{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:13:05Z","timestamp":1790251985251,"version":"4.1.0"},"reference-count":69,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,1,25]],"date-time":"2018-01-25T00:00:00Z","timestamp":1516838400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2018.00053","type":"journal-article","created":{"date-parts":[[2018,1,25]],"date-time":"2018-01-25T04:14:18Z","timestamp":1516853658000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":138,"title":["Role of SLC7A5 in Metabolic Reprogramming of Human Monocyte\/Macrophage Immune Responses"],"prefix":"10.3389","volume":"9","author":[{"given":"Bo Ruem","family":"Yoon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoon-Jeong","family":"Oh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong Wook","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Bong","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won-Woo","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,1,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1146\/annurev.immunol.021908.132557","article-title":"Blood monocytes: development, heterogeneity, and relationship with dendritic cells","volume":"27","author":"Auffray","year":"2009","journal-title":"Annu Rev Immunol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"514","DOI":"10.3389\/fimmu.2014.00514","article-title":"From monocytes to M1\/M2 macrophages: phenotypical vs. functional differentiation","volume":"5","author":"Italiani","year":"2014","journal-title":"Front Immunol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1038\/nri3070","article-title":"Monocyte recruitment during infection and inflammation","volume":"11","author":"Shi","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"4048","DOI":"10.1074\/jbc.M115.680298","article-title":"Preferential induction of the T cell auxiliary signaling molecule B7-H3 on synovial monocytes in rheumatoid arthritis","volume":"291","author":"Yoon","year":"2016","journal-title":"J Biol Chem"},{"key":"B5","doi-asserted-by":"publisher","first-page":"34533","DOI":"10.1038\/srep34533","article-title":"Monosodium urate crystal-induced pro-interleukin-1beta production is post-transcriptionally regulated via the p38 signaling pathway in human monocytes","volume":"6","author":"Chung","year":"2016","journal-title":"Sci Rep"},{"key":"B6","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1016\/j.immuni.2015.02.001","article-title":"Human monocytes undergo functional re-programming during sepsis mediated by hypoxia-inducible factor-1alpha","volume":"42","author":"Shalova","year":"2015","journal-title":"Immunity"},{"key":"B7","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1038\/nm.3189","article-title":"Inflammatory monocytes regulate pathologic responses to commensals during acute gastrointestinal infection","volume":"19","author":"Grainger","year":"2013","journal-title":"Nat Med"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1038\/nm.3265","article-title":"Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes","volume":"19","author":"Jourdan","year":"2013","journal-title":"Nat Med"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1250684","DOI":"10.1126\/science.1250684","article-title":"mTOR- and HIF-1alpha-mediated aerobic glycolysis as metabolic basis for trained immunity","volume":"345","author":"Cheng","year":"2014","journal-title":"Science"},{"key":"B10","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.celrep.2015.05.046","article-title":"mTORC1-induced HK1-dependent glycolysis regulates NLRP3 inflammasome activation","volume":"12","author":"Moon","year":"2015","journal-title":"Cell Rep"},{"key":"B11","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1038\/nri.2016.70","article-title":"A guide to immunometabolism for immunologists","volume":"16","author":"O\u2019Neill","year":"2016","journal-title":"Nat Rev Immunol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1126\/science.1160809","article-title":"Understanding the Warburg effect: the metabolic requirements of cell proliferation","volume":"324","author":"Vander Heiden","year":"2009","journal-title":"Science"},{"key":"B13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1074\/jbc.R115.693903","article-title":"Immunometabolism: cellular metabolism turns immune regulator","volume":"291","author":"Loftus","year":"2016","journal-title":"J Biol Chem"},{"key":"B14","doi-asserted-by":"publisher","first-page":"420","DOI":"10.3389\/fimmu.2014.00420","article-title":"Metabolic reprograming in macrophage polarization","volume":"5","author":"Galvan-Pena","year":"2014","journal-title":"Front Immunol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1042\/BST20150107","article-title":"Metabolic signatures linked to macrophage polarization: from glucose metabolism to oxidative phosphorylation","volume":"43","author":"Bosca","year":"2015","journal-title":"Biochem Soc Trans"},{"key":"B16","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1017\/S000711450769936X","article-title":"Amino acids and immune