{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T07:00:16Z","timestamp":1772780416525,"version":"3.50.1"},"reference-count":70,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["5U19A109945"],"award-info":[{"award-number":["5U19A109945"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2017.01372","type":"journal-article","created":{"date-parts":[[2017,10,26]],"date-time":"2017-10-26T04:12:51Z","timestamp":1508991171000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":46,"title":["Transcriptome Analysis of Circulating Immune Cell Subsets Highlight the Role of Monocytes in Zaire Ebola Virus Makona Pathogenesis"],"prefix":"10.3389","volume":"8","author":[{"given":"Andrea R.","family":"Menicucci","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krista","family":"Versteeg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Courtney","family":"Woolsey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chad E.","family":"Mire","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan B.","family":"Geisbert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert W.","family":"Cross","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krystle N.","family":"Agans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allen","family":"Jankeel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas W.","family":"Geisbert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilhem","family":"Messaoudi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2017,10,26]]},"reference":[{"key":"B1","article-title":"\u201cFiloviridae: Marburg and Ebola viruses,\u201d","volume-title":"Fields Virology","author":"Feldmann","year":"2013"},{"key":"B2","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1016\/S0140-6736(10)60667-8","article-title":"Ebola haemorrhagic fever","volume":"377","author":"Feldmann","year":"2011","journal-title":"Lancet"},{"key":"B3","unstructured":"2014 Ebola Outbreak in West Africa \u2013 Case Counts2016"},{"key":"B4","doi-asserted-by":"publisher","first-page":"2347","DOI":"10.1016\/S0002-9440(10)63591-2","article-title":"Pathogenesis of Ebola hemorrhagic fever in cynomolgus macaques: evidence that dendritic cells are early and sustained targets of infection","volume":"163","author":"Geisbert","year":"2003","journal-title":"Am J Pathol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/S0165-2478(01)00327-3","article-title":"Proinflammatory response during Ebola virus infection of primate models: possible involvement of the tumor necrosis factor receptor superfamily","volume":"80","author":"Hensley","year":"2002","journal-title":"Immunol Lett"},{"key":"B6","doi-asserted-by":"publisher","first-page":"11025","DOI":"10.1128\/JVI.75.22.11025-11033.2001","article-title":"Infection and activation of monocytes by Marburg and Ebola viruses","volume":"75","author":"Stroher","year":"2001","journal-title":"J Virol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1006\/viro.2001.0836","article-title":"Monocyte-derived human macrophages and peripheral blood mononuclear cells infected with Ebola virus secrete MIP-1alpha and TNF-alpha and inhibit poly-IC-induced IFN-alpha in vitro","volume":"284","author":"Gupta","year":"2001","journal-title":"Virology"},{"key":"B8","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1046\/j.1365-2249.2002.01800.x","article-title":"Inflammatory responses in Ebola virus-infected patients","volume":"128","author":"Baize","year":"2002","journal-title":"Clin Exp Immunol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"S991","DOI":"10.1093\/infdis\/jir336","article-title":"Host response dynamics following lethal infection of rhesus macaques with Zaire Ebolavirus","volume":"204","author":"Ebihara","year":"2011","journal-title":"J Infect Dis"},{"key":"B10","doi-asserted-by":"publisher","first-page":"10370","DOI":"10.1128\/JVI.78.19.10370-10377.2004","article-title":"Analysis of human peripheral blood samples from fatal and nonfatal cases of Ebola (Sudan) hemorrhagic fever: cellular responses, virus load, and nitric oxide levels","volume":"78","author":"Sanchez","year":"2004","journal-title":"J Virol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"S188","DOI":"10.1086\/514283","article-title":"Markedly elevated levels of interferon (IFN)-gamma, IFN-alpha, interleukin (IL)-2, IL-10, and tumor necrosis factor-alpha associated with fatal Ebola virus