{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T19:31:28Z","timestamp":1772825488556,"version":"3.50.1"},"reference-count":28,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","award":["E-26\/010.001.498\/2016, E-26\/110.511\/2014"],"award-info":[{"award-number":["E-26\/010.001.498\/2016, E-26\/110.511\/2014"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2017.01704","type":"journal-article","created":{"date-parts":[[2017,12,7]],"date-time":"2017-12-07T04:18:48Z","timestamp":1512620328000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":23,"title":["Placental Histopathology and Clinical Presentation of Severe Congenital Zika Syndrome in a Human Immunodeficiency Virus-Exposed Uninfected Infant"],"prefix":"10.3389","volume":"8","author":[{"given":"K\u00edssila","family":"Rabelo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Regina C\u00e9lia","family":"de Souza Campos Fernandes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz Jos\u00e9 de","family":"Souza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thais","family":"Louvain de Souza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fl\u00e1via Barreto dos","family":"Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priscila Conrado","family":"Guerra Nunes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elzinandes Leal de","family":"Azeredo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nat\u00e1lia Gede\u00e3o","family":"Salom\u00e3o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gisela Freitas","family":"Trindade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos A.","family":"Bas\u00edlio-de-Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge Jos\u00e9 de","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrique","family":"Medina-Acosta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marciano Viana","family":"Paes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2017,12,7]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.jneuroim.2017.03.001","article-title":"Zika virus: history, epidemiology, transmission, and clinical presentation","volume":"308","author":"Song","year":"2017","journal-title":"J Neuroimmunol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1587","DOI":"10.1016\/S0140-6736(16)00650-4","article-title":"Teratogenic effects of the Zika virus and the role of the placenta","volume":"387","author":"Adibi","year":"2016","journal-title":"Lancet"},{"key":"B3","doi-asserted-by":"publisher","first-page":"68","DOI":"10.5858\/arpa.2016-0343-OA","article-title":"Autopsy and postmortem studies are concordant: pathology of Zika virus infection is neurotropic in fetuses and infants with microcephaly following transplacental transmission","volume":"141","author":"Schwartz","year":"2017","journal-title":"Arch Pathol Lab Med"},{"key":"B4","doi-asserted-by":"publisher","first-page":"191","DOI":"10.2471\/BLT.16.178608","article-title":"Risk of microcephaly after Zika virus infection in Brazil, 2015 to 2016","volume":"95","author":"Jaenisch","year":"2017","journal-title":"Bull World Health Organ"},{"key":"B5","doi-asserted-by":"publisher","first-page":"e2636","DOI":"10.1371\/journal.pntd.0002636","article-title":"Molecular evolution of Zika virus during its emergence in the 20th century","volume":"8","author":"Faye","year":"2014","journal-title":"PLoS Negl Trop Dis"},{"key":"B6","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1146\/annurev.mi.44.100190.003245","article-title":"Flavivirus genome organization, expression and replication","volume":"44","author":"Chambers","year":"1990","journal-title":"Annu Rev Microbiol"},{"key":"B7","first-page":"1871","article-title":"Retroviridae: the retroviruses and their replication","volume-title":"Fields Virology","author":"Goff","year":"2001"},{"key":"B8","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1038\/nature22401","article-title":"Epidemic establishment and cryptic transmission of Zika virus in Brazil and the Americas","volume":"546","author":"Faria","year":"2017","journal-title":"Nature"},{"key":"B9","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1590\/0074-02760160085","article-title":"Zika virus damages the human placental barrier and presents marked fetal neurotropism","volume":"111","author":"De Noronha","year":"2016","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"B10","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1016\/S1473-3099(16)00095-5","article-title":"Detection and sequencing of Zika virus from amniotic fluid of fetuses with microcephaly in Brazil : a case study","volume":"16","author":"Calvet","year":"2016","journal-title":"Lancet"},{"key":"B11","doi-asserted-by":"publisher","first-page":"2142","DOI":"10.1056\/NEJMoa1601824","article-title":"Zika virus infection with prolonged maternal viremia and fetal brain abnormalities","volume":"374","author":"Driggers","year":"2016","journal-title":"N Engl J Med"},{"key":"B12","doi-asserted-by":"publisher","first-page":"405","DOI":"10.3201\/eid2303.161499","article-title":"Zika virus RNA replication and persistence in brain and placental tissue","volume":"23","author":"Bhatnagar","year":"2017","journal-title":"Emerg Infect