function","volume":"98","author":"Li","year":"2007","journal-title":"Br J Nutr"},{"key":"B17","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1038\/nature11986","article-title":"Succinate is an inflammatory signal that induces IL-1beta through HIF-1alpha","volume":"496","author":"Tannahill","year":"2013","journal-title":"Nature"},{"key":"B18","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1038\/nchembio.1961","article-title":"Branched-chain amino acid catabolism fuels adipocyte differentiation and lipogenesis","volume":"12","author":"Green","year":"2016","journal-title":"Nat Chem Biol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1126\/science.aab2674","article-title":"Sestrin2 is a leucine sensor for the mTORC1 pathway","volume":"351","author":"Wolfson","year":"2016","journal-title":"Science"},{"key":"B20","doi-asserted-by":"publisher","first-page":"re5","DOI":"10.1126\/scisignal.aaf2885","article-title":"Sestrin regulation of TORC1: is Sestrin a leucine sensor?","volume":"9","author":"Lee","year":"2016","journal-title":"Sci Signal"},{"key":"B21","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1038\/ni.3655","article-title":"Chronic signaling via the metabolic checkpoint kinase mTORC1 induces macrophage granuloma formation and marks sarcoidosis progression","volume":"18","author":"Linke","year":"2017","journal-title":"Nat Immunol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1242\/jcs.096040","article-title":"CD98 at the crossroads of adaptive immunity and cancer","volume":"125","author":"Cantor","year":"2012","journal-title":"J Cell Sci"},{"key":"B23","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1152\/physrev.00018.2006","article-title":"Amino acid transport across mammalian intestinal and renal epithelia","volume":"88","author":"Broer","year":"2008","journal-title":"Physiol Rev"},{"key":"B24","first-page":"1281","article-title":"L-type amino acid transport and cancer: targeting the mTORC1 pathway to inhibit neoplasia","volume":"5","author":"Wang","year":"2015","journal-title":"Am J Cancer Res"},{"key":"B25","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1111\/j.1349-7006.2009.01386.x","article-title":"L-type amino acid transporter 1 inhibitors inhibit tumor cell growth","volume":"101","author":"Oda","year":"2010","journal-title":"Cancer Sci"},{"key":"B26","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1254\/jphs.13154FP","article-title":"JPH203, an L-type amino acid transporter 1-selective compound, induces apoptosis of YD-38 human oral cancer cells","volume":"124","author":"Yun","year":"2014","journal-title":"J Pharmacol Sci"},{"key":"B27","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1038\/ni.2556","article-title":"Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation","volume":"14","author":"Sinclair","year":"2013","journal-title":"Nat Immunol"},{"key":"B28","doi-asserted-by":"publisher","first-page":"4080","DOI":"10.4049\/jimmunol.1300923","article-title":"LAT1 is a critical transporter of essential amino acids for immune reactions in activated human T cells","volume":"191","author":"Hayashi","year":"2013","journal-title":"J Immunol"},{"key":"B29","doi-asserted-by":"publisher","first-page":"e2655","DOI":"10.1038\/cddis.2016.222","article-title":"Amino-acid transporters in T-cell activation and differentiation","volume":"8","author":"Ren","year":"2017","journal-title":"Cell Death Dis"},{"key":"B30","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1046\/j.1365-2249.1996.d01-820.x","article-title":"Blood monocyte activation in rheumatoid arthritis: increased monocyte adhesiveness, integrin expression, and cytokine release","volume":"106","author":"Liote","year":"1996","journal-title":"Clin Exp Immunol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1046\/j.1365-2249.1999.00817.x","article-title":"Monocyte activation in rheumatoid arthritis (RA): increased integrin, Fc gamma and complement receptor expression and the effect of glucocorticoids","volume":"115","author":"Torsteinsdottir","year":"1999","journal-title":"Clin Exp Immunol"},{"key":"B32","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1002\/art.33418","article-title":"The CD14(bright) CD16+ monocyte subset is expanded in rheumatoid arthritis and promotes expansion of the Th17 cell population","volume":"64","author":"Rossol","year":"2012","journal-title":"Arthritis Rheum"},{"key":"B33","doi-asserted-by":"publisher","first-page":"1769","DOI":"10.1111\/j.1462-5822.2012.01837.x","article-title":"Francisella tularensis regulates the expression of the amino acid transporter SLC1A5 in infected THP-1 human monocytes","volume":"14","author":"Barel","year":"2012","journal-title":"Cell Microbiol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/S0005-2736(01)00384-4","article-title":"Human L-type amino acid transporter 1 (LAT1): characterization of function and expression in tumor cell lines","volume":"1514","author":"Yanagida","year":"2001","journal-title":"Biochim Biophys