{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:40:26Z","timestamp":1790271626643,"version":"4.1.0"},"reference-count":53,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,4,10]],"date-time":"2018-04-10T00:00:00Z","timestamp":1523318400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81573332, 81773620"],"award-info":[{"award-number":["81573332, 81773620"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2018.00758","type":"journal-article","created":{"date-parts":[[2018,4,10]],"date-time":"2018-04-10T04:15:51Z","timestamp":1523333751000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":117,"title":["NOD-Like Receptor Protein 3 Inflammasome-Dependent IL-1\u03b2 Accelerated ConA-Induced Hepatitis"],"prefix":"10.3389","volume":"9","author":[{"given":"Jingyun","family":"Luan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuyao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaofei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yubin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajun","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Zai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sijia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yichen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingkuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangxun","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dianwen","family":"Ju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,4,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"S100","DOI":"10.1016\/j.jhep.2015.03.005","article-title":"Autoimmune hepatitis \u2013 update 2015","volume":"62","author":"Manns","year":"2015","journal-title":"J Hepatol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1433","DOI":"10.1016\/S0140-6736(12)62163-1","article-title":"Autoimmune hepatitis","volume":"382","author":"Heneghan","year":"2013","journal-title":"Lancet"},{"key":"B3","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1056\/NEJMra050408","article-title":"Autoimmune hepatitis","volume":"354","author":"Krawitt","year":"2006","journal-title":"N Engl J Med"},{"key":"B4","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1002\/hep.22034","article-title":"Liver: an organ with predominant innate immunity","volume":"47","author":"Gao","year":"2008","journal-title":"Hepatology"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1002\/hep.26583","article-title":"Dysfunctional CD39POS regulatory T cells and aberrant control of T-helper type 17 cells in autoimmune hepatitis","volume":"59","author":"Grant","year":"2014","journal-title":"Hepatology"},{"key":"B6","doi-asserted-by":"publisher","first-page":"5498","DOI":"10.1073\/pnas.040566697","article-title":"Critical contribution of liver natural killer T cells to a murine model of hepatitis","volume":"97","author":"Takeda","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1526","DOI":"10.1053\/j.gastro.2012.02.041","article-title":"Inhibition of interleukin-17 promotes differentiation of CD25-cells into stable T regulatory cells in patients with autoimmune hepatitis","volume":"142","author":"Longhi","year":"2012","journal-title":"Gastroenterology"},{"key":"B8","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.jhep.2014.01.032","article-title":"Anti-TNF-induced autoimmune hepatitis","volume":"61","author":"Borman","year":"2014","journal-title":"J Hepatol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"e18909","DOI":"10.1371\/journal.pone.0018909","article-title":"Interleukin-17 contributes to the pathogenesis of autoimmune hepatitis through inducing hepatic interleukin-6 expression","volume":"6","author":"Li","year":"2011","journal-title":"PLoS One"},{"key":"B10","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1016\/j.jhep.2013.05.046","article-title":"Infliximab as rescue therapy in paediatric autoimmune hepatitis","volume":"59","author":"Rajanayagam","year":"2013","journal-title":"J Hepatol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/j.jhep.2012.11.010","article-title":"Infliximab as a rescue treatment in difficult-to-treat autoimmune hepatitis","volume":"58","author":"Weiler-Normann","year":"2013","journal-title":"J Hepatol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1016\/j.intimp.2013.08.012","article-title":"A critical role for interleukin-1\u03b2 in the progression of autoimmune diseases","volume":"17","author":"Zhao","year":"2013","journal-title":"Int Immunopharmacol"},{"key":"B13","first-page":"571","article-title":"Proinflammatory cytokines and endotoxin stimulate ICAM-1 gene expression and secretion by normal human hepatocytes","volume":"82","author":"Satoh","year":"1994","journal-title":"Immunology"},{"key":"B14","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.jaut.2012.11.002","article-title":"Autoimmune hepatitis: a comprehensive review","volume":"41","author":"Liberal","year":"2013","journal-title":"J Autoimmun"},{"key":"B15","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1016\/j.jhep.2012.03.035","article-title":"Inflammasomes in liver diseases","volume":"57","author":"Szabo","year":"2012","journal-title":"J Hepatol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"e1005155","DOI":"10.1371\/journal.ppat.1005155","article-title":"The NLRP3 inflammasome and IL-1\u03b2 accelerate immunologically mediated pathology in experimental viral fulminant hepatitis","volume":"11","author":"Guo","year":"2015","journal-title":"PLoS