{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T02:21:10Z","timestamp":1792894870403,"version":"4.5.0"},"reference-count":36,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,2,19]],"date-time":"2018-02-19T00:00:00Z","timestamp":1518998400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003074","name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["PICT2013\/2177"],"award-info":[{"award-number":["PICT2013\/2177"]}],"id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005363","name":"Universidad de Buenos Aires","doi-asserted-by":"publisher","award":["20020130100744BA"],"award-info":[{"award-number":["20020130100744BA"]}],"id":[{"id":"10.13039\/501100005363","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002923","name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2018.00269","type":"journal-article","created":{"date-parts":[[2018,2,19]],"date-time":"2018-02-19T03:45:45Z","timestamp":1519011945000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":98,"title":["Autophagy Mediates Interleukin-1\u03b2 Secretion in Human Neutrophils"],"prefix":"10.3389","volume":"9","author":[{"given":"Leonardo","family":"Iula","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene A.","family":"Keitelman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florencia","family":"Sabbione","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Fuentes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauricio","family":"Guzman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerem\u00edas Gast\u00f3n","family":"Galletti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pehu\u00e9n Pereyra","family":"Gerber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mat\u00edas","family":"Ostrowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge R.","family":"Geffner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina C.","family":"Jancic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anal\u00eda S.","family":"Trevani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,2,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e1004546","DOI":"10.1371\/journal.ppat.1004546","article-title":"Virus-induced NETs \u2013 critical component of host defense or pathogenic mediator?","volume":"11","author":"Jenne","year":"2015","journal-title":"PLoS Pathog"},{"key":"B2","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1146\/annurev-immunol-020711-074942","article-title":"Neutrophil function: from mechanisms to disease","volume":"30","author":"Amulic","year":"2012","journal-title":"Annu Rev Immunol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"16961","DOI":"10.1074\/jbc.R700045200","article-title":"Biological roles for the NOX family NADPH oxidases","volume":"283","author":"Nauseef","year":"2008","journal-title":"J Biol Chem"},{"key":"B4","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1189\/jlb.1212619","article-title":"Proteome profiling of human neutrophil granule subsets, secretory vesicles, and cell membrane: correlation with transcriptome profiling of neutrophil precursors","volume":"94","author":"R\u00f8rvig","year":"2013","journal-title":"J Leukoc Biol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1038\/nri3024","article-title":"Neutrophils in the activation and regulation of innate and adaptive immunity","volume":"11","author":"Mantovani","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1146\/annurev.immunol.021908.132612","article-title":"Immunological and inflammatory functions of the interleukin-1 family","volume":"27","author":"Dinarello","year":"2009","journal-title":"Annu Rev Immunol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"3324","DOI":"10.1002\/eji.201243089","article-title":"NADPH oxidase derived reactive oxygen species are involved in human neutrophil IL-1\u03b2 secretion but not in inflammasome activation","volume":"43","author":"Gabelloni","year":"2013","journal-title":"Eur J Immunol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"e1003047","DOI":"10.1371\/journal.ppat.1003047","article-title":"Neutrophil-derived IL-1\u03b2 is sufficient for abscess formation in immunity against Staphylococcus aureus in mice","volume":"8","author":"Cho","year":"2012","journal-title":"PLoS Pathog"},{"key":"B9","doi-asserted-by":"publisher","first-page":"8974","DOI":"10.1128\/JVI.01070-15","article-title":"Partial attenuation of respiratory syncytial virus with a deletion of a small HYDROPHOBIC gene is associated with elevated interleukin-1beta responses","volume":"89","author":"Russell","year":"2015","journal-title":"J Virol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"e0160249","DOI":"10.1371\/journal.pone.0160249","article-title":"Neutrophils directly recognize group B streptococci and contribute to interleukin-1\u03b2 production during infection","volume":"11","author":"Mohammadi","year":"2016","journal-title":"PLoS One"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1763","DOI":"10.4049\/jimmunol.1401624","article-title":"Neutrophil IL-1\u03b2 processing induced by pneumolysin is mediated by the NLRP3\/ASC inflammasome and caspase-1 activation and is dependent on K+ efflux","volume":"194","author":"Karmakar","year":"2015","journal-title":"J Immunol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"L902","DOI":"10.1152\/ajplung.00228.2015","article-title":"Differential ASC requirements reveal a key role for neutrophils and a noncanonical IL-1\u03b2 response to Pseudomonas aeruginosa","volume":"309","author":"Patankar","year":"2015","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/j.smim.2013.10.007","article-title":"The secretion of IL-1\u03b2 and options for release","volume":"25","author":"Piccioli","year":"2013","journal-title":"Semin Immunol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1159\/000346707","article-title":"Secretory versus degradative autophagy: unconventional secretion of inflammatory mediators","volume":"5","author":"Jiang","year":"2013","journal-title":"J Innate Immun"},{"key":"B15","doi-asserted-by":"publisher","first-page":"4701","DOI":"10.1038\/emboj.2011.398","article-title":"Autophagy-based unconventional secretory pathway for extracellular delivery of IL-1\u03b2","volume":"30","author":"Dupont","year":"2011","journal-title":"EMBO