{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T07:46:39Z","timestamp":1780731999060,"version":"3.54.1"},"reference-count":110,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,5,15]],"date-time":"2018-05-15T00:00:00Z","timestamp":1526342400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2018.00776","type":"journal-article","created":{"date-parts":[[2018,5,15]],"date-time":"2018-05-15T04:28:07Z","timestamp":1526358487000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":21,"title":["SV-BR-1-GM, a Clinically Effective GM-CSF-Secreting Breast Cancer Cell Line, Expresses an Immune Signature and Directly Activates CD4+ T Lymphocytes"],"prefix":"10.3389","volume":"9","author":[{"given":"Markus D.","family":"Lacher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Bauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Fury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanne","family":"Graeve","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily L.","family":"Fledderman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tye D.","family":"Petrie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dane P.","family":"Coleal-Bergum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tia","family":"Hackett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas H.","family":"Perotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying Y.","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William W.","family":"Kwok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph P.","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles L.","family":"Wiseman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William V.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,5,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2625","DOI":"10.1182\/blood-2013-11-492231","article-title":"Antibody-modified T cells: CARs take the front seat for hematologic malignancies","volume":"123","author":"Maus","year":"2014","journal-title":"Blood"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1507","DOI":"10.1056\/NEJMoa1407222","article-title":"Chimeric antigen receptor T cells for sustained remissions in leukemia","volume":"371","author":"Maude","year":"2014","journal-title":"N Engl J Med"},{"key":"B3","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1016\/j.drudis.2015.02.008","article-title":"Bispecific antibodies","volume":"20","author":"Kontermann","year":"2015","journal-title":"Drug Discov Today"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1158\/1078-0432.CCR-14-2708","article-title":"A pilot trial using lymphocytes genetically engineered with an NY-ESO-1-reactive T-cell receptor: long-term follow-up and correlates with response","volume":"21","author":"Robbins","year":"2015","journal-title":"Clin Cancer Res"},{"key":"B5","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1158\/2326-6066.CIR-15-0215","article-title":"Durable complete response from metastatic melanoma after transfer of autologous T cells recognizing 10 mutated tumor antigens","volume":"4","author":"Prickett","year":"2016","journal-title":"Cancer Immunol Res"},{"key":"B6","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1002\/ijc.22309","article-title":"Cancer\/testis antigen expression and specific cytotoxic T lymphocyte responses in non small cell lung cancer","volume":"120","author":"Groeper","year":"2007","journal-title":"Int J Cancer"},{"key":"B7","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1158\/2326-6066.CIR-14-0058","article-title":"A feasibility study of cyclophosphamide, trastuzumab, and an allogeneic GM-CSF-secreting breast tumor vaccine for HER2+ metastatic breast cancer","volume":"2","author":"Chen","year":"2014","journal-title":"Cancer Immunol Res"},{"key":"B8","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1097\/CJI.0b013e3182a80237","article-title":"Phase II trial of a GM-CSF-producing and CD40L-expressing bystander cell line combined with an allogeneic tumor cell-based vaccine for refractory lung adenocarcinoma","volume":"36","author":"Creelan","year":"2013","journal-title":"J Immunother"},{"key":"B9","first-page":"52","article-title":"GM-CSF-secreting vaccines for solid tumors: moving forward","volume":"10","author":"Gupta","year":"2010","journal-title":"Discov