{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T14:48:13Z","timestamp":1790261293822,"version":"4.1.0"},"reference-count":50,"publisher":"Frontiers Media SA","content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2017.01237","type":"journal-article","created":{"date-parts":[[2017,9,29]],"date-time":"2017-09-29T04:30:01Z","timestamp":1506659401000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":33,"title":["Microarray Analysis Identifies the Potential Role of Long Non-Coding RNA in Regulating Neuroinflammation during Japanese Encephalitis Virus Infection"],"prefix":"10.3389","volume":"8","author":[{"given":"Yunchuan","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bibo","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Usama","family":"Ashraf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuping","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dengyuan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bohan","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunfeng","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanchun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengbo","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2017,9,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"322","DOI":"10.5694\/mja11.11026","article-title":"Murray valley encephalitis: a review of clinical features, diagnosis and treatment","volume":"196","author":"Knox","year":"2012","journal-title":"Med J Aust"},{"key":"B2","doi-asserted-by":"publisher","first-page":"e2208","DOI":"10.1371\/journal.pntd.0002208","article-title":"Review of climate, landscape, and viral genetics as drivers of the Japanese encephalitis virus ecology","volume":"7","author":"Le Flohic","year":"2013","journal-title":"PLoS Negl Trop Dis"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3201\/eid1501.080311","article-title":"Past, present, and future of Japanese encephalitis","volume":"15","author":"Erlanger","year":"2009","journal-title":"Emerg Infect Dis"},{"key":"B4","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1002\/glia.20474","article-title":"Proinflammatory mediators released by activated microglia induces neuronal death in Japanese encephalitis","volume":"55","author":"Ghoshal","year":"2007","journal-title":"Glia"},{"key":"B5","doi-asserted-by":"publisher","first-page":"12107","DOI":"10.1128\/JVI.78.22.12107-12119.2004","article-title":"Upregulation of RANTES gene expression in neuroglia by Japanese encephalitis virus infection","volume":"78","author":"Chen","year":"2004","journal-title":"J Virol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1002\/glia.21254","article-title":"Regulation of microglia effector functions by tumor necrosis factor signaling","volume":"60","author":"Harms","year":"2012","journal-title":"Glia"},{"key":"B7","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.brainresbull.2011.10.004","article-title":"Role of pro-inflammatory cytokines released from microglia in neurodegenerative diseases","volume":"87","author":"Smith","year":"2012","journal-title":"Brain Res Bull"},{"key":"B8","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.micinf.2009.09.013","article-title":"Highly permissive infection of microglial cells by Japanese encephalitis virus: a possible role as a viral reservoir","volume":"12","author":"Thongtan","year":"2010","journal-title":"Microbes Infect"},{"key":"B9","doi-asserted-by":"publisher","first-page":"2251","DOI":"10.4049\/jimmunol.1500370","article-title":"MicroRNA-15b modulates Japanese encephalitis virus-mediated inflammation via targeting RNF125","volume":"195","author":"Zhu","year":"2015","journal-title":"J Immunol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"3722","DOI":"10.1128\/JVI.03242-15","article-title":"MicroRNA-33a-5p modulates Japanese encephalitis virus replication by targeting eukaryotic translation elongation factor 1A1","volume":"90","author":"Chen","year":"2016","journal-title":"J Virol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"4780","DOI":"10.1128\/JVI.02586-15","article-title":"MicroRNA-19b-3p modulates Japanese encephalitis virus-mediated inflammation via targeting RNF11","volume":"90","author":"Ashraf","year":"2016","journal-title":"J Virol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"ra98","DOI":"10.1126\/scisignal.aaf5132","article-title":"Quantitative phosphoproteomic analysis identifies the critical role of JNK1 in neuroinflammation induced by Japanese encephalitis virus","volume":"9","author":"Ye","year":"2016","journal-title":"Sci Signal"},{"key":"B13","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.cell.2013.06.020","article-title":"lincRNAs: genomics, evolution, and mechanisms","volume":"154","author":"Ulitsky","year":"2013","journal-title":"Cell"},{"key":"B14","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.gene.2012.01.012","article-title":"Long non-coding RNA UCA1 regulated cell cycle distribution via CREB through PI3-K dependent pathway in bladder carcinoma cells","volume":"496","author":"Yang","year":"2012","journal-title":"Gene"},{"key":"B15","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/j.tig.2012.03.013","article-title":"Regulation