{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T22:21:22Z","timestamp":1790979682591,"version":"4.1.0"},"reference-count":45,"publisher":"Frontiers Media SA","content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2017.01628","type":"journal-article","created":{"date-parts":[[2017,11,23]],"date-time":"2017-11-23T23:15:00Z","timestamp":1511478900000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":51,"title":["Regulatory T Cells Suppress Inflammation and Blistering in Pemphigoid Diseases"],"prefix":"10.3389","volume":"8","author":[{"given":"Katja","family":"Bieber","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shijie","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mareike","family":"Witte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anika","family":"Kasprick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Foteini","family":"Beltsiou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Behnen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tam\u00e1s","family":"Laskay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franziska S.","family":"Schulze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Pipi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niklas","family":"Reichhelm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9","family":"Pagel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Detlef","family":"Zillikens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enno","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Sparwasser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrin","family":"Kalies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf J.","family":"Ludwig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2017,11,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"178","DOI":"10.3389\/fimmu.2012.00178","article-title":"Multiple treg suppressive modules and their adaptability","volume":"3","author":"Wing","year":"2012","journal-title":"Front Immunol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"3307","DOI":"10.1002\/eji.200939498","article-title":"Antigen-specific Treg regulate Th17-mediated lung neutrophilic inflammation, B-cell recruitment and polymeric IgA and IgM levels in the airways","volume":"39","author":"Jaffar","year":"2009","journal-title":"Eur J Immunol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1172\/JCI42280","article-title":"Bidirectional homing of Tregs between the skin and lymph nodes","volume":"120","author":"Matsushima","year":"2010","journal-title":"J Clin Invest"},{"key":"B4","doi-asserted-by":"publisher","first-page":"333","DOI":"10.3389\/fimmu.2014.00333","article-title":"Organ-specific and memory Treg cells: specificity, development, function, and maintenance","volume":"5","author":"Gratz","year":"2014","journal-title":"Front Immunol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1084\/jem.20061852","article-title":"Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease","volume":"204","author":"Lahl","year":"2007","journal-title":"J Exp Med"},{"key":"B6","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1002\/eji.1830260125","article-title":"Disease in the scurfy (sf) mouse is associated with overexpression of cytokine genes","volume":"26","author":"Kanangat","year":"1996","journal-title":"Eur J Immunol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1111\/j.1365-2567.2010.03333.x","article-title":"Novel role of regulatory T cells in limiting early neutrophil responses in skin","volume":"131","author":"Richards","year":"2010","journal-title":"Immunology"},{"key":"B8","doi-asserted-by":"publisher","first-page":"7155","DOI":"10.4049\/jimmunol.177.10.7155","article-title":"Lipopolysaccharide-activated CD4+CD25+ T regulatory cells inhibit neutrophil function and promote their apoptosis and death","volume":"177","author":"Lewkowicz","year":"2006","journal-title":"J Immunol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"603","DOI":"10.3389\/fimmu.2017.00603","article-title":"Mechanisms of autoantibody-induced pathology","volume":"8","author":"Ludwig","year":"2017","journal-title":"Front Immunol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1155\/2013\/812029","article-title":"Clinical presentation, pathogenesis, diagnosis, and treatment of epidermolysis bullosa acquisita","volume":"2013","author":"Ludwig","year":"2013","journal-title":"ISRN Dermatol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1016\/S0140-6736(12)61140-4","article-title":"Pemphigoid diseases","volume":"381","author":"Schmidt","year":"2013","journal-title":"Lancet"},{"key":"B12","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1517\/14728222.2016.1148686","article-title":"Discovering potential drug-targets for personalized treatment of autoimmune disorders \u2013 what we learn from epidermolysis bullosa acquisita","volume":"20","author":"Witte","year":"2016","journal-title":"Expert Opin Ther