{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T12:10:26Z","timestamp":1790511026725,"version":"4.1.0"},"reference-count":26,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT0607212"],"award-info":[{"award-number":["GNT0607212"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2017.01506","type":"journal-article","created":{"date-parts":[[2017,11,9]],"date-time":"2017-11-09T04:21:07Z","timestamp":1510201267000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":18,"title":["Low T-Cell Responses to Mitogen Stimulation Predicts Poor Survival in Recipients of Allogeneic Hematopoietic Stem Cell Transplantation"],"prefix":"10.3389","volume":"8","author":[{"given":"Michelle K.","family":"Yong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul U.","family":"Cameron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica A.","family":"Slavin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allen C.","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Orla","family":"Morrissey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krystal","family":"Bergin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Spencer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Ritchie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon R.","family":"Lewin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2017,11,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2091","DOI":"10.1056\/NEJMoa1004383","article-title":"Reduced mortality after allogeneic hematopoietic-cell transplantation","volume":"363","author":"Gooley","year":"2010","journal-title":"N Engl J Med"},{"key":"B2","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1038\/sj.bmt.1704966","article-title":"Immune restoration following hematopoietic stem cell transplantation: an evolving target","volume":"35","author":"Auletta","year":"2005","journal-title":"Bone Marrow Transplant"},{"key":"B3","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1056\/NEJMoa1213299","article-title":"ST2 as a marker for risk of therapy-resistant graft-versus-host disease and death","volume":"369","author":"Vander Lugt","year":"2013","journal-title":"N Engl J Med"},{"key":"B4","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1111\/tri.12527","article-title":"The use of novel diagnostics to individualize immunosuppression following transplantation","volume":"28","author":"Schlickeiser","year":"2015","journal-title":"Transpl Int"},{"key":"B5","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1182\/blood-2015-03-636753","article-title":"Plasma biomarkers of acute GVHD and nonrelapse mortality: predictive value of measurements before GVHD onset and treatment","volume":"126","author":"McDonald","year":"2015","journal-title":"Blood"},{"key":"B6","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1038\/clpt.2011.111","article-title":"Biomarkers of over-immunosuppression","volume":"90","author":"Budde","year":"2011","journal-title":"Clin Pharmacol Ther"},{"key":"B7","doi-asserted-by":"publisher","first-page":"e0156777","DOI":"10.1371\/journal.pone.0156777","article-title":"Rapid recovery of CD3+CD8+ T cells on day 90 predicts superior survival after unmanipulated haploidentical blood and marrow transplantation","volume":"11","author":"Tian","year":"2016","journal-title":"PLoS One"},{"key":"B8","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1038\/sj.bmt.1705584","article-title":"Immune recovery in children undergoing allogeneic stem cell transplantation: absolute CD8+ CD3+ count reconstitution is associated with survival","volume":"39","author":"Koehl","year":"2007","journal-title":"Bone Marrow Transplant"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1007\/s15010-014-0685-2","article-title":"Risk factor for death in hematopoietic stem cell transplantation: are biomarkers useful to foresee the prognosis in this population of patients?","volume":"42","author":"Massaro","year":"2014","journal-title":"Infection"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1418","DOI":"10.1016\/j.bbmt.2015.04.002","article-title":"Design and validation of an augmented hematopoietic cell transplantation-comorbidity index comprising pretransplant ferritin, albumin, and platelet count for prediction of outcomes after allogeneic transplantation","volume":"21","author":"Vaughn","year":"2015","journal-title":"Biol Blood Marrow Transplant"},{"key":"B11","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1111\/cei.12072","article-title":"Cellular immune function monitoring after allogeneic haematopoietic cell transplantation: evaluation of a new assay","volume":"172","author":"Israeli","year":"2013","journal-title":"Clin Exp Immunol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"e74744","DOI":"10.1371\/journal.pone.0074744","article-title":"Clinical assessment of anti-viral CD8+ T cell immune monitoring using QuantiFERON-CMV(R) assay to identify high risk allogeneic hematopoietic stem cell transplant