Med"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.1200\/JCO.2014.57.4244","article-title":"Safety and survival with GVAX pancreas prime and Listeria monocytogenes-expressing mesothelin (CRS-207) boost vaccines for metastatic pancreatic cancer","volume":"33","author":"Le","year":"2015","journal-title":"J Clin Oncol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1186\/s12967-015-0572-3","article-title":"Safety and immunologic correlates of melanoma GVAX, a GM-CSF secreting allogeneic melanoma cell vaccine administered in the adjuvant setting","volume":"13","author":"Lipson","year":"2015","journal-title":"J Transl Med"},{"key":"B12","doi-asserted-by":"publisher","first-page":"467","DOI":"10.3390\/vaccines3020467","article-title":"The promise of preventive cancer vaccines","volume":"3","author":"Lollini","year":"2015","journal-title":"Vaccines (Basel)"},{"key":"B13","doi-asserted-by":"publisher","first-page":"1735","DOI":"10.1093\/annonc\/mdu211","article-title":"Final report of the phase I\/II clinical trial of the E75 (nelipepimut-S) vaccine with booster inoculations to prevent disease recurrence in high-risk breast cancer patients","volume":"25","author":"Mittendorf","year":"2014","journal-title":"Ann Oncol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/s40425-014-0031-3","article-title":"Myeloid derived suppressor and dendritic cell subsets are related to clinical outcome in prostate cancer patients treated with prostate GVAX and ipilimumab","volume":"2","author":"Santegoets","year":"2014","journal-title":"J Immunother Cancer"},{"key":"B15","doi-asserted-by":"publisher","first-page":"52","DOI":"10.4161\/hv.26568","article-title":"Allogeneic tumor cell vaccines: the promise and limitations in clinical trials","volume":"10","author":"Srivatsan","year":"2014","journal-title":"Hum Vaccin Immunother"},{"key":"B16","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1111\/j.1075-122X.2006.00319.x","article-title":"Objective clinical regression of metastatic breast cancer in disparate sites after use of whole-cell vaccine genetically modified to release sargramostim","volume":"12","author":"Wiseman","year":"2006","journal-title":"Breast J"},{"key":"B17","doi-asserted-by":"publisher","first-page":"4","DOI":"10.2174\/1876817201002010004","article-title":"Phase I study with SV-BR-1 breast cancer cell line vaccine and GM-CSF: clinical experience in 14 patients","volume":"2","author":"Wiseman","year":"2010","journal-title":"Open Breast Cancer J"},{"key":"B18","doi-asserted-by":"publisher","first-page":"794968","DOI":"10.1155\/2015\/794968","article-title":"Beyond the immune suppression: the immunotherapy in prostate cancer","volume":"2015","author":"Silvestri","year":"2015","journal-title":"Biomed Res Int"},{"key":"B19","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1053\/j.seminoncol.2012.02.007","article-title":"Whole cell vaccines \u2013 past progress and future strategies","volume":"39","author":"Keenan","year":"2012","journal-title":"Semin Oncol"},{"key":"B20","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1002\/ijc.28973","article-title":"Development of thyroglobulin antibodies after GVAX immunotherapy is associated with prolonged survival","volume":"136","author":"De Remigis","year":"2015","journal-title":"Int J Cancer"},{"key":"B21","doi-asserted-by":"publisher","first-page":"43005","DOI":"10.18632\/oncotarget.5656","article-title":"TGF-beta blockade depletes T regulatory cells from metastatic pancreatic tumors in a vaccine dependent manner","volume":"6","author":"Soares","year":"2015","journal-title":"Oncotarget"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1736","DOI":"10.1182\/blood-2009-02-205278","article-title":"Granulocyte-macrophage colony-stimulating factor (GM-CSF)-secreting cellular immunotherapy in combination with autologous stem cell transplantation (ASCT) as postremission therapy for acute myeloid leukemia (AML)","volume":"114","author":"Borrello","year":"2009","journal-title":"Blood"},{"key":"B23","doi-asserted-by":"publisher","first-page":"5911","DOI":"10.1200\/JCO.2009.23.3494","article-title":"Timed sequential treatment with cyclophosphamide, doxorubicin, and an allogeneic granulocyte-macrophage colony-stimulating factor-secreting breast tumor vaccine: a chemotherapy dose-ranging factorial study of safety and immune