{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T08:34:24Z","timestamp":1789893264421,"version":"4.0.1"},"reference-count":60,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,3,21]],"date-time":"2018-03-21T00:00:00Z","timestamp":1521590400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2018.00570","type":"journal-article","created":{"date-parts":[[2018,3,21]],"date-time":"2018-03-21T08:46:36Z","timestamp":1521621996000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Anti-Type VII Collagen Antibodies Are Identified in a Subpopulation of Bullous Pemphigoid Patients With Relapse"],"prefix":"10.3389","volume":"9","author":[{"given":"Delphine","family":"Giusti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gr\u00e9gory","family":"Gatouillat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Le Jan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Pl\u00e9e","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Bernard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Antonicelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bach-Nga","family":"Pham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,3,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/00005792-195302000-00001","article-title":"Pemphigus","volume":"32","author":"Lever","year":"1953","journal-title":"Medicine"},{"key":"B2","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1016\/S0140-6736(12)61140-4","article-title":"Pemphigoid diseases","volume":"381","author":"Schmidt","year":"2013","journal-title":"Lancet"},{"key":"B3","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1007\/s40257-017-0264-2","article-title":"Bullous pemphigoid: a review of its diagnosis, associations and treatment","volume":"18","author":"Bernard","year":"2017","journal-title":"Am J Clin Dermatol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1007\/s12016-017-8633-4","article-title":"Autoimmune subepidermal bullous diseases of the skin and mucosae: clinical features, diagnosis, and management","volume":"54","author":"Amber","year":"2018","journal-title":"Clin Rev Allergy Immunol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1172\/JCI114812","article-title":"Isolation of a human epidermal cDNA corresponding to the 180-kD autoantigen recognized by bullous pemphigoid and herpes gestationis sera. Immunolocalization of this protein to the hemidesmosome","volume":"86","author":"Diaz","year":"1990","journal-title":"J Clin Invest"},{"key":"B6","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.4049\/jimmunol.136.4.1231","article-title":"Molecular heterogeneity of the bullous pemphigoid antigens as detected by immunoblotting","volume":"136","author":"Labib","year":"1986","journal-title":"J Immunol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1443","DOI":"10.1172\/JCI114036","article-title":"Pemphigus and pemphigoid as paradigms of organ-specific, autoantibody-mediated diseases","volume":"83","author":"Stanley","year":"1989","journal-title":"J Clin Invest"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1154","DOI":"10.1111\/exd.13446","article-title":"Structural proteins of the dermal-epidermal junction targeted by autoantibodies in pemphigoid diseases","volume":"26","author":"Goletz","year":"2017","journal-title":"Exp Dermatol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1752","DOI":"10.3389\/fimmu.2017.01752","article-title":"BP180 is critical in the autoimmunity of bullous pemphigoid","volume":"8","author":"Liu","year":"2017","journal-title":"Front Immunol"},{"key":"B10","doi-asserted-by":"crossref","first-page":"5742","DOI":"10.4049\/jimmunol.151.10.5742","article-title":"Bullous pemphigoid and herpes gestationis autoantibodies recognize a common non-collagenous site on the BP180 ectodomain","volume":"151","author":"Giudice","year":"1993","journal-title":"J Immunol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1046\/j.1523-1747.1999.00497.x","article-title":"IgG autoantibodies from bullous pemphigoid (BP) patients bind antigenic sites on both the extracellular and the intracellular domains of the BP antigen 180","volume":"112","author":"Perriard","year":"1999","journal-title":"J Invest Dermatol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1046\/j.1523-1747.2002.19529.x","article-title":"Severity and phenotype of bullous pemphigoid relate to autoantibody profile against the NH2- and COOH-terminal regions of the BP180 ectodomain","volume":"119","author":"Hofmann","year":"2002","journal-title":"J Invest Dermatol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/j.clim.2008.04.012","article-title":"Multicenter prospective study of the humoral autoimmune response in bullous pemphigoid","volume":"128","author":"Di Zenzo","year":"2008","journal-title":"Clin