Targets"},{"key":"B13","doi-asserted-by":"publisher","first-page":"918","DOI":"10.2119\/molmed.2015.00206","article-title":"Reduced skin blistering in experimental epidermolysis bullosa acquisita after anti-TNF treatment","volume":"22","author":"Hirose","year":"2016","journal-title":"Mol Med"},{"key":"B14","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.jaut.2008.08.009","article-title":"Subepidermal blistering induced by human autoantibodies to BP180 requires innate immune players in a humanized bullous pemphigoid mouse model","volume":"31","author":"Liu","year":"2008","journal-title":"J Autoimmun"},{"key":"B15","doi-asserted-by":"publisher","first-page":"1462","DOI":"10.1002\/eji.201444769","article-title":"Conditional depletion of mast cells has no impact on the severity of experimental epidermolysis bullosa acquisita","volume":"45","author":"Kasprick","year":"2015","journal-title":"Eur J Immunol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"38357","DOI":"10.1038\/srep38357","article-title":"T cells mediate autoantibody-induced cutaneous inflammation and blistering in epidermolysis bullosa acquisita","volume":"6","author":"Bieber","year":"2016","journal-title":"Sci Rep"},{"key":"B17","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1111\/jdv.12091","article-title":"Regulatory T cells in skin lesions and blood of patients with bullous pemphigoid","volume":"28","author":"Antiga","year":"2014","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1111\/j.1600-0625.2011.01378.x","article-title":"Lesional Th17\u2009cells and regulatory T cells in bullous pemphigoid","volume":"20","author":"Arakawa","year":"2011","journal-title":"Exp Dermatol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1038\/JID.2015.356","article-title":"Epidermolysis bullosa acquisita: from pathophysiology to novel therapeutic options","volume":"136","author":"Kasperkiewicz","year":"2016","journal-title":"J Invest Dermatol"},{"key":"B20","doi-asserted-by":"publisher","first-page":"2185","DOI":"10.1016\/j.ajpath.2014.05.007","article-title":"Fcgamma receptors III and IV mediate tissue destruction in a novel adult mouse model of bullous pemphigoid","volume":"184","author":"Schulze","year":"2014","journal-title":"Am J Pathol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/exd.13415","article-title":"In vitro and in vivo models to investigate the pathomechanisms and novel treatments for pemphigoid diseases","author":"Bieber","year":"2017","journal-title":"Exp Dermatol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1954","DOI":"10.4049\/jimmunol.1400478","article-title":"Immobilized immune complexes induce neutrophil extracellular trap release by human neutrophil granulocytes via FcgammaRIIIB and Mac-1","volume":"193","author":"Behnen","year":"2014","journal-title":"J Immunol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"184","DOI":"10.3389\/fimmu.2017.00184","article-title":"Extracellular acidification inhibits the ROS-dependent formation of neutrophil extracellular traps","volume":"8","author":"Behnen","year":"2017","journal-title":"Front Immunol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"e67746","DOI":"10.1371\/journal.pone.0067746","article-title":"Dose-dependent induction of murine Th1\/Th2 responses to sheep red blood cells occurs in two steps: antigen presentation during second encounter is decisive","volume":"8","author":"Stamm","year":"2013","journal-title":"PLoS One"},{"key":"B25","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/s00430-011-0201-6","article-title":"The protective Th1 response in mice is induced in the T-cell zone only three weeks after infection with Leishmania major and not during early T-cell activation","volume":"201","author":"Barthelmann","year":"2012","journal-title":"Med Microbiol Immunol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1172\/JCI200521386","article-title":"Induction of dermal-epidermal separation in mice by passive transfer of antibodies specific to type VII collagen","volume":"115","author":"Sitaru","year":"2005","journal-title":"J Clin Invest"},{"key":"B27","doi-asserted-by":"publisher","first-page":"3656","DOI":"10.4049\/jimmunol.1402688","article-title":"Caspase-1-independent IL-1 release mediates blister formation in autoantibody-induced tissue injury through modulation of endothelial adhesion molecules","volume":"194","author":"Sadeghi","year":"2015","journal-title":"J Immunol"},{"key":"B28","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1083\/jcb.120.3.785","article-title":"Neutrophil migration across cultured intestinal epithelial monolayers is modulated by epithelial exposure to IFN-gamma in a highly polarized fashion","volume":"120","author":"Colgan","year":"1993","journal-title":"J Cell Biol"},{"key":"B29","doi-asserted-by":"publisher","first-page":"21292","DOI":"10.1074\/jbc.M115.649855","article-title":"The positively charged COOH-terminal Glycosaminoglycan-binding CXCL9(74-103) peptide inhibits CXCL8-induced