{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T15:43:44Z","timestamp":1792079024813,"version":"4.4.0"},"reference-count":43,"publisher":"Frontiers Media SA","content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2017.01214","type":"journal-article","created":{"date-parts":[[2017,9,28]],"date-time":"2017-09-28T13:22:34Z","timestamp":1506604954000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":99,"title":["Cannabinoid Receptor 1 Participates in Liver Inflammation by Promoting M1 Macrophage Polarization via RhoA\/NF-\u03baB p65 and ERK1\/2 Pathways, Respectively, in Mouse Liver Fibrogenesis"],"prefix":"10.3389","volume":"8","author":[{"given":"Lei","family":"Tian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiyang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoting","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofang","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieshi","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liying","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2017,9,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1090","DOI":"10.1016\/j.jhep.2013.12.025","article-title":"Macrophage heterogeneity in liver injury and fibrosis","volume":"60","author":"Tacke","year":"2014","journal-title":"J Hepatol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"2034","DOI":"10.1002\/hep.26754","article-title":"Macrophage plasticity and polarization in liver homeostasis and pathology","volume":"59","author":"Sica","year":"2014","journal-title":"Hepatology"},{"key":"B3","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1172\/JCI59643","article-title":"Macrophage plasticity and polarization: in vivo veritas","volume":"122","author":"Sica","year":"2012","journal-title":"J Clin Invest"},{"key":"B4","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1007\/s12026-012-8291-9","article-title":"Macrophage polarization and plasticity in health and disease","volume":"53","author":"Biswas","year":"2012","journal-title":"Immunol Res"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1038\/nm.3265","article-title":"Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes","volume":"19","author":"Jourdan","year":"2013","journal-title":"Nat Med"},{"key":"B6","doi-asserted-by":"publisher","first-page":"2966","DOI":"10.2337\/db16-0317","article-title":"DPP-4 inhibition by linagliptin attenuates obesity-related inflammation and insulin resistance by regulating M1\/M2 macrophage polarization","volume":"65","author":"Zhuge","year":"2016","journal-title":"Diabetes"},{"key":"B7","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1016\/j.imbio.2008.11.009","article-title":"Alternative activation of macrophages: immune function and cellular biology","volume":"214","author":"Varin","year":"2009","journal-title":"Immunobiology"},{"key":"B8","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1146\/annurev.immunol.021908.132532","article-title":"Alternative activation of macrophages: an immunologic functional perspective","volume":"27","author":"Martinez","year":"2009","journal-title":"Annu Rev Immunol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.smim.2015.10.003","article-title":"Molecular and epigenetic basis of macrophage polarized activation","volume":"27","author":"Porta","year":"2015","journal-title":"Semin Immunol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1002\/path.4133","article-title":"Macrophage plasticity and polarization in tissue repair and remodelling","volume":"229","author":"Mantovani","year":"2013","journal-title":"J Pathol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.prostaglandins.2013.02.002","article-title":"Endogenous cannabinoids revisited: a biochemistry perspective","volume":"10","author":"Fonseca","year":"2013","journal-title":"Prostaglandins Other Lipid Mediat"},{"key":"B12","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/j.neuropharm.2004.07.030","article-title":"Cannabinoid physiology and pharmacology: 30 years of progress","volume":"47","author":"Howlett","year":"2004","journal-title":"Neuropharmacology"},{"key":"B13","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1002\/hep.26606","article-title":"Hepatic cannabinoid-1 receptors mediate diet-induced insulin resistance by increasing de novo synthesis of long-chain