Immunol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1001\/archdermatol.2011.21","article-title":"Enzyme-linked immunosorbent assay for the combination of bullous pemphigoid antigens 1 and 2 in the diagnosis of bullous pemphigoid","volume":"147","author":"Roussel","year":"2011","journal-title":"Arch Dermatol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1001\/archdermatol.2011.23","article-title":"Usefulness of BP230 and BP180-NC16a enzyme-linked immunosorbent assays in the initial diagnosis of bullous pemphigoid: a retrospective study of 138 patients","volume":"147","author":"Charneux","year":"2011","journal-title":"Arch Dermatol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1001\/jamadermatol.2013.5757","article-title":"Clinical and immunologic factors associated with bullous pemphigoid relapse during the first year of treatment: a multicenter, prospective study","volume":"150","author":"Fichel","year":"2014","journal-title":"JAMA Dermatol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1046\/j.1365-2133.1998.02396.x","article-title":"Immunoreactivity of bullous pemphigoid (BP) autoantibodies against the NC16A and C-terminal domains of the 180 kDa BP antigen (BP180): immunoblot analysis and enzyme-linked immunosorbent assay using BP180 recombinant proteins","volume":"139","author":"Nakatani","year":"1998","journal-title":"Br J Dermatol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"91","DOI":"10.3109\/08916934.2011.606450","article-title":"Epidermolysis bullosa acquisita: autoimmunity to anchoring fibril collagen","volume":"45","author":"Chen","year":"2012","journal-title":"Autoimmunity"},{"key":"B19","doi-asserted-by":"publisher","first-page":"307","DOI":"10.2340\/00015555-1065","article-title":"Epidermolysis bullosa acquisita: a retrospective clinical analysis of 30 cases","volume":"91","author":"Kim","year":"2011","journal-title":"Acta Derm Venereol"},{"key":"B20","doi-asserted-by":"publisher","first-page":"812029","DOI":"10.1155\/2013\/812029","article-title":"Clinical presentation, pathogenesis, diagnosis, and treatment of epidermolysis bullosa acquisita","volume":"2013","author":"Ludwig","year":"2013","journal-title":"ISRN Dermatol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1111\/exd.13415","article-title":"In vitro and in vivo models to investigate the pathomechanisms and novel treatments for pemphigoid diseases","volume":"26","author":"Bieber","year":"2017","journal-title":"Exp Dermatol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"603","DOI":"10.3389\/fimmu.2017.00603","article-title":"Mechanisms of autoantibody-induced pathology","volume":"8","author":"Ludwig","year":"2017","journal-title":"Front Immunol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.jaut.2008.08.009","article-title":"Subepidermal blistering induced by human autoantibodies to BP180 requires innate immune players in a humanized bullous pemphigoid mouse model","volume":"31","author":"Liu","year":"2008","journal-title":"J Autoimmun"},{"key":"B24","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1111\/1523-1747.ep12337492","article-title":"Tight clustering of extracellular BP180 epitopes recognized by bullous pemphigoid autoantibodies","volume":"109","author":"Zillikens","year":"1997","journal-title":"J Invest Dermatol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1001\/archderm.136.2.174","article-title":"Serum levels of autoantibodies to BP180 correlate with disease activity in patients with bullous pemphigoid","volume":"136","author":"Schmidt","year":"2000","journal-title":"Arch Dermatol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1038\/sj.jid.5602955","article-title":"Detection of IgG autoantibodies in the sera of patients with bullous and gestational pemphigoid: ELISA studies utilizing a baculovirus-encoded form of bullous pemphigoid antigen 2","volume":"110","author":"Haase","year":"1998","journal-title":"J Invest Dermatol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1001\/archdermatol.2009.53","article-title":"Risk factors for relapse in patients with bullous pemphigoid in clinical remission: a multicenter, prospective, cohort study","volume":"145","author":"Bernard","year":"2009","journal-title":"Arch Dermatol"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1681","DOI":"10.1038\/jid.2008.412","article-title":"A comparison of two regimens of topical corticosteroids in the treatment of patients with bullous pemphigoid: a multicenter randomized study","volume":"129","author":"Joly","year":"2009","journal-title":"J Invest Dermatol"},{"key":"B29","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1056\/NEJMoa011592","article-title":"A comparison of oral and topical corticosteroids in patients with bullous pemphigoid","volume":"346","author":"Joly","year":"2002","journal-title":"N