Acta"},{"key":"B35","doi-asserted-by":"publisher","first-page":"7303","DOI":"10.4049\/jimmunol.177.10.7303","article-title":"Transcriptional profiling of the human monocyte-to-macrophage differentiation and polarization: new molecules and patterns of gene expression","volume":"177","author":"Martinez","year":"2006","journal-title":"J Immunol"},{"key":"B36","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1016\/j.imbio.2014.05.002","article-title":"Human macrophage polarization in vitro: maturation and activation methods compared","volume":"219","author":"Vogel","year":"2014","journal-title":"Immunobiology"},{"key":"B37","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1084\/jem.20150900","article-title":"The glycolytic enzyme PKM2 bridges metabolic and inflammatory dysfunction in coronary artery disease","volume":"213","author":"Shirai","year":"2016","journal-title":"J Exp Med"},{"key":"B38","doi-asserted-by":"publisher","first-page":"13280","DOI":"10.1038\/ncomms13280","article-title":"PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation","volume":"7","author":"Xie","year":"2016","journal-title":"Nat Commun"},{"key":"B39","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1016\/j.smim.2015.08.001","article-title":"Control of macrophage metabolism and activation by mTOR and Akt signaling","volume":"27","author":"Covarrubias","year":"2015","journal-title":"Semin Immunol"},{"key":"B40","doi-asserted-by":"publisher","first-page":"4477","DOI":"10.4049\/jimmunol.1401558","article-title":"mTORC1-dependent metabolic reprogramming is a prerequisite for NK cell effector function","volume":"193","author":"Donnelly","year":"2014","journal-title":"J Immunol"},{"key":"B41","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1038\/ni.2936","article-title":"The metabolic checkpoint kinase mTOR is essential for IL-15 signaling during the development and activation of NK cells","volume":"15","author":"Marcais","year":"2014","journal-title":"Nat Immunol"},{"key":"B42","doi-asserted-by":"publisher","first-page":"18793","DOI":"10.1074\/jbc.M114.554113","article-title":"Cytosolic branched chain aminotransferase (BCATc) regulates mTORC1 signaling and glycolytic metabolism in CD4+ T cells","volume":"289","author":"Ananieva","year":"2014","journal-title":"J Biol Chem"},{"key":"B43","doi-asserted-by":"publisher","first-page":"605","DOI":"10.4049\/jimmunol.0901698","article-title":"Substrate fate in activated macrophages: a comparison between innate, classic, and alternative activation","volume":"185","author":"Rodriguez-Prados","year":"2010","journal-title":"J Immunol"},{"key":"B44","doi-asserted-by":"publisher","first-page":"6082","DOI":"10.4049\/jimmunol.1402469","article-title":"Pyruvate dehydrogenase kinase 1 participates in macrophage polarization via regulating glucose metabolism","volume":"194","author":"Tan","year":"2015","journal-title":"J Immunol"},{"key":"B45","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.cmet.2017.06.001","article-title":"Specific and complex reprogramming of cellular metabolism in myeloid cells during innate immune responses","volume":"26","author":"Stienstra","year":"2017","journal-title":"Cell Metab"},{"key":"B46","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.immuni.2014.05.010","article-title":"Macrophages, immunity, and metabolic disease","volume":"41","author":"McNelis","year":"2014","journal-title":"Immunity"},{"key":"B47","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1038\/nri3793","article-title":"Cholesterol, inflammation and innate immunity","volume":"15","author":"Tall","year":"2015","journal-title":"Nat Rev Immunol"},{"key":"B48","doi-asserted-by":"publisher","first-page":"1898","DOI":"10.1136\/ard.2010.134684","article-title":"State-of-the-art: rheumatoid arthritis","volume":"69","author":"McInnes","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"B49","doi-asserted-by":"publisher","first-page":"2205","DOI":"10.1056\/NEJMra1004965","article-title":"The pathogenesis of rheumatoid arthritis","volume":"365","author":"McInnes","year":"2011","journal-title":"N Engl J Med"},{"key":"B50","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1038\/nri2094","article-title":"Cytokines in the pathogenesis of rheumatoid arthritis","volume":"7","author":"McInnes","year":"2007","journal-title":"Nat Rev Immunol"},{"key":"B51","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.coi.2017.04.010","article-title":"Metabolic signatures of T-cells and macrophages in rheumatoid arthritis","volume":"46","author":"Weyand","year":"2017","journal-title":"Curr Opin Immunol"},{"key":"B52","doi-asserted-by":"publisher","first-page":"2771","DOI":"10.1038\/leu.2017.160","article-title":"Control of amino acid transport coordinates metabolic reprogramming in T-cell malignancy","volume":"31","author":"Grzes","year":"2017","journal-title":"Leukemia"},{"key":"B53","doi-asserted-by":"publisher","first-page":"2529","DOI":"10.1002\/ijc.30371","article-title":"LAT1 is a putative therapeutic target in endometrioid endometrial carcinoma","volume":"139","author":"Marshall","year":"2016","journal-title":"Int