{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:09:28Z","timestamp":1784246968570,"version":"3.55.0"},"reference-count":43,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,1,25]],"date-time":"2018-01-25T00:00:00Z","timestamp":1516838400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2018.00049","type":"journal-article","created":{"date-parts":[[2018,1,25]],"date-time":"2018-01-25T09:22:20Z","timestamp":1516872140000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":38,"title":["Fowl Adenovirus Serotype 4 SD0828 Infections Causes High Mortality Rate and Cytokine Levels in Specific Pathogen-Free Chickens Compared to Ducks"],"prefix":"10.3389","volume":"9","author":[{"given":"Rong","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaojie","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolan","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyu","family":"Weng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengjiao","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingli","family":"Shang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongjie","family":"Chai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangmeng","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,1,25]]},"reference":[{"key":"B1","first-page":"1","article-title":"A treatise on Angara disease (hydropericardium-pulmonary oedema-hepatonephritis syndrome)","volume":"34","author":"Jaffery","year":"1988","journal-title":"J Pak Vet Med Assoc"},{"key":"B2","first-page":"127","article-title":"Isolation of an adenovirus from hydropericardium syndrome in broiler chicks","volume":"28","author":"Khawaja","year":"1988","journal-title":"Pak J Vet Res"},{"key":"B3","doi-asserted-by":"crossref","DOI":"10.1007\/978-0-387-95919-1","volume-title":"The Springer Index of Viruses","author":"Tidona","year":"2011"},{"key":"B4","first-page":"213","article-title":"Family adenoviridae","volume-title":"Virus Taxonomy: VIIIth Report of the International Committee on Taxonomy of Viruses","author":"Benk\u00f6","year":"2005"},{"key":"B5","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1080\/03079450050045440","article-title":"Detection and differentiation of avian adenoviruses: a review","volume":"29","author":"Hess","year":"2000","journal-title":"Avian Pathol"},{"key":"B6","volume-title":"Virus Taxonomy: VIIIth Report of the International Committee on Taxonomy of Viruses","author":"Fauquet","year":"2005"},{"key":"B7","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.vetmic.2016.11.005","article-title":"Characterization of fowl adenoviruses isolated between 2007 and 2014 in China","volume":"197","author":"Changjing","year":"2016","journal-title":"Vet Microbiol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1080\/03079450310001652086","article-title":"Phylogenetic analysis of fowl adenoviruses","volume":"33","author":"Meulemans","year":"2004","journal-title":"Avian Pathol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1128\/JCM.01567-08","article-title":"Classification of fowl adenovirus serotypes by use of high-resolution melting-curve analysis of the hexon gene region","volume":"47","author":"Steer","year":"2009","journal-title":"J Clin Microbiol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1177\/104063871002200207","article-title":"Characterization of fowl adenovirus serotype 4 isolated from chickens with hydropericardium syndrome based on analysis of the short fiber protein gene","volume":"22","author":"Mase","year":"2010","journal-title":"J Vet Diag Invest"},{"key":"B11","doi-asserted-by":"publisher","first-page":"e117","DOI":"10.1038\/emi.2016.115","article-title":"Genetic characterization of novel fowl aviadenovirus 4 isolates from outbreaks of hepatitis-hydropericardium syndrome in broiler chickens in China","volume":"5","author":"Liu","year":"2016","journal-title":"Emerg Microbes Infect"},{"key":"B12","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1080\/03079459808419335","article-title":"Some strains of serotype 4 fowl adenoviruses cause inclusion body hepatitis and hydropericardium syndrome in chickens","volume":"27","author":"Mazaheri","year":"1998","journal-title":"Avian Pathol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1637\/8178-112207-Case","article-title":"Outbreaks of hydropericardium syndrome and molecular characterization of Korean fowl adenoviral isolates","volume":"52","author":"Kim","year":"2008","journal-title":"Avian