activation","volume":"27","author":"Emens","year":"2009","journal-title":"J Clin Oncol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1007\/BF02966444","article-title":"Adenoviral GM-CSF gene transduction into breast cancer cells induced long-lasting antitumor immunity in mice","volume":"6","author":"Ogawa","year":"1999","journal-title":"Breast Cancer"},{"key":"B25","doi-asserted-by":"publisher","first-page":"3439","DOI":"10.1158\/0008-5472.CAN-11-3912","article-title":"Regulatory T-cell modulation using cyclophosphamide in vaccine approaches: a current perspective","volume":"72","author":"Le","year":"2012","journal-title":"Cancer Res"},{"key":"B26","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1089\/jir.2011.0077","article-title":"Interferon-alpha as antiviral and antitumor vaccine adjuvants: mechanisms of action and response signature","volume":"32","author":"Arico","year":"2012","journal-title":"J Interferon Cytokine Res"},{"key":"B27","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1038\/ng0506-500","article-title":"GenePattern 2.0","volume":"38","author":"Reich","year":"2006","journal-title":"Nat Genet"},{"key":"B28","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1093\/nar\/30.1.207","article-title":"Gene expression omnibus: NCBI gene expression and hybridization array data repository","volume":"30","author":"Edgar","year":"2002","journal-title":"Nucleic Acids Res"},{"key":"B29","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1101\/gr.4041005","article-title":"An atlas of human gene expression from massively parallel signature sequencing (MPSS)","volume":"15","author":"Jongeneel","year":"2005","journal-title":"Genome Res"},{"key":"B30","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1186\/s13059-015-0748-4","article-title":"The senescent methylome and its relationship with cancer, ageing and germline genetic variation in humans","volume":"16","author":"Lowe","year":"2015","journal-title":"Genome Biol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"R134","DOI":"10.1186\/bcr3334","article-title":"Phenotypic and functional characterisation of the luminal cell hierarchy of the mammary gland","volume":"14","author":"Shehata","year":"2012","journal-title":"Breast Cancer Res"},{"key":"B32","doi-asserted-by":"publisher","first-page":"105108","DOI":"10.1155\/2013\/105108","article-title":"The novelty of human cancer\/testis antigen encoding genes in evolution","volume":"2013","author":"Dobrynin","year":"2013","journal-title":"Int J Genomics"},{"key":"B33","doi-asserted-by":"publisher","first-page":"601","DOI":"10.2217\/bmm.13.58","article-title":"Elevated expression of cancer\/testis antigen FSIP1 in ER-positive breast tumors","volume":"7","author":"Chapman","year":"2013","journal-title":"Biomark Med"},{"key":"B34","doi-asserted-by":"publisher","first-page":"D816","DOI":"10.1093\/nar\/gkn673","article-title":"CTdatabase: a knowledge-base of high-throughput and curated data on cancer-testis antigens","volume":"37","author":"Almeida","year":"2009","journal-title":"Nucleic Acids Res"},{"key":"B35","doi-asserted-by":"publisher","first-page":"12794","DOI":"10.1128\/JVI.01160-13","article-title":"Yellow fever vaccination elicits broad functional CD4+ T cell responses that recognize structural and nonstructural proteins","volume":"87","author":"James","year":"2013","journal-title":"J Virol"},{"key":"B36","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.1016\/j.humimm.2013.06.025","article-title":"Six-locus high resolution HLA haplotype frequencies derived from mixed-resolution DNA typing for the entire US donor registry","volume":"74","author":"Gragert","year":"2013","journal-title":"Hum Immunol"},{"key":"B37","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1016\/j.str.2016.05.017","article-title":"Conformational changes in the GM-CSF receptor suggest a molecular mechanism for affinity conversion and receptor signaling","volume":"24","author":"Broughton","year":"2016","journal-title":"Structure"},{"key":"B38","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1111\/j.1432-1033.1994.0873b.x","article-title":"Mapping of human granulocyte-macrophage-colony-stimulating-factor domains interacting with the human granulocyte-macrophage-colony-stimulating-factor-receptor alpha-subunit","volume":"225","author":"Brown","year":"1994","journal-title":"Eur