Pathog"},{"key":"B17","doi-asserted-by":"publisher","first-page":"3476","DOI":"10.1172\/JCI60777","article-title":"IL-1 receptor antagonist ameliorates inflammasome-dependent alcoholic steatohepatitis in mice","volume":"122","author":"Petrasek","year":"2012","journal-title":"J Clin Invest"},{"key":"B18","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1016\/j.jhep.2017.01.022","article-title":"NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice","volume":"66","author":"Mridha","year":"2017","journal-title":"J Hepatol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1016\/j.cell.2014.04.007","article-title":"Mechanisms and functions of inflammasomes","volume":"157","author":"Lamkanfi","year":"2014","journal-title":"Cell"},{"key":"B20","doi-asserted-by":"publisher","first-page":"17479","DOI":"10.18632\/oncotarget.8243","article-title":"Mitochondrial reactive oxygen species-mediated NLRP3 inflammasome activation contributes to aldosterone-induced renal tubular cells injury","volume":"7","author":"Ding","year":"2016","journal-title":"Oncotarget"},{"key":"B21","doi-asserted-by":"publisher","first-page":"710457","DOI":"10.1155\/2015\/720457","article-title":"ROS-mediated NLRP3 inflammasome activity is essential for burn-induced acute lung injury","volume":"2015","author":"Han","year":"2015","journal-title":"Mediators Inflamm"},{"key":"B22","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.biomaterials.2016.03.003","article-title":"CdSe\/ZnS quantum dots induce hepatocyte pyroptosis and liver inflammation via NLRP3 inflammasome activation","volume":"90","author":"Lu","year":"2016","journal-title":"Biomaterials"},{"key":"B23","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.jhep.2015.10.003","article-title":"Autophagy in macrophages regulates the inflammasome and protects against liver injury","volume":"64","author":"Ding","year":"2016","journal-title":"J Hepatol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.biopha.2016.03.012","article-title":"15d-PGJ2 alleviates ConA-induced acute liver injury in mice by up-regulating HO-1 and reducing hepatic cell autophagy","volume":"80","author":"Chen","year":"2016","journal-title":"Biomed Pharmacother"},{"key":"B25","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1002\/hep.21498","article-title":"IL-10, regulatory T cells, and Kupffer cells mediate tolerance in Concanavalin A-induced liver injury in mice","volume":"45","author":"Erhardt","year":"2007","journal-title":"Hepatology"},{"key":"B26","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1002\/hep.1840210131","article-title":"Concanavalin A-induced T-cell-mediated hepatic injury in mice: the role of tumor necrosis factor","volume":"21","author":"Gantner","year":"1995","journal-title":"Hepatology"},{"key":"B27","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1172\/JCI115836","article-title":"A T cell-dependent experimental liver injury in mice inducible by Concanavalin A","volume":"90","author":"Tiegs","year":"1992","journal-title":"J Clin Invest"},{"key":"B28","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1016\/j.immuni.2009.04.012","article-title":"A mutation in the Nlrp3 gene causing inflammasome hyperactivation potentiates Th17 cell-dominant immune responses","volume":"30","author":"Meng","year":"2009","journal-title":"Immunity"},{"key":"B29","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1038\/cr.2013.6","article-title":"Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock","volume":"23","author":"Mao","year":"2013","journal-title":"Cell Res"},{"key":"B30","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1038\/nature12940","article-title":"Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection","volume":"505","author":"Doitsh","year":"2014","journal-title":"Nature"},{"key":"B31","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1016\/j.immuni.2015.10.010","article-title":"Inflammasomes coordinate pyroptosis and natural killer cell cytotoxicity to clear infection by a ubiquitous environmental bacterium","volume":"43","author":"Maltez","year":"2015","journal-title":"Immunity"},{"key":"B32","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1016\/j.immuni","article-title":"The interleukin-1 family: back to the future","volume":"39","author":"Garlanda","year":"2013","journal-title":"Immunity"},{"key":"B33","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1126\/science.1156995","article-title":"Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica","volume":"320","author":"Dostert","year":"2008","journal-title":"Science"},{"key":"B34","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1038\/ni.1831","article-title":"Thioredoxin-interacting protein links oxidative stress to inflammasome activation","volume":"11","author":"Zhou","year":"2010","journal-title":"Nat Immunol"},{"key":"B35","doi-asserted-by":"publisher","first-page":"630265","DOI":"10.1155\/2015\/630265","article-title":"Interleukin-1 family cytokines in liver diseases","volume":"2015","author":"Tsutsui","year":"2015","journal-title":"Mediators Inflamm"},{"key":"B36","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1002\/hep.26592","article-title":"NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice","volume":"59","author":"Wree","year":"2014","journal-title":"Hepatology"},{"key":"B37","doi-asserted-by":"publisher","first-page":"35","DOI":"10.4161\/self.2.1.15639","article-title":"A