Dis"},{"key":"B13","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.chom.2016.07.002","article-title":"Zika virus targets different primary human placental cells, suggesting two routes for vertical transmission","volume":"20","author":"Tabata","year":"2016","journal-title":"Cell Host Microbe"},{"key":"B14","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.chom.2016.05.015","article-title":"Zika virus infects human placental macrophages","volume":"20","author":"Quicke","year":"2016","journal-title":"Cell Host Microbe"},{"key":"B15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/INF.0000000000001482","article-title":"Zika virus infection associated with congenital birth defects in a HIV-infected pregnant woman","volume":"36","author":"Jo\u00e3o","year":"2016","journal-title":"Pediatr Infect Dis J"},{"key":"B16","doi-asserted-by":"publisher","first-page":"830","DOI":"10.4269\/ajtmh.1982.31.830","article-title":"Dengue virus-specific and flavivirus group determinants identified with monoclonal antibodies by indirect immunofluorescence","volume":"31","author":"Henchal","year":"1982","journal-title":"Am J Trop Med Hyg"},{"key":"B17","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1148\/radiol.2016161584","article-title":"Congenital brain abnormalities and Zika virus: what the radiologist can expect to see prenatally and postnatally","volume":"281","author":"Soares de Oliveira-Szejnfeld","year":"2016","journal-title":"Radiology"},{"key":"B18","doi-asserted-by":"publisher","first-page":"2015","DOI":"10.15585\/mmwr.mm6506e1","article-title":"Evidence of Zika virus infection in brain and placental tissues from two congenitally infected newborns and two fetal losses\u2014Brazil 2015","volume":"65","author":"Martines","year":"2016","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"B19","doi-asserted-by":"publisher","first-page":"1361","DOI":"10.1007\/s00404-017-4361-5","article-title":"Viral infection, proliferation, and hyperplasia of Hofbauer cells and absence of inflammation characterize the placental pathology of fetuses with congenital Zika virus infection","volume":"295","author":"Schwartz","year":"2017","journal-title":"Arch Gynecol Obstet"},{"key":"B20","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.clim.2016.01.005","article-title":"Characterization of clinical and immunological features in patients coinfected with dengue virus and HIV","volume":"164","author":"Torrentes-Carvalho","year":"2016","journal-title":"Clin Immunol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1111\/tmi.12858","article-title":"Placental pathology in HIV infection at term: a comparison with HIV-uninfected women","volume":"22","author":"Kalk","year":"2017","journal-title":"Trop Med Int Health"},{"key":"B22","doi-asserted-by":"publisher","first-page":"S507","DOI":"10.1097\/QAD.0000000000000412","article-title":"Recent HIV prevalence trends among pregnant women and all women in sub-Saharan Africa","volume":"28","author":"Eaton","year":"2014","journal-title":"AIDS"},{"key":"B23","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1093\/cid\/cix472","article-title":"Maternal Zika virus disease severity, virus load, prior dengue antibodies and their relationship to birth outcomes","volume":"65","author":"Halai","year":"2017","journal-title":"Clin Infect Dis"},{"key":"B24","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1186\/s12859-015-0618-9","article-title":"Discrimination of cell cycle phases in PCNA-immunolabeled cells","volume":"16","author":"Sch\u00f6nenberger","year":"2015","journal-title":"BMC Bioinformatics"},{"key":"B25","doi-asserted-by":"publisher","first-page":"7109","DOI":"10.1074\/jbc.M113.520429","article-title":"A small molecule inhibitor of monoubiquitinated proliferating cell nuclear antigen (PCNA) inhibits repair of interstrand DNA cross-link, enhances DNA double strand break, and sensitizes cancer cells to cisplatin","volume":"289","author":"Inoue","year":"2014","journal-title":"J Biol Chem"},{"key":"B26","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.dnarep.2015.09.008","article-title":"The interaction between ALKBH2 DNA repair enzyme and PCNA is direct, mediated by the hydrophobic pocket of PCNA and perturbed in naturally-occurring ALKBH2 variants","volume":"35","author":"Fu","year":"2015","journal-title":"DNA Repair (Amst)"},{"key":"B27","first-page":"204","article-title":"Retrospective study on dengue fatal cases","volume":"16","author":"Miagostovich","year":"1997","journal-title":"Clin Neuropathol"},{"key":"B28","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1097\/QCO.0000000000000267","article-title":"HIV-1 at the placenta","volume":"29","author":"Johnson","year":"2016","journal-title":"Curr Opin Infect Dis"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2017.01704\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,12,7]],"date-time":"2017-12-07T04:18:52Z","timestamp":1512620332000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2017.01704\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,7]]},"references-count":28,"alternative-id":["10.3389\/fimmu.2017.01704"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2017.01704","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,7]]},"article-number":"1704"}}