J Cancer"},{"key":"B54","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1517\/14728222.2015.1044975","article-title":"Targeting L-type amino acid transporter 1 for anticancer therapy: clinical impact from diagnostics to therapeutics","volume":"19","author":"Jin","year":"2015","journal-title":"Expert Opin Ther Targets"},{"key":"B55","doi-asserted-by":"publisher","first-page":"5480","DOI":"10.1073\/pnas.1218165110","article-title":"Structure-based ligand discovery for the large-neutral amino acid transporter 1, LAT-1","volume":"110","author":"Geier","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B56","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/S0171-2985(00)80048-0","article-title":"Proliferation of a subpopulation of human peripheral blood monocytes in the presence of colony stimulating factors may contribute to the inflammatory process in diseases such as rheumatoid arthritis","volume":"202","author":"Moss","year":"2000","journal-title":"Immunobiology"},{"key":"B57","doi-asserted-by":"publisher","first-page":"1913","DOI":"10.1084\/jem.20170355","article-title":"The fate and lifespan of human monocyte subsets in steady state and systemic inflammation","volume":"214","author":"Patel","year":"2017","journal-title":"J Exp Med"},{"key":"B58","doi-asserted-by":"publisher","first-page":"227","DOI":"10.3389\/fimmu.2015.00227","article-title":"Aerobic glycolysis: beyond proliferation","volume":"6","author":"Jones","year":"2015","journal-title":"Front Immunol"},{"key":"B59","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1016\/j.cell.2013.05.016","article-title":"Posttranscriptional control of T cell effector function by aerobic glycolysis","volume":"153","author":"Chang","year":"2013","journal-title":"Cell"},{"key":"B60","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.cmet.2014.12.005","article-title":"Pyruvate kinase M2 regulates Hif-1alpha activity and IL-1beta induction and is a critical determinant of the Warburg effect in LPS-activated macrophages","volume":"21","author":"Palsson-McDermott","year":"2015","journal-title":"Cell Metab"},{"key":"B61","doi-asserted-by":"publisher","first-page":"14484","DOI":"10.1074\/jbc.273.23.14484","article-title":"Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism","volume":"273","author":"Hara","year":"1998","journal-title":"J Biol Chem"},{"key":"B62","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1016\/j.cell.2012.02.044","article-title":"Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway","volume":"149","author":"Han","year":"2012","journal-title":"Cell"},{"key":"B63","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1126\/science.aad2087","article-title":"Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway","volume":"351","author":"Saxton","year":"2016","journal-title":"Science"},{"key":"B64","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1038\/s41467-017-00785-0","article-title":"Control of leucine-dependent mTORC1 pathway through chemical intervention of leucyl-tRNA synthetase and RagD interaction","volume":"8","author":"Kim","year":"2017","journal-title":"Nat Commun"},{"key":"B65","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1038\/ni.3438","article-title":"Asymmetric inheritance of mTORC1 kinase activity during division dictates CD8(+) T cell differentiation","volume":"17","author":"Pollizzi","year":"2016","journal-title":"Nat Immunol"},{"key":"B66","doi-asserted-by":"publisher","first-page":"16040","DOI":"10.1038\/ncomms16040","article-title":"BCAT1 controls metabolic reprogramming in activated human macrophages and is associated with inflammatory diseases","volume":"8","author":"Papathanassiu","year":"2017","journal-title":"Nat Commun"},{"key":"B67","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1038\/nri3682","article-title":"Post-transcriptional regulation of gene expression in innate immunity","volume":"14","author":"Carpenter","year":"2014","journal-title":"Nat Rev Immunol"},{"key":"B68","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1016\/j.molcel.2012.09.017","article-title":"HIF2alpha acts as an mTORC1 activator through the amino acid carrier SLC7A5","volume":"48","author":"Elorza","year":"2012","journal-title":"Mol Cell"},{"key":"B69","doi-asserted-by":"publisher","first-page":"3720","DOI":"10.1182\/blood-2010-07-273417","article-title":"Interleukin-1 in the pathogenesis and treatment of inflammatory diseases","volume":"117","author":"Dinarello","year":"2011","journal-title":"Blood"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2018.00053\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,5,15]],"date-time":"2018-05-15T14:27:02Z","timestamp":1526394422000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2018.00053\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,25]]},"references-count":69,"alternative-id":["10.3389\/fimmu.2018.00053"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2018.00053","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,25]]},"article-number":"53"}}