{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T03:48:31Z","timestamp":1791863311952,"version":"4.3.4"},"reference-count":182,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81371372, 81571596"],"award-info":[{"award-number":["81371372, 81571596"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2017.01785","type":"journal-article","created":{"date-parts":[[2017,12,11]],"date-time":"2017-12-11T23:18:19Z","timestamp":1513034299000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":51,"title":["Immunopathogenesis in Myasthenia Gravis and Neuromyelitis Optica"],"prefix":"10.3389","volume":"8","author":[{"given":"Zhen","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaping","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2017,12,12]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2570","DOI":"10.1056\/NEJMra1602678","article-title":"Myasthenia gravis","volume":"375","author":"Gilhus","year":"2016","journal-title":"N Engl J Med"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1016\/S1474-4422(15)00145-3","article-title":"Myasthenia gravis: subgroup classification and therapeutic strategies","volume":"14","author":"Gilhus","year":"2015","journal-title":"Lancet Neurol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1016\/S1474-4422(09)70063-8","article-title":"Autoimmune myasthenia gravis: emerging clinical and biological heterogeneity","volume":"8","author":"Meriggioli","year":"2009","journal-title":"Lancet Neurol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1038\/nrneurol.2016.44","article-title":"Myasthenia gravis \u2013 autoantibody characteristics and their implications for therapy","volume":"12","author":"Gilhus","year":"2016","journal-title":"Nat Rev Neurol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.coi.2017.07.006","article-title":"Pathophysiology and immunological profile of myasthenia gravis and its subgroups","volume":"49","author":"Romi","year":"2017","journal-title":"Curr Opin Immunol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"2122","DOI":"10.1016\/S0140-6736(00)05186-2","article-title":"Myasthenia gravis","volume":"357","author":"Vincent","year":"2001","journal-title":"Lancet"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1136\/jnnp.52.10.1121","article-title":"The natural course of myasthenia gravis: a long term follow up study","volume":"52","author":"Oosterhuis","year":"1989","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"B8","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1186\/1471-2377-10-46","article-title":"A systematic review of population based epidemiological studies in myasthenia gravis","volume":"10","author":"Carr","year":"2010","journal-title":"BMC Neurol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1212\/WNL.0b013e31827b907b","article-title":"Complete stable remission and autoantibody specificity in myasthenia gravis","volume":"80","author":"Baggi","year":"2013","journal-title":"Neurology"},{"key":"B10","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1016\/S1474-4422(07)70216-8","article-title":"The spectrum of neuromyelitis optica","volume":"6","author":"Wingerchuk","year":"2007","journal-title":"Lancet Neurol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"2106","DOI":"10.1016\/S0140-6736(04)17551-X","article-title":"A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosis","volume":"364","author":"Lennon","year":"2004","journal-title":"Lancet"},{"key":"B12","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1212\/WNL.0000000000001729","article-title":"International consensus diagnostic criteria for neuromyelitis optica spectrum disorders","volume":"85","author":"Wingerchuk","year":"2015","journal-title":"Neurology"},{"key":"B13","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/B978-0-444-63432-0.00021-9","article-title":"Autoimmune AQP4 channelopathies and neuromyelitis optica spectrum disorders","volume":"133","author":"Hinson","year":"2016","journal-title":"Handb Clin Neurol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1212\/WNL.0b013e318248dec1","article-title":"Serologic diagnosis of NMO: a multicenter comparison of aquaporin-4-IgG assays","volume":"78","author":"Waters","year":"2012","journal-title":"Neurology"},{"key":"B15","doi-asserted-by":"publisher","first-page":"e11","DOI":"10.1212\/NXI.0000000000000011","article-title":"AQP4 autoantibody assay performance in clinical laboratory service","volume":"1","author":"Fryer","year":"2014","journal-title":"Neurol Neuroimmunol Neuroinflamm"},{"key":"B16","doi-asserted-by":"publisher","first-page":"e110","DOI":"10.1212\/NXI.0000000000000110","article-title":"Aquaporin-4 autoimmunity","volume":"2","author":"Zekeridou","year":"2015","journal-title":"Neurol Neuroimmunol Neuroinflamm"},{"key":"B17","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1146\/annurev-med-043010-193843","article-title":"Aquaporins in clinical medicine","volume":"63","author":"Verkman","year":"2012","journal-title":"Annu Rev Med"},{"key":"B18","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/S1474-4422(12)70133-3","article-title":"Aquaporin 4 and neuromyelitis optica","volume":"11","author":"Papadopoulos","year":"2012","journal-title":"Lancet Neurol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1212\/WNL.0000000000000101","article-title":"Distinction between MOG antibody-positive and AQP4 antibody-positive NMO spectrum disorders","volume":"82","author":"Sato","year":"2014","journal-title":"Neurology"},{"key":"B20","doi-asserted-by":"publisher","first-page":"866","DOI":"10.1177\/1352458514555785","article-title":"Antibodies to MOG and AQP4 in adults with neuromyelitis optica and suspected limited forms of the disease","volume":"21","author":"H\u00f6ftberger","year":"2015","journal-title":"Mult Scler"},{"key":"B21","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1016\/S1474-4422(16)30043-6","article-title":"Atypical inflammatory demyelinating syndromes of the CNS","volume":"15","author":"Hardy","year":"2016","journal-title":"Lancet Neurol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"e225","DOI":"10.1212\/NXI.0000000000000225","article-title":"Neuromyelitis optica spectrum disorders: comparison according to the phenotype and serostatus","volume":"3","author":"Sep\u00falveda","year":"2016","journal-title":"Neurol Neuroimmunol Neuroinflamm"},{"key":"B23","doi-asserted-by":"publisher","first-page":"1270","DOI":"10.1007\/s11427-015-4997-y","article-title":"Autoantibody