{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T03:39:06Z","timestamp":1768621146862,"version":"3.49.0"},"reference-count":57,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,2,16]],"date-time":"2018-02-16T00:00:00Z","timestamp":1518739200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2018.00228","type":"journal-article","created":{"date-parts":[[2018,2,16]],"date-time":"2018-02-16T04:13:31Z","timestamp":1518754411000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":35,"title":["The Host Restriction Factor Interferon-Inducible Transmembrane Protein 3 Inhibits Vaccinia Virus Infection"],"prefix":"10.3389","volume":"9","author":[{"given":"Chang","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shouwen","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingyao","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jieying","family":"Bai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronglan","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maopeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yilong","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiyuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shipin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ningyi","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fuchu","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2018,2,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1038\/ni.2229","article-title":"Intrinsic antiviral immunity","volume":"13","author":"Yan","year":"2012","journal-title":"Nat Immunol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"6844","DOI":"10.1128\/JVI.02200-10","article-title":"Viral replication and innate host responses in primary human alveolar epithelial cells and alveolar macrophages infected with influenza H5N1 and H1N1 viruses","volume":"85","author":"Yu","year":"2011","journal-title":"J Virol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1007\/978-3-642-37765-5_3","article-title":"The antiviral activities of tetherin","volume":"371","author":"Neil","year":"2013","journal-title":"Curr Top Microbiol Immunol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1016\/j.cell.2009.12.017","article-title":"The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus","volume":"139","author":"Brass","year":"2009","journal-title":"Cell"},{"key":"B5","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.coviro.2013.11.004","article-title":"IFITM proteins-cellular inhibitors of viral entry","volume":"4","author":"Smith","year":"2014","journal-title":"Curr Opin Virol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1111\/j.1432-1033.1991.tb16139.x","article-title":"Molecular analysis of a human interferon-inducible gene family","volume":"199","author":"Lewin","year":"1991","journal-title":"Eur J Biochem"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1497","DOI":"10.1359\/jbmr.080412","article-title":"Bril: a novel bone-specific modulator of mineralization","volume":"23","author":"Moffatt","year":"2008","journal-title":"J Bone Miner Res"},{"key":"B8","doi-asserted-by":"publisher","first-page":"e1004048","DOI":"10.1371\/journal.ppat.1004048","article-title":"IFITM3 restricts influenza A virus entry by blocking the formation of fusion pores following virus-endosome hemifusion","volume":"10","author":"Desai","year":"2014","journal-title":"PLoS Pathog"},{"key":"B9","doi-asserted-by":"publisher","first-page":"e34508","DOI":"10.1371\/journal.pone.0034508","article-title":"IFITM proteins restrict antibody-dependent enhancement of dengue virus infection","volume":"7","author":"Chan","year":"2012","journal-title":"PLoS One"},{"key":"B10","doi-asserted-by":"publisher","first-page":"S210","DOI":"10.1093\/infdis\/jiv255","article-title":"Interferon-induced transmembrane protein-mediated inhibition of host cell entry of ebolaviruses","volume":"212","author":"Wrensch","year":"2015","journal-title":"J Infect Dis"},{"key":"B11","doi-asserted-by":"publisher","first-page":"e1001258","DOI":"10.1371\/journal.ppat.1001258","article-title":"Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus","volume":"7","author":"Huang","year":"2011","journal-title":"PLoS Pathog"},{"key":"B12","doi-asserted-by":"publisher","first-page":"8451","DOI":"10.1128\/JVI.03382-12","article-title":"IFITM-2 and IFITM-3 but not IFITM-1 restrict Rift Valley fever virus","volume":"87","author":"Mudhasani","year":"2013","journal-title":"J Virol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1111\/tra.12416","article-title":"Alphavirus restriction by IFITM proteins","volume":"17","author":"Weston","year":"2016","journal-title":"Traffic"},{"key":"B14","doi-asserted-by":"publisher","first-page":"2126","DOI":"10.1128\/JVI.01531-10","article-title":"The IFITM proteins inhibit HIV-1 infection","volume":"85","author":"Lu","year":"2011","journal-title":"J Virol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1016\/j.chom.2014.11.001","article-title":"IFITM proteins incorporated into HIV-1 virions impair viral fusion and spread","volume":"16","author":"Compton","year":"2014","journal-title":"Cell Host Microbe"},{"key":"B16","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1099\/vir.0.066555-0","article-title":"Human respiratory syncytial virus infection is inhibited by IFN-induced transmembrane proteins","volume":"96","author":"Zhang","year":"2015","journal-title":"J Gen Virol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"2323","DOI":"10.1016\/j.celrep.2016.05.074","article-title":"The IFITMs inhibit Zika virus replication","volume":"15","author":"Savidis","year":"2016","journal-title":"Cell