Engl J Med"},{"key":"B30","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1046\/j.1365-4362.1999.00754.x","article-title":"Re-evaluation of the natural course of bullous pemphigoid. A prospective study","volume":"38","author":"Kyriakis","year":"1999","journal-title":"Int J Dermatol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1111\/exd.13444","article-title":"Variation of the epidermal expression of glucocorticoid receptor-beta as potential predictive marker of bullous pemphigoid outcome","volume":"26","author":"Brulefert","year":"2017","journal-title":"Exp Dermatol"},{"key":"B32","doi-asserted-by":"crossref","first-page":"119","DOI":"10.47102\/annals-acadmedsg.V44N4p119","article-title":"Anti-BP180 NC16A IgG titres as an indicator of disease activity and outcome in Asian patients with bullous pemphigoid","volume":"44","author":"Cai","year":"2015","journal-title":"Ann Acad Med Singapore"},{"key":"B33","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1001\/archderm.134.9.1075","article-title":"Evaluation of clinical criteria for diagnosis of bullous pemphigoid. French Bullous Study Group","volume":"134","author":"Vaillant","year":"1998","journal-title":"Arch Dermatol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/j.jaad.2011.06.032","article-title":"Definitions and outcome measures for bullous pemphigoid: recommendations by an international panel of experts","volume":"66","author":"Murrell","year":"2012","journal-title":"J Am Acad Dermatol"},{"key":"B35","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1111\/bjd.12011","article-title":"Diagnosis and disease severity assessment of epidermolysis bullosa acquisita by ELISA for anti-type VII collagen autoantibodies: an Italian multicentre study","volume":"168","author":"Marzano","year":"2013","journal-title":"Br J Dermatol"},{"key":"B36","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/S0923-1811(02)00109-3","article-title":"BP180 ELISA using bacterial recombinant NC16a protein as a diagnostic and monitoring tool for bullous pemphigoid","volume":"30","author":"Kobayashi","year":"2002","journal-title":"J Dermatol Sci"},{"key":"B37","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.jdermsci.2005.11.002","article-title":"Enzyme-linked immunosorbent assay using bacterial recombinant proteins of human BP230 as a diagnostic tool for bullous pemphigoid","volume":"41","author":"Yoshida","year":"2006","journal-title":"J Dermatol Sci"},{"key":"B38","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/1471-2172-13-16","article-title":"Prevalence of collagen VII-specific autoantibodies in patients with autoimmune and inflammatory diseases","volume":"13","author":"Licarete","year":"2012","journal-title":"BMC Immunol"},{"key":"B39","doi-asserted-by":"publisher","first-page":"1166","DOI":"10.1016\/j.jaad.2016.01.005","article-title":"Comparison of 3 type VII collagen (C7) assays for serologic diagnosis of epidermolysis bullosa acquisita (EBA)","volume":"74","author":"Seta","year":"2016","journal-title":"J Am Acad Dermatol"},{"key":"B40","doi-asserted-by":"publisher","first-page":"1683","DOI":"10.1111\/bjd.15800","article-title":"Serological diagnostics in the detection of IgG autoantibodies against human collagen VII in epidermolysis bullosa acquisita \u2013 a multicenter analysis","volume":"177","author":"Schmidt","year":"2017","journal-title":"Br J Dermatol"},{"key":"B41","doi-asserted-by":"publisher","first-page":"479","DOI":"10.3389\/fimmu.2018.00479","article-title":"Mucosal involvement in bullous pemphigoid is mostly associated with disease severity and to absence of anti-BP230 autoantibody","volume":"9","author":"Clap\u00e9","year":"2018","journal-title":"Front Immunol"},{"key":"B42","doi-asserted-by":"publisher","first-page":"2271","DOI":"10.1038\/jid.2011.180","article-title":"Demonstration of epitope-spreading phenomena in bullous pemphigoid: results of a prospective multicenter study","volume":"131","author":"Di Zenzo","year":"2011","journal-title":"J Invest Dermatol"},{"key":"B43","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1046\/j.1523-1747.1998.00107.x","article-title":"Epitope spreading: lessons from autoimmune skin diseases","volume":"110","author":"Chan","year":"1998","journal-title":"J Invest Dermatol"},{"key":"B44","doi-asserted-by":"publisher","first-page":"18001","DOI":"10.1038\/srep18001","article-title":"Integrating longitudinal serum IL-17 and IL-23 follow-up, along with autoantibodies variation, contributes to predict bullous pemphigoid outcome","volume":"5","author":"Pl\u00e9e","year":"2015","journal-title":"Sci Rep"},{"key":"B45","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1016\/j.jaci.2016.08.012","article-title":"Bullous pemphigoid outcome is associated with CXCL10-induced