to MOG suggests two distinct clinical subtypes of NMOSD","volume":"59","author":"Yan","year":"2016","journal-title":"Sci China Life Sci"},{"key":"B24","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1002\/ana.24617","article-title":"Epidemiology of aquaporin-4 autoimmunity and neuromyelitis optica spectrum","volume":"79","author":"Flanagan","year":"2016","journal-title":"Ann Neurol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1834","DOI":"10.1093\/brain\/aws109","article-title":"Prognostic factors and disease course in aquaporin-4 antibody-positive patients with neuromyelitis optica spectrum disorder from the United Kingdom and Japan","volume":"135","author":"Kitley","year":"2012","journal-title":"Brain"},{"key":"B26","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.jaut.2013.12.001","article-title":"Genetic basis of myasthenia gravis \u2013 a comprehensive review","volume":"52","author":"Avidan","year":"2014","journal-title":"J Autoimmun"},{"key":"B27","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.jns.2015.05.034","article-title":"Epidemiological, clinical, and immunological characteristics of neuromyelitis optica: a review","volume":"355","author":"Pereira","year":"2015","journal-title":"J Neurol Sci"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1177\/1352458516671203","article-title":"Influence of female sex and fertile age on neuromyelitis optica spectrum disorders","volume":"23","author":"Borisow","year":"2017","journal-title":"Mult Scler"},{"key":"B29","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.jaut.2013.12.011","article-title":"Myasthenia gravis: a comprehensive review of immune dysregulation and etiological mechanisms","volume":"52","author":"Berrih-Aknin","year":"2014","journal-title":"J Autoimmun"},{"key":"B30","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/978-1-59745-156-7_3","article-title":"Immunopathogenesis of Myasthenia Gravis","volume-title":"Myasthenia Gravis and Related Disorders. Current Clinical Neurology","author":"Conti-Fine","year":"2009"},{"key":"B31","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1111\/nyas.12118","article-title":"Immunology of neuromyelitis optica: a T cell-B cell collaboration","volume":"1283","author":"Mitsdoerffer","year":"2013","journal-title":"Ann N Y Acad Sci"},{"key":"B32","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1177\/1352458511431077","article-title":"The emerging relationship between neuromyelitis optica and systemic rheumatologic autoimmune disease","volume":"18","author":"Wingerchuk","year":"2012","journal-title":"Mult Scler"},{"key":"B33","doi-asserted-by":"publisher","first-page":"362","DOI":"10.3109\/08916934.2015.1030614","article-title":"Complicating autoimmune diseases in myasthenia gravis: a review","volume":"48","author":"Nacu","year":"2015","journal-title":"Autoimmunity"},{"key":"B34","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1152\/physrev.00015.2008","article-title":"Mammalian nicotinic acetylcholine receptors: from structure to function","volume":"89","author":"Albuquerque","year":"2009","journal-title":"Physiol Rev"},{"key":"B35","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/S0022-510X(99)00205-1","article-title":"Does myasthenia gravis affect the brain","volume":"170","author":"Keesey","year":"1999","journal-title":"J Neurol Sci"},{"key":"B36","doi-asserted-by":"publisher","first-page":"1644","DOI":"10.1177\/1352458515571446","article-title":"Role of membrane complement regulators in neuromyelitis optica","volume":"21","author":"Saadoun","year":"2015","journal-title":"Mult Scler"},{"key":"B37","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.bbi.2017.04.023","article-title":"Low expression of complement inhibitory protein CD59 contributes to humoral autoimmunity against astrocytes","volume":"65","author":"Wang","year":"2017","journal-title":"Brain Behav Immun"},{"key":"B38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jaut.2014.05.001","article-title":"Myasthenia gravis: paradox versus paradigm in autoimmunity","volume":"52","author":"Berrih-Aknin","year":"2014","journal-title":"J Autoimmun"},{"key":"B39","doi-asserted-by":"publisher","first-page":"1450","DOI":"10.1093\/brain\/awf151","article-title":"A role for humoral mechanisms in the pathogenesis of Devic\u2019s neuromyelitis optica","volume":"125","author":"Lucchinetti","year":"2002","journal-title":"Brain"},{"key":"B40","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.jns.2015.11.049","article-title":"Study of the prevalence of familial autoimmune myasthenia gravis in a Spanish cohort","volume":"360","author":"Salvado","year":"2016","journal-title":"J Neurol Sci"},{"key":"B41","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1001\/archneur.1971.00490010059009","article-title":"Familial myasthenia gravis. Report of 27 patients in 12 families and review of 164 patients in 73 families","volume":"25","author":"Namba","year":"1971","journal-title":"Arch Neurol"},{"key":"B42","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1375\/twin.14.2.129","article-title":"Utilizing twins concordance rates to infer the predisposition to myasthenia gravis","volume":"14","author":"Ramanujam","year":"2011","journal-title":"Twin Res Hum Genet"},{"key":"B43","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1212\/WNL.0b013e3181ea9f15","article-title":"Familial neuromyelitis optica","volume":"75","author":"Matiello","year":"2010","journal-title":"Neurology"},{"key":"B44","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/j.jns.2015.06.034","article-title":"Familial forms of multiple sclerosis and neuromyelitis optica at an MS center in Rio de Janeiro State, Brazil","volume":"356","author":"Papais-Alvarenga","year":"2015","journal-title":"J Neurol Sci"},{"key":"B45","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1093\/brain\/61.4.430","article-title":"Familial neuromyelitis optica: its occurrence in identical twins","volume":"61","author":"McAlpine","year":"1938","journal-title":"Brain"},{"key":"B46","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1038\/nri1805","article-title":"MHC class II proteins and disease: a structural perspective","volume":"6","author":"Jones","year":"2006","journal-title":"Nat Rev Immunol"},{"key":"B47","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1016\/S0140-6736(13)60954-X","article-title":"Immunopathogenic