Rep"},{"key":"B18","doi-asserted-by":"publisher","first-page":"17261","DOI":"10.1074\/jbc.M112.438515","article-title":"Interferon-inducible transmembrane protein 3 (IFITM3) restricts reovirus cell entry","volume":"288","author":"Anafu","year":"2013","journal-title":"J Biol Chem"},{"key":"B19","doi-asserted-by":"publisher","first-page":"e96579","DOI":"10.1371\/journal.pone.0096579","article-title":"The antiviral restriction factors IFITM1, 2 and 3 do not inhibit infection of human papillomavirus, cytomegalovirus and adenovirus","volume":"9","author":"Warren","year":"2014","journal-title":"PLoS One"},{"key":"B20","doi-asserted-by":"publisher","first-page":"e1002909","DOI":"10.1371\/journal.ppat.1002909","article-title":"Ifitm3 limits the severity of acute influenza in mice","volume":"8","author":"Bailey","year":"2012","journal-title":"PLoS Pathog"},{"key":"B21","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1038\/nature10921","article-title":"IFITM3 restricts the morbidity and mortality associated with influenza","volume":"484","author":"Everitt","year":"2012","journal-title":"Nature"},{"key":"B22","doi-asserted-by":"publisher","first-page":"8212","DOI":"10.1128\/JVI.00581-16","article-title":"The interferon-stimulated gene Ifitm3 restricts West Nile virus infection and pathogenesis","volume":"90","author":"Gorman","year":"2016","journal-title":"J Virol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"8780","DOI":"10.1128\/JVI.00655-16","article-title":"The interferon-stimulated gene IFITM3 restricts infection and pathogenesis of arthritogenic and encephalitic alphaviruses","volume":"90","author":"Poddar","year":"2016","journal-title":"J Virol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"e1002337","DOI":"10.1371\/journal.ppat.1002337","article-title":"IFITM3 inhibits influenza A virus infection by preventing cytosolic entry","volume":"7","author":"Feeley","year":"2011","journal-title":"PLoS Pathog"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1067\/mjd.2001.109302","article-title":"An overview of poxviruses","volume":"44","author":"Diven","year":"2001","journal-title":"J Am Acad Dermatol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"e1003756","DOI":"10.1371\/journal.ppat.1003756","article-title":"An increasing danger of zoonotic orthopoxvirus infections","volume":"9","author":"Shchelkunov","year":"2013","journal-title":"PLoS Pathog"},{"key":"B27","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/S1473-3099(04)01140-5","article-title":"Human monkeypox: an emerging zoonosis","volume":"4","author":"Di Giulio","year":"2004","journal-title":"Lancet Infect Dis"},{"key":"B28","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1099\/vir.0.070219-0","article-title":"Orthopoxvirus infection among wildlife in Zambia","volume":"96","author":"Orba","year":"2014","journal-title":"J Gen Virol"},{"key":"B29","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.vetmic.2011.04.010","article-title":"Zoonotic cases of camelpox infection in India","volume":"152","author":"Bera","year":"2011","journal-title":"Vet Microbiol"},{"key":"B30","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1093\/cid\/ciu790","article-title":"Novel poxvirus infection in 2 patients from the United States","volume":"60","author":"Osadebe","year":"2014","journal-title":"Clin Infect Dis"},{"key":"B31","doi-asserted-by":"publisher","first-page":"961","DOI":"10.4161\/hv.21080","article-title":"A vaccinia virus renaissance: new vaccine and immunotherapeutic uses after smallpox eradication","volume":"8","author":"Verardi","year":"2012","journal-title":"Hum Vaccin Immunother"},{"key":"B32","doi-asserted-by":"publisher","first-page":"8899","DOI":"10.1128\/JVI.01053-06","article-title":"Vaccinia virus entry into cells via a low-pH-dependent endosomal pathway","volume":"80","author":"Townsley","year":"2006","journal-title":"J Virol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"e1002446","DOI":"10.1371\/journal.ppat.1002446","article-title":"The membrane fusion step of vaccinia virus entry is cooperatively mediated by multiple viral proteins and host cell components","volume":"7","author":"Laliberte","year":"2011","journal-title":"PLoS Pathog"},{"key":"B34","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1126\/science.1155164","article-title":"Vaccinia virus uses macropinocytosis and apoptotic mimicry to enter host cells","volume":"320","author":"Mercer","year":"2008","journal-title":"Science"},{"key":"B35","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.jviromet.2012.06.022","article-title":"Construction and evaluation of a new triple-gene expression cassette vaccinia virus shuttle vector","volume":"185","author":"Du","year":"2012","journal-title":"J Virol Methods"},{"key":"B36","first-page":"16.7.1","article-title":"Generation of recombinant vaccinia viruses","volume-title":"Current Protocols in Molecular Biology","author":"Earl","year":"1998"},{"key":"B37","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1111\/cmi.12339","article-title":"IFITM3-containing exosome as a novel mediator for anti-viral response in dengue virus infection","volume":"17","author":"Zhu","year":"2015","journal-title":"Cell Microbiol"},{"key":"B38","doi-asserted-by":"publisher","first-page":"169","DOI":"10.3390\/v8060169","article-title":"Stress beyond translation: poxviruses and more","volume":"8","author":"Liem","year":"2016","journal-title":"Viruses"},{"key":"B39","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1016\/0042-6822(92)90556-5","article-title":"Vaccinia virus-mediated inhibition of host protein synthesis involves neither degradation nor underphosphorylation of components of the cap-binding eukaryotic