{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T03:30:04Z","timestamp":1772508604734,"version":"3.50.1"},"reference-count":33,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,2,19]],"date-time":"2018-02-19T00:00:00Z","timestamp":1518998400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["Dnr 521-2011-3095"],"award-info":[{"award-number":["Dnr 521-2011-3095"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007949","name":"Reumatikerf\u00f6rbundet","doi-asserted-by":"publisher","award":["R474951, R568881"],"award-info":[{"award-number":["R474951, R568881"]}],"id":[{"id":"10.13039\/501100007949","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2018.00285","type":"journal-article","created":{"date-parts":[[2018,2,19]],"date-time":"2018-02-19T14:34:39Z","timestamp":1519050879000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Regulatory T-Cells Mediate IFN-\u03b1-Induced Resistance against Antigen-Induced Arthritis"],"prefix":"10.3389","volume":"9","author":[{"given":"Sudeep","family":"Chenna Narendra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaya Prakash","family":"Chalise","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Biggs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich","family":"Kalinke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mattias","family":"Magnusson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2018,2,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2053","DOI":"10.1084\/jem.20101664","article-title":"Type I interferon: friend or foe?","volume":"207","author":"Trinchieri","year":"2010","journal-title":"J Exp Med"},{"key":"B2","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.smim.2011.01.009","article-title":"The type I interferon system in the development of lupus","volume":"23","author":"Ronnblom","year":"2011","journal-title":"Semin Immunol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.jneuroim.2009.04.015","article-title":"Recombinant interferon-beta therapy and neuromuscular disorders","volume":"212","author":"Stubgen","year":"2009","journal-title":"J Neuroimmunol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1172\/JCI22996C1","article-title":"Toll-like receptor 9-induced type I IFN protects mice from experimental colitis","volume":"115","author":"Katakura","year":"2005","journal-title":"J Clin Invest"},{"key":"B5","doi-asserted-by":"publisher","first-page":"2204","DOI":"10.4049\/jimmunol.178.4.2204","article-title":"Suppression of the effector phase of inflammatory arthritis by double-stranded RNA is mediated by type I IFNs","volume":"178","author":"Yarilina","year":"2007","journal-title":"J Immunol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1687","DOI":"10.1002\/eji.201040956","article-title":"Type I IFN protects against antigen-induced arthritis","volume":"41","author":"Ying","year":"2011","journal-title":"Eur J Immunol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"R143","DOI":"10.1186\/ar4326","article-title":"Interferon alpha inhibits antigen-specific production of proinflammatory cytokines and enhances antigen-specific transforming growth factor beta production in antigen-induced arthritis","volume":"15","author":"Chalise","year":"2013","journal-title":"Arthritis Res Ther"},{"key":"B8","doi-asserted-by":"publisher","first-page":"3142","DOI":"10.4049\/jimmunol.1502125","article-title":"IDO1 and TGF-beta mediate protective effects of IFN-alpha in antigen-induced arthritis","volume":"197","author":"Chalise","year":"2016","journal-title":"J Immunol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1038\/nri3464","article-title":"The plasticity and stability of regulatory T cells","volume":"13","author":"Sakaguchi","year":"2013","journal-title":"Nat Rev Immunol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/cmi.12746","article-title":"The Yin and Yang of regulatory T cells in infectious diseases and avenues to target them","volume":"19","author":"Stephen-Victor","year":"2017","journal-title":"Cell Microbiol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1146\/annurev.immunol.25.022106.141623","article-title":"Regulatory T cells: mechanisms of differentiation and function","volume":"30","author":"Josefowicz","year":"2012","journal-title":"Annu Rev Immunol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1016\/S1471-4906(03)00072-3","article-title":"Tolerance, DCs and tryptophan: much ado about IDO","volume":"24","author":"Grohmann","year":"2003","journal-title":"Trends Immunol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"3190","DOI":"10.4049\/jimmunol.0903670","article-title":"An interaction between kynurenine and the aryl hydrocarbon receptor can generate regulatory T cells","volume":"185","author":"Mezrich","year":"2010","journal-title":"J Immunol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.cytogfr.2014.10.012","article-title":"Divergent effects of type-I interferons on regulatory T cells","volume":"26","author":"Piconese","year":"2015","journal-title":"Cytokine Growth Factor Rev"},{"key":"B15","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1084\/jem.20131556","article-title":"Type I interferons directly inhibit regulatory T cells to allow optimal antiviral T cell responses during acute LCMV infection","volume":"211","author":"Srivastava","year":"2014","journal-title":"J Exp Med"},{"key":"B16","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.jneuroim.2006.09.012","article-title":"Interferon beta-1a therapy