mechanisms of systemic autoimmune disease","volume":"382","author":"Wahren-Herlenius","year":"2013","journal-title":"Lancet"},{"key":"B48","doi-asserted-by":"publisher","first-page":"15464","DOI":"10.1073\/pnas.0406756101","article-title":"Pleiotropic effects of the 8.1 HLA haplotype in patients with autoimmune myasthenia gravis and thymus hyperplasia","volume":"101","author":"Vandiedonck","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B49","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.clim.2016.05.003","article-title":"Genetic heterogeneity within the HLA region in three distinct clinical subgroups of myasthenia gravis","volume":"16","author":"Saruhan-Direskeneli","year":"2016","journal-title":"Clin Immunol"},{"key":"B50","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1001\/jamaneurol.2014.4103","article-title":"A genome-wide association study of myasthenia gravis","volume":"72","author":"Renton","year":"2015","journal-title":"JAMA Neurol"},{"key":"B51","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.jneuroim.2012.03.018","article-title":"HLA-DQA1*03:02\/DQB1*03:03:02 is strongly associated with susceptibility to childhood-onset ocular myasthenia gravis in Southern Han Chinese","volume":"247","author":"Zhu","year":"2012","journal-title":"J Neuroimmunol"},{"key":"B52","doi-asserted-by":"publisher","first-page":"1524","DOI":"10.1016\/j.jocn.2011.05.002","article-title":"Association between HLA-DRB1 and myasthenia gravis in a northern Han Chinese population","volume":"18","author":"Xie","year":"2011","journal-title":"J Clin Neurosci"},{"key":"B53","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.jns.2016.02.031","article-title":"HLA-DRB1*14 and DQB1*05 are associated with Japanese anti-MuSK antibody-positive myasthenia gravis patients","volume":"363","author":"Kanai","year":"2016","journal-title":"J Neurol Sci"},{"key":"B54","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/j.jns.2015.11.021","article-title":"Association of HLA class II (DRB1, DQA1, DQB1) alleles and haplotypes with myasthenia gravis and its subgroups in the Iranian population","volume":"359","author":"Ehsan","year":"2015","journal-title":"J Neurol Sci"},{"key":"B55","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1212\/01.wnl.0000339103.08830.86","article-title":"HLA class II allele analysis in MuSK-positive myasthenia gravis suggests a role for DQ5","volume":"72","author":"Bartoccioni","year":"2009","journal-title":"Neurology"},{"key":"B56","doi-asserted-by":"publisher","first-page":"1772","DOI":"10.1212\/01.wnl.0000218159.79769.5c","article-title":"Strong association of MuSK antibody-positive myasthenia gravis and HLA-DR14-DQ5","volume":"66","author":"Niks","year":"2006","journal-title":"Neurology"},{"key":"B57","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1002\/ana.23691","article-title":"Risk for myasthenia gravis maps to a (151) Pro\u2192Ala change in TNIP1 and to human leukocyte antigen-B*08","volume":"72","author":"Gregersen","year":"2012","journal-title":"Ann Neurol"},{"key":"B58","doi-asserted-by":"publisher","first-page":"769","DOI":"10.2119\/molmed.2015.00232","article-title":"Genome-wide association study of late-onset myasthenia gravis: confirmation of TNFRSF11A, and identification of ZBTB10 and three distinct HLA associations","volume":"21","author":"Seldin","year":"2015","journal-title":"Mol Med"},{"key":"B59","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1038\/sj.gene.6364041","article-title":"Association of the gene encoding the delta-subunit of the muscle acetylcholine receptor (CHRND) with acquired autoimmune myasthenia gravis","volume":"5","author":"Giraud","year":"2004","journal-title":"Genes Immun"},{"key":"B60","doi-asserted-by":"publisher","first-page":"1460","DOI":"10.1212\/WNL.52.7.1460","article-title":"Association of acetylcholine receptor alpha-subunit gene expression in mixed thymoma with myasthenia gravis","volume":"52","author":"Wilisch","year":"1999","journal-title":"Neurology"},{"key":"B61","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1177\/1352458508102085","article-title":"Is neuromyelitis optica associated with human leukocyte antigen","volume":"15","author":"Z\u00e9phir","year":"2009","journal-title":"Mult Scler"},{"key":"B62","doi-asserted-by":"publisher","first-page":"1689","DOI":"10.1093\/brain\/122.9.1689","article-title":"HLA-DPB1*0501-associated opticospinal multiple sclerosis: clinical, neuroimaging and immunogenetic studies","volume":"122","author":"Yamasaki","year":"1999","journal-title":"Brain"},{"key":"B63","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.jneuroim.2010.11.004","article-title":"HLA-DPB1 0501 is associated with susceptibility to anti-aquaporin-4 antibodies positive neuromyelitis optica in southern Han Chinese","volume":"233","author":"Wang","year":"2011","journal-title":"J Neuroimmunol"},{"key":"B64","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1136\/jnnp-2012-302925","article-title":"Distinct genetic and infectious profiles in Japanese neuromyelitis optica patients according to anti-aquaporin 4 antibody status","volume":"84","author":"Yoshimura","year":"2013","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"B65","first-page":"146","article-title":"[HLA-DRB1 typing in Caucasians patients with neuromyelitis optica]","volume":"53","author":"Blanco","year":"2011","journal-title":"Rev Neurol"},{"key":"B66","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1177\/1352458509350741","article-title":"HLA-DRB association in neuromyelitis optica is different from that observed in multiple sclerosis","volume":"16","author":"Brum","year":"2010","journal-title":"Mult Scler"},{"key":"B67","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1177\/1352458510382810","article-title":"Different HLA class II (DRB1 and DQB1) alleles determine either susceptibility or resistance to NMO and multiple sclerosis among the French Afro-Caribbean population","volume":"17","author":"Deschamps","year":"2011","journal-title":"Mult Scler"},{"key":"B68","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1177\/1352458515574149","article-title":"Human leukocyte antigen association with neuromyelitis optica in a south Indian population","volume":"21","author":"Pandit","year":"2015","journal-title":"Mult Scler"},{"key":"B69","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.jns.2011.11.005","article-title":"Interleukin 