of chromatin structure by long noncoding RNAs: focus on natural antisense transcripts","volume":"28","author":"Magistri","year":"2012","journal-title":"Trends Genet"},{"key":"B16","doi-asserted-by":"publisher","first-page":"R56","DOI":"10.1186\/gb-2010-11-5-r56","article-title":"Evidence for natural antisense transcript-mediated inhibition of microRNA function","volume":"11","author":"Faghihi","year":"2010","journal-title":"Genome Biol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1016\/j.bbrc.2012.11.101","article-title":"lncRNA expression signatures in response to enterovirus 71 infection","volume":"430","author":"Yin","year":"2013","journal-title":"Biochem Biophys Res Commun"},{"key":"B18","doi-asserted-by":"publisher","first-page":"e206","DOI":"10.1128\/mBio.00206-10","article-title":"Unique signatures of long noncoding RNA expression in response to virus infection and altered innate immune signaling","volume":"1","author":"Peng","year":"2010","journal-title":"MBio"},{"key":"B19","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1016\/j.chom.2014.10.001","article-title":"NRAV, a long noncoding RNA, modulates antiviral responses through suppression of interferon-stimulated gene transcription","volume":"16","author":"Ouyang","year":"2014","journal-title":"Cell Host Microbe"},{"key":"B20","doi-asserted-by":"publisher","first-page":"2085","DOI":"10.1002\/eji.201344126","article-title":"The human long noncoding RNA lnc-IL7R regulates the inflammatory response","volume":"44","author":"Cui","year":"2014","journal-title":"Eur J Immunol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1186\/s12864-015-1270-5","article-title":"Expression and regulation of long noncoding RNAs in TLR4 signaling in mouse macrophages","volume":"16","author":"Mao","year":"2015","journal-title":"BMC Genomics"},{"key":"B22","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1126\/science.1240925","article-title":"A long noncoding RNA mediates both activation and repression of immune response genes","volume":"341","author":"Carpenter","year":"2013","journal-title":"Science"},{"key":"B23","doi-asserted-by":"publisher","first-page":"e00762","DOI":"10.7554\/eLife.00762","article-title":"A mammalian pseudogene lncRNA at the interface of inflammation and anti-inflammatory therapeutics","volume":"2","author":"Rapicavoli","year":"2013","journal-title":"Elife"},{"key":"B24","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","article-title":"MicroRNAs: genomics, biogenesis, mechanism, and function","volume":"116","author":"Bartel","year":"2004","journal-title":"Cell"},{"key":"B25","doi-asserted-by":"publisher","first-page":"476","DOI":"10.3389\/fncel.2015.00476","article-title":"Neuroinflammation and depression: microglia activation, extracellular microvesicles and microRNA dysregulation","volume":"9","author":"Brites","year":"2015","journal-title":"Front Cell Neurosci"},{"key":"B26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.coph.2015.09.001","article-title":"Role of microRNAs in the regulation of innate immune cells under neuroinflammatory conditions","volume":"26","author":"Cardoso","year":"2016","journal-title":"Curr Opin Pharmacol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1186\/1743-422X-6-196","article-title":"Enhanced detection and study of murine norovirus-1 using a more efficient microglial cell line","volume":"6","author":"Cox","year":"2009","journal-title":"Virol J"},{"key":"B28","doi-asserted-by":"publisher","first-page":"D322","DOI":"10.1093\/nar\/gkj021","article-title":"The gene ontology (GO) project in 2006","volume":"34","author":"Harris","year":"2006","journal-title":"Nucleic Acids Res"},{"key":"B29","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/75556","article-title":"Gene ontology: tool for the unification of biology. The Gene Ontology Consortium","volume":"25","author":"Ashburner","year":"2000","journal-title":"Nat Genet"},{"key":"B30","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1038\/nbt1305","article-title":"Genome-scale analysis of in vivo spatiotemporal promoter activity in Caenorhabditis elegans","volume":"25","author":"Dupuy","year":"2007","journal-title":"Nat Biotechnol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"D277","DOI":"10.1093\/nar\/gkh063","article-title":"The KEGG resource for deciphering the genome","volume":"32","author":"Kanehisa","year":"2004","journal-title":"Nucleic Acids Res"},{"key":"B32","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/1471-2105-7-30","article-title":"WholePathwayScope: a comprehensive pathway-based analysis tool for high-throughput data","volume":"7","author":"Yi","year":"2006","journal-title":"BMC Bioinformatics"},{"key":"B33","doi-asserted-by":"publisher","first-page":"1537","DOI":"10.1101\/gr.6202607","article-title":"A systems biology approach for pathway level analysis","volume":"17","author":"Draghici","year":"2007","journal-title":"Genome Res"},{"key":"B34","doi-asserted-by":"publisher","first-page":"e3911","DOI":"10.1371\/journal.pone.0003911","article-title":"Human gene coexpression landscape: confident network