enhances CD4+ regulatory T-cell function: an ex vivo and in vitro longitudinal study in relapsing-remitting multiple sclerosis","volume":"182","author":"de Andres","year":"2007","journal-title":"J Neuroimmunol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1038\/ni.2077","article-title":"Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells","volume":"12","author":"Pallotta","year":"2011","journal-title":"Nat Immunol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1007\/978-1-59745-402-5_18","article-title":"Murine antigen-induced arthritis","volume":"136","author":"van den Berg","year":"2007","journal-title":"Methods Mol Med"},{"key":"B19","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1007\/978-1-61737-979-6_10","article-title":"In vivo depletion of FoxP3+ Tregs using the DEREG mouse model","volume":"707","author":"Lahl","year":"2011","journal-title":"Methods Mol Biol"},{"key":"B20","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1038\/nri1416","article-title":"Seventeen-colour flow cytometry: unravelling the immune system","volume":"4","author":"Perfetto","year":"2004","journal-title":"Nat Rev Immunol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"2259","DOI":"10.3791\/2259","article-title":"The use of carboxyfluorescein diacetate succinimidyl ester (CFSE) to monitor lymphocyte proliferation","volume":"44","author":"Quah","year":"2010","journal-title":"J Vis Exp"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jim.2007.01.025","article-title":"A CFSE based assay for measuring CD4+CD25+ regulatory T cell mediated suppression of auto-antigen specific and polyclonal T cell responses","volume":"322","author":"Venken","year":"2007","journal-title":"J Immunol Methods"},{"key":"B23","doi-asserted-by":"publisher","first-page":"4682","DOI":"10.4049\/jimmunol.176.8.4682","article-title":"Direct stimulation of T cells by type I IFN enhances the CD8+ T cell response during cross-priming","volume":"176","author":"Le Bon","year":"2006","journal-title":"J Immunol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"5396","DOI":"10.4049\/jimmunol.181.8.5396","article-title":"The indoleamine 2,3-dioxygenase pathway is essential for human plasmacytoid dendritic cell-induced adaptive T regulatory cell generation","volume":"181","author":"Chen","year":"2008","journal-title":"J Immunol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1016\/j.humimm.2015.06.015","article-title":"TGF-beta1-induced regulatory T cells","volume":"76","author":"Hadaschik","year":"2015","journal-title":"Hum Immunol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"J103","DOI":"10.1016\/j.jaut.2011.09.007","article-title":"Regulatory T cells protect from autoimmune arthritis during pregnancy","volume":"3","author":"Munoz-Suano","year":"2012","journal-title":"J Autoimmun"},{"key":"B27","doi-asserted-by":"publisher","first-page":"888","DOI":"10.1016\/j.jhep.2016.12.019","article-title":"Increased peripheral CD4+ regulatory T cells persist after successful direct-acting antiviral treatment of chronic hepatitis C","volume":"66","author":"Langhans","year":"2016","journal-title":"J Hepatol"},{"key":"B28","doi-asserted-by":"publisher","first-page":"2992","DOI":"10.4049\/jimmunol.1500411","article-title":"IFN-beta facilitates neuroantigen-dependent induction of CD25+ FOXP3+ regulatory T cells that suppress experimental autoimmune encephalomyelitis","volume":"197","author":"Wang","year":"2016","journal-title":"J Immunol"},{"key":"B29","doi-asserted-by":"publisher","first-page":"5969","DOI":"10.4049\/jimmunol.0900526","article-title":"APC activation by IFN-alpha decreases regulatory T cell and enhances Th cell functions","volume":"184","author":"Pace","year":"2010","journal-title":"J Immunol"},{"key":"B30","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1111\/j.1365-2567.2010.03280.x","article-title":"Interferon-alpha regulates the dynamic balance between human activated regulatory and effector T cells: implications for antiviral and autoimmune responses","volume":"131","author":"Golding","year":"2010","journal-title":"Immunology"},{"key":"B31","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1053\/j.gastro.2012.03.042","article-title":"Type I interferons maintain Foxp3 expression and T-regulatory cell functions under inflammatory conditions in mice","volume":"143","author":"Lee","year":"2012","journal-title":"Gastroenterology"},{"key":"B32","doi-asserted-by":"publisher","first-page":"4265","DOI":"10.4049\/jimmunol.1500036","article-title":"IFN-\u03b1\/\u03b2 receptor signaling promotes regulatory T cell development and function under stress conditions","volume":"194","author":"Metidji","year":"2015","journal-title":"J Immunol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.jaut.2016.07.004","article-title":"IDO-orchestrated crosstalk between pDCs and Tregs inhibits autoimmunity","volume":"75","author":"Lippens","year":"2016","journal-title":"J Autoimmun"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2018.00285\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,2,19]],"date-time":"2018-02-19T14:34:43Z","timestamp":1519050883000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2018.00285\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,19]]},"references-count":33,"alternative-id":["10.3389\/fimmu.2018.00285"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2018.00285","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,19]]},"article-number":"285"}}