{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T23:59:41Z","timestamp":1778111981662,"version":"3.51.4"},"reference-count":41,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81430034, 91542123"],"award-info":[{"award-number":["81430034, 91542123"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2017.01192","type":"journal-article","created":{"date-parts":[[2017,9,22]],"date-time":"2017-09-22T04:25:51Z","timestamp":1506054351000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":17,"title":["IFN-\u03b3\u2013STAT1\u2013iNOS Induces Myeloid Progenitors to Acquire Immunosuppressive Activity"],"prefix":"10.3389","volume":"8","author":[{"given":"Shu-Han","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Qing","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cai-Yue","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang-Huan","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-Di","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Eric","family":"Gershwin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhe-Xiong","family":"Lian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2017,9,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1084\/jem.20091318","article-title":"Heterogeneity and hierarchy within the most primitive hematopoietic stem cell compartment","volume":"207","author":"Morita","year":"2010","journal-title":"J Exp Med"},{"key":"B2","doi-asserted-by":"publisher","first-page":"2443","DOI":"10.1182\/blood-2015-07-533588","article-title":"The hematopoietic stem cell niche in homeostasis and disease","volume":"126","author":"Calvi","year":"2015","journal-title":"Blood"},{"key":"B3","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1016\/j.cell.2007.09.047","article-title":"Immunosurveillance by hematopoietic progenitor cells trafficking through blood, lymph, and peripheral tissues","volume":"131","author":"Massberg","year":"2007","journal-title":"Cell"},{"key":"B4","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1038\/nri3062","article-title":"Inflammatory modulation of HSCs: viewing the HSC as a foundation for the immune response","volume":"11","author":"King","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1182\/blood-2015-07-533588","article-title":"The hematopoietic stem cell niche in homeostasis and disease","volume":"126","author":"Laura","year":"2015","journal-title":"Blood"},{"key":"B6","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.it.2010.12.003","article-title":"Inflammatory signals regulate hematopoietic stem cells","volume":"32","author":"Baldridge","year":"2011","journal-title":"Trends Immunol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"e28669","DOI":"10.1371\/journal.pone.0028669.g001","article-title":"Transient activation of hematopoietic stem and progenitor cells by IFN\u03b3 during acute bacterial infection","volume":"6","author":"MacNamara","year":"2011","journal-title":"PLoS One"},{"key":"B8","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1038\/nrrheum.2017.7","article-title":"Haematopoietic stem cell transplantation for autoimmune diseases","volume":"13","author":"Swart","year":"2017","journal-title":"Nat Rev Rheumatol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.1172\/JCI40310","article-title":"CCR2 mediates hematopoietic stem and progenitor cell trafficking to sites of inflammation in mice","volume":"120","author":"Si","year":"2010","journal-title":"J Clin Invest"},{"key":"B10","doi-asserted-by":"publisher","first-page":"723","DOI":"10.5966\/sctm.2015-0268","article-title":"Expansion and hepatic differentiation of adult blood-derived CD34+ progenitor cells and promotion of liver regeneration after acute injury","volume":"5","author":"Hu","year":"2016","journal-title":"Stem Cells Transl Med"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1016\/j.immuni.2012.08.025","article-title":"Dysregulated hematopoietic stem and progenitor cell activity promotes interleukin-23-driven chronic intestinal inflammation","volume":"37","author":"Griseri","year":"2012","journal-title":"Immunity"},{"key":"B12","doi-asserted-by":"publisher","first-page":"4091","DOI":"10.1172\/jci43873","article-title":"Mammalian target of rapamycin activation underlies HSC defects in autoimmune disease and inflammation in mice","volume":"120","author":"Chen","year":"2010","journal-title":"J Clin