17 gene polymorphism is associated with anti-aquaporin 4 antibody-positive neuromyelitis optica in the Southern Han Chinese \u2013 a case control study","volume":"314","author":"Wang","year":"2012","journal-title":"J Neurol Sci"},{"key":"B70","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/j.nbd.2009.10.013","article-title":"Common CYP7A1 promoter polymorphism associated with risk of neuromyelitis optica","volume":"37","author":"Kim","year":"2010","journal-title":"Neurobiol Dis"},{"key":"B71","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1111\/j.1365-2990.2012.01304.x","article-title":"Associations of CD6, TNFRSF1A and IRF8 polymorphisms with risk of inflammatory demyelinating diseases","volume":"39","author":"Park","year":"2013","journal-title":"Neuropathol Appl Neurobiol"},{"key":"B72","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1186\/1471-2377-14-57","article-title":"CD58 polymorphisms associated with the risk of neuromyelitis optica in a Korean population","volume":"14","author":"Kim","year":"2014","journal-title":"BMC Neurol"},{"key":"B73","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1002\/ana.24511","article-title":"Copy number variations in multiple sclerosis and neuromyelitis optica","volume":"78","author":"Sato","year":"2015","journal-title":"Ann Neurol"},{"key":"B74","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1177\/1352458511417480","article-title":"HLA, PTPN22 and PD-1 associations as markers of autoimmunity in neuromyelitis optica","volume":"18","author":"Asgari","year":"2012","journal-title":"Mult Scler"},{"key":"B75","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1212\/WNL.0b013e31822f045b","article-title":"Genetic analysis of aquaporin-4 in neuromyelitis optica","volume":"77","author":"Matiello","year":"2011","journal-title":"Neurology"},{"key":"B76","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.jaut.2017.05.005","article-title":"Methylome and transcriptome profiling in myasthenia gravis monozygotic twins","volume":"82","author":"Mamrut","year":"2017","journal-title":"J Autoimmun"},{"key":"B77","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1186\/s12974-016-0648-x","article-title":"Circulating microRNAs as biomarkers for rituximab therapy, in neuromyelitis optica (NMO)","volume":"13","author":"Vaknin-Dembinsky","year":"2016","journal-title":"J Neuroinflammation"},{"key":"B78","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1111\/j.1365-3083.2008.02127.x","article-title":"The complex role of vitamin D in autoimmune diseases","volume":"68","author":"Szodoray","year":"2008","journal-title":"Scand J Immunol"},{"key":"B79","doi-asserted-by":"publisher","first-page":"1554","DOI":"10.1111\/j.1468-1331.2012.03773.x","article-title":"Vitamin D deficiency in patients with myasthenia gravis and improvement of fatigue after supplementation of vitamin D3: a pilot study","volume":"19","author":"Askmark","year":"2012","journal-title":"Eur J Neurol"},{"key":"B80","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.jneuroim.2015.03.008","article-title":"Regulatory function of CD4+CD25++ T cells in patients with myasthenia gravis is associated with phenotypic changes and STAT5 signaling: 1,25-Dihydroxyvitamin D3 modulates the suppressor activity","volume":"281","author":"Alahgholi-Hajibehzad","year":"2015","journal-title":"J Neuroimmunol"},{"key":"B81","doi-asserted-by":"publisher","first-page":"51","DOI":"10.12659\/AJCR.894849","article-title":"Remission of severe myasthenia gravis after massive-dose vitamin D treatment","volume":"17","author":"Cadegiani","year":"2016","journal-title":"Am J Case Rep"},{"key":"B82","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1001\/archneurol.2011.1974","article-title":"Low serum vitamin D levels and recurrent inflammatory spinal cord disease","volume":"69","author":"Mealy","year":"2012","journal-title":"Arch Neurol"},{"key":"B83","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.jneuroim.2016.09.006","article-title":"Serum 25-hydroxyvitamin D3 is associated with disease status in patients with neuromyelitis optica spectrum disorders in south China","volume":"299","author":"Shan","year":"2016","journal-title":"J Neuroimmunol"},{"key":"B84","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.jneuroim.2016.03.016","article-title":"Vitamin D level status in Thai neuromyelitis optica patients","volume":"29","author":"Jitprapaikulsan","year":"2016","journal-title":"J Neuroimmunol"},{"key":"B85","doi-asserted-by":"publisher","first-page":"1701","DOI":"10.1007\/s10072-015-2229-7","article-title":"Reduced serum vitamin D levels in neuromyelitis optica","volume":"36","author":"T\u00fcz\u00fcn","year":"2015","journal-title":"Neurol Sci"},{"key":"B86","doi-asserted-by":"publisher","first-page":"e107274","DOI":"10.1371\/journal.pone.0107274","article-title":"Low levels of vitamin D in neuromyelitis optica spectrum disorder: association with disease disability","volume":"9","author":"Min","year":"2014","journal-title":"PLoS One"},{"key":"B87","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1038\/nature18848","article-title":"The microbiota in adaptive immune homeostasis and disease","volume":"535","author":"Honda","year":"2016","journal-title":"Nature"},{"key":"B88","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1365-2249.2010.04139.x","article-title":"The \u2019hygiene hypothesis\u2019 for autoimmune and allergic diseases: an update","volume":"160","author":"Okada","year":"2010","journal-title":"Clin Exp Immunol"},{"key":"B89","doi-asserted-by":"publisher","first-page":"e52119","DOI":"10.1371\/journal.pone.0052119","article-title":"Prophylactic effect of probiotics on the development of experimental autoimmune myasthenia gravis","volume":"7","author":"Chae","year":"2012","journal-title":"PLoS One"},{"key":"B90","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1002\/ana.24718","article-title":"Gut microbiome analysis in neuromyelitis optica reveals overabundance of Clostridium perfringens","volume":"80","author":"Cree","year":"2016","journal-title":"Ann Neurol"},{"key":"B91","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1002\/ana.23651","article-title":"Aquaporin 4-specific T cells in neuromyelitis optica exhibit a Th17 bias and recognize Clostridium ABC transporter","volume":"72","author":"Varrin-Doyer","year":"2012","journal-title":"Ann