Dis"},{"key":"B14","doi-asserted-by":"publisher","first-page":"1260","DOI":"10.1099\/vir.0.030064-0","article-title":"Coding potential and transcript analysis of fowl adenovirus 4: insight into upstream ORFs as common sequence features in adenoviral transcripts","volume":"92","author":"Griffin","year":"2011","journal-title":"J General Virol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.1016\/j.vaccine.2013.12.056","article-title":"Recombinant FAdV-4 fiber-2 protein protects chickens against hepatitis-hydropericardium syndrome (HHS)","volume":"32","author":"Anna","year":"2014","journal-title":"Vaccine"},{"key":"B16","first-page":"25","article-title":"Hydropericardium syndrome (HPS) virus: immunofluorescence studies on aspects of pathogenesis in chickens","volume":"1","author":"Kumar","year":"2013","journal-title":"Adv Anim Vet Sci"},{"key":"B17","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.meegid.2016.09.006","article-title":"Fowl adenovirus species C serotype 4 is attributed to the emergence of hepatitis-hydropericardium syndrome in chickens in China","volume":"45","author":"Li","year":"2016","journal-title":"Infect Genet Evol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.1042\/BST0351437","article-title":"Building an immune system from nine domains","volume":"35","author":"P\u00e5lsson-McDermott","year":"2007","journal-title":"Biochem Soc Trans"},{"key":"B19","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1038\/nri2690","article-title":"Intracellular DNA recognition","volume":"10","author":"Hornung","year":"2010","journal-title":"Nat Rev Immunol"},{"key":"B20","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1016\/j.cell.2006.02.015","article-title":"Pathogen recognition and innate immunity","volume":"124","author":"Akira","year":"2006","journal-title":"Cell"},{"key":"B21","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/j.molmed.2009.06.003","article-title":"Cytoplasmic nucleic acid sensors in antiviral immunity","volume":"15","author":"Ranjan","year":"2009","journal-title":"Trends Mol Med"},{"key":"B22","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1016\/j.it.2006.06.003","article-title":"TLRs, NLRs and RLRs: a trinity of pathogen sensors that co-operate in innate immunity","volume":"27","author":"Creagh","year":"2006","journal-title":"Trends Immunol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"377","DOI":"10.3389\/fimmu.2016.00377","article-title":"Cherry valley ducks mitochondrial antiviral-signaling protein-mediated signaling pathway and antiviral activity research","volume":"7","author":"Ning","year":"2016","journal-title":"Front Immunol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1038\/ni1087","article-title":"The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses","volume":"5","author":"Yoneyama","year":"2004","journal-title":"Nat Immunol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"5913","DOI":"10.1073\/pnas.1001755107","article-title":"Association of RIG-I with innate immunity of ducks to influenza","volume":"107","author":"Barber","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B26","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1177\/1040638714523426","article-title":"Development of a new real-time polymerase chain reaction assay to detect duck adenovirus A DNA and application to samples from Swiss poultry flocks","volume":"26","author":"Schybli","year":"2014","journal-title":"J Vet Diagn Invest"},{"key":"B27","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.virol.2016.03.004","article-title":"Molecular characterization, phylogeny analysis and pathogenicity of a Muscovy duck adenovirus strain isolated in China in 2014","volume":"493","author":"Zhang","year":"2016","journal-title":"Virology"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.1111\/tbed.12500","article-title":"Hydropericardium hepatitis syndrome emerged in cherry valley ducks in China","volume":"64","author":"Chen","year":"2016","journal-title":"Transbound Emerg Dis"},{"key":"B29","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/S0166-0934(98)00062-7","article-title":"Growth characteristics of fowl adenovirus type 8 in a chicken hepatoma cell line","volume":"74","author":"Alexander","year":"1998","journal-title":"J Virol Methods"},{"key":"B30","first-page":"493","article-title":"A simple method of estimating fifty