{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T22:11:27Z","timestamp":1781561487941,"version":"3.54.5"},"reference-count":26,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2017\/02998-0, 2013\/04088-0, and 2016\/10446-4"],"award-info":[{"award-number":["2017\/02998-0, 2013\/04088-0, and 2016\/10446-4"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2017.01820","type":"journal-article","created":{"date-parts":[[2017,12,18]],"date-time":"2017-12-18T04:19:20Z","timestamp":1513570760000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":35,"title":["Targeting and Recognition of Toll-Like Receptors by Plant and Pathogen Lectins"],"prefix":"10.3389","volume":"8","author":[{"given":"Rafael","family":"Ricci-Azevedo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria-Cristina","family":"Roque-Barreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J.","family":"Gay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2017,12,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1038\/ni.1863","article-title":"The role of pattern-recognition receptors in innate immunity: update on toll-like receptors","volume":"11","author":"Kawai","year":"2010","journal-title":"Nat Immunol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1038\/nri3446","article-title":"The history of toll-like receptors \u2013 redefining innate immunity","volume":"13","author":"O\u2019Neill","year":"2013","journal-title":"Nat Rev Immunol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1146\/annurev.immunol.20.083001.084359","article-title":"Innate immune recognition","volume":"20","author":"Janeway","year":"2002","journal-title":"Annu Rev Immunol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.smim.2003.10.003","article-title":"TLR signaling pathways","volume":"16","author":"Takeda","year":"2004","journal-title":"Semin Immunol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1038\/90609","article-title":"Toll-like receptors: critical proteins linking innate and acquired immunity","volume":"2","author":"Akira","year":"2001","journal-title":"Nat Immunol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1038\/nrd3203","article-title":"Targeting toll-like receptors: emerging therapeutics?","volume":"9","author":"Hennessy","year":"2010","journal-title":"Nat Rev Drug Discov"},{"key":"B7","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1124\/pr.109.001073","article-title":"Therapeutic targeting of toll-like receptors for infectious and inflammatory diseases and cancer","volume":"61","author":"O\u2019Neill","year":"2009","journal-title":"Pharmacol Rev"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.1007\/s12272-016-0806-9","article-title":"Toll-like receptors: promising therapeutic targets for inflammatory diseases","volume":"39","author":"Achek","year":"2016","journal-title":"Arch Pharm Res"},{"key":"B9","doi-asserted-by":"publisher","first-page":"79","DOI":"10.3389\/fimmu.2014.00079","article-title":"TLR agonists as modulators of the innate immune response and their potential as agents against infectious disease","volume":"5","author":"Mifsud","year":"2014","journal-title":"Front Immunol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/j.str.2011.02.004","article-title":"The structural biology of toll-like receptors","volume":"19","author":"Botos","year":"2011","journal-title":"Structure"},{"key":"B11","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1038\/nri3713","article-title":"Assembly and localization of toll-like receptor signalling complexes","volume":"14","author":"Gay","year":"2014","journal-title":"Nat Rev Immunol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1457","DOI":"10.1042\/BST0361457","article-title":"Lectins: past, present and future","volume":"36","author":"Sharon","year":"2008","journal-title":"Biochem Soc Trans"},{"key":"B13","doi-asserted-by":"publisher","first-page":"34589","DOI":"10.1074\/jbc.M403830200","article-title":"Four N-linked glycosylation sites in human toll-like receptor 2 cooperate to direct efficient biosynthesis and secretion","volume":"279","author":"Weber","year":"2004","journal-title":"J Biol Chem"},{"key":"B14","doi-asserted-by":"publisher","first-page":"e3317","DOI":"10.1371\/journal.pntd.0003317","article-title":"Therapeutic administration of recombinant paracoccin confers protection against Paracoccidioides brasiliensis infection: involvement of TLRs","volume":"8","author":"Alegre-Maller","year":"2014","journal-title":"PLoS Negl Trop Dis"},{"key":"B15","doi-asserted-by":"publisher","first-page":"e98512","DOI":"10.1371\/journal.pone.0098512","article-title":"Recognition of TLR2 N-glycans: critical role in ArtinM immunomodulatory activity","volume":"9","author":"Mariano","year":"2014","journal-title":"PLoS One"},{"key":"B16","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1016\/j.ijpara.2011.06.003","article-title":"Pathogenic bacteria prime the induction of toll-like receptor signalling in human colonic cells by the Gal\/GalNAc lectin carbohydrate recognition domain of Entamoeba histolytica","volume":"41","author":"Galv\u00e1n-Moroyoqui","year":"2011","journal-title":"Int J Parasitol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1038\/nrrheum.2009.136","article-title":"Sensors of the innate immune system: their mode of action","volume":"5","author":"Baccala","year":"2009","journal-title":"Nat Rev Rheumatol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"359","DOI":"10.3109\/10409238.2015.1033511","article-title":"Advances in toll-like receptor biology: modes of activation by diverse stimuli","volume":"50","author":"Bryant","year":"2015","journal-title":"Crit Rev Biochem Mol Biol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"423","DOI":"10.2353\/ajpath.2008.080126","article-title":"Therapeutic administration of KM+ lectin protects mice against Paracoccidioides brasiliensis infection via interleukin-12 production in a toll-like receptor 2-dependent mechanism","volume":"173","author":"Coltri","year":"2008","journal-title":"Am J Pathol"},{"key":"B20","doi-asserted-by":"publisher","first-page":"7083","DOI":"10.1038\/s41598-017-07397-0","article-title":"CD14 is critical for TLR2-mediated M1 macrophage activation triggered by N-glycan recognition","volume":"7","author":"da Silva","year":"2017","journal-title":"Sci Rep"},{"key":"B21","doi-asserted-by":"publisher","first-page":"1324","DOI":"10.1016\/j.bcp.2011.03.010","article-title":"Plant lectins are novel toll-like receptor agonists","volume":"81","author":"Unitt","year":"2011","journal-title":"Biochem Pharmacol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1016\/j.bbrc.2010.04.169","article-title":"TLR4-mediated activation of mouse macrophages by Korean mistletoe lectin-C (KML-C)","volume":"396","author":"Park","year":"2010","journal-title":"Biochem Biophys Res Commun"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1101\/187690","article-title":"Toxoplasma gondii microneme proteins 1 and 4 bind to toll-like receptors 2 and 4 N-glycans triggering innate immune response","author":"Sardinha-Silva","year":"2017","journal-title":"bioRxiv"},{"key":"B24","doi-asserted-by":"publisher","first-page":"e0149721","DOI":"10.1371\/journal.pone.0149721","article-title":"IL-17 induction by ArtinM is due to stimulation of IL-23 and IL-1 release and\/or interaction with CD3 in CD4+ T cells","volume":"11","author":"da Silva","year":"2016","journal-title":"PLoS One"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1584","DOI":"10.1016\/j.dib.2016.04.053","article-title":"Data on IL-17 production induced by plant lectins","volume":"7","author":"da Silva","year":"2016","journal-title":"Data Brief"},{"key":"B26","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1007\/s12281-010-0034-6","article-title":"T-cell subsets and antifungal host defenses","volume":"4","author":"Van De Veerdonk","year":"2010","journal-title":"Curr Fungal Infect Rep"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2017.01820\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,12,18]],"date-time":"2017-12-18T04:19:24Z","timestamp":1513570764000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2017.01820\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,18]]},"references-count":26,"alternative-id":["10.3389\/fimmu.2017.01820"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2017.01820","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,18]]},"article-number":"1820"}}