matrix metalloproteinase 9 secretion from monocytes and neutrophils but not lymphocytes","volume":"139","author":"Riani","year":"2016","journal-title":"J Allergy Clin Immunol"},{"key":"B46","doi-asserted-by":"publisher","first-page":"4833","DOI":"10.1038\/s41598-017-04687-5","article-title":"Eosinophil Cationic Protein (ECP), a predictive marker of bullous pemphigoid severity and outcome","volume":"7","author":"Giusti","year":"2017","journal-title":"Sci Rep"},{"key":"B47","doi-asserted-by":"publisher","first-page":"1240","DOI":"10.1111\/exd.13459","article-title":"Biomarkers related to bullous pemphigoid activity and outcome","volume":"26","author":"Giusti","year":"2017","journal-title":"Exp Dermatol"},{"key":"B48","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1038\/cmi.2015.23","article-title":"Tissue resident regulatory T cells: novel therapeutic targets for human disease","volume":"12","author":"Zhou","year":"2015","journal-title":"Cell Mol Immunol"},{"key":"B49","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1111\/ced.13135","article-title":"T regulatory cells and other lymphocyte subsets in patients with bullous pemphigoid","volume":"42","author":"Gambichler","year":"2017","journal-title":"Clin Exp Dermatol"},{"key":"B50","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1111\/jdv.12091","article-title":"Regulatory T cells in skin lesions and blood of patients with bullous pemphigoid","volume":"28","author":"Antiga","year":"2014","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"B51","doi-asserted-by":"publisher","first-page":"1628","DOI":"10.3389\/fimmu.2017.01628","article-title":"Regulatory T cells suppress inflammation and blistering in pemphigoid diseases","volume":"8","author":"Bieber","year":"2017","journal-title":"Front Immunol"},{"key":"B52","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1111\/bjd.12936","article-title":"BP180- and BP230-specific IgG autoantibodies in pruritic disorders of the elderly: a preclinical stage of bullous pemphigoid?","volume":"171","author":"Schmidt","year":"2014","journal-title":"Br J Dermatol"},{"key":"B53","doi-asserted-by":"publisher","first-page":"2908","DOI":"10.1038\/jid.2014.263","article-title":"Innate immune cell-produced IL-17 sustains inflammation in bullous pemphigoid","volume":"134","author":"Le Jan","year":"2014","journal-title":"J Invest Dermatol"},{"key":"B54","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1111\/j.1600-0625.2011.01378.x","article-title":"Lesional Th17\u2009cells and regulatory T cells in bullous pemphigoid","volume":"20","author":"Arakawa","year":"2011","journal-title":"Exp Dermatol"},{"key":"B55","first-page":"123","article-title":"Cytokines and bullous pemphigoid","volume":"10","author":"D\u2019Auria","year":"1999","journal-title":"Eur Cytokine Netw"},{"key":"B56","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1111\/j.1468-3083.1999.tb00801.x","article-title":"Increased serum IL-6, TNF-alpha and IL-10 levels in patients with bullous pemphigoid: relationships with disease activity","volume":"12","author":"D\u2019Auria","year":"1999","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"B57","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1046\/j.1365-2133.1998.02169.x","article-title":"Cytokine pattern in blister fluid and serum of patients with bullous pemphigoid: relationships with disease intensity","volume":"138","author":"Ameglio","year":"1998","journal-title":"Br J Dermatol"},{"key":"B58","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1001\/jamadermatol.2013.1434","article-title":"Prevalence and clinical significance of anti-laminin 332 autoantibodies detected by a novel enzyme-linked immunosorbent assay in mucous membrane pemphigoid","volume":"149","author":"Bernard","year":"2013","journal-title":"JAMA Dermatol"},{"key":"B59","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1111\/bjd.14629","article-title":"Clinical and immunological features and outcome of anti-p200 pemphigoid","volume":"175","author":"Commin","year":"2016","journal-title":"Br J Dermatol"},{"key":"B60","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1111\/exd.13469","article-title":"New insights into pemphigoid diseases","volume":"26","author":"Antonicelli","year":"2017","journal-title":"Exp Dermatol"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2018.00570\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T18:21:34Z","timestamp":1693592494000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2018.00570\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,21]]},"references-count":60,"alternative-id":["10.3389\/fimmu.2018.00570"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2018.00570","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,21]]},"article-number":"570"}}