{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T05:40:57Z","timestamp":1788932457810,"version":"build-2803163510"},"reference-count":39,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,3,22]],"date-time":"2018-03-22T00:00:00Z","timestamp":1521676800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["Cluster 306\/2, RI 1056 11\/1-2, RTG 1727\/1 TP2"],"award-info":[{"award-number":["Cluster 306\/2, RI 1056 11\/1-2, RTG 1727\/1 TP2"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2018.00428","type":"journal-article","created":{"date-parts":[[2018,3,22]],"date-time":"2018-03-22T11:24:59Z","timestamp":1521717899000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["Autoantibodies in Serum of Systemic Scleroderma Patients: Peptide-Based Epitope Mapping Indicates Increased Binding to Cytoplasmic Domains of CXCR3"],"prefix":"10.3389","volume":"9","author":[{"given":"Andreas","family":"Recke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann-Katrin","family":"Regensburger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Weigold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antje","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"Heidecke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Marschner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph M.","family":"Hammers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf J.","family":"Ludwig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Riemekasten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,3,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2737","DOI":"10.1002\/art.38098","article-title":"2013 classification criteria for systemic sclerosis: an American College of Rheumatology\/European League against Rheumatism collaborative initiative","volume":"65","author":"van den Hoogen","year":"2013","journal-title":"Arthritis Rheum"},{"key":"B2","doi-asserted-by":"publisher","first-page":"603","DOI":"10.3389\/fimmu.2017.00603","article-title":"Mechanisms of autoantibody-induced pathology","volume":"8","author":"Ludwig","year":"2017","journal-title":"Front Immunol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1172\/JCI31139","article-title":"Systemic sclerosis: a prototypic multisystem fibrotic disorder","volume":"117","author":"Varga","year":"2007","journal-title":"J Clin Invest"},{"key":"B4","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1097\/BOR.0000000000000113","article-title":"Scleroderma: the role of serum autoantibodies in defining specific clinical phenotypes and organ system involvement","volume":"26","author":"Domsic","year":"2014","journal-title":"Curr Opin Rheumatol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1038\/nrrheum.2017.134","article-title":"Functional autoantibodies targeting G protein-coupled receptors in rheumatic diseases","volume":"13","author":"Cabral-Marques","year":"2017","journal-title":"Nat Rev Rheumatol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1016\/j.autrev.2016.04.004","article-title":"Antibodies against angiotensin II type 1 receptor (AT1R) and endothelin receptor type A (ETAR) in systemic sclerosis (SSc)-response","volume":"15","author":"Riemekasten","year":"2016","journal-title":"Autoimmun Rev"},{"key":"B7","volume-title":"Antibodies against Chemokine Receptors CXCR3 and CXCR4 Predict Progressive Deterioration of Lung Function in Patients with Systemic Sclerosis","author":"Weigold","year":"2017"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1016\/j.autrev.2017.07.019","article-title":"Role of anti-receptor autoantibodies in pathophysiology of scleroderma","volume":"16","author":"Berger","year":"2017","journal-title":"Autoimmun Rev"},{"key":"B9","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1136\/ard.2010.135772","article-title":"Involvement of functional autoantibodies against vascular receptors in systemic sclerosis","volume":"70","author":"Riemekasten","year":"2011","journal-title":"Ann Rheum Dis"},{"key":"B10","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1007\/s00281-014-0425-9","article-title":"Agonistic autoantibodies directed against G-protein-coupled receptors and their relationship to cardiovascular diseases","volume":"36","author":"Wallukat","year":"2014","journal-title":"Semin Immunopathol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1056\/NEJMoa035717","article-title":"Angiotensin II type 1-receptor activating antibodies in renal-allograft rejection","volume":"352","author":"Dragun","year":"2005","journal-title":"N Engl J Med"},{"key":"B12","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1007\/978-1-62703-493-7_19","article-title":"The detection of antibodies to the angiotensin II-type 1 receptor in transplantation","volume":"1034","author":"Dragun","year":"2013","journal-title":"Methods Mol Biol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"1801","DOI":"10.3899\/jrheum.150061","article-title":"Autoantibodies against endothelin 1 type A receptor are strong predictors of digital ulcers in systemic sclerosis","volume":"42","author":"Avouac","year":"2015","journal-title":"J Rheumatol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1164\/rccm.201403-0442OC","article-title":"Vascular receptor autoantibodies in pulmonary arterial hypertension associated with systemic sclerosis","volume":"190","author":"Becker","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"key":"B15","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1038\/icb.2010.158","article-title":"CXCR3 ligands: redundant, collaborative and antagonistic functions","volume":"89","author":"Groom","year":"2011","journal-title":"Immunol Cell Biol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"594","DOI":"10.4161\/mabs.2.6.13420","article-title":"Therapeutic antibodies directed at G protein-coupled receptors","volume":"2","author":"Hutchings","year":"2010","journal-title":"mAbs"},{"key":"B17","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1002\/art.24136","article-title":"CXCR3+CD4+ T cells are enriched in inflamed kidneys and urine and provide a new biomarker for acute nephritis flares in systemic lupus erythematosus patients","volume":"60","author":"Enghard","year":"2009","journal-title":"Arthritis Rheum"},{"key":"B18","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1002\/ijc.2910600419","article-title":"Shedding of the soluble form of CD30 from the