ceramides","volume":"59","author":"Cinar","year":"2014","journal-title":"Hepatology"},{"key":"B14","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1038\/ki.2015.63","article-title":"Cannabinoid receptor 1 is a major mediator of renal fibrosis","volume":"88","author":"Lecru","year":"2015","journal-title":"Kidney Int"},{"key":"B15","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1242\/dev.121731","article-title":"Cannabinoid receptor signaling regulates liver development and metabolism","volume":"143","author":"Liu","year":"2016","journal-title":"Development"},{"key":"B16","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1016\/j.tem.2015.07.007","article-title":"The endocannabinoid system: pivotal orchestrator of obesity and metabolic disease","volume":"26","author":"Mazier","year":"2015","journal-title":"Trends Endocrinol Metab"},{"key":"B17","doi-asserted-by":"publisher","first-page":"1615","DOI":"10.1002\/hep.27686","article-title":"Cannabinoid receptor 1 promotes hepatocellular carcinoma initiation and progression through multiple mechanisms","volume":"61","author":"Mukhopadhyay","year":"2015","journal-title":"Hepatology"},{"key":"B18","doi-asserted-by":"publisher","first-page":"716","DOI":"10.2337\/db11-0477","article-title":"Cannabinoid 1 receptor promotes cardiac dysfunction, oxidative stress, inflammation, and fibrosis in diabetic cardiomyopathy","volume":"61","author":"Rajesh","year":"2012","journal-title":"Diabetes"},{"key":"B19","doi-asserted-by":"publisher","first-page":"1721","DOI":"10.1136\/gutjnl-2015-310212","article-title":"Opposite roles of cannabinoid receptors 1 and 2 in hepatocarcinogenesis","volume":"65","author":"Suk","year":"2016","journal-title":"Gut"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1751","DOI":"10.1210\/en.2015-1384","article-title":"Bisphenol A induces fatty liver by an endocannabinoid-mediated positive feedback loop","volume":"157","author":"Martella","year":"2016","journal-title":"Endocrinology"},{"key":"B21","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1002\/hep.24077","article-title":"Endocannabinoids in liver disease","volume":"53","author":"Tam","year":"2011","journal-title":"Hepatology"},{"key":"B22","doi-asserted-by":"publisher","first-page":"3390","DOI":"10.4049\/jimmunol.1403205","article-title":"Endocannabinoid system contributes to liver injury and inflammation by activation of bone marrow-derived monocytes\/macrophages in a CB1-dependent manner","volume":"195","author":"Mai","year":"2015","journal-title":"J Immunol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.jri.2012.10.003","article-title":"Immunity and early pregnancy events: are endocannabinoids the missing link?","volume":"96","author":"Bambang","year":"2012","journal-title":"J Reprod Immunol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1007\/s11481-015-9603-3","article-title":"Effects of cannabinoids on T-cell function and resistance to infection","volume":"10","author":"Eisenstein","year":"2015","journal-title":"J Neuroimmune Pharmacol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"R224","DOI":"10.1152\/ajpregu.00104.2013","article-title":"Cannabinoid 1 receptors are critical for the innate immune response to TLR4 stimulation","volume":"305","author":"Duncan","year":"2013","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1111\/dom.12646","article-title":"Endocannabinoid regulation of beta-cell functions: implications for glycaemic control and diabetes","volume":"18","author":"Jourdan","year":"2016","journal-title":"Diabetes Obes Metab"},{"key":"B27","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/j.autrev.2016.02.008","article-title":"Cannabinoids and autoimmune diseases: a systematic review","volume":"15","author":"Katchan","year":"2016","journal-title":"Autoimmun Rev"},{"key":"B28","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/nrgastro.2015.200","article-title":"Immunology in the liver \u2013 from homeostasis to disease","volume":"13","author":"Heymann","year":"2016","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"B29","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/j.cell.2013.03.026","article-title":"A direct in vivo RNAi screen identifies MKK4 as a key regulator of liver regeneration","volume":"153","author":"Wuestefeld","year":"2013","journal-title":"Cell"},{"key":"B30","doi-asserted-by":"publisher","first-page":"1720","DOI":"10.1002\/hep.29051","article-title":"An