{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T18:53:04Z","timestamp":1772736784644,"version":"3.50.1"},"reference-count":32,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,2,26]],"date-time":"2018-02-26T00:00:00Z","timestamp":1519603200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003407","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","award":["PRIN 20077FPJ22_001"],"award-info":[{"award-number":["PRIN 20077FPJ22_001"]}],"id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007416","name":"Japan Health Sciences Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007416","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001102","name":"Cancer Council NSW","doi-asserted-by":"publisher","award":["1047672"],"award-info":[{"award-number":["1047672"]}],"id":[{"id":"10.13039\/501100001102","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005189","name":"Leukemia and Lymphoma Society","doi-asserted-by":"publisher","award":["7413, 7001-13"],"award-info":[{"award-number":["7413, 7001-13"]}],"id":[{"id":"10.13039\/100005189","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2018.00370","type":"journal-article","created":{"date-parts":[[2018,2,26]],"date-time":"2018-02-26T08:38:09Z","timestamp":1519634289000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":43,"title":["Soluble Fas Ligand Is Essential for Blister Formation in Pemphigus"],"prefix":"10.3389","volume":"9","author":[{"given":"Roberta","family":"Lotti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"En","family":"Shu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiziana","family":"Petrachi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Marconi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabetta","family":"Palazzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marika","family":"Quadri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorraine A.","family":"O\u2019Reilly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Pincelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2018,2,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"17026","DOI":"10.1038\/nrdp.2017.26","article-title":"Pemphigus","volume":"3","author":"Kasperkiewicz","year":"2017","journal-title":"Nat Rev Dis Primers"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1800","DOI":"10.1056\/NEJMra061111","article-title":"Pemphigus, bullous impetigo, and the staphylococcal scalded-skin syndrome","volume":"355","author":"Stanley","year":"2006","journal-title":"N Engl J Med"},{"key":"B3","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1172\/JCI8748","article-title":"Use of autoantigen-knockout mice in developing an active autoimmune disease model for pemphigus","volume":"105","author":"Amagai","year":"2000","journal-title":"J Clin Invest"},{"key":"B4","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1111\/j.1600-0625.2006.00499_1.x","article-title":"Are desmoglein autoantibodies essential for the immunopathogenesis of pemphigus vulgaris, or just \"witnesses of disease\"?","volume":"10","author":"Amagai","year":"2006","journal-title":"Exp Dermatol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"3068","DOI":"10.1038\/jid.2015.324","article-title":"Loss of desmoglein binding is not sufficient for keratinocyte dissociation in pemphigus","volume":"135","author":"Vielmuth","year":"2015","journal-title":"J Invest Dermatol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1111\/j.1600-0625.2009.00934.x","article-title":"Apoptolysis: a novel mechanism of skin blistering in pemphigus vulgaris linking the apoptotic pathways to basal cell shrinkage and suprabasal acantholysis","volume":"18","author":"Grando","year":"2009","journal-title":"Exp Dermatol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1023\/B:APPT.0000018795.05766.1f","article-title":"Possible apoptotic mechanism in epidermal cell acantholysis induced by pemphigus vulgaris autoimmunoglobulins","volume":"9","author":"Wang","year":"2004","journal-title":"Apoptosis"},{"key":"B8","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1196\/annals.1313.040","article-title":"The interaction of pemphigus autoimmunoglobulins with epidermal cells: activation of the Fas apoptotic pathway and the use of caspase activity for pathogenicity tests of pemphigus patients","volume":"1050","author":"Frusic-Zlotkin","year":"2005","journal-title":"Ann N Y Acad Sci"},{"key":"B9","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1002\/j.1460-2075.1995.tb07096.x","article-title":"Expression of the functional soluble form of human Fas ligand in activated lymphocytes","volume":"14","author":"Tanaka","year":"1995","journal-title":"EMBO J"},{"key":"B10","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/S0031-6865(99)00038-2","article-title":"Apoptosis induced by death receptors","volume":"74","author":"Schneider","year":"2000","journal-title":"Pharm Acta Helv"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1428","DOI":"10.1128\/MCB.23.4.1428-1440.2003","article-title":"Two adjacent trimeric Fas ligands are required for Fas signaling and formation of a death-inducing signaling complex","volume":"23","author":"Holler","year":"2003","journal-title":"Mol Cell Biol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1038\/nature08402","article-title":"Membrane-bound Fas ligand only is essential for Fas-induced apoptosis","volume":"461","author":"O\u2019Reilly","year":"2009","journal-title":"Nature"},{"key":"B13","doi-asserted-by":"publisher","first-page":"16183","DOI":"10.1074\/jbc.M212188200","article-title":"Intracellular localization of keratinocyte Fas ligand explains lack of cytolytic activity under physiological conditions","volume":"278","author":"Viard-Leveugle","year":"2003","journal-title":"J Biol Chem"},{"key":"B14","doi-asserted-by":"publisher","first-page":"1531","DOI":"10.1016\/S0002-9440(10)61239-4","article-title":"Novel