patients with CMV infection complications","volume":"8","author":"Tey","year":"2013","journal-title":"PLoS One"},{"key":"B13","doi-asserted-by":"publisher","first-page":"1684","DOI":"10.1093\/infdis\/jix192","article-title":"Identifying cytomegalovirus (CMV) complications using the quantiferon-CMV assay after allogeneic hematopoietic stem cell transplantation","volume":"215","author":"Yong","year":"2017","journal-title":"J Infect Dis"},{"key":"B14","doi-asserted-by":"publisher","first-page":"277","DOI":"10.3343\/alm.2017.37.3.277","article-title":"Clinical usefulness of monitoring cytomegalovirus-specific immunity by quantiferon-CMV in pediatric allogeneic hematopoietic stem cell transplantation recipients","volume":"37","author":"Lee","year":"2017","journal-title":"Ann Lab Med"},{"key":"B15","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1111\/j.1399-3062.2006.00199.x","article-title":"Ex vivo monitoring of human cytomegalovirus-specific CD8+ T-cell responses using QuantiFERON-CMV","volume":"9","author":"Walker","year":"2007","journal-title":"Transpl Infect Dis"},{"key":"B16","doi-asserted-by":"publisher","first-page":"1749","DOI":"10.1111\/j.1600-6143.2008.02294.x","article-title":"Linking CMV serostatus to episodes of CMV reactivation following lung transplantation by measuring CMV-specific CD8+ T-cell immunity","volume":"8","author":"Westall","year":"2008","journal-title":"Am J Transplant"},{"key":"B17","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1046\/j.1365-2141.1997.1112925.x","article-title":"IBMTR severity index for grading acute graft-versus-host disease: retrospective comparison with Glucksberg grade","volume":"97","author":"Rowlings","year":"1997","journal-title":"Br J Haematol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.clim.2007.04.018","article-title":"Human cytomegalovirus (CMV)-specific CD8+ T cell responses are reduced in HIV-infected individuals with a history of CMV disease despite CD4+ T cell recovery","volume":"124","author":"Singh","year":"2007","journal-title":"Clin Immunol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1038\/bmt.2012.282","article-title":"Suggestions on the use of statistical methodologies in studies of the European Group for Blood and Marrow Transplantation","volume":"48","author":"Iacobelli","year":"2013","journal-title":"Bone Marrow Transplant"},{"key":"B20","doi-asserted-by":"publisher","first-page":"2024","DOI":"10.1097\/TP.0000000000001321","article-title":"Establishing biomarkers in transplant medicine: a critical review of current approaches","volume":"100","author":"Anglicheau","year":"2016","journal-title":"Transplantation"},{"key":"B21","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1038\/nri3820","article-title":"Immune biomarkers: the promises and pitfalls of personalized medicine","volume":"15","author":"Willis","year":"2015","journal-title":"Nat Rev Immunol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1111\/vox.12521","article-title":"Functionality testing of stem cell grafts to predict infectious complications after allogeneic hematopoietic stem cell transplantation","volume":"112","author":"Nilsson","year":"2017","journal-title":"Vox Sang"},{"key":"B23","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1007\/s12185-016-2145-5","article-title":"Pharmacodynamics of T cell function for monitoring pharmacologic immunosuppression after allogeneic hematopoietic stem cell transplantation","volume":"105","author":"Martinez","year":"2017","journal-title":"Int J Hematol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1007\/BF03256246","article-title":"T-cell function monitoring in stable renal transplant patients treated with sirolimus monotherapy","volume":"11","author":"Brunet","year":"2007","journal-title":"Mol Diagn Ther"},{"key":"B25","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.trim.2015.09.001","article-title":"CD4 T-cell function assay using Cylex ImmuKnow and lymphocyte subset recovery following allogeneic hematopoietic stem cell transplantation","volume":"33","author":"Jo","year":"2015","journal-title":"Transpl Immunol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1038\/bmt.2009.182","article-title":"Assessment of CD4 T-lymphocyte reactivity by the Cylex ImmuKnow assay in patients following allogeneic hematopoietic SCT","volume":"45","author":"Gesundheit","year":"2010","journal-title":"Bone Marrow Transplant"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2017.01506\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,11,9]],"date-time":"2017-11-09T04:21:11Z","timestamp":1510201271000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2017.01506\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,9]]},"references-count":26,"alternative-id":["10.3389\/fimmu.2017.01506"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2017.01506","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,9]]},"article-number":"1506"}}