role of IL-1R1 signaling in the differentiation of Th17 cells and the development of autoimmune diseases","volume":"2","author":"Sha","year":"2011","journal-title":"Self Nonself"},{"key":"B38","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1084\/jem.20141388","article-title":"Small intestinal eosinophils regulate Th17 cells by producing IL-1 receptor antagonist","volume":"213","author":"Sugawara","year":"2016","journal-title":"J Exp Med"},{"key":"B39","doi-asserted-by":"publisher","first-page":"4135","DOI":"10.7150\/thno.20955","article-title":"Tethering interleukin-22 to apolipoprotein A-I ameliorates mice from acetaminophen-induced liver injury","volume":"7","author":"Chen","year":"2017","journal-title":"Theranostics"},{"key":"B40","doi-asserted-by":"publisher","first-page":"5652","DOI":"10.4049\/jimmunol.176.9.5652","article-title":"STAT3 and NF-\u03baB signal pathway is required for IL-23-mediated IL-17 production in spontaneous arthritis animal model IL-1 receptor antagonist-deficient mice","volume":"176","author":"Cho","year":"2006","journal-title":"J Immunol"},{"key":"B41","doi-asserted-by":"publisher","first-page":"5986","DOI":"10.1073\/pnas.1035999100","article-title":"IL-17 production from activated T cells is required for the spontaneous development of destructive arthritis in mice deficient in IL-1 receptor antagonist","volume":"100","author":"Nakae","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B42","doi-asserted-by":"publisher","first-page":"3461","DOI":"10.1002\/art.23957","article-title":"Interleukin-1 drives pathogenic Th17 cells during spontaneous arthritis in interleukin-1 receptor antagonist-deficient mice","volume":"58","author":"Koenders","year":"2008","journal-title":"Arthritis Rheum"},{"key":"B43","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1016\/j.jhep.2015.04.010","article-title":"Heatstroke induces liver injury via IL-1\u03b2 and HMGB1-induced pyroptosis","volume":"63","author":"Geng","year":"2015","journal-title":"J Hepatol"},{"key":"B44","doi-asserted-by":"crossref","first-page":"4082","DOI":"10.4049\/jimmunol.160.8.4082","article-title":"Disparate roles for TNF-\u03b1 and Fas ligand in Concanavalin A-induced hepatitis","volume":"160","author":"Ksontini","year":"1998","journal-title":"J Immunol"},{"key":"B45","doi-asserted-by":"publisher","first-page":"2082","DOI":"10.4049\/jimmunol.1600145","article-title":"Plant lectins activate the NLRP3 inflammasome to promote inflammatory disorders","volume":"198","author":"Gong","year":"2017","journal-title":"J Immunol"},{"key":"B46","doi-asserted-by":"publisher","first-page":"3627","DOI":"10.3892\/mmr.2016.4980","article-title":"Protectin D1 reduces Concanavalin A-induced liver injury by inhibiting NF-\u03baB-mediated CX3CL1\/CX3CR1 axis and NLR family, pyrin domain containing 3 inflammasome activation","volume":"13","author":"Ren","year":"2016","journal-title":"Mol Med Rep"},{"key":"B47","doi-asserted-by":"publisher","first-page":"e0149754","DOI":"10.1371\/journal.pone.0149754","article-title":"Atg7 knockdown augments Concanavalin A-induced acute hepatitis through an ROS-mediated p38\/MAPK pathway","volume":"11","author":"Zhuang","year":"2016","journal-title":"PLoS One"},{"key":"B48","doi-asserted-by":"publisher","first-page":"1294","DOI":"10.1002\/eji.201142204","article-title":"Mice deficient in hepatocyte-specific IL-1Ra show delayed resolution of Concanavalin A-induced hepatitis","volume":"42","author":"Lamacchia","year":"2012","journal-title":"Eur J Immunol"},{"key":"B49","doi-asserted-by":"publisher","first-page":"10791","DOI":"10.1038\/ncomms10791","article-title":"IL-1 receptor antagonist ameliorates inflammasome-dependent inflammation in murine and human cystic fibrosis","volume":"7","author":"Iannitti","year":"2016","journal-title":"Nat Commun"},{"key":"B50","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1053\/j.gastro.2014.07.018","article-title":"Cell death and cell death responses in liver disease: mechanisms and clinical relevance","volume":"147","author":"Luedde","year":"2014","journal-title":"Gastroenterology"},{"key":"B51","doi-asserted-by":"publisher","first-page":"119","DOI":"10.3748\/wjg.v18.i2.119","article-title":"Immune mechanisms of Concanavalin A model of autoimmune hepatitis","volume":"18","author":"Wang","year":"2012","journal-title":"World J Gastroenterol"},{"key":"B52","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1136\/jcp.2005.029348","article-title":"Centrilobular necrosis in autoimmune hepatitis: a histological feature associated with acute clinical presentation","volume":"59","author":"Hofer","year":"2006","journal-title":"J Clin Pathol"},{"key":"B53","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1136\/gut.41.2.269","article-title":"Autoimmune hepatitis: a histological variant associated with prominent centrilobular necrosis","volume":"41","author":"Te","year":"1997","journal-title":"Gut"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2018.00758\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T00:34:37Z","timestamp":1693614877000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2018.00758\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,10]]},"references-count":53,"alternative-id":["10.3389\/fimmu.2018.00758"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2018.00758","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,10]]},"article-number":"758"}}