infection","volume":"179","author":"Villinger","year":"1999","journal-title":"J Infect Dis"},{"key":"B12","doi-asserted-by":"publisher","first-page":"e837","DOI":"10.1371\/journal.pntd.0000837","article-title":"Human fatal zaire Ebola virus infection is associated with an aberrant innate immunity and with massive lymphocyte apoptosis","volume":"4","author":"Wauquier","year":"2010","journal-title":"PLoS Negl Trop Dis"},{"key":"B13","doi-asserted-by":"publisher","first-page":"4649","DOI":"10.1128\/JVI.75.10.4649-4654.2001","article-title":"Passive transfer of antibodies protects immunocompetent and imunodeficient mice against lethal Ebola virus infection without complete inhibition of viral replication","volume":"75","author":"Gupta","year":"2001","journal-title":"J Virol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1023\/A:1009657006550","article-title":"Apoptosis in fatal Ebola infection. Does the virus toll the bell for immune system?","volume":"5","author":"Baize","year":"2000","journal-title":"Apoptosis"},{"key":"B15","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1038\/labinvest.3780021","article-title":"Apoptosis induced in vitro and in vivo during infection by Ebola and Marburg viruses","volume":"80","author":"Geisbert","year":"2000","journal-title":"Lab Invest"},{"key":"B16","doi-asserted-by":"publisher","first-page":"1618","DOI":"10.1086\/379724","article-title":"Mechanisms underlying coagulation abnormalities in Ebola hemorrhagic fever: overexpression of tissue factor in primate monocytes\/macrophages is a key event","volume":"188","author":"Geisbert","year":"2003","journal-title":"J Infect Dis"},{"key":"B17","doi-asserted-by":"publisher","first-page":"3801","DOI":"10.1128\/JVI.02695-12","article-title":"Ebola virus exploits a monocyte differentiation program to promote its entry","volume":"87","author":"Martinez","year":"2013","journal-title":"J Virol"},{"key":"B18","first-page":"140","article-title":"Lethal experimental infection of rhesus monkeys with Ebola-Zaire (Mayinga) virus by the oral and conjunctival route of exposure","volume":"120","author":"Jaax","year":"1996","journal-title":"Arch Pathol Lab Med"},{"key":"B19","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1038\/7422","article-title":"Defective humoral responses and extensive intravascular apoptosis are associated with fatal outcome in Ebola virus-infected patients","volume":"5","author":"Baize","year":"1999","journal-title":"Nat Med"},{"key":"B20","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1089\/vim.2004.17.390","article-title":"Depletion of peripheral blood T lymphocytes and NK cells during the course of Ebola hemorrhagic fever in cynomolgus macaques","volume":"17","author":"Reed","year":"2004","journal-title":"Viral Immunol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"2371","DOI":"10.1016\/S0002-9440(10)63592-4","article-title":"Pathogenesis of Ebola hemorrhagic fever in primate models: evidence that hemorrhage is not a direct effect of virus-induced cytolysis of endothelial cells","volume":"163","author":"Geisbert","year":"2003","journal-title":"Am J Pathol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.virol.2007.02.017","article-title":"Ebola virus infection of human PBMCs causes massive death of macrophages, CD4 and CD8 T cell sub-populations in vitro","volume":"364","author":"Gupta","year":"2007","journal-title":"Virology"},{"key":"B23","doi-asserted-by":"publisher","first-page":"S203","DOI":"10.1086\/514305","article-title":"Pathogenesis of experimental Ebola virus infection in guinea pigs","volume":"179","author":"Connolly","year":"1999","journal-title":"J Infect Dis"},{"key":"B24","doi-asserted-by":"crossref","first-page":"3155","DOI":"10.1128\/JVI.72.4.3155-3160.1998","article-title":"Characterization of Ebola virus entry by using pseudotyped viruses: identification of receptor-deficient cell lines","volume":"72","author":"Wool-Lewis","year":"1998","journal-title":"J Virol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"2519","DOI":"10.1096\/fj.06-6151com","article-title":"Implication of a retrovirus-like glycoprotein peptide in the immunopathogenesis of Ebola and Marburg viruses","volume":"20","author":"Yaddanapudi","year":"2006","journal-title":"FASEB J"},{"key":"B26","doi-asserted-by":"publisher","first-page":"9730","DOI":"10.1038\/s41598-017-09963-y","article-title":"Infection