neutrophil extravasation and monosodium urate crystal-induced gout in mice","volume":"290","author":"Vanheule","year":"2015","journal-title":"J Biol Chem"},{"key":"B30","doi-asserted-by":"publisher","first-page":"e6","DOI":"10.1016\/j.jaci.2015.10.018","article-title":"IL-10 mediates plasmacytosis-associated immunodeficiency by inhibiting complement-mediated neutrophil migration","volume":"137","author":"Kulkarni","year":"2016","journal-title":"J Allergy Clin Immunol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1002\/path.2157","article-title":"NADPH oxidase is required for neutrophil-dependent autoantibody-induced tissue damage","volume":"212","author":"Chiriac","year":"2007","journal-title":"J Pathol"},{"key":"B32","doi-asserted-by":"crossref","first-page":"3764","DOI":"10.4049\/jimmunol.153.8.3764","article-title":"CD4+CD8- T cells are the effector cells in disease pathogenesis in the scurfy (sf) mouse","volume":"153","author":"Blair","year":"1994","journal-title":"J Immunol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"1941","DOI":"10.1038\/jid.2014.83","article-title":"TNF-alpha and Th2 cytokines induce atopic dermatitis-like features on epidermal differentiation proteins and stratum corneum lipids in human skin equivalents","volume":"134","author":"Danso","year":"2014","journal-title":"J Invest Dermatol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"1639","DOI":"10.1016\/j.jaci.2016.07.013","article-title":"Early-onset pediatric atopic dermatitis is TH2 but also TH17 polarized in skin","volume":"138","author":"Esaki","year":"2016","journal-title":"J Allergy Clin Immunol"},{"key":"B35","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.clim.2012.07.015","article-title":"IL-2 controls trafficking receptor gene expression and Th2 response for skin and lung inflammation","volume":"145","author":"Ju","year":"2012","journal-title":"Clin Immunol"},{"key":"B36","doi-asserted-by":"publisher","first-page":"2609","DOI":"10.1002\/eji.201646421","article-title":"Increased Th2 activity and diminished skin barrier function cooperate in allergic skin inflammation","volume":"46","author":"Sehra","year":"2016","journal-title":"Eur J Immunol"},{"key":"B37","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.cytogfr.2009.02.004","article-title":"Interferon-gamma: a historical perspective","volume":"20","author":"Billiau","year":"2009","journal-title":"Cytokine Growth Factor Rev"},{"key":"B38","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1016\/j.jbspin.2009.03.012","article-title":"Interferons and autoimmune disorders","volume":"76","author":"Meyer","year":"2009","journal-title":"Joint Bone Spine"},{"key":"B39","first-page":"123","article-title":"Interferon-gamma and systemic autoimmunity","volume":"16","author":"Pollard","year":"2013","journal-title":"Discov Med"},{"key":"B40","first-page":"21","article-title":"The importance of the type I interferon system in autoimmunity","volume":"34","author":"Ronnblom","year":"2016","journal-title":"Clin Exp Rheumatol"},{"key":"B41","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1002\/ibd.21038","article-title":"Fontolizumab in moderate to severe Crohn\u2019s disease: a phase 2, randomized, double-blind, placebo-controlled, multiple-dose study","volume":"16","author":"Reinisch","year":"2010","journal-title":"Inflamm Bowel Dis"},{"key":"B42","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1016\/j.autrev.2017.07.001","article-title":"Does type-I interferon drive systemic autoimmunity?","volume":"16","author":"Picard","year":"2017","journal-title":"Autoimmun Rev"},{"key":"B43","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1084\/jem.186.8.1357","article-title":"Neutrophil emigration in the skin, lungs, and peritoneum: different requirements for CD11\/CD18 revealed by CD18-deficient mice","volume":"186","author":"Mizgerd","year":"1997","journal-title":"J Exp Med"},{"key":"B44","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.4049\/jimmunol.1301777","article-title":"Cutting edge: self-antigen controls the balance between effector and regulatory T cells in peripheral tissues","volume":"192","author":"Gratz","year":"2014","journal-title":"J Immunol"},{"key":"B45","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1038\/nrrheum.2014.105","article-title":"TREG-cell therapies for autoimmune rheumatic diseases","volume":"10","author":"Miyara","year":"2014","journal-title":"Nat Rev Rheumatol"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2017.01628\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T21:47:30Z","timestamp":1693259250000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2017.01628\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,24]]},"references-count":45,"alternative-id":["10.3389\/fimmu.2017.01628"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2017.01628","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,24]]},"article-number":"1628"}}