Neurol"},{"key":"B92","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1016\/j.autrev.2013.03.010","article-title":"Etiology of myasthenia gravis: innate immunity signature in pathological thymus","volume":"12","author":"Cavalcante","year":"2013","journal-title":"Autoimmun Rev"},{"key":"B93","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1002\/ana.21902","article-title":"Epstein-Barr virus persistence and reactivation in myasthenia gravis thymus","volume":"67","author":"Cavalcante","year":"2010","journal-title":"Ann Neurol"},{"key":"B94","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1111\/j.1468-1331.2011.03636.x","article-title":"High anti-EBNA-1 IgG levels are associated with early-onset myasthenia gravis","volume":"19","author":"Csuka","year":"2012","journal-title":"Eur J Neurol"},{"key":"B95","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1002\/ana.22522","article-title":"Lack of evidence for Epstein-Barr virus infection in myasthenia gravis thymus","volume":"70","author":"Meyer","year":"2011","journal-title":"Ann Neurol"},{"key":"B96","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1136\/jnnp-2014-308095","article-title":"Epstein-Barr virus persistence and reactivation in neuromyelitis optica","volume":"86","author":"Masuda","year":"2015","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"B97","doi-asserted-by":"publisher","first-page":"453","DOI":"10.3109\/08916934.2015.1070836","article-title":"Immunization of mice with a peptide derived from the HTLV-1 TAX1BP1 protein induces cross-reactive antibodies against aquaporin 4","volume":"48","author":"Kampylafka","year":"2015","journal-title":"Autoimmunity"},{"key":"B98","doi-asserted-by":"publisher","first-page":"e39372","DOI":"10.1371\/journal.pone.0039372","article-title":"Aquaporin-4 antibodies are not related to HTLV-1 associated myelopathy","volume":"7","author":"von","year":"2012","journal-title":"PLoS One"},{"key":"B99","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1038\/ni.3731","article-title":"The multiple pathways to autoimmunity","volume":"18","author":"Theofilopoulos","year":"2017","journal-title":"Nat Immunol"},{"key":"B100","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1038\/nri.2016.90","article-title":"Sex differences in immune responses","volume":"16","author":"Klein","year":"2016","journal-title":"Nat Rev Immunol"},{"key":"B101","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1016\/S1473-3099(10)70049-9","article-title":"The Xs and Y of immune responses to viral vaccines","volume":"10","author":"Klein","year":"2010","journal-title":"Lancet Infect Dis"},{"key":"B102","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1177\/096120339900800510","article-title":"Gender differences in some host defense mechanisms","volume":"8","author":"Spitzer","year":"1999","journal-title":"Lupus"},{"key":"B103","doi-asserted-by":"crossref","first-page":"656","DOI":"10.4049\/jimmunol.132.2.656","article-title":"Sex-associated differences in the regulation of immune responses controlled by the MHC of the mouse","volume":"132","author":"Weinstein","year":"1984","journal-title":"J Immunol"},{"key":"B104","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.cellimm.2011.10.009","article-title":"Gender effect on in vitro lymphocyte subset levels of healthy individuals","volume":"272","author":"Abdullah","year":"2012","journal-title":"Cell Immunol"},{"key":"B105","first-page":"567","article-title":"CD4+CD25(hi) regulatory T cells in healthy males and females mediate gender difference in the prevalence of autoimmune diseases","volume":"58","author":"Afshan","year":"2012","journal-title":"Clin Lab"},{"key":"B106","doi-asserted-by":"publisher","first-page":"28495","DOI":"10.1038\/srep28495","article-title":"Gender-specific differences in PPAR\u03b3 regulation of follicular helper T cell responses with estrogen","volume":"6","author":"Park","year":"2016","journal-title":"Sci Rep"},{"key":"B107","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1210\/er.2007-0001","article-title":"The complex role of estrogens in inflammation","volume":"28","author":"Straub","year":"2007","journal-title":"Endocr Rev"},{"key":"B108","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1136\/jnnp.40.11.1060","article-title":"Acetylcholinesterase activity and menstrual remissions in myasthenia gravis","volume":"40","author":"Vijayan","year":"1977","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"B109","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1212\/WNL.52.3.447","article-title":"Course and treatment of myasthenia gravis during pregnancy","volume":"52","author":"Batocchi","year":"1999","journal-title":"Neurology"},{"key":"B110","doi-asserted-by":"publisher","first-page":"2345","DOI":"10.1210\/en.2004-1003","article-title":"Differential estrogen receptor expression in autoimmune myasthenia gravis","volume":"146","author":"Nancy","year":"2005","journal-title":"Endocrinology"},{"key":"B111","doi-asserted-by":"publisher","first-page":"e288","DOI":"10.1212\/NXI.0000000000000288","article-title":"Immunology of neuromyelitis optica during pregnancy","volume":"3","author":"Davoudi","year":"2016","journal-title":"Neurol Neuroimmunol Neuroinflamm"},{"key":"B112","doi-asserted-by":"publisher","first-page":"e339","DOI":"10.1212\/NXI.0000000000000339","article-title":"Female hormonal exposures and neuromyelitis optica symptom onset in a multicenter study","volume":"4","author":"Bove","year":"2017","journal-title":"Neurol Neuroimmunol Neuroinflamm"},{"key":"B113","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1002\/ana.23791","article-title":"Implication of double-stranded RNA signaling in the etiology of autoimmune myasthenia gravis","volume":"73","author":"Cufi","year":"2013","journal-title":"Ann Neurol"},{"key":"B114","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/B978-0-12-800100-4.00006-4","article-title":"Immunopathogenesis of neuromyelitis optica","volume":"121","author":"Levy","year":"2014","journal-title":"Adv Immunol"},{"key":"B115","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1038\/nri.2016.53","article-title":"Division of labour by CD4(+) T helper cells","volume":"16","author":"Ziegler","year":"2016","journal-title":"Nat Rev Immunol"},{"key":"B116","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/0165-5728(94)90080-9","article-title":"Augmented interferon-gamma, interleukin-4 and transforming growth factor-beta mRNA expression in blood