year":"2007","journal-title":"Nat Struct Mol Biol"},{"key":"B28","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1038\/ni.1756","article-title":"Structural and functional implications of the alternative complement pathway C3 convertase stabilized by a staphylococcal inhibitor","volume":"10","author":"Rooijakkers","year":"2009","journal-title":"Nat Immunol"},{"key":"B29","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.4049\/jimmunol.129.6.2603","article-title":"C3 convertase of human complement: enhanced formation and stability of the enzyme generated with nickel instead of magnesium","volume":"129","author":"Fishelson","year":"1982","journal-title":"J Immunol"},{"key":"B30","doi-asserted-by":"publisher","first-page":"7347","DOI":"10.4049\/jimmunol.0902310","article-title":"Coexistence of closed and open conformations of complement factor B in the alternative pathway C3bB(Mg2+) proconvertase","volume":"183","author":"Torreira","year":"2009","journal-title":"J Immunol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"e0004771","DOI":"10.1371\/journal.pntd.0004771","article-title":"Molecular diversity between salivary proteins from new world and old world sand flies with emphasis on Bichromomyia olmeca, the sand fly vector of Leishmania mexicana in Mesoamerica","volume":"10","author":"Abdeladhim","year":"2016","journal-title":"PLoS Negl Trop Dis"},{"key":"B32","doi-asserted-by":"publisher","first-page":"e1400","DOI":"10.1371\/journal.pone.0001400","article-title":"Variability and action mechanism of a family of anticomplement proteins in Ixodes ricinus","volume":"3","author":"Couvreur","year":"2008","journal-title":"PLoS One"},{"key":"B33","doi-asserted-by":"publisher","first-page":"3964","DOI":"10.4049\/jimmunol.180.6.3964","article-title":"A novel mechanism of complement inhibition unmasked by a tick salivary protein that binds to properdin","volume":"180","author":"Tyson","year":"2008","journal-title":"J Immunol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"18717","DOI":"10.1074\/jbc.M001486200","article-title":"Purification, cloning, and expression of a novel salivary anticomplement protein from the tick, Ixodes scapularis","volume":"275","author":"Valenzuela","year":"2000","journal-title":"J Biol Chem"},{"key":"B35","doi-asserted-by":"publisher","first-page":"e40489","DOI":"10.1371\/journal.pone.0040489","article-title":"Novel scabies mite serpins inhibit the three pathways of the human complement system","volume":"7","author":"Mika","year":"2012","journal-title":"PLoS One"},{"key":"B36","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1186\/s13071-016-1726-8","article-title":"Saliva of Rhipicephalus (Boophilus) microplus (Acari: Ixodidae) inhibits classical and alternative complement pathways","volume":"9","author":"Silva","year":"2016","journal-title":"Parasit Vectors"},{"key":"B37","doi-asserted-by":"publisher","first-page":"6704","DOI":"10.1073\/pnas.97.12.6704","article-title":"Delayed-type hypersensitivity to Phlebotomus papatasi sand fly bite: an adaptive response induced by the fly?","volume":"97","author":"Belkaid","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B38","doi-asserted-by":"publisher","first-page":"1290","DOI":"10.1111\/j.1462-5822.2009.01348.x","article-title":"The impact of vector-mediated neutrophil recruitment on cutaneous leishmaniasis","volume":"11","author":"Peters","year":"2009","journal-title":"Cell Microbiol"},{"key":"B39","doi-asserted-by":"publisher","first-page":"8346","DOI":"10.4049\/jimmunol.175.12.8346","article-title":"Saliva from Lutzomyia longipalpis induces CC chemokine ligand 2\/monocyte chemoattractant protein-1 expression and macrophage recruitment","volume":"175","author":"Teixeira","year":"2005","journal-title":"J Immunol"},{"key":"B40","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.chom.2012.11.013","article-title":"Malaria parasites co-opt human factor H to prevent complement-mediated lysis in the mosquito midgut","volume":"13","author":"Simon","year":"2013","journal-title":"Cell Host Microbe"},{"key":"B41","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1590\/S0074-02762006000100016","article-title":"Ingestion of saliva during carbohydrate feeding by Lutzomyia longipalpis (Diptera; Psychodidae)","volume":"101","author":"Cavalcante","year":"2006","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"B42","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1084\/jem.20011319","article-title":"Complement interaction with trypanosomatid promastigotes in normal human serum","volume":"195","author":"Dominguez","year":"2002","journal-title":"J Exp Med"},{"key":"B43","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.4049\/jimmunol.132.3.1501","article-title":"Activation of the alternative complement pathway by Leishmania promastigotes: parasite lysis and attachment to macrophages","volume":"132","author":"Mosser","year":"1984","journal-title":"J Immunol"},{"key":"B44","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1038\/ni1102-1041","article-title":"Evasion of innate immunity by parasitic protozoa","volume":"3","author":"Sacks","year":"2002","journal-title":"Nat Immunol"},{"key":"B45","doi-asserted-by":"publisher","first-page":"1941","DOI":"10.1084\/jem.188.10.1941","article-title":"Development of a natural model of cutaneous leishmaniasis: powerful effects of vector saliva and saliva preexposure on the long-term outcome of Leishmania major infection in the mouse ear dermis","volume":"188","author":"Belkaid","year":"1998","journal-title":"J Exp Med"},{"key":"B46","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/j.parint.2009.07.013","article-title":"Challenges and perspectives in vaccination against leishmaniasis","volume":"58","author":"Oliveira","year":"2009","journal-title":"Parasitol Int"},{"key":"B47","doi-asserted-by":"publisher","first-page":"7845","DOI":"10.1073\/pnas.0712153105","article-title":"Immunity to a salivary protein of a sand fly vector protects against the fatal outcome of visceral leishmaniasis in a hamster model","volume":"105","author":"Gomes","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B48","doi-asserted-by":"publisher","first-page":"1765","DOI":"10.1016\/S1286-4579(00)01331-9","article-title":"The biological and immunomodulatory properties of sand fly saliva and its role in the establishment of Leishmania infections","volume":"2","author":"Kamhawi","year":"2000","journal-title":"Microbes Infect"},{"key":"B49","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1084\/jem.194.3.331","article-title":"Toward a defined anti-Leishmania vaccine targeting vector antigens: characterization of a protective salivary protein","volume":"194","author":"Valenzuela","year":"2001","journal-title":"J Exp Med"},{"key":"B50","doi-asserted-by":"publisher","first-page":"32383","DOI":"10.1074\/jbc.M111.268904","article-title":"Structure and function of a \u201cyellow\u201d protein from saliva of the sand fly Lutzomyia longipalpis that confers protective immunity against Leishmania major infection","volume":"286","author":"Xu","year":"2011","journal-title":"J Biol Chem"},{"key":"B51","doi-asserted-by":"publisher","first-page":"e1169","DOI":"10.1371\/journal.pntd.0001169","article-title":"Lutzomyia longipalpis saliva or salivary protein LJM19 protects against Leishmania braziliensis and the saliva of its vector, Lutzomyia intermedia","volume":"5","author":"Tavares","year":"2011","journal-title":"PLoS Negl Trop Dis"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2017.01065\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T09:56:55Z","timestamp":1692957415000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2017.01065\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,31]]},"references-count":51,"alternative-id":["10.3389\/fimmu.2017.01065"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2017.01065","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,31]]},"article-number":"1065"}}