J Biochem"},{"key":"B39","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1016\/j.cell.2008.05.053","article-title":"The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation","volume":"134","author":"Hansen","year":"2008","journal-title":"Cell"},{"key":"B40","first-page":"1025","article-title":"Establishment and characterization of two novel cytokine-responsive acute myeloid and monocytic leukemia cell lines, MUTZ-2 and MUTZ-3","volume":"10","author":"Hu","year":"1996","journal-title":"Leukemia"},{"key":"B41","doi-asserted-by":"publisher","first-page":"2265","DOI":"10.4049\/jimmunol.177.4.2265","article-title":"Dendritic cell-lysosomal-associated membrane protein (LAMP) and LAMP-1-HIV-1 gag chimeras have distinct cellular trafficking pathways and prime T and B cell responses to a diverse repertoire of epitopes","volume":"177","author":"Arruda","year":"2006","journal-title":"J Immunol"},{"key":"B42","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1038\/mi.2014.79","article-title":"Dendritic cell CD83 homotypic interactions regulate inflammation and promote mucosal homeostasis","volume":"8","author":"Bates","year":"2015","journal-title":"Mucosal Immunol"},{"key":"B43","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1084\/jem.180.4.1263","article-title":"Activation of human dendritic cells through CD40 cross-linking","volume":"180","author":"Caux","year":"1994","journal-title":"J Exp Med"},{"key":"B44","doi-asserted-by":"publisher","first-page":"3856","DOI":"10.3390\/cancers3043856","article-title":"Cytokines in cancer immunotherapy","volume":"3","author":"Lee","year":"2011","journal-title":"Cancers (Basel)"},{"key":"B45","unstructured":"LeitnerJ AustriaUniversity of ViennaThe Role of Costimulatory Pathways During the Activation of Human T Cells2011"},{"key":"B46","doi-asserted-by":"crossref","first-page":"3838","DOI":"10.4049\/jimmunol.159.8.3838","article-title":"Expression and function of OX40 ligand on human dendritic cells","volume":"159","author":"Ohshima","year":"1997","journal-title":"J Immunol"},{"key":"B47","doi-asserted-by":"publisher","first-page":"1661","DOI":"10.1084\/jem.192.11.1661","article-title":"Fas engagement induces the maturation of dendritic cells (DCs), the release of interleukin (IL)-1beta, and the production of interferon gamma in the absence of IL-12 during DC-T cell cognate interaction: a new role for Fas ligand in inflammatory responses","volume":"192","author":"Rescigno","year":"2000","journal-title":"J Exp Med"},{"key":"B48","doi-asserted-by":"publisher","first-page":"2075","DOI":"10.1084\/jem.186.12.2075","article-title":"TRANCE (tumor necrosis factor [TNF]-related activation-induced cytokine), a new TNF family member predominantly expressed in T cells, is a dendritic cell-specific survival factor","volume":"186","author":"Wong","year":"1997","journal-title":"J Exp Med"},{"key":"B49","first-page":"186","article-title":"Cytokines in the generation and maturation of dendritic cells: recent advances","volume":"13","author":"Zou","year":"2002","journal-title":"Eur Cytokine Netw"},{"key":"B50","doi-asserted-by":"crossref","first-page":"2248","DOI":"10.1002\/(SICI)1521-4141(199907)29:07<2248::AID-IMMU2248>3.0.CO;2-9","article-title":"Co-stimulation of T cells results in distinct IL-10 and TNF-alpha cytokine profiles dependent on binding to ICAM-1, ICAM-2 or ICAM-3","volume":"29","author":"Bleijs","year":"1999","journal-title":"Eur J Immunol"},{"key":"B51","doi-asserted-by":"publisher","first-page":"6403","DOI":"10.1073\/pnas.88.15.6403","article-title":"Vascular cell adhesion molecule 1 induces T-cell antigen receptor-dependent activation of CD4+T lymphocytes","volume":"88","author":"Damle","year":"1991","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B52","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1084\/jem.188.2.373","article-title":"Selective recruitment of immature and mature dendritic cells by distinct chemokines expressed in different anatomic sites","volume":"188","author":"Dieu","year":"1998","journal-title":"J Exp Med"},{"key":"B53","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1111\/cbdd.12138","article-title":"Immunosuppression by co-stimulatory molecules: inhibition of CD2-CD48\/CD58 interaction by peptides from CD2 to suppress progression of