mononuclear cells in myasthenia gravis","volume":"51","author":"Link","year":"1994","journal-title":"J Neuroimmunol"},{"key":"B117","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.ejphar.2009.10.040","article-title":"Clinical implications of the type 1\/type 2 balance of helper T cells and P-glycoprotein function in peripheral T lymphocytes of myasthenia gravis patients","volume":"627","author":"Masuda","year":"2010","journal-title":"Eur J Pharmacol"},{"key":"B118","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1002\/mus.22070","article-title":"Increased serum interleukin-17 levels in patients with myasthenia gravis","volume":"44","author":"Roche","year":"2011","journal-title":"Muscle Nerve"},{"key":"B119","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1111\/j.1365-3083.2012.02703.x","article-title":"T helper type 17 cells expand in patients with myasthenia-associated thymoma","volume":"76","author":"Wang","year":"2012","journal-title":"Scand J Immunol"},{"key":"B120","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.jaut.2013.12.015","article-title":"Both Treg cells and Tconv cells are defective in the myasthenia gravis thymus: roles of IL-17 and TNF-\u03b1","volume":"52","author":"Gradolatto","year":"2014","journal-title":"J Autoimmun"},{"key":"B121","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1111\/cei.12272","article-title":"Serum cytokine and chemokine profiles in patients with myasthenia gravis","volume":"176","author":"Uzawa","year":"2014","journal-title":"Clin Exp Immunol"},{"key":"B122","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.jaut.2013.12.005","article-title":"Characterization of CD4 and CD8 T cell responses in MuSK myasthenia gravis","volume":"52","author":"Yi","year":"2014","journal-title":"J Autoimmun"},{"key":"B123","doi-asserted-by":"publisher","first-page":"e0123546","DOI":"10.1371\/journal.pone.0123546","article-title":"Differential cytokine changes in patients with myasthenia gravis with antibodies against AChR and MuSK","volume":"10","author":"Yilmaz","year":"2015","journal-title":"PLoS One"},{"key":"B124","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1186\/1471-2377-10-113","article-title":"Expression of chemokine receptors on peripheral blood lymphocytes in multiple sclerosis and neuromyelitis optica","volume":"10","author":"Uzawa","year":"2010","journal-title":"BMC Neurol"},{"key":"B125","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1159\/000329576","article-title":"Association of Th1\/Th2-related chemokine receptors in peripheral T cells with disease activity in patients with multiple sclerosis and neuromyelitis optica","volume":"66","author":"Shimizu","year":"2011","journal-title":"Eur Neurol"},{"key":"B126","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.cyto.2015.10.001","article-title":"CSF cytokines\/chemokines as biomarkers in neuroinflammatory CNS disorders: a systematic review","volume":"77","author":"Kothur","year":"2016","journal-title":"Cytokine"},{"key":"B127","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1111\/bpa.12097","article-title":"Cytokines and chemokines in neuromyelitis optica: pathogenetic and therapeutic implications","volume":"24","author":"Uzawa","year":"2014","journal-title":"Brain Pathol"},{"key":"B128","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.cca.2014.11.004","article-title":"Biomarkers for neuromyelitis optica","volume":"440","author":"Chang","year":"2015","journal-title":"Clin Chim Acta"},{"key":"B129","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1159\/000464135","article-title":"Cytokine and chemokine profiles in patients with neuromyelitis optica spectrum disorder","volume":"23","author":"Wang","year":"2016","journal-title":"Neuroimmunomodulation"},{"key":"B130","doi-asserted-by":"publisher","first-page":"1302","DOI":"10.1212\/WNL.0000000000000317","article-title":"Efficacy of the anti-IL-6 receptor antibody tocilizumab in neuromyelitis optica: a pilot study","volume":"82","author":"Araki","year":"2014","journal-title":"Neurology"},{"key":"B131","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1038\/nrcardio.2015.169","article-title":"Regulatory T cells in cardiovascular diseases","volume":"13","author":"Meng","year":"2016","journal-title":"Nat Rev Cardiol"},{"key":"B132","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.clim.2012.09.012","article-title":"Impaired regulatory function in circulating CD4(+)CD25(high)CD127(low\/-) T cells in patients with myasthenia gravis","volume":"145","author":"Thiruppathi","year":"2012","journal-title":"Clin Immunol"},{"key":"B133","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1182\/blood-2003-11-3900","article-title":"Functional defect of regulatory CD4(+)CD25+ T cells in the thymus of patients with autoimmune myasthenia gravis","volume":"105","author":"Balandina","year":"2005","journal-title":"Blood"},{"key":"B134","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.jneuroim.2010.03.016","article-title":"Clinical implication of peripheral CD4+CD25+ regulatory T cells and Th17\u2009cells in myasthenia gravis patients","volume":"225","author":"Masuda","year":"2010","journal-title":"J Neuroimmunol"},{"key":"B135","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1146\/annurev-immunol-031210-101400","article-title":"Follicular helper CD4 T cells (TFH)","volume":"29","author":"Crotty","year":"2011","journal-title":"Annu Rev Immunol"},{"key":"B136","doi-asserted-by":"publisher","first-page":"2610","DOI":"10.4049\/jimmunol.1500725","article-title":"Augmentation of circulating follicular helper T cells and their impact on autoreactive B cells in myasthenia gravis","volume":"197","author":"Zhang","year":"2016","journal-title":"J Immunol"},{"key":"B137","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.jneuroim.2014.11.011","article-title":"Association of circulating follicular helper T cells with disease course of NMO spectrum disorders","volume":"278","author":"Li","year":"2015","journal-title":"J Neuroimmunol"},{"key":"B138","doi-asserted-by":"publisher","first-page":"3678152","DOI":"10.1155\/2016\/3678152","article-title":"Circulating memory T follicular helper cells in patients with neuromyelitis optica\/neuromyelitis optica spectrum disorders","volume":"2016","author":"Fan","year":"2016","journal-title":"Mediators Inflamm"},{"key":"B139","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1038\/nri844","article-title":"BAFF: