{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:06:28Z","timestamp":1791389188041,"version":"4.3.3"},"reference-count":35,"publisher":"Frontiers Media SA","content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2018.00728","type":"journal-article","created":{"date-parts":[[2018,4,10]],"date-time":"2018-04-10T11:35:40Z","timestamp":1523360140000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Genome-Wide Analysis to Identify HLA Factors Potentially Associated With Severe Dengue"],"prefix":"10.3389","volume":"9","author":[{"given":"Sudheer","family":"Gupta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankita","family":"Agarwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amod","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debasis","family":"Biswas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,4,10]]},"reference":[{"key":"B1","unstructured":"World Health Organization. Dengue 20132013"},{"key":"B2","unstructured":"CDC 20162016"},{"key":"B3","unstructured":"2016"},{"key":"B4","doi-asserted-by":"publisher","first-page":"E2046","DOI":"10.1073\/pnas.1305227110","article-title":"Comprehensive analysis of dengue virus-specific responses supports an HLA-linked protective role for CD8+ T cells","volume":"110","author":"Weiskopf","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B5","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1038\/nm887","article-title":"Original antigenic sin and apoptosis in the pathogenesis of dengue hemorrhagic fever","volume":"9","author":"Mongkolsapaya","year":"2003","journal-title":"Nat Med"},{"key":"B6","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1128\/CMR.00035-09","article-title":"Dengue virus pathogenesis: an integrated view","volume":"22","author":"Martina","year":"2009","journal-title":"Clin Microbiol Rev"},{"key":"B7","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1016\/0140-6736(93)91692-F","article-title":"A primary dengue 2 epidemic with spontaneous haemorrhagic manifestations","volume":"342","author":"Streatfield","year":"1993","journal-title":"Lancet"},{"key":"B8","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1017\/S0950268804003541","article-title":"Serological and virological features of dengue fever and dengue haemorrhagic fever in Thailand from 1999 to 2002","volume":"133","author":"Anantapreecha","year":"2005","journal-title":"Epidemiol Infect"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1442","DOI":"10.1086\/597422","article-title":"TNF and LTA gene, allele, and extended HLA haplotype associations with severe dengue virus infection in ethnic Thais","volume":"199","author":"Vejbaesya","year":"2009","journal-title":"J Infect Dis"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1950","DOI":"10.1016\/j.ajpath.2013.02.027","article-title":"Inflammatory and innate immune responses in dengue infection: protection versus disease induction","volume":"182","author":"Costa","year":"2013","journal-title":"Am J Pathol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/j.jiph.2014.05.005","article-title":"Dengue hemorrhagic fever: comparison of patients with primary and secondary infections","volume":"7","author":"Khurram","year":"2014","journal-title":"J Infect Public Health"},{"key":"B12","doi-asserted-by":"publisher","first-page":"e617","DOI":"10.1371\/journal.pntd.0000617","article-title":"Serotype-specific differences in the risk of dengue hemorrhagic fever: an analysis of data collected in Bangkok, Thailand from 1994 to 2006","volume":"4","author":"Fried","year":"2010","journal-title":"PLoS Negl Trop Dis"},{"key":"B13","doi-asserted-by":"publisher","first-page":"e1311","DOI":"10.1371\/journal.pntd.0001311","article-title":"Preexisting Japanese encephalitis virus neutralizing antibodies and increased symptomatic dengue illness in a school-based cohort in Thailand","volume":"5","author":"Anderson","year":"2011","journal-title":"PLoS Negl Trop Dis"},{"key":"B14","doi-asserted-by":"publisher","first-page":"36288","DOI":"10.1038\/srep36288","article-title":"Identification of a new broadly cross-reactive epitope within domain III of the duck tembusu virus E protein","volume":"6","author":"Li","year":"2016","journal-title":"Sci Rep"},{"key":"B15","doi-asserted-by":"publisher","first-page":"D593","DOI":"10.1093\/nar\/gkr859","article-title":"ViPR: an open bioinformatics database and analysis resource for virology research","volume":"40","author":"Pickett","year":"2012","journal-title":"Nucleic Acids Res"},{"key":"B16","doi-asserted-by":"publisher","first-page":"278","DOI":"10.3389\/fimmu.2017.00278","article-title":"The immune epitope database and analysis resource in epitope discovery and synthetic vaccine design","volume":"8","author":"Fleri","year":"2017","journal-title":"Front Immunol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1007\/s00251-011-0513-0","article-title":"Functional classification of class II human leukocyte antigen (HLA) molecules reveals seven different supertypes and a surprising degree of repertoire sharing across supertypes","volume":"63","author":"Greenbaum","year":"2011","journal-title":"Immunogenetics"},{"key":"B18","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1186\/s12967-016-0928-3","article-title":"ProInflam: a webserver for the prediction of proinflammatory antigenicity of peptides and proteins","volume":"14","author":"Gupta","year":"2016","journal-title":"J Transl