collagen-induced arthritis in mice","volume":"82","author":"Gokhale","year":"2013","journal-title":"Chem Biol Drug Des"},{"key":"B54","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/1756-9966-29-37","article-title":"CCL3 and CCL20-recruited dendritic cells modified by melanoma antigen gene-1 induce anti-tumor immunity against gastric cancer ex vivo and in vivo","volume":"29","author":"He","year":"2010","journal-title":"J Exp Clin Cancer Res"},{"key":"B55","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.imlet.2009.11.009","article-title":"Receptors and ligands implicated in human T cell costimulatory processes","volume":"128","author":"Leitner","year":"2010","journal-title":"Immunol Lett"},{"key":"B56","doi-asserted-by":"publisher","first-page":"5895","DOI":"10.4049\/jimmunol.1301458","article-title":"CD55 costimulation induces differentiation of a discrete T regulatory type 1 cell population with a stable phenotype","volume":"191","author":"Sutavani","year":"2013","journal-title":"J Immunol"},{"key":"B57","doi-asserted-by":"publisher","first-page":"491","DOI":"10.3389\/fimmu.2014.00491","article-title":"Macrophage cytokines: involvement in immunity and infectious diseases","volume":"5","author":"Arango Duque","year":"2014","journal-title":"Front Immunol"},{"key":"B58","doi-asserted-by":"publisher","first-page":"3283","DOI":"10.4049\/jimmunol.1003049","article-title":"A brief history of IL-9","volume":"186","author":"Goswami","year":"2011","journal-title":"J Immunol"},{"key":"B59","doi-asserted-by":"publisher","first-page":"1528","DOI":"10.1182\/blood-2005-05-2073","article-title":"Engagement of CD83 ligand induces prolonged expansion of CD8+ T cells and preferential enrichment for antigen specificity","volume":"107","author":"Hirano","year":"2006","journal-title":"Blood"},{"key":"B60","doi-asserted-by":"publisher","first-page":"15036","DOI":"10.1074\/jbc.272.23.15036","article-title":"The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4","volume":"272","author":"Imai","year":"1997","journal-title":"J Biol Chem"},{"key":"B61","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1172\/JCI15883","article-title":"EphB6 crosslinking results in costimulation of T cells","volume":"110","author":"Luo","year":"2002","journal-title":"J Clin Invest"},{"key":"B62","doi-asserted-by":"publisher","first-page":"659","DOI":"10.4161\/onci.20387","article-title":"CD26 expression and adenosine deaminase activity in regulatory T cells (Treg) and CD4(+) T effector cells in patients with head and neck squamous cell carcinoma","volume":"1","author":"Mandapathil","year":"2012","journal-title":"Oncoimmunology"},{"key":"B63","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.imlet.2007.10.001","article-title":"Dendritic cell CD83: a therapeutic target or innocent bystander?","volume":"115","author":"Prazma","year":"2008","journal-title":"Immunol Lett"},{"key":"B64","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1111\/j.1365-2249.1992.tb06977.x","article-title":"T lymphocyte adhesion to fibronectin (FN): a possible mechanism for T cell accumulation in the rheumatoid joint","volume":"89","author":"Rodriguez","year":"1992","journal-title":"Clin Exp Immunol"},{"key":"B65","doi-asserted-by":"crossref","first-page":"59","DOI":"10.4049\/jimmunol.145.1.59","article-title":"Costimulation of proliferative responses of resting CD4+ T cells by the interaction of VLA-4 and VLA-5 with fibronectin or VLA-6 with laminin","volume":"145","author":"Shimizu","year":"1990","journal-title":"J Immunol"},{"key":"B66","doi-asserted-by":"publisher","first-page":"2563","DOI":"10.1016\/j.bbamcr.2014.05.014","article-title":"Cytokines and chemokines: at the crossroads of cell signalling and inflammatory disease","volume":"1843","author":"Turner","year":"2014","journal-title":"Biochim Biophys Acta"},{"key":"B67","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.1111\/bph.12010","article-title":"IFN-alpha subtypes: distinct biological activities in anti-viral therapy","volume":"168","author":"Gibbert","year":"2013","journal-title":"Br J Pharmacol"},{"key":"B68","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1158\/2326-6066.CIR-13-0214","article-title":"IL-10: master switch from tumor-promoting inflammation to antitumor immunity","volume":"2","author":"Oft","year":"2014","journal-title":"Cancer