endoplasmic reticulum protein, Nogo-B, facilitates alcoholic liver disease through regulation of Kupffer cell polarization","volume":"65","author":"Park","year":"2017","journal-title":"Hepatology"},{"key":"B31","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1677\/JME-08-0190","article-title":"Signal transduction of the CB1 cannabinoid receptor","volume":"44","author":"Turu","year":"2010","journal-title":"J Mol Endocrinol"},{"key":"B32","doi-asserted-by":"publisher","first-page":"1640","DOI":"10.1002\/jcp.24911","article-title":"Cannabinoid receptor 1 but not 2 mediates macrophage phagocytosis by G(alpha)i\/o\/RhoA\/ROCK signaling pathway","volume":"230","author":"Mai","year":"2015","journal-title":"J Cell Physiol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"602","DOI":"10.3389\/fimmu.2015.00602","article-title":"Macrophages during the fibrotic process: M2 as friend and foe","volume":"6","author":"Braga","year":"2015","journal-title":"Front Immunol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"2238","DOI":"10.1016\/j.ajpath.2016.06.003","article-title":"Pathogenesis of Kupffer cells in cholestatic liver injury","volume":"186","author":"Sato","year":"2016","journal-title":"Am J Pathol"},{"key":"B35","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1002\/hep.22034","article-title":"Liver: an organ with predominant innate immunity","volume":"47","author":"Gao","year":"2008","journal-title":"Hepatology"},{"key":"B36","doi-asserted-by":"publisher","first-page":"308","DOI":"10.4049\/jimmunol.168.1.308","article-title":"Complementary adhesion molecules promote neutrophil-Kupffer cell interaction and the elimination of bacteria taken up by the liver","volume":"168","author":"Gregory","year":"2002","journal-title":"J Immunol"},{"key":"B37","doi-asserted-by":"publisher","first-page":"E391","DOI":"10.3390\/nu8070391","article-title":"Novel action of carotenoids on non-alcoholic fatty liver disease: macrophage polarization and liver homeostasis","volume":"8","author":"Ni","year":"2016","journal-title":"Nutrients"},{"key":"B38","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.immuni.2014.12.020","article-title":"Liver-resident macrophage necroptosis orchestrates type 1 microbicidal inflammation and type-2-mediated tissue repair during bacterial infection","volume":"42","author":"Bleriot","year":"2015","journal-title":"Immunity"},{"key":"B39","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1002\/hep.24524","article-title":"Cannabinoid CB2 receptors protect against alcoholic liver disease by regulating Kupffer cell polarization in mice","volume":"54","author":"Louvet","year":"2011","journal-title":"Hepatology"},{"key":"B40","doi-asserted-by":"publisher","first-page":"614","DOI":"10.3389\/fimmu.2014.00614","article-title":"Molecular mechanisms that influence the macrophage m1-m2 polarization balance","volume":"5","author":"Wang","year":"2014","journal-title":"Front Immunol"},{"key":"B41","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1038\/nri.2015.8","article-title":"Self-regulation and cross-regulation of pattern-recognition receptor signalling in health and disease","volume":"16","author":"Cao","year":"2016","journal-title":"Nat Rev Immunol"},{"key":"B42","doi-asserted-by":"publisher","first-page":"3652","DOI":"10.4049\/jimmunol.167.7.3652","article-title":"STAT5 induces macrophage differentiation of M1 leukemia cells through activation of IL-6 production mediated by NF-kappaB p65","volume":"167","author":"Kawashima","year":"2001","journal-title":"J Immunol"},{"key":"B43","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1038\/pcan.2016.19","article-title":"The cannabinoid WIN 55,212-2 prevents neuroendocrine differentiation of LNCaP prostate cancer cells","volume":"19","author":"Morell","year":"2016","journal-title":"Prostate Cancer Prostatic Dis"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2017.01214\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,9,28]],"date-time":"2017-09-28T13:22:37Z","timestamp":1506604957000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2017.01214\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,28]]},"references-count":43,"alternative-id":["10.3389\/fimmu.2017.01214"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2017.01214","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,28]]},"article-number":"1214"}}