Hodgkin-analogous cell line L540 is strongly inhibited by a new CD30-specific antibody (Ki-4)","volume":"60","author":"Horn-Lohrens","year":"1995","journal-title":"Int J Cancer"},{"key":"B19","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1161\/CIRCRESAHA.113.300752","article-title":"Angiotensin receptor agonistic autoantibodies and hypertension: preeclampsia and beyond","volume":"113","author":"Xia","year":"2013","journal-title":"Circ Res"},{"key":"B20","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.jdermsci.2011.11.012","article-title":"Mapping of B cell epitopes on desmoglein 3 in pemphigus vulgaris patients by the use of overlapping peptides","volume":"65","author":"Dworschak","year":"2012","journal-title":"J Dermatol Sci"},{"key":"B21","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/0022-2836(82)90515-0","article-title":"A simple method for displaying the hydropathic character of a protein","volume":"157","author":"Kyte","year":"1982","journal-title":"J Mol Biol"},{"key":"B22","volume-title":"R: A Language and Environment for Statistical Computing","year":"2012"},{"key":"B23","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.csda.2013.04.014","article-title":"Bayesian computing with INLA: new features","volume":"67","author":"Martins","year":"2013","journal-title":"Comput Stat Data Anal"},{"key":"B24","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1111\/j.1467-9868.2008.00700.x","article-title":"Approximate Bayesian inference for latent Gaussian models by using integrated nested Laplace approximations","volume":"71","author":"Rue","year":"2009","journal-title":"J R Stat Soc Ser B"},{"key":"B25","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.jaut.2015.05.004","article-title":"Allelic and copy-number variations of Fc\u03b3Rs affect granulocyte function and susceptibility for autoimmune blistering diseases","volume":"61","author":"Recke","year":"2015","journal-title":"J Autoimmun"},{"key":"B26","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-642-56970-8","volume-title":"Einf\u00fchrung in die Bayes-Statistik","author":"Koch","year":"2000"},{"key":"B27","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1093\/bioinformatics\/16.5.412","article-title":"Assessing the accuracy of prediction algorithms for classification: an overview","volume":"16","author":"Baldi","year":"2000","journal-title":"Bioinforma Oxf Engl"},{"key":"B28","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/0014-5793(90)80535-Q","article-title":"A semi-empirical method for prediction of antigenic determinants on protein antigens","volume":"276","author":"Kolaskar","year":"1990","journal-title":"FEBS Lett"},{"key":"B29","doi-asserted-by":"publisher","first-page":"e0121673","DOI":"10.1371\/journal.pone.0121673","article-title":"Dissecting antibodies with regards to linear and conformational epitopes","volume":"10","author":"Forsstr\u00f6m","year":"2015","journal-title":"PLoS One"},{"key":"B30","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.1001\/archderm.142.11.1513","article-title":"Autoantibodies from patients with BSLE inducing recruitment of leukocytes to the dermoepidermal junction and subepidermal splits in cryosections of human skin","volume":"142","author":"Herrero-Gonz\u00e1lez","year":"2006","journal-title":"Arch Dermatol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1038\/nature08144","article-title":"The structure and function of G-protein-coupled receptors","volume":"459","author":"Rosenbaum","year":"2009","journal-title":"Nature"},{"key":"B32","doi-asserted-by":"publisher","first-page":"1544","DOI":"10.1016\/S0140-6736(04)16154-0","article-title":"Autoantibodies as predictors of disease","volume":"363","author":"Scofield","year":"2004","journal-title":"Lancet"},{"key":"B33","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1016\/j.bcp.2005.07.005","article-title":"A high-affinity monoclonal antibody with functional activity against the 5-hydroxytryptaminergic (5-HT4) receptor","volume":"70","author":"Kamel","year":"2005","journal-title":"Biochem Pharmacol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1111\/j.1365-2133.2008.08858.x","article-title":"IgE autoantibodies against the intracellular domain of BP180","volume":"160","author":"Dresow","year":"2009","journal-title":"Br J Dermatol"},{"key":"B35","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.jaut.2011.01.004","article-title":"Fine specificity of antibodies against AQP4: epitope mapping reveals intracellular epitopes","volume":"36","author":"Kampylafka","year":"2011","journal-title":"J Autoimmun"},{"key":"B36","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1006\/jaut.1996.0038","article-title":"The penetration of autoantibodies into cells may induce tolerance to self by apoptosis of autoreactive lymphocytes and cause autoimmune disease by dysregulation and\/or cell damage","volume":"9","author":"Alarc\u00f3n-Segovia","year":"1996","journal-title":"J Autoimmun"},{"key":"B37","doi-asserted-by":"publisher","first-page":"5601","DOI":"10.1073\/pnas.95.10.5601","article-title":"Polyreactive anti-DNA monoclonal antibodies and a derived peptide as vectors for the intracytoplasmic and intranuclear translocation of macromolecules","volume":"95","author":"Avrameas","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B38","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1517\/14712598.5.2.237","article-title":"TransMabs: cell-penetrating antibodies, the next generation","volume":"5","author":"Muller","year":"2005","journal-title":"Expert Opin Biol Ther"},{"key":"B39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2011\/829751","article-title":"The role of intravenous immunoglobulin preparations in the treatment of systemic sclerosis","volume":"2011","author":"Baleva","year":"2011","journal-title":"Int J Rheumatol"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2018.00428\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,3,22]],"date-time":"2018-03-22T11:25:06Z","timestamp":1521717906000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2018.00428\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,22]]},"references-count":39,"alternative-id":["10.3389\/fimmu.2018.00428"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2018.00428","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,22]]},"article-number":"428"}}