translation initiation factor complex eIF-4F","volume":"188","author":"Schnierle","year":"1992","journal-title":"Virology"},{"key":"B40","doi-asserted-by":"publisher","first-page":"e98431","DOI":"10.1371\/journal.pone.0098431","article-title":"A loss of function analysis of host factors influencing vaccinia virus replication by RNA interference","volume":"9","author":"Beard","year":"2014","journal-title":"PLoS One"},{"key":"B41","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.1099\/vir.0.80831-0","article-title":"Entry of the vaccinia virus intracellular mature virion and its interactions with glycosaminoglycans","volume":"86","author":"Carter","year":"2005","journal-title":"J Gen Virol"},{"key":"B42","doi-asserted-by":"publisher","first-page":"25946","DOI":"10.1074\/jbc.M115.657346","article-title":"The interferon-induced transmembrane proteins, IFITM1, IFITM2, and IFITM3 inhibit hepatitis C virus entry","volume":"290","author":"Narayana","year":"2015","journal-title":"J Biol Chem"},{"key":"B43","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1146\/annurev-virology-031413-085537","article-title":"IFITM-family proteins: the cell\u2019s first line of antiviral defense","volume":"1","author":"Bailey","year":"2014","journal-title":"Annu Rev Virol"},{"key":"B44","doi-asserted-by":"publisher","first-page":"e67816","DOI":"10.1371\/journal.pone.0067816","article-title":"A functional promoter polymorphism of IFITM3 is associated with susceptibility to pediatric tuberculosis in Han Chinese population","volume":"8","author":"Shen","year":"2013","journal-title":"PLoS One"},{"key":"B45","doi-asserted-by":"publisher","first-page":"1687","DOI":"10.1099\/0022-1317-65-10-1687","article-title":"The inhibition of HeLa cell RNA synthesis following infection with vaccinia virus","volume":"65","author":"Pedley","year":"1984","journal-title":"J Gen Virol"},{"key":"B46","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1073\/pnas.51.4.577","article-title":"Messenger RNA in cells infected with vaccinia virus","volume":"51","author":"Becker","year":"1964","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B47","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1128\/JVI.47.3.529-539.1983","article-title":"Vaccinia virus induces cellular mRNA degradation","volume":"47","author":"Rice","year":"1983","journal-title":"J Virol"},{"key":"B48","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1038\/s41467-017-00101-w","article-title":"TRIM29 promotes DNA virus infections by inhibiting innate immune response","volume":"8","author":"Xing","year":"2017","journal-title":"Nat Commun"},{"key":"B49","doi-asserted-by":"publisher","first-page":"13985","DOI":"10.1073\/pnas.94.25.13985","article-title":"Use of differential display analysis to assess the effect of human cytomegalovirus infection on the accumulation of cellular RNAs: induction of interferon-responsive RNAs","volume":"94","author":"Zhu","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B50","doi-asserted-by":"publisher","first-page":"2215","DOI":"10.1099\/0022-1317-81-9-2215","article-title":"Activation of cellular interferon-responsive genes after infection of human cells with herpes simplex virus type 1","volume":"81","author":"Nicholl","year":"2000","journal-title":"J Gen Virol"},{"key":"B51","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1073\/pnas.1321748111","article-title":"Early hypercytokinemia is associated with interferon-induced transmembrane protein-3 dysfunction and predictive of fatal H7N9 infection","volume":"111","author":"Wang","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B52","doi-asserted-by":"publisher","first-page":"2293","DOI":"10.1099\/vir.0.18942-0","article-title":"Vaccinia virus transcription","volume":"84","author":"Broyles","year":"2003","journal-title":"J Gen Virol"},{"key":"B53","doi-asserted-by":"publisher","first-page":"11513","DOI":"10.1073\/pnas.1006594107","article-title":"Simultaneous high-resolution analysis of vaccinia virus and host cell transcriptomes by deep RNA sequencing","volume":"107","author":"Yang","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B54","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/j.virol.2008.12.029","article-title":"Vaccinia virus exhibits cell-type-dependent entry characteristics","volume":"385","author":"Whitbeck","year":"2009","journal-title":"Virology"},{"key":"B55","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.coviro.2011.11.007","article-title":"Poxvirus host cell entry","volume":"2","author":"Schmidt","year":"2012","journal-title":"Curr Opin Virol"},{"key":"B56","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.antiviral.2014.06.008","article-title":"Swine interferon-induced transmembrane protein, sIFITM3, inhibits foot-and-mouth disease virus infection in vitro and in vivo","volume":"109","author":"Xu","year":"2014","journal-title":"Antiviral Res"},{"key":"B57","doi-asserted-by":"publisher","first-page":"4937","DOI":"10.1016\/j.jmb.2013.09.024","article-title":"IFITMs restrict the replication of multiple pathogenic viruses","volume":"425","author":"Perreira","year":"2013","journal-title":"J Mol Biol"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2018.00228\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T06:11:53Z","timestamp":1603865513000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2018.00228\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,16]]},"references-count":57,"alternative-id":["10.3389\/fimmu.2018.00228"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2018.00228","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,16]]},"article-number":"228"}}