J"},{"key":"B16","doi-asserted-by":"publisher","first-page":"83","DOI":"10.3389\/fimmu.2013.00083","article-title":"Autophagy and IL-1 family cytokines","volume":"4","author":"Harris","year":"2013","journal-title":"Front Immunol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"10555","DOI":"10.1038\/ncomms10555","article-title":"Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1\u03b2 secretion in response to ATP","volume":"7","author":"Karmakar","year":"2016","journal-title":"Nat Commun"},{"key":"B18","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.1080\/15548627.2015.1066957","article-title":"Bafilomycin A1 disrupts autophagic flux by inhibiting both V-ATPase-dependent acidification and Ca-P60A\/SERCA-dependent autophagosome-lysosome fusion","volume":"11","author":"Mauvezin","year":"2015","journal-title":"Autophagy"},{"key":"B19","doi-asserted-by":"publisher","first-page":"445","DOI":"10.4161\/auto.19496","article-title":"Guidelines for the use and interpretation of assays for monitoring autophagy","volume":"8","author":"Agholme","year":"2012","journal-title":"Autophagy"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.1007\/s10495-012-0738-x","article-title":"Differential effects of the autophagy inhibitors 3-methyladenine and chloroquine on spontaneous and TNF-\u03b1-induced neutrophil apoptosis","volume":"17","author":"Pliyev","year":"2012","journal-title":"Apoptosis"},{"key":"B21","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1111\/imr.12452","article-title":"Molecular mechanisms regulating secretory organelles and endosomes in neutrophils and their implications for inflammation","volume":"273","author":"Ramadass","year":"2016","journal-title":"Immunol Rev"},{"key":"B22","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1038\/nrm2245","article-title":"Autophagy: from phenomenology to molecular understanding in less than a decade","volume":"8","author":"Klionsky","year":"2007","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1016\/j.immuni.2015.06.003","article-title":"Proteolytic processing of interleukin-1 family cytokines: variations on a common theme","volume":"42","author":"Afonina","year":"2015","journal-title":"Immunity"},{"key":"B24","doi-asserted-by":"publisher","first-page":"e50300","DOI":"10.1371\/journal.pone.0050300","article-title":"PROSPER: an integrated feature-based tool for predicting protease substrate cleavage sites","volume":"7","author":"Song","year":"2012","journal-title":"PLoS One"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.7554\/eLife.11205","article-title":"Translocation of interleukin-1beta into a vesicle intermediate in autophagy-mediated secretion","volume":"4","author":"Zhang","year":"2015","journal-title":"Elife"},{"key":"B26","doi-asserted-by":"publisher","first-page":"5952","DOI":"10.4049\/jimmunol.1303213","article-title":"Dectin-1 pathway activates robust autophagy-dependent unconventional protein secretion in human macrophages","volume":"192","author":"\u00d6hman","year":"2014","journal-title":"J Immunol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1038\/nature07383","article-title":"Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production","volume":"456","author":"Saitoh","year":"2008","journal-title":"Nature"},{"key":"B28","doi-asserted-by":"publisher","first-page":"9587","DOI":"10.1074\/jbc.M110.202911","article-title":"Autophagy controls IL-1beta secretion by targeting pro-IL-1beta for degradation","volume":"286","author":"Harris","year":"2011","journal-title":"J Biol Chem"},{"key":"B29","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1038\/ni.1980","article-title":"Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome","volume":"12","author":"Nakahira","year":"2011","journal-title":"Nat Immunol"},{"key":"B30","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1038\/sj.cdd.4401320","article-title":"Functional characterization of mitochondria in neutrophils: a role restricted to apoptosis","volume":"11","author":"Maianski","year":"2004","journal-title":"Cell Death Differ"},{"key":"B31","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1038\/ni.2215","article-title":"Activation of autophagy by inflammatory signals limits IL-1\u03b2 production by targeting ubiquitinated inflammasomes for destruction","volume":"13","author":"Shi","year":"2012","journal-title":"Nat Immunol"},{"key":"B32","doi-asserted-by":"publisher","first-page":"613","DOI":"10.4049\/jimmunol.1100613","article-title":"Cutting edge: reactive oxygen species inhibitors block priming, but not activation, of the NLRP3 inflammasome","volume":"187","author":"Bauernfeind","year":"2011","journal-title":"J Immunol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"42","DOI":"10.15252\/embj.201695081","article-title":"Dedicated SNAREs and specialized TRIM cargo receptors mediate secretory autophagy","volume":"36","author":"Kimura","year":"2017","journal-title":"EMBO J"},{"key":"B34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/15548627.2017.1307486","article-title":"Cellular and molecular mechanism for secretory autophagy","volume":"8627","author":"Kimura","year":"2017","journal-title":"Autophagy"},{"key":"B35","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1189\/jlb.3A0514-254RR","article-title":"An essential role of syntaxin 3 protein for granule exocytosis and secretion of IL-1, IL-1, IL-12b, and CCL4 from differentiated HL-60 cells","volume":"97","author":"Naegelen","year":"2015","journal-title":"J Leukoc Biol"},{"key":"B36","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1038\/nature09663","article-title":"A role for mitochondria in NLRP3 inflammasome activation","volume":"469","author":"Zhou","year":"2011","journal-title":"Nature"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2018.00269\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,2,19]],"date-time":"2018-02-19T03:45:51Z","timestamp":1519011951000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2018.00269\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,19]]},"references-count":36,"alternative-id":["10.3389\/fimmu.2018.00269"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2018.00269","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,19]]},"article-number":"269"}}