{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:29:33Z","timestamp":1790036973209,"version":"4.0.1"},"reference-count":37,"publisher":"Frontiers Media SA","content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2017.01625","type":"journal-article","created":{"date-parts":[[2017,11,23]],"date-time":"2017-11-23T23:13:46Z","timestamp":1511478826000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":90,"title":["Hypoxic Stress-Induced Tumor and Immune Plasticity, Suppression, and Impact on Tumor Heterogeneity"],"prefix":"10.3389","volume":"8","author":[{"given":"St\u00e9phane","family":"Terry","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie","family":"Buart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salem","family":"Chouaib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2017,11,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/j.cell.2007.04.019","article-title":"Hypoxia-inducible factors, stem cells, and cancer","volume":"129","author":"Keith","year":"2007","journal-title":"Cell"},{"key":"B2","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/j.cell.2012.01.021","article-title":"Hypoxia-inducible factors in physiology and medicine","volume":"148","author":"Semenza","year":"2012","journal-title":"Cell"},{"key":"B3","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1038\/onc.2009.441","article-title":"Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics","volume":"29","author":"Semenza","year":"2010","journal-title":"Oncogene"},{"key":"B4","doi-asserted-by":"publisher","first-page":"5976","DOI":"10.1158\/0008-5472.CAN-11-1094","article-title":"Blocking hypoxia-induced autophagy in tumors restores cytotoxic T-cell activity and promotes regression","volume":"71","author":"Noman","year":"2011","journal-title":"Cancer Res"},{"key":"B5","doi-asserted-by":"publisher","first-page":"3510","DOI":"10.4049\/jimmunol.0800854","article-title":"The cooperative induction of hypoxia-inducible factor-1 alpha and STAT3 during hypoxia induced an impairment of tumor susceptibility to CTL-mediated cell lysis","volume":"182","author":"Noman","year":"2009","journal-title":"J Immunol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"4629","DOI":"10.1158\/0008-5472.CAN-12-1383","article-title":"Hypoxia-inducible miR-210 regulates the susceptibility of tumor cells to lysis by cytotoxic T cells","volume":"72","author":"Noman","year":"2012","journal-title":"Cancer Res"},{"key":"B7","doi-asserted-by":"publisher","first-page":"7433","DOI":"10.1158\/0008-5472.CAN-11-2104","article-title":"Hypoxia induces escape from innate immunity in cancer cells via increased expression of ADAM10: role of nitric oxide","volume":"71","author":"Barsoum","year":"2011","journal-title":"Cancer Res"},{"key":"B8","doi-asserted-by":"publisher","first-page":"17591","DOI":"10.18632\/oncotarget.7540","article-title":"The multifaceted role of autophagy in tumor evasion from immune surveillance","volume":"7","author":"Janji","year":"2016","journal-title":"Oncotarget"},{"key":"B9","doi-asserted-by":"publisher","first-page":"17450","DOI":"10.1073\/pnas.1304790110","article-title":"Granzyme B degradation by autophagy decreases tumor cell susceptibility to natural killer-mediated lysis under hypoxia","volume":"110","author":"Baginska","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B10","doi-asserted-by":"publisher","first-page":"6820","DOI":"10.1158\/0008-5472.CAN-14-0303","article-title":"ITPR1 protects renal cancer cells against natural killer cells by inducing autophagy","volume":"74","author":"Messai","year":"2014","journal-title":"Cancer Res"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1944","DOI":"10.1080\/15548627.2015.1083666","article-title":"ITPRs\/inositol 1,4,5-trisphosphate receptors in autophagy: from enemy to ally","volume":"11","author":"Decuypere","year":"2015","journal-title":"Autophagy"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.1158\/1078-0432.CCR-11-1591","article-title":"Molecular pathways: hypoxia response in immune cells fighting or promoting cancer","volume":"18","author":"Palazon","year":"2012","journal-title":"Clin Cancer Res"},{"key":"B13","doi-asserted-by":"publisher","first-page":"C569","DOI":"10.1152\/ajpcell.00207.2015","article-title":"Hypoxia: a key player in antitumor immune response. A review in the theme: cellular responses to hypoxia","volume":"309","author":"Noman","year":"2015","journal-title":"Am J Physiol Cell Physiol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"3723","DOI":"10.1182\/blood-2008-02-142091","article-title":"Divergent effects of hypoxia on dendritic cell functions","volume":"112","author":"Mancino","year":"2008","journal-title":"Blood"},{"key":"B15","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1038\/nature10169","article-title":"Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and T(reg) cells","volume":"475","author":"Facciabene","year":"2011","journal-title":"Nature"},{"key":"B16","doi-asserted-by":"publisher","first-page":"1062","DOI":"10.1016\/j.immuni.2015.05.016","article-title":"E3 ubiquitin ligase VHL regulates hypoxia-inducible factor-1alpha to maintain regulatory T cell stability and suppressive capacity","volume":"42","author":"Lee","year":"2015","journal-title":"Immunity"},{"key":"B17","doi-asserted-by":"publisher","first-page":"E2784","DOI":"10.1073\/pnas.1202366109","article-title":"Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa","volume":"109","author":"Clambey","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B18","doi-asserted-by":"publisher","first-page":"5802","DOI":"10.4049\/jimmunol.1302140","article-title":"Cutting edge: hypoxia-induced Nanog favors the intratumoral infiltration of regulatory T cells and