with the Makona variant results in a delayed and distinct host immune response compared to previous Ebola virus variants","volume":"7","author":"Versteeg","year":"2017","journal-title":"Sci Rep"},{"key":"B27","doi-asserted-by":"publisher","first-page":"1777","DOI":"10.3201\/eid2110.150259","article-title":"Delayed disease progression in cynomolgus macaques infected with Ebola virus Makona strain","volume":"21","author":"Marzi","year":"2015","journal-title":"Emerg Infect Dis"},{"key":"B28","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1186\/s12859-016-1241-0","article-title":"systemPipeR: NGS workflow and report generation environment","volume":"17","author":"Backman","year":"2016","journal-title":"BMC Bioinformatics"},{"key":"B29","doi-asserted-by":"publisher","first-page":"12524","DOI":"10.1038\/srep12524","article-title":"Transcriptional profiling of macrophages derived from monocytes and iPS cells identifies a conserved response to LPS and novel alternative transcription","volume":"5","author":"Alasoo","year":"2015","journal-title":"Sci Rep"},{"key":"B30","first-page":"65","article-title":"A simple sequentially rejective multiple test procedure","volume":"6","author":"Holm","year":"1979","journal-title":"Scand J Statist"},{"key":"B31","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1146\/annurev.immunol.20.091301.131133","article-title":"MAP kinases in the immune response","volume":"20","author":"Dong","year":"2002","journal-title":"Annu Rev Immunol"},{"key":"B32","doi-asserted-by":"publisher","first-page":"2601","DOI":"10.1182\/blood-2015-06-651331","article-title":"Slan-defined subsets of CD16-positive monocytes: impact of granulomatous inflammation and M-CSF receptor mutation","volume":"126","author":"Hofer","year":"2015","journal-title":"Blood"},{"key":"B33","doi-asserted-by":"publisher","first-page":"29046","DOI":"10.1038\/srep29046","article-title":"Transcriptome analysis on monocytes from patients with neovascular age-related macular degeneration","volume":"6","author":"Grunin","year":"2016","journal-title":"Sci Rep"},{"key":"B34","doi-asserted-by":"publisher","first-page":"5752","DOI":"10.4049\/jimmunol.1103426","article-title":"Defining GM-CSF- and macrophage-CSF-dependent macrophage responses by in vitro models","volume":"188","author":"Lacey","year":"2012","journal-title":"J Immunol"},{"key":"B35","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/j.semcancer.2007.06.009","article-title":"Tumor immunoediting and immunosculpting pathways to cancer progression","volume":"17","author":"Reiman","year":"2007","journal-title":"Semin Cancer Biol"},{"key":"B36","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1002\/eji.201141907","article-title":"Transcript profiling of CD16-positive monocytes reveals a unique molecular fingerprint","volume":"42","author":"Frankenberger","year":"2012","journal-title":"Eur J Immunol"},{"key":"B37","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1146\/annurev-immunol-032713-120231","article-title":"Interferon-stimulated genes: a complex web of host defenses","volume":"32","author":"Schneider","year":"2014","journal-title":"Annu Rev Immunol"},{"key":"B38","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/j.tips.2009.02.005","article-title":"Siglecs as targets for therapy in immune-cell-mediated disease","volume":"30","author":"O\u2019Reilly","year":"2009","journal-title":"Trends Pharmacol Sci"},{"key":"B39","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1080\/713773639","article-title":"Monocyte chemoattractant protein-1 (CCL2) in inflammatory disease and adaptive immunity: therapeutic opportunities and controversies","volume":"10","author":"Daly","year":"2003","journal-title":"Microcirculation"},{"key":"B40","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1016\/j.ygeno.2003.09.019","article-title":"CCL3L1 and CCL4L1 chemokine genes are located in a segmental duplication at chromosome 17ql2","volume":"83","author":"Modi","year":"2004","journal-title":"Genomics"},{"key":"B41","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1189\/jlb.0313153","article-title":"Cellular stress response and innate immune signaling: integrating pathways in host defense and inflammation","volume":"94","author":"Muralidharan","year":"2013","journal-title":"J Leukoc