a fundamental survival factor for B cells","volume":"2","author":"Mackay","year":"2002","journal-title":"Nat Rev Immunol"},{"key":"B140","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1016\/j.autrev.2013.03.011","article-title":"Ectopic germinal centers, BAFF and anti-B-cell therapy in myasthenia gravis","volume":"12","author":"Berrihaknin","year":"2013","journal-title":"Autoimmun Rev"},{"key":"B141","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1016\/j.nmd.2017.06.012","article-title":"Memory B cell resurgence requires repeated rituximab in myasthenia gravis","volume":"27","author":"Muto","year":"2017","journal-title":"Neuromuscul Disord"},{"key":"B142","doi-asserted-by":"publisher","first-page":"3701","DOI":"10.1073\/pnas.1017385108","article-title":"Interleukin 6 signaling promotes anti-aquaporin 4 autoantibody production from plasmablasts in neuromyelitis optica","volume":"108","author":"Chihara","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B143","doi-asserted-by":"publisher","first-page":"1412","DOI":"10.1001\/archneurol.2011.154","article-title":"Repeated treatment with rituximab based on the assessment of peripheral circulating memory B cells in patients with relapsing neuromyelitis optica over 2 years","volume":"68","author":"Kim","year":"2011","journal-title":"Arch Neurol"},{"key":"B144","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.1212\/WNL.0b013e3182152881","article-title":"Long-term follow-up of patients with neuromyelitis optica after repeated therapy with rituximab","volume":"76","author":"Pellkofer","year":"2011","journal-title":"Neurology"},{"key":"B145","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1002\/jnr.23749","article-title":"Role of regulatory b cells in neuroimmunologic disorders","volume":"94","author":"Han","year":"2016","journal-title":"J Neurosci Res"},{"key":"B146","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.jneuroim.2016.05.004","article-title":"Impaired regulatory B cells in myasthenia gravis","volume":"297","author":"Sheng","year":"2016","journal-title":"J Neuroimmunol"},{"key":"B147","doi-asserted-by":"publisher","first-page":"43","DOI":"10.3389\/fneur.2017.00043","article-title":"Regulatory B cells in seropositive myasthenia gravis versus healthy controls","volume":"8","author":"Karim","year":"2017","journal-title":"Front Neurol"},{"key":"B148","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1177\/1352458512454771","article-title":"Impaired regulatory function and enhanced intrathecal activation of B cells in neuromyelitis optica: distinct from multiple sclerosis","volume":"19","author":"Quan","year":"2013","journal-title":"Mult Scler"},{"key":"B149","doi-asserted-by":"publisher","first-page":"1797","DOI":"10.1056\/NEJM199406233302507","article-title":"Myasthenia gravis","volume":"330","author":"Drachman","year":"1994","journal-title":"N Engl J Med"},{"key":"B150","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1007\/s00401-013-1172-z","article-title":"Involvement of antibody-dependent cell-mediated cytotoxicity in inflammatory demyelination in a mouse model of neuromyelitis optica","volume":"126","author":"Ratelade","year":"2013","journal-title":"Acta Neuropathol"},{"key":"B151","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1038\/nrneurol.2014.141","article-title":"Treatment of neuromyelitis optica: state-of-the-art and emerging therapies","volume":"10","author":"Papadopoulos","year":"2014","journal-title":"Nat Rev Neurol"},{"key":"B152","doi-asserted-by":"publisher","first-page":"1224","DOI":"10.1093\/brain\/awm047","article-title":"Loss of aquaporin 4 in lesions of neuromyelitis optica: distinction from multiple sclerosis","volume":"130","author":"Misu","year":"2007","journal-title":"Brain"},{"key":"B153","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1093\/brain\/awl371","article-title":"Pattern-specific loss of aquaporin-4 immunoreactivity distinguishes neuromyelitis optica from multiple sclerosis","volume":"130","author":"Roemer","year":"2007","journal-title":"Brain"},{"key":"B154","doi-asserted-by":"publisher","first-page":"eaai9111","DOI":"10.1126\/scitranslmed.aai9111","article-title":"Glucose-regulated protein 78 autoantibody associates with blood-brain barrier disruption in neuromyelitis optica","volume":"9","author":"Shimizu","year":"2017","journal-title":"Sci Transl Med"},{"key":"B155","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1212\/WNL.0b013e318214332c","article-title":"Neuromyelitis optica unique area postrema lesions: nausea, vomiting, and pathogenic implications","volume":"76","author":"Popescu","year":"2011","journal-title":"Neurology"},{"key":"B156","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.1073\/pnas.1109980108","article-title":"Molecular outcomes of neuromyelitis optica (NMO)-IgG binding to aquaporin-4 in astrocytes","volume":"109","author":"Hinson","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B157","doi-asserted-by":"publisher","first-page":"45","DOI":"10.4103\/0028-3886.173638","article-title":"Coexistence of autoimmune diseases and autoantibodies in patients with myasthenia gravis","volume":"64","author":"Tamer","year":"2016","journal-title":"Neurol India"},{"key":"B158","doi-asserted-by":"publisher","first-page":"154","DOI":"10.3109\/08916934.2014.883501","article-title":"A review of the current literature and a guide to the early diagnosis of autoimmune disorders associated with neuromyelitis optica","volume":"47","author":"Iyer","year":"2014","journal-title":"Autoimmunity"},{"key":"B159","doi-asserted-by":"publisher","first-page":"1601","DOI":"10.1212\/WNL.0b013e31825644ff","article-title":"Myasthenia gravis and neuromyelitis optica spectrum disorder: a multicenter study of 16 patients","volume":"78","author":"Leite","year":"2012","journal-title":"Neurology"},{"key":"B160","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1002\/mus.21197","article-title":"Coexistence of myasthenia gravis and serological markers of neurological autoimmunity in neuromyelitis optica","volume":"39","author":"McKeon","year":"2009","journal-title":"Muscle Nerve"},{"key":"B161","doi-asserted-by":"publisher","first-page":"1557","DOI":"10.1001\/archneurol.2011.200","article-title":"Myasthenia gravis-associated neuromyelitis optica-like disease: an immunological link between the central nervous system and