Immunol Res"},{"key":"B69","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1016\/S0092-8674(00)80693-5","article-title":"Identification of DC-SIGN, a novel dendritic cell-specific ICAM-3 receptor that supports primary immune responses","volume":"100","author":"Geijtenbeek","year":"2000","journal-title":"Cell"},{"key":"B70","first-page":"95","article-title":"Chemokines and chemokine receptors: their manifold roles in homeostasis and disease","volume":"1","author":"Le","year":"2004","journal-title":"Cell Mol Immunol"},{"key":"B71","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1111\/j.1440-1711.2005.01365.x","article-title":"Differential expression of inflammatory chemokines by Th1- and Th2-cell promoting dendritic cells: a role for different mature dendritic cell populations in attracting appropriate effector cells to peripheral sites of inflammation","volume":"83","author":"Lebre","year":"2005","journal-title":"Immunol Cell Biol"},{"key":"B72","doi-asserted-by":"publisher","first-page":"2826","DOI":"10.4161\/cc.7.18.6752","article-title":"Emerging functions of c-kit and its ligand stem cell factor in dendritic cells: regulators of T cell differentiation","volume":"7","author":"Ray","year":"2008","journal-title":"Cell Cycle"},{"key":"B73","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1038\/sj.gene.6363862","article-title":"Increased heterozygosity for MHC class II lineages in newborn males","volume":"3","author":"Dorak","year":"2002","journal-title":"Genes Immun"},{"key":"B74","doi-asserted-by":"crossref","DOI":"10.5772\/57507","article-title":"HLA-E, HLA-F and HLA-G \u2014 the non-classical side of the MHC cluster","volume-title":"HLA and Associated Important Diseases","author":"Foroni","year":"2014"},{"key":"B75","doi-asserted-by":"publisher","first-page":"443","DOI":"10.3389\/fimmu.2013.00443","article-title":"Exposing the specific roles of the invariant chain isoforms in shaping the MHC class II peptidome","volume":"4","author":"Fortin","year":"2013","journal-title":"Front Immunol"},{"key":"B76","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1038\/jhg.2008.5","article-title":"The HLA genomic loci map: expression, interaction, diversity and disease","volume":"54","author":"Shiina","year":"2009","journal-title":"J Hum Genet"},{"key":"B77","doi-asserted-by":"publisher","first-page":"1638","DOI":"10.1002\/cncr.24953","article-title":"Killing tumor cells through their surface beta(2)-microglobulin or major histocompatibility complex class I molecules","volume":"116","author":"Yang","year":"2010","journal-title":"Cancer"},{"key":"B78","doi-asserted-by":"publisher","first-page":"e87631","DOI":"10.1371\/journal.pone.0087631","article-title":"HTLV-1 specific CD8+ T cell function augmented by blockade of 2B4\/CD48 interaction in HTLV-1 infection","volume":"9","author":"Ezinne","year":"2014","journal-title":"PLoS One"},{"key":"B79","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.smim.2009.05.010","article-title":"The role of CD40 and CD154\/CD40L in dendritic cells","volume":"21","author":"Ma","year":"2009","journal-title":"Semin Immunol"},{"key":"B80","doi-asserted-by":"publisher","first-page":"10117","DOI":"10.1074\/jbc.M609157200","article-title":"Caveolin-1 triggers T-cell activation via CD26 in association with CARMA1","volume":"282","author":"Ohnuma","year":"2007","journal-title":"J Biol Chem"},{"key":"B81","doi-asserted-by":"publisher","first-page":"1696","DOI":"10.3390\/toxins6061696","article-title":"Type I interferons as regulators of human antigen presenting cell functions","volume":"6","author":"Gessani","year":"2014","journal-title":"Toxins (Basel)"},{"key":"B82","doi-asserted-by":"publisher","first-page":"3197","DOI":"10.1002\/eji.201243288","article-title":"Subtypes of type I IFN differentially enhance cytokine expression by suboptimally stimulated CD4(+) T cells","volume":"43","author":"Hillyer","year":"2013","journal-title":"Eur J Immunol"},{"key":"B83","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1164\/rccm.201403-0601OC","article-title":"IL-6 receptor alpha defines effector memory CD8+ T cells producing Th2 cytokines and expanding in asthma","volume":"190","author":"Lee","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"key":"B84","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1038\/nsmb.2460","article-title":"HLA-DO