Biol"},{"key":"B42","doi-asserted-by":"publisher","first-page":"5667","DOI":"10.1021\/bi00367a048","article-title":"Thrombospondin is a substrate for blood coagulation factor XIIIa","volume":"25","author":"Bale","year":"1986","journal-title":"Biochem"},{"key":"B43","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1038\/cdd.2011.158","article-title":"BCL2A1: the underdog in the BCL2 family","volume":"19","author":"Vogler","year":"2012","journal-title":"Cell Death Differ"},{"key":"B44","doi-asserted-by":"crossref","first-page":"4793","DOI":"10.1016\/S0021-9258(19)43735-6","article-title":"Mitochondrial superoxide dismutase \u2013 site of synthesis and intramitochondrial localization","volume":"248","author":"Weisiger","year":"1973","journal-title":"J Biol Chem"},{"key":"B45","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/j.freeradbiomed.2014.10.575","article-title":"Regulation of iNOS function and cellular redox state by macrophage Gch1 reveals specific requirements for tetrahydrobiopterin in NRF2 activation","volume":"79","author":"McNeill","year":"2015","journal-title":"Free Radic Biol Med"},{"key":"B46","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1161\/01.RES.0000111527.42357.62","article-title":"Matrix metalloproteinase-9 is required for adequate angiogenic revascularization of ischemic tissues \u2013 potential role in capillary branching","volume":"94","author":"Johnson","year":"2004","journal-title":"Circ Res"},{"key":"B47","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.immuni.2007.05.016","article-title":"Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses","volume":"27","author":"Butte","year":"2007","journal-title":"Immunity"},{"key":"B48","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.4049\/jimmunol.155.3.1428","article-title":"Il-8 Induces neutrophil chemotaxis predominantly via type-I Il-8 receptors","volume":"155","author":"Hammond","year":"1995","journal-title":"J Immunol"},{"key":"B49","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1084\/jem.176.1.59","article-title":"Structural and functional identification of two human, tumor-derived monocyte chemotactic proteins (MCP-2 and MCP-3) belonging to the chemokine family","volume":"176","author":"Van Damme","year":"1992","journal-title":"J Exp Med"},{"key":"B50","doi-asserted-by":"publisher","first-page":"4051","DOI":"10.18632\/oncotarget.13266","article-title":"Isochaihulactone-induced DDIT3 causes ER stress-PERK independent apoptosis in glioblastoma multiforme cells","volume":"8","author":"Tsai","year":"2016","journal-title":"Oncotarget"},{"key":"B51","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1146\/annurev.physiol.61.1.243","article-title":"Heat-shock proteins, molecular chaperones, and the stress response: evolutionary and ecological physiology","volume":"61","author":"Feder","year":"1999","journal-title":"Annu Rev Physiol"},{"key":"B52","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1038\/40657","article-title":"Inhibition of death receptor signals by cellular FLIP","volume":"388","author":"Irmler","year":"1997","journal-title":"Nature"},{"key":"B53","doi-asserted-by":"publisher","first-page":"2559","DOI":"10.1158\/0008-5472.CAN-08-2929","article-title":"MMP13, Birc2 (cIAP1), and Birc3 (cIAP2), amplified on chromosome 9, collaborate with p53 deficiency in mouse osteosarcoma progression","volume":"69","author":"Ma","year":"2009","journal-title":"Cancer Res"},{"key":"B54","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1038\/icb.2010.57","article-title":"A role for the atopy-associated gene PHF11 in T-cell activation and viability","volume":"88","author":"Rahman","year":"2010","journal-title":"Immunol Cell Biol"},{"key":"B55","doi-asserted-by":"publisher","first-page":"10495","DOI":"10.1073\/pnas.0802423105","article-title":"Triggering receptor expressed on myeloid cell-like transcript 2 (TLT-2) is a counter-receptor for B7-H3 and enhances T cell responses","volume":"105","author":"Hashiguchi","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B56","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1016\/0042-6822(87)90283-2","article-title":"Identification and analysis of Ebola virus messenger RNA","volume":"157","author":"Sanchez","year":"1987","journal-title":"Virology"},{"key":"B57","doi-asserted-by":"publisher","first-page":"4174","DOI":"10.1128\/JVI.80.8.4174-4178.2006","article-title":"Role