Invest"},{"key":"B13","doi-asserted-by":"publisher","first-page":"1986","DOI":"10.1182\/blood-2012-05-433755","article-title":"The function of hematopoietic stem cells is altered by both genetic and inflammatory factors in lupus mice","volume":"121","author":"Niu","year":"2013","journal-title":"Blood"},{"key":"B14","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1016\/s0168-8278(03)00387-8","article-title":"Hemopoietic progenitor cells and bone marrow stromal cells in patients with autoimmune hepatitis type 1 and primary biliary cirrhosis","volume":"39","author":"Kyriakou","year":"2003","journal-title":"J Hepatol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"e2439","DOI":"10.1038\/cddis.2016.348","article-title":"Block of both TGF-beta and IL-2 signaling impedes neurophilin-1+ regulatory T cell and follicular regulatory T cell development","volume":"7","author":"Li","year":"2016","journal-title":"Cell Death Dis"},{"key":"B16","doi-asserted-by":"publisher","first-page":"e39757","DOI":"10.1371\/journal.pone.0039757","article-title":"Blocking of PDL-1 interaction enhances primary and secondary CD8 T cell response to herpes simplex virus-1 infection","volume":"7","author":"Channappanavar","year":"2012","journal-title":"PLoS One"},{"key":"B17","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1002\/stem.252","article-title":"Brief report: interferon-gamma induces expansion of Lin(-)Sca-1(+)C-Kit(+) cells","volume":"28","author":"Zhao","year":"2010","journal-title":"Stem Cells"},{"key":"B18","doi-asserted-by":"publisher","first-page":"23115","DOI":"10.1038\/srep23115","article-title":"Identification of early myeloid progenitors as immunosuppressive cells","volume":"6","author":"Pu","year":"2016","journal-title":"Sci Rep"},{"key":"B19","doi-asserted-by":"publisher","first-page":"4221","DOI":"10.1073\/pnas.1320753111","article-title":"Circulating hematopoietic stem and progenitor cells are myeloid-biased in cancer patients","volume":"111","author":"Wu","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B20","doi-asserted-by":"publisher","first-page":"E566","DOI":"10.1073\/pnas.1424927112","article-title":"Invasive breast cancer reprograms early myeloid differentiation in the bone marrow to generate immunosuppressive neutrophils","volume":"112","author":"Casbon","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B21","doi-asserted-by":"publisher","first-page":"989","DOI":"10.4049\/jimmunol.172.2.989","article-title":"Antigen-specific inhibition of CD8+ T cell response by immature myeloid cells in cancer is mediated by reactive oxygen species","volume":"172","author":"Kusmartsev","year":"2004","journal-title":"J Immunol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1038\/nri2506","article-title":"Myeloid-derived suppressor cells as regulators of the immune system","volume":"9","author":"Gabrilovich","year":"2009","journal-title":"Nat Rev Immunol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1016\/j.ccr.2012.04.025","article-title":"Tumor-derived granulocyte-macrophage colony-stimulating factor regulates myeloid inflammation and T cell immunity in pancreatic cancer","volume":"21","author":"Bayne","year":"2012","journal-title":"Cancer Cell"},{"key":"B24","doi-asserted-by":"publisher","first-page":"2052","DOI":"10.1002\/eji.201142230","article-title":"Tumor-induced myeloid-derived suppressor cell function is independent of IFN-gamma and IL-4Ralpha","volume":"42","author":"Sinha","year":"2012","journal-title":"Eur J Immunol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"3533","DOI":"10.1002\/eji.200526172","article-title":"Myeloid dendritic cell precursors generated from bone marrow suppress T cell responses via cell contact and nitric oxide production in vitro","volume":"35","author":"Rossner","year":"2005","journal-title":"Eur J Immunol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"928","DOI":"10.1158\/0008-5472.CAN-11-2863","article-title":"Antigen-specific CD4(+) T cells regulate function of myeloid-derived suppressor cells in cancer via retrograde MHC class II signaling","volume":"72","author":"Nagaraj","year":"2012","journal-title":"Cancer Res"},{"key":"B27","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.1002\/eji.1830260614","article-title":"Differential modulation of B7-1 and B7-2 isoform expression on human monocytes by cytokines which influence the development of T helper cell phenotype","volume":"26","author":"Creery","year":"1996","journal-title":"Eur