Med"},{"key":"B19","doi-asserted-by":"publisher","first-page":"e20581","DOI":"10.1371\/journal.pone.0020581","article-title":"HLA class I and class II associations in dengue viral infections in a Sri Lankan population","volume":"6","author":"Malavige","year":"2011","journal-title":"PLoS One"},{"key":"B20","doi-asserted-by":"publisher","first-page":"e13029","DOI":"10.1371\/journal.pone.0013029","article-title":"Susceptible and protective HLA class 1 alleles against dengue fever and dengue hemorrhagic fever patients in a Malaysian population","volume":"5","author":"Appanna","year":"2010","journal-title":"PLoS One"},{"key":"B21","doi-asserted-by":"publisher","first-page":"648475","DOI":"10.1155\/2013\/648475","article-title":"HLA-B *44 is associated with dengue severity caused by DENV-3 in a Brazilian population","volume":"2013","author":"Xavier Eurico De Alencar","year":"2013","journal-title":"J Trop Med"},{"key":"B22","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1007\/978-3-642-02215-9_8","article-title":"HLA and other gene associations with dengue disease severity","volume":"338","author":"Stephens","year":"2010","journal-title":"Curr Top Microbiol Immunol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"e0115619","DOI":"10.1371\/journal.pone.0115619","article-title":"HLA-A*33:01 as protective allele for severe dengue in a population of Filipino children","volume":"10","author":"Mercado","year":"2015","journal-title":"PLoS One"},{"key":"B24","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1089\/vim.2010.0006","article-title":"Meta-analysis of all immune epitope data in the Flavivirus genus: inventory of current immune epitope data status in the context of virus immunity and immunopathology","volume":"23","author":"Vaughan","year":"2010","journal-title":"Viral Immunol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1590\/S0074-02762012000200012","article-title":"HLA-A*01 allele: a risk factor for dengue haemorrhagic fever in Brazil\u2019s population","volume":"107","author":"Monteiro","year":"2012","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"B26","doi-asserted-by":"publisher","first-page":"e117","DOI":"10.1038\/cti.2016.72","article-title":"Dengue virus antibodies enhance Zika virus infection","volume":"5","author":"Paul","year":"2016","journal-title":"Clin Transl Immunology"},{"key":"B27","doi-asserted-by":"publisher","first-page":"1362","DOI":"10.1126\/science.355.6332.1362","article-title":"Dengue may bring out the worst in Zika","volume":"355","author":"Cohen","year":"2017","journal-title":"Science"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1369","DOI":"10.1086\/324320","article-title":"Strong HLA class I \u2013 restricted T cell responses in dengue hemorrhagic fever: a double-edged sword?","volume":"184","author":"Loke","year":"2001","journal-title":"J Infect Dis"},{"key":"B29","doi-asserted-by":"publisher","first-page":"2243","DOI":"10.1099\/0022-1317-76-9-2243","article-title":"Flavivirus-cross-reactive, HLA-DR15-restricted epitope on NS3 recognized by human CD4+ CD8- cytotoxic T lymphocyte clones","volume":"76","author":"Kurane","year":"1995","journal-title":"J Gen Virol"},{"key":"B30","doi-asserted-by":"publisher","first-page":"5665","DOI":"10.1128\/JVI.79.9.5665-5675.2005","article-title":"Early T-cell responses to dengue virus epitopes in Vietnamese adults with secondary dengue virus infections","volume":"79","author":"Simmons","year":"2005","journal-title":"J Virol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"3821","DOI":"10.4049\/jimmunol.176.6.3821","article-title":"T cell responses in dengue hemorrhagic fever: are cross-reactive T cells suboptimal?","volume":"176","author":"Mongkolsapaya","year":"2006","journal-title":"J Immunol"},{"key":"B32","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1002\/jmv.24167","article-title":"Identification of cytotoxic T lymphocyte epitopes in dengue virus serotype 1","volume":"87","author":"Duan","year":"2015","journal-title":"J Med Virol"},{"key":"B33","doi-asserted-by":"crossref","first-page":"3999","DOI":"10.1128\/JVI.72.5.3999-4004.1998","article-title":"Predominance of HLA-restricted cytotoxic T-lymphocyte responses to serotype-cross-reactive epitopes on nonstructural proteins following natural secondary dengue virus infection","volume":"72","author":"Mathew","year":"1998","journal-title":"J Virol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"5959","DOI":"10.4049\/jimmunol.168.11.5959","article-title":"T cell responses to an HLA-B*07-restricted epitope on the dengue NS3 protein correlate with disease severity","volume":"168","author":"Zivna","year":"2002","journal-title":"J Immunol"},{"key":"B35","doi-asserted-by":"publisher","first-page":"9733","DOI":"10.1128\/JVI.00694-10","article-title":"Viral mutation rates","volume":"84","author":"Sanjuan","year":"2010","journal-title":"J Virol"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2018.00728\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,31]],"date-time":"2020-10-31T12:33:55Z","timestamp":1604147635000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2018.00728\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,10]]},"references-count":35,"alternative-id":["10.3389\/fimmu.2018.00728"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2018.00728","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,10]]},"article-number":"728"}}