mechanisms of target cell death and survival and of therapeutic action of IVIg in pemphigus","volume":"167","author":"Arredondo","year":"2005","journal-title":"Am J Pathol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1046\/j.1523-1747.2003.12014.x","article-title":"Fas ligand in pemphigus sera induces keratinocyte apoptosis through the activation of caspase-8","volume":"120","author":"Puviani","year":"2003","journal-title":"J Invest Dermatol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1111\/1523-1747.ep12340768","article-title":"Autocrine nerve growth factor protects human keratinocytes from apoptosis through its high affinity receptor (TRK): a role for BCL-2","volume":"109","author":"Pincelli","year":"1997","journal-title":"J Invest Dermatol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1111\/1523-1747.ep12274679","article-title":"Experimentally induced pemphigus vulgaris in neonatal BALB\/c mice: a time-course study of clinical, immunologic, ultrastructural, and cytochemical changes","volume":"84","author":"Takahashi","year":"1985","journal-title":"J Invest Dermatol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"41175","DOI":"10.1074\/jbc.M105769200","article-title":"The fate of desmosomal proteins in apoptotic cells","volume":"276","author":"Weiske","year":"2001","journal-title":"J Biol Chem"},{"key":"B19","doi-asserted-by":"publisher","first-page":"3614","DOI":"10.1074\/jbc.M508258200","article-title":"The differentiation-dependent desmosomal cadherin desmoglein 1 is a novel caspase-3 target that regulates apoptosis in keratinocytes","volume":"281","author":"Dusek","year":"2006","journal-title":"J Biol Chem"},{"key":"B20","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1111\/j.0022-202X.2005.23714.x","article-title":"In vitro keratinocyte dissociation assay for evaluation of the pathogenicity of anti-desmoglein 3 IgG autoantibodies in pemphigus vulgaris","volume":"124","author":"Ishii","year":"2005","journal-title":"J Invest Dermatol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"1825","DOI":"10.4049\/jimmunol.181.3.1825","article-title":"Pemphigus vulgaris IgG directly inhibit desmoglein 3-mediated transinteraction","volume":"181","author":"Heupel","year":"2008","journal-title":"J Immunol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.jid.2017.06.022","article-title":"Mechanisms causing loss of keratinocyte cohesion in pemphigus","volume":"138","author":"Spindler","year":"2018","journal-title":"J Invest Dermatol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"C162","DOI":"10.1152\/ajpcell.00161.2008","article-title":"Apoptosis is not required for acantholysis in pemphigus vulgaris","volume":"296","author":"Schmidt","year":"2009","journal-title":"Am J Physiol Cell Physiol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"711","DOI":"10.4049\/jimmunol.182.1.711","article-title":"Involvement of the apoptotic mechanism in pemphigus foliaceous autoimmune injury of the skin","volume":"182","author":"Li","year":"2009","journal-title":"J Immunol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1798","DOI":"10.1038\/jid.2012.46","article-title":"Population-specific association between a polymorphic variant in ST18, encoding a pro-apoptotic molecule, and pemphigus vulgaris","volume":"132","author":"Sarig","year":"2012","journal-title":"J Invest Dermatol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"e1006008","DOI":"10.1371\/journal.pgen.1006008","article-title":"Identification of a functional risk variant for pemphigus vulgaris in the ST18 gene","volume":"12","author":"Vodo","year":"2016","journal-title":"PLoS Genet"},{"key":"B27","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1083\/jcb.201208162","article-title":"Keratins control intercellular adhesion involving PKC-\u03b1-mediated desmoplakin phosphorylation","volume":"201","author":"Kr\u00f6ger","year":"2013","journal-title":"J Cell Biol"},{"key":"B28","doi-asserted-by":"publisher","first-page":"2528","DOI":"10.1016\/j.ajpath.2014.05.016","article-title":"A desmoplakin point mutation with enhanced keratin association ameliorates pemphigus vulgaris autoantibody-mediated loss of cell cohesion","volume":"184","author":"Dehner","year":"2014","journal-title":"Am J Pathol"},{"key":"B29","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/j.cell.2007.04.031","article-title":"The CD95 receptor: apoptosis revisited","volume":"129","author":"Peter","year":"2007","journal-title":"Cell"},{"key":"B30","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1038\/nri.2015.7","article-title":"Converging roles of caspases in inflammasome activation, cell death and innate immunity","volume":"16","author":"Man","year":"2016","journal-title":"Nat Rev Immunol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1111\/j.1365-2133.2004.06147.x","article-title":"In vivo blockade of pemphigus vulgaris acantholysis by inhibition of intracellular signal transduction cascades","volume":"151","author":"S\u00e1nchez-Carpintero","year":"2004","journal-title":"Br J Dermatol"},{"key":"B32","doi-asserted-by":"publisher","first-page":"12855","DOI":"10.1073\/pnas.0602973103","article-title":"p38MAPK inhibition prevents disease in pemphigus vulgaris mice","volume":"103","author":"Berkowitz","year":"2006","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2018.00370\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,11]],"date-time":"2019-10-11T20:51:48Z","timestamp":1570827108000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2018.00370\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,26]]},"references-count":32,"alternative-id":["10.3389\/fimmu.2018.00370"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2018.00370","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,26]]},"article-number":"370"}}