J Immunol"},{"key":"B28","doi-asserted-by":"publisher","first-page":"4187","DOI":"10.4049\/jimmunol.171.11.6297-a","article-title":"IFN-gamma-induced MHC class II expression: transactivation of class II transactivator promoter IV by IFN regulatory factor-1 is regulated by protein kinase C-alpha","volume":"171","author":"Giroux","year":"2003","journal-title":"J Immunol"},{"key":"B29","doi-asserted-by":"publisher","first-page":"5336","DOI":"10.1073\/pnas.0931259100","article-title":"PD-L1 and PD-L2 are differentially regulated by Th1 and Th2 cells","volume":"100","author":"Loke","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B30","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1038\/nature09135","article-title":"Quiescent haematopoietic stem cells are activated by IFN-gamma in response to chronic infection","volume":"465","author":"Baldridge","year":"2010","journal-title":"Nature"},{"key":"B31","doi-asserted-by":"publisher","first-page":"3699","DOI":"10.1182\/blood-2014-01-549527","article-title":"IFN-gamma causes aplastic anemia by altering hematopoietic stem\/progenitor cell composition and disrupting lineage differentiation","volume":"124","author":"Lin","year":"2014","journal-title":"Blood"},{"key":"B32","doi-asserted-by":"publisher","first-page":"iii37","DOI":"10.1136\/ard.2006.058446","article-title":"Role of nitric oxide in the regulation of T cell functions","volume":"65","author":"Niedbala","year":"2006","journal-title":"Ann Rheum Dis"},{"key":"B33","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1006\/niox.1996.0112","article-title":"A tutorial on the diffusibility and reactivity of free nitric oxide","volume":"1","author":"Lancaster","year":"1997","journal-title":"Nitric Oxide"},{"key":"B34","first-page":"H2163","article-title":"Estimation of nitric oxide production and reaction rates in tissue by use of a mathematical model","volume":"274","author":"Vaughn","year":"1998","journal-title":"Am J Physiol"},{"key":"B35","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/B978-012370420-7\/50014-9","volume-title":"Nitric Oxide Biology and Pathobiology","author":"Lancaster","year":"2000"},{"key":"B36","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1084\/jem.20110132","article-title":"The bone marrow stem cell niche grows up: mesenchymal stem cells and macrophages move in","volume":"208","author":"Ehninger","year":"2011","journal-title":"J Exp Med"},{"key":"B37","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1038\/nature10160","article-title":"In vivo imaging of Treg cells providing immune privilege to the haematopoietic stem-cell niche","volume":"474","author":"Fujisaki","year":"2011","journal-title":"Nature"},{"key":"B38","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.immuni.2005.01.008","article-title":"Bone marrow is a major reservoir and site of recruitment for central memory CD8+ T cells","volume":"22","author":"Mazo","year":"2005","journal-title":"Immunity"},{"key":"B39","doi-asserted-by":"publisher","first-page":"2251","DOI":"10.2337\/db07-0502","article-title":"Bone marrow is a preferential homing site for autoreactive T-cells in type 1 diabetes","volume":"56","author":"Li","year":"2007","journal-title":"Diabetes"},{"key":"B40","doi-asserted-by":"publisher","first-page":"6965","DOI":"10.4049\/jimmunol.1100243","article-title":"Human bone marrow hosts polyfunctional memory CD4+ and CD8+ T cells with close contact to IL-15-producing cells","volume":"186","author":"Herndler-Brandstetter","year":"2011","journal-title":"J Immunol"},{"key":"B41","doi-asserted-by":"publisher","first-page":"140","DOI":"10.3389\/fphar.2017.00140","article-title":"Sophocarpine protects mice from ConA-induced hepatitis via inhibition of the IFN-gamma\/STAT1 pathway","volume":"8","author":"Sang","year":"2017","journal-title":"Front Pharmacol"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2017.01192\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,9,22]],"date-time":"2017-09-22T04:25:55Z","timestamp":1506054355000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2017.01192\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,22]]},"references-count":41,"alternative-id":["10.3389\/fimmu.2017.01192"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2017.01192","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,22]]},"article-number":"1192"}}