acts as a substrate mimic to inhibit HLA-DM by a competitive mechanism","volume":"20","author":"Guce","year":"2013","journal-title":"Nat Struct Mol Biol"},{"key":"B85","unstructured":"EdgecombeAD CanadaFaculty of Medicine, Memorial University of NewfoundlandHLA Class II Expression on Breast Cancer Cells2002"},{"key":"B86","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1093\/intimm\/dxs155","article-title":"Transport of misfolded endoplasmic reticulum proteins to the cell surface by MHC class II molecules","volume":"25","author":"Jiang","year":"2013","journal-title":"Int Immunol"},{"key":"B87","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/1465-9921-12-15","article-title":"Phenotypic characteristics of human type II alveolar epithelial cells suitable for antigen presentation to T lymphocytes","volume":"12","author":"Corbiere","year":"2011","journal-title":"Respir Res"},{"key":"B88","doi-asserted-by":"publisher","first-page":"492","DOI":"10.4251\/wjgo.v7.i12.492","article-title":"Targeting cancer testis antigens for biomarkers and immunotherapy in colorectal cancer: current status and challenges","volume":"7","author":"Suri","year":"2015","journal-title":"World J Gastrointest Oncol"},{"key":"B89","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.molonc.2011.02.001","article-title":"The biology of cancer testis antigens: putative function, regulation and therapeutic potential","volume":"5","author":"Fratta","year":"2011","journal-title":"Mol Oncol"},{"key":"B90","doi-asserted-by":"publisher","first-page":"15772","DOI":"10.18632\/oncotarget.4694","article-title":"Oncogenic cancer\/testis antigens: prime candidates for immunotherapy","volume":"6","author":"Gjerstorff","year":"2015","journal-title":"Oncotarget"},{"key":"B91","first-page":"144","article-title":"A single bout of dynamic exercise enhances the expansion of MAGE-A4 and PRAME-specific cytotoxic T-cells from healthy adults","volume":"21","author":"LaVoy","year":"2015","journal-title":"Exerc Immunol Rev"},{"key":"B92","doi-asserted-by":"publisher","first-page":"122","DOI":"10.3389\/fonc.2013.00122","article-title":"Tailoring DNA vaccines: designing strategies against HER2-positive cancers","volume":"3","author":"Marchini","year":"2013","journal-title":"Front Oncol"},{"key":"B93","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1084\/jem.182.5.1415","article-title":"A reassessment of the role of B7-1 expression in tumor rejection","volume":"182","author":"Wu","year":"1995","journal-title":"J Exp Med"},{"key":"B94","doi-asserted-by":"publisher","first-page":"e27897","DOI":"10.4161\/onci.28184","article-title":"Drag cells in immunity (plasmacytoid DCs dress up as cancer cells)","volume":"3","author":"Bonaccorsi","year":"2014","journal-title":"Oncoimmunology"},{"key":"B95","doi-asserted-by":"publisher","first-page":"672","DOI":"10.3389\/fimmu.2014.00672","article-title":"Antigen presentation by MHC-dressed cells","volume":"5","author":"Nakayama","year":"2015","journal-title":"Front Immunol"},{"key":"B96","doi-asserted-by":"publisher","first-page":"3212","DOI":"10.4049\/jimmunol.181.5.3212","article-title":"The relative efficiency of acquisition of MHC:peptide complexes and cross-presentation depends on dendritic cell type","volume":"181","author":"Smyth","year":"2008","journal-title":"J Immunol"},{"key":"B97","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1084\/jem.183.3.769","article-title":"Does B7-1 expression confer antigen-presenting cell capacity to tumors in vivo?","volume":"183","author":"Huang","year":"1996","journal-title":"J Exp Med"},{"key":"B98","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1126\/science.7513904","article-title":"Role of bone marrow-derived cells in presenting MHC class I-restricted tumor antigens","volume":"264","author":"Huang","year":"1994","journal-title":"Science"},{"key":"B99","doi-asserted-by":"publisher","first-page":"e28217","DOI":"10.1371\/journal.pone.0028217","article-title":"gamma-Radiation promotes immunological recognition of cancer cells through increased expression of cancer-testis antigens in vitro and in vivo","volume":"6","author":"Sharma","year":"2011","journal-title":"PLoS One"},{"key":"B100","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1