per cent endpoints","volume":"27","author":"Reed","year":"1938","journal-title":"Am J Trop Med Hygiene"},{"key":"B31","doi-asserted-by":"crossref","first-page":"2939","DOI":"10.1128\/JVI.70.5.2939-2949.1996","article-title":"The complete DNA sequence and genomic organization of the avian adenovirus CELO","volume":"70","author":"Chiocca","year":"1996","journal-title":"J Virol"},{"key":"B32","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/j.vetmic.2013.09.025","article-title":"Molecular typing of fowl adenoviruses, isolated in Hungary recently, reveals high diversity","volume":"167","author":"Kaj\u00e1n","year":"2013","journal-title":"Vet Microbiol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"2684","DOI":"10.1099\/jgv.0.000567","article-title":"Hydropericardium syndrome outbreak caused by fowl adenovirus serotype 4 in China in 2015","volume":"97","author":"Niu","year":"2016","journal-title":"J General Virol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1016\/j.molimm.2010.12.011","article-title":"Immune-related gene expression in response to H5N1 avian influenza virus infection in chicken and duck embryonic fibroblasts","volume":"48","author":"Liang","year":"2011","journal-title":"Mol Immunol"},{"key":"B35","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1016\/j.vetmic.2013.06.019","article-title":"Host immune responses of ducks infected with H5N1 highly pathogenic avian influenza viruses of different pathogenicities","volume":"166","author":"Wei","year":"2013","journal-title":"Vet Microbiol"},{"key":"B36","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1080\/03079458308436147","article-title":"Fowl adenoviruses: studies on aspects of the pathogenicity of six strains for 1-day-old chicks","volume":"12","author":"Cook","year":"1983","journal-title":"Avian Pathol"},{"key":"B37","doi-asserted-by":"publisher","first-page":"e77601","DOI":"10.1371\/journal.pone.0077601","article-title":"Pathogenicity and cytokine gene expression pattern of a serotype 4 fowl adenovirus isolate","volume":"8","author":"Grgi\u0107","year":"2013","journal-title":"PLoS One"},{"key":"B38","doi-asserted-by":"publisher","first-page":"e0133073","DOI":"10.1371\/journal.pone.0133073","article-title":"Pathogenicity and complete genome characterization of fowl adenoviruses isolated from chickens associated with inclusion body hepatitis and hydropericardium syndrome in China","volume":"10","author":"Zhao","year":"2015","journal-title":"PLoS One"},{"key":"B39","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.3389\/fmicb.2017.01005","article-title":"Different dynamic distribution in chickens and ducks of the hypervirulent, novel genotype fowl adenovirus serotype 4 recently emerged in China","volume":"8","author":"Pan","year":"2017","journal-title":"Front Microbiol"},{"key":"B40","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1186\/1465-9921-6-135","article-title":"Proinflammatory cytokine responses induced by influenza A (H5N1) viruses in primary human alveolar and bronchial epithelial cells","volume":"6","author":"Chan","year":"2005","journal-title":"Respir Res"},{"key":"B41","doi-asserted-by":"publisher","first-page":"425","DOI":"10.3389\/fmicb.2015.00425","article-title":"Immune responses of ducks infected with duck Tembusu virus","volume":"6","author":"Li","year":"2015","journal-title":"Front Microbiol"},{"key":"B42","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.tim.2014.12.003","article-title":"Mx GTPases: dynamin-like antiviral machines of innate immunity","volume":"23","author":"Haller","year":"2015","journal-title":"Trends Microbiol"},{"key":"B43","doi-asserted-by":"publisher","first-page":"1755","DOI":"10.1007\/s00018-016-2435-3","article-title":"A novel anti-viral role for STAT3 in IFN-\u03b1 signalling responses","volume":"74","author":"Mahony","year":"2017","journal-title":"Cell Mol Life Sci"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2018.00049\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,26]],"date-time":"2020-10-26T02:57:29Z","timestamp":1603681049000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2018.00049\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,25]]},"references-count":43,"alternative-id":["10.3389\/fimmu.2018.00049"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2018.00049","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,25]]},"article-number":"49"}}