{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T21:56:24Z","timestamp":1775253384364,"version":"3.50.1"},"reference-count":24,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,3,21]],"date-time":"2018-03-21T00:00:00Z","timestamp":1521590400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004329","name":"Javna Agencija za Raziskovalno Dejavnost RS","doi-asserted-by":"publisher","award":["L7-8274 and P3-0360"],"award-info":[{"award-number":["L7-8274 and P3-0360"]}],"id":[{"id":"10.13039\/501100004329","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2018.00500","type":"journal-article","created":{"date-parts":[[2018,3,21]],"date-time":"2018-03-21T08:30:11Z","timestamp":1521621011000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Functional Complement Analysis Can Predict Genetic Testing Results and Long-Term Outcome in Patients With Complement Deficiencies"],"prefix":"10.3389","volume":"9","author":[{"given":"\u0160tefan","family":"Blazina","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maru\u0161a","family":"Debeljak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitja","family":"Ko\u0161nik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sa\u0161a","family":"Sim\u010di\u010d","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanja","family":"Stopin\u0161ek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ga\u0161per","family":"Markelj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nata\u0161a","family":"Toplak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Kopa\u010d","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Breda","family":"Zakotnik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marko","family":"Pokorn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadej","family":"Av\u010din","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2018,3,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1038\/nri3761","article-title":"Complement \u2013 tapping into new sites and effector systems","volume":"14","author":"Kolev","year":"2014","journal-title":"Nat Rev Immunol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1097\/01.md.0000152371.22747.1e","article-title":"Hereditary C2 deficiency in Sweden: frequent occurrence of invasive infection, atherosclerosis, and rheumatic disease","volume":"84","author":"J\u00f6nsson","year":"2005","journal-title":"Medicine (Baltimore)"},{"key":"B3","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1111\/j.1749-6632.1997.tb52069.x","article-title":"Complement deficiency and autoimmunity","volume":"815","author":"Walport","year":"1997","journal-title":"Ann N Y Acad Sci"},{"key":"B4","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.molimm.2015.05.007","article-title":"Classical pathway deficiencies \u2013 a short analytical review","volume":"68","author":"Truedsson","year":"2015","journal-title":"Mol Immunol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1643","DOI":"10.1016\/j.molimm.2011.05.001","article-title":"Complement deficiency states and associated infections","volume":"48","author":"Skattum","year":"2011","journal-title":"Mol Immunol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1007\/s10875-015-0137-5","article-title":"Spectrum and management of complement immunodeficiencies (excluding hereditary angioedema) across Europe","volume":"35","author":"Turley","year":"2015","journal-title":"J Clin Immunol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1007\/s10875-016-0330-1","article-title":"Autoimmune and inflammatory manifestations in 247 patients with primary immunodeficiency\u2014a report from the Slovenian national registry","volume":"36","author":"Blazina","year":"2016","journal-title":"J Clin Immunol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"S51","DOI":"10.1016\/j.jaci.2004.06.047","article-title":"Hereditary and acquired angioedema: problems and progress: proceedings of the third C1 esterase inhibitor deficiency workshop and beyond","volume":"114","author":"Agostoni","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1710-1492-7-1","article-title":"Hereditary angioedema: beyond international consensus \u2013 circa December 2010 \u2013 the Canadian society of allergy and clinical immunology Dr. David McCourtie lecture","volume":"7","author":"Bowen","year":"2011","journal-title":"Allergy Asthma Clin Immunol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1111\/j.1398-9995.2010.02456.x","article-title":"Mutational spectrum and phenotypes in Danish families with hereditary angioedema because of C1 inhibitor deficiency","volume":"66","author":"Bygum","year":"2011","journal-title":"Allergy"},{"key":"B11","doi-asserted-by":"publisher","first-page":"e56712","DOI":"10.1371\/journal.pone.0056712","article-title":"Hereditary angioedema nationwide study in Slovenia reveals four novel mutations in SERPING1 gene","volume":"8","author":"Rijavec","year":"2013","journal-title":"PLoS One"},{"key":"B12","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1007\/s10875-015-0201-1","article-title":"Primary immunodeficiency diseases: an update on the classification from the international union of immunological societies expert committee for primary immunodeficiency","volume":"35","author":"Picard","year":"2015","journal-title":"J Clin Immunol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1111\/j.1365-2249.1991.tb05656.x","article-title":"Functionally active complement proteins C6 and C7 detected in C6- and C7-deficient individuals","volume":"83","author":"W\u00fcrzner","year":"1991","journal-title":"Clin Exp Immunol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/S0065-2776(01)76021-X","article-title":"Systemic lupus erythematosus, complement deficiency, and apoptosis","volume":"76","author":"Pickering","year":"2000","journal-title":"Adv Immunol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1016\/J.CLIM.2010.02.021","article-title":"The French national registry of primary immunodeficiency diseases","volume":"135","author":"Beaut\u00e9","year":"2010","journal-title":"Clin Immunol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1111\/cei.12105","article-title":"The German national registry for primary immunodeficiencies (PID)","volume":"173","author":"Gathmann","year":"2013","journal-title":"Clin Exp Immunol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1007\/s10875-014-0066-8","article-title":"Primary immunodeficiency diseases: a 30-year patient registry from the referral center for primary immunodeficiencies in Greece","volume":"34","author":"Michos","year":"2014","journal-title":"J Clin Immunol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1111\/cei.12661","article-title":"The Swiss National Registry for Primary immunodeficiencies: report on the first 6 years\u2019 activity from 2008 to 2014","volume":"182","author":"Marschall","year":"2015","journal-title":"Clin Exp Immunol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"3838","DOI":"10.1016\/j.molimm.2007.06.150","article-title":"Complement analysis in the 21st century","volume":"44","author":"Mollnes","year":"2007","journal-title":"Mol Immunol"},{"key":"B20","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.molimm.2014.06.030","article-title":"Are complement deficiencies really rare? Overview on prevalence, clinical importance and modern diagnostic approach","volume":"61","author":"Grumach","year":"2014","journal-title":"Mol Immunol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1046\/j.1365-2249.2000.01130.x","article-title":"Development of antibodies against tetravalent meningococcal polysaccharides in revaccinated complement-deficient patients","volume":"119","author":"Drogari-Apiranthitou","year":"2000","journal-title":"Clin Exp Immunol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"e3548","DOI":"10.1097\/MD.0000000000003548","article-title":"Infections revealing complement deficiency in adults: a French nationwide study enrolling 41 patients","volume":"95","author":"Audemard-Verger","year":"2016","journal-title":"Medicine (Baltimore)"},{"key":"B23","first-page":"S95","article-title":"Complement deficiency: predisposing factor to autoimmune syndromes","volume":"7","author":"Atkinson","year":"1989","journal-title":"Clin Exp Rheumatol"},{"key":"B24","doi-asserted-by":"crossref","first-page":"578","DOI":"10.4049\/jimmunol.161.2.578","article-title":"A novel type II complement C2 deficiency allele in an African-American family","volume":"161","author":"Zhu","year":"1998","journal-title":"J Immunol"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2018.00500\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T05:19:32Z","timestamp":1719897572000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2018.00500\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,21]]},"references-count":24,"alternative-id":["10.3389\/fimmu.2018.00500"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2018.00500","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,21]]},"article-number":"500"}}