derived from tissue transcriptomic profiles","volume":"3","author":"Prieto","year":"2008","journal-title":"PLoS One"},{"key":"B35","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1038\/30918","article-title":"Collective dynamics of \u2018small-world\u2019 networks","volume":"393","author":"Watts","year":"1998","journal-title":"Nature"},{"key":"B36","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/1471-2164-7-40","article-title":"Gene connectivity, function, and sequence conservation: predictions from modular yeast co-expression networks","volume":"7","author":"Carlson","year":"2006","journal-title":"BMC Genomics"},{"key":"B37","doi-asserted-by":"publisher","first-page":"51784","DOI":"10.18632\/oncotarget.10108","article-title":"Long non-coding RNA NEAT1 promotes non-small cell lung cancer progression through regulation of miR-377-3p-E2F3 pathway","volume":"7","author":"Sun","year":"2016","journal-title":"Oncotarget"},{"key":"B38","doi-asserted-by":"publisher","first-page":"1915","DOI":"10.1101\/gad.17446611","article-title":"Integrative annotation of human large intergenic noncoding RNAs reveals global properties and specific subclasses","volume":"25","author":"Cabili","year":"2011","journal-title":"Genes Dev"},{"key":"B39","doi-asserted-by":"publisher","first-page":"7405","DOI":"10.1038\/srep07405","article-title":"p38alpha (MAPK14) critically regulates the immunological response and the production of specific cytokines and chemokines in astrocytes","volume":"4","author":"Lo","year":"2014","journal-title":"Sci Rep"},{"key":"B40","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1042\/0264-6021:3520145","article-title":"Synergistic activation of stress-activated protein kinase 1\/c-Jun N-terminal kinase (SAPK1\/JNK) isoforms by mitogen-activated protein kinase kinase 4 (MKK4) and MKK7","volume":"352","author":"Fleming","year":"2000","journal-title":"Biochem J"},{"key":"B41","doi-asserted-by":"publisher","first-page":"6158","DOI":"10.1038\/sj.onc.1203173","article-title":"Diverse functions of JNK signaling and c-Jun in stress response and apoptosis","volume":"18","author":"Leppa","year":"1999","journal-title":"Oncogene"},{"key":"B42","doi-asserted-by":"publisher","first-page":"1760","DOI":"10.1101\/gr.135350.111","article-title":"GENCODE: the reference human genome annotation for The ENCODE Project","volume":"22","author":"Harrow","year":"2012","journal-title":"Genome Res"},{"key":"B43","doi-asserted-by":"publisher","first-page":"2132","DOI":"10.1166\/jnn.2015.9161","article-title":"Differentially expressed miRNA in inflammatory mucosa of chronic rhinosinusitis","volume":"15","author":"Xia","year":"2015","journal-title":"J Nanosci Nanotechnol"},{"key":"B44","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1186\/s13073-015-0162-2","article-title":"Transcriptomic landscape of lncRNAs in inflammatory bowel disease","volume":"7","author":"Mirza","year":"2015","journal-title":"Genome Med"},{"key":"B45","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1002\/wrna.1321","article-title":"lncRNAs regulate the innate immune response to viral infection","volume":"7","author":"Ouyang","year":"2016","journal-title":"Wiley Interdiscip Rev RNA"},{"key":"B46","doi-asserted-by":"publisher","first-page":"10668","DOI":"10.1093\/nar\/gku713","article-title":"Negative regulation of the interferon response by an interferon-induced long non-coding RNA","volume":"42","author":"Kambara","year":"2014","journal-title":"Nucleic Acids Res"},{"key":"B47","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1038\/nri3581","article-title":"Regulation of type I interferon responses","volume":"14","author":"Ivashkiv","year":"2014","journal-title":"Nat Rev Immunol"},{"key":"B48","doi-asserted-by":"publisher","first-page":"5908","DOI":"10.1128\/JVI.02714-05","article-title":"Blocking of interferon-induced Jak-Stat signaling by Japanese encephalitis virus NS5 through a protein tyrosine phosphatase-mediated mechanism","volume":"80","author":"Lin","year":"2006","journal-title":"J Virol"},{"key":"B49","doi-asserted-by":"publisher","first-page":"328","DOI":"10.3389\/fimmu.2012.00328","article-title":"NOD1 and NOD2 signaling in infection and inflammation","volume":"3","author":"Moreira","year":"2012","journal-title":"Front Immunol"},{"key":"B50","doi-asserted-by":"publisher","first-page":"20263","DOI":"10.1038\/srep20263","article-title":"Dynamic changes in global microRNAome and transcriptome reveal complex miRNA-mRNA regulated host response to Japanese encephalitis virus in microglial cells","volume":"6","author":"Kumari","year":"2016","journal-title":"Sci Rep"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2017.01237\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,9,29]],"date-time":"2017-09-29T04:30:04Z","timestamp":1506659404000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2017.01237\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,29]]},"references-count":50,"alternative-id":["10.3389\/fimmu.2017.01237"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2017.01237","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,29]]},"article-number":"1237"}}