macrophages via direct regulation of TGF-beta1","volume":"191","author":"Hasmim","year":"2013","journal-title":"J Immunol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1182\/blood-2010-01-261792","article-title":"Opposing roles for HIF-1alpha and HIF-2alpha in the regulation of angiogenesis by mononuclear phagocytes","volume":"117","author":"Eubank","year":"2011","journal-title":"Blood"},{"key":"B20","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/j.molcel.2010.09.022","article-title":"Hypoxia-inducible factors and the response to hypoxic stress","volume":"40","author":"Majmundar","year":"2010","journal-title":"Mol Cell"},{"key":"B21","doi-asserted-by":"publisher","first-page":"2439","DOI":"10.1084\/jem.20100587","article-title":"HIF-1alpha regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment","volume":"207","author":"Corzo","year":"2010","journal-title":"J Exp Med"},{"key":"B22","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1084\/jem.20131916","article-title":"PD-L1 is a novel direct target of HIF-1alpha, and its blockade under hypoxia enhanced MDSC-mediated T cell activation","volume":"211","author":"Noman","year":"2014","journal-title":"J Exp Med"},{"key":"B23","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1158\/0008-5472.CAN-13-0992","article-title":"A mechanism of hypoxia-mediated escape from adaptive immunity in cancer cells","volume":"74","author":"Barsoum","year":"2014","journal-title":"Cancer Res"},{"key":"B24","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.cell.2016.06.028","article-title":"Emt: 2016","volume":"166","author":"Nieto","year":"2016","journal-title":"Cell"},{"key":"B25","doi-asserted-by":"publisher","first-page":"13464","DOI":"10.18632\/oncotarget.7229","article-title":"Targeting hypoxic response for cancer therapy","volume":"7","author":"Paolicchi","year":"2016","journal-title":"Oncotarget"},{"key":"B26","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1016\/j.ccr.2009.03.018","article-title":"Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells","volume":"15","author":"Li","year":"2009","journal-title":"Cancer Cell"},{"key":"B27","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/j.stem.2011.02.006","article-title":"Targeting HIF1alpha eliminates cancer stem cells in hematological malignancies","volume":"8","author":"Wang","year":"2011","journal-title":"Cell Stem Cell"},{"key":"B28","doi-asserted-by":"publisher","first-page":"E2047","DOI":"10.1073\/pnas.1602883113","article-title":"Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m(6)A-demethylation of NANOG mRNA","volume":"113","author":"Zhang","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B29","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1038\/sj.bjc.6605491","article-title":"Circulating tumour cells demonstrate an altered response to hypoxia and an aggressive phenotype","volume":"102","author":"Ameri","year":"2010","journal-title":"Br J Cancer"},{"key":"B30","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1038\/nrc3498","article-title":"Plasticity of tumour and immune cells: a source of heterogeneity and a cause for therapy resistance?","volume":"13","author":"Holzel","year":"2013","journal-title":"Nat Rev Cancer"},{"key":"B31","doi-asserted-by":"publisher","first-page":"841","DOI":"10.18632\/oncoscience.226","article-title":"EMT in immuno-resistance","volume":"2","author":"Terry","year":"2015","journal-title":"Oncoscience"},{"key":"B32","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1002\/1878-0261.12093","article-title":"New insights into the role of EMT in tumor immune escape","volume":"11","author":"Terry","year":"2017","journal-title":"Mol Oncol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"e1271858","DOI":"10.1080\/2162402X.2016.1271858","article-title":"Acquisition of tumor cell phenotypic diversity along the EMT spectrum under hypoxic pressure: consequences on susceptibility to cell-mediated cytotoxicity","volume":"6","author":"Terry","year":"2017","journal-title":"Oncoimmunology"},{"key":"B34","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1038\/bjc.2015.29","article-title":"Epithelial-to-mesenchymal transition (EMT) induced by inflammatory priming elicits mesenchymal stromal cell-like immune-modulatory properties in cancer cells","volume":"112","author":"Ricciardi","year":"2015","journal-title":"Br J Cancer"},{"key":"B35","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1158\/0008-5472.CAN-15-0977","article-title":"Hypoxia-induced epithelial-to-mesenchymal transition in hepatocellular carcinoma induces an immunosuppressive tumor microenvironment to promote metastasis","volume":"76","author":"Ye","year":"2016","journal-title":"Cancer Res"},{"key":"B36","doi-asserted-by":"publisher","first-page":"E6215","DOI":"10.1073\/pnas.1520032112","article-title":"HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells","volume":"112","author":"Zhang","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B37","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1038\/nm.3931","article-title":"CD47 blockade triggers T cell-mediated destruction of immunogenic tumors","volume":"21","author":"Liu","year":"2015","journal-title":"Nat Med"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2017.01625\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,11,23]],"date-time":"2017-11-23T23:13:47Z","timestamp":1511478827000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2017.01625\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,24]]},"references-count":37,"alternative-id":["10.3389\/fimmu.2017.01625"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2017.01625","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,24]]},"article-number":"1625"}}