muscle","volume":"68","author":"Vaknin-Dembinsky","year":"2011","journal-title":"Arch Neurol"},{"key":"B162","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/0165-5728(87)90075-0","article-title":"Antibodies in sera from patients with myasthenia gravis do not bind to nicotinic acetylcholine receptors from human brain","volume":"16","author":"Whiting","year":"1987","journal-title":"J Neuroimmunol"},{"key":"B163","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1001\/jamaneurol.2015.1444","article-title":"Clinical utility of acetylcholine receptor antibody testing in ocular myasthenia gravis","volume":"72","author":"Peeler","year":"2015","journal-title":"JAMA Neurol"},{"key":"B164","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1016\/j.autrev.2013.03.003","article-title":"Complement associated pathogenic mechanisms in myasthenia gravis","volume":"12","author":"T\u00fcz\u00fcn","year":"2013","journal-title":"Autoimmun Rev"},{"key":"B165","doi-asserted-by":"publisher","first-page":"e55611","DOI":"10.1371\/journal.pone.0055611","article-title":"Extraocular muscle characteristics related to myasthenia gravis susceptibility","volume":"8","author":"Liu","year":"2013","journal-title":"PLoS One"},{"key":"B166","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1038\/nrd4226","article-title":"Aquaporins: important but elusive drug targets","volume":"13","author":"Verkman","year":"2014","journal-title":"Nat Rev Drug Discov"},{"key":"B167","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1093\/brain\/awm062","article-title":"Anti-aquaporin-4 antibody is involved in the pathogenesis of NMO: a study on antibody titre","volume":"130","author":"Takahashi","year":"2007","journal-title":"Brain"},{"key":"B168","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1001\/jamaneurol.2013.3124","article-title":"Aquaporin 4 expression and tissue susceptibility to neuromyelitis optica","volume":"70","author":"Matiello","year":"2013","journal-title":"JAMA Neurol"},{"key":"B169","doi-asserted-by":"publisher","first-page":"35850","DOI":"10.1074\/jbc.M109.071670","article-title":"Live cell analysis of aquaporin-4 m1\/m23 interactions and regulated orthogonal array assembly in glial cells","volume":"284","author":"Crane","year":"2009","journal-title":"J Biol Chem"},{"key":"B170","doi-asserted-by":"publisher","first-page":"16516","DOI":"10.1074\/jbc.M111.227298","article-title":"Binding affinity and specificity of neuromyelitis optica autoantibodies to aquaporin-4 M1\/M23 isoforms and orthogonal arrays","volume":"286","author":"Crane","year":"2011","journal-title":"J Biol Chem"},{"key":"B171","doi-asserted-by":"publisher","first-page":"13829","DOI":"10.1074\/jbc.M112.344325","article-title":"Complement-dependent cytotoxicity in neuromyelitis optica requires aquaporin-4 protein assembly in orthogonal arrays","volume":"287","author":"Phuan","year":"2012","journal-title":"J Biol Chem"},{"key":"B172","doi-asserted-by":"publisher","first-page":"964","DOI":"10.1001\/archneur.63.7.964","article-title":"Neuromyelitis optica brain lesions localized at sites of high aquaporin 4 expression","volume":"63","author":"Pittock","year":"2006","journal-title":"Arch Neurol"},{"key":"B173","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1007\/s00401-017-1682-1","article-title":"Pathogenic implications of cerebrospinal fluid barrier pathology in neuromyelitis optica","volume":"133","author":"Guo","year":"2017","journal-title":"Acta Neuropathol"},{"key":"B174","doi-asserted-by":"publisher","first-page":"e104","DOI":"10.1212\/NXI.0000000000000104","article-title":"B lymphocytes in neuromyelitis optica","volume":"2","author":"Bennett","year":"2015","journal-title":"Neurol Neuroimmunol Neuroinflamm"},{"key":"B175","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1002\/acn3.418","article-title":"CNS Aquaporin-4-specific B cells connect with multiple B-cell compartments in neuromyelitis optica spectrum disorder","volume":"4","author":"Kowarik","year":"2017","journal-title":"Ann Clin Transl Neurol"},{"key":"B176","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1002\/ana.22686","article-title":"Neutrophil protease inhibition reduces neuromyelitis optica-immunoglobulin G-induced damage in mouse brain","volume":"71","author":"Saadoun","year":"2012","journal-title":"Ann Neurol"},{"key":"B177","doi-asserted-by":"publisher","first-page":"2306","DOI":"10.1172\/JCI67554","article-title":"Eosinophil pathogenicity mechanisms and therapeutics in neuromyelitis optica","volume":"123","author":"Zhang","year":"2013","journal-title":"J Clin Invest"},{"key":"B178","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.coi.2017.03.004","article-title":"An antigen to remember: regulation of B cell memory in health and disease","volume":"45","author":"Pupovac","year":"2017","journal-title":"Curr Opin Immunol"},{"key":"B179","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2017.05.008","article-title":"Role of CD11c(+) T-bet(+) B cells in human health and disease","author":"Karnell","year":"2017","journal-title":"Cell Immunol"},{"key":"B180","doi-asserted-by":"publisher","first-page":"3525","DOI":"10.4049\/jimmunol.1600017","article-title":"Cutting edge: BAFF promotes autoantibody production via TACI-dependent activation of transitional B cells","volume":"196","author":"Jacobs","year":"2016","journal-title":"J Immunol"},{"key":"B181","doi-asserted-by":"publisher","first-page":"14993","DOI":"10.1073\/pnas.0806044105","article-title":"Local BAFF gene silencing suppresses Th17-cell generation and ameliorates autoimmune arthritis","volume":"105","author":"Lai","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B182","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1002\/art.38950","article-title":"BAFF regulates follicular helper t cells and affects their accumulation and interferon-\u03b3 production in autoimmunity","volume":"67","author":"Coquery","year":"2015","journal-title":"Arthritis Rheumatol"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2017.01785\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T17:04:26Z","timestamp":1693328666000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2017.01785\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,12]]},"references-count":182,"alternative-id":["10.3389\/fimmu.2017.01785"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2017.01785","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,12]]},"article-number":"1785"}}