of endosomal cathepsins in entry mediated by the Ebola virus glycoprotein","volume":"80","author":"Schornberg","year":"2006","journal-title":"J Virol"},{"key":"B58","doi-asserted-by":"publisher","first-page":"e1359","DOI":"10.1371\/journal.pntd.0001359","article-title":"Ebola virion attachment and entry into human macrophages profoundly effects early cellular gene expression","volume":"5","author":"Wahl-Jensen","year":"2011","journal-title":"PLoS Negl Trop Dis"},{"key":"B59","doi-asserted-by":"publisher","first-page":"e1004509","DOI":"10.1371\/journal.ppat.1004509","article-title":"Shed GP of Ebola virus triggers immune activation and increased vascular permeability","volume":"10","author":"Escudero-Perez","year":"2014","journal-title":"PLoS Pathog"},{"key":"B60","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.virol.2012.01.006","article-title":"Type 1 IFN-independent activation of a subset of interferon stimulated genes in West Nile virus Eg101-infected mouse cells","volume":"425","author":"Pulit-Penaloza","year":"2012","journal-title":"Virology"},{"key":"B61","doi-asserted-by":"publisher","first-page":"2690","DOI":"10.1074\/mcp.M110.003418","article-title":"Identification of essential filovirion-associated host factors by serial proteomic analysis and RNAi screen","volume":"9","author":"Spurgers","year":"2010","journal-title":"Mol Cell Proteomics"},{"key":"B62","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.antiviral.2014.07.004","article-title":"HSPA5 is an essential host factor for Ebola virus infection","volume":"109","author":"Reid","year":"2014","journal-title":"Antiviral Res"},{"key":"B63","doi-asserted-by":"publisher","first-page":"9060","DOI":"10.1128\/JVI.00659-11","article-title":"Functional genomics reveals the induction of inflammatory response and metalloproteinase gene expression during lethal Ebola virus infection","volume":"85","author":"Cilloniz","year":"2011","journal-title":"J Virol"},{"key":"B64","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1038\/nature17949","article-title":"Unique human immune signature of Ebola virus disease in Guinea","volume":"533","author":"Ruibal","year":"2016","journal-title":"Nature"},{"key":"B65","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/s13059-016-1137-3","article-title":"Transcriptomic signatures differentiate survival from fatal outcomes in humans infected with Ebola virus","volume":"18","author":"Liu","year":"2017","journal-title":"Genome Biol"},{"key":"B66","doi-asserted-by":"publisher","first-page":"eaai9321","DOI":"10.1126\/scitranslmed.aai9321","article-title":"Longitudinal peripheral blood transcriptional analysis of a patient with severe Ebola virus disease","volume":"9","author":"Kash","year":"2017","journal-title":"Sci Transl Med"},{"key":"B67","doi-asserted-by":"publisher","first-page":"5255","DOI":"10.4049\/jimmunol.171.10.5255","article-title":"Differential responses to IFN-alpha subtypes in human T cells and dendritic cells","volume":"171","author":"Hilkens","year":"2003","journal-title":"J Immunol"},{"key":"B68","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1126\/science.1235208","article-title":"Blockade of chronic type I interferon signaling to control persistent LCMV infection","volume":"340","author":"Wilson","year":"2013","journal-title":"Science"},{"key":"B69","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1126\/science.1235214","article-title":"Persistent LCMV infection is controlled by blockade of type I interferon signaling","volume":"340","author":"Teijaro","year":"2013","journal-title":"Science"},{"key":"B70","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1038\/icb.2010.169","article-title":"Ebolavirus VP35 suppresses IFN production from conventional but not plasmacytoid dendritic cells","volume":"89","author":"Leung","year":"2011","journal-title":"Immunol Cell Biol"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2017.01372\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T16:11:10Z","timestamp":1693152670000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2017.01372\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,26]]},"references-count":70,"alternative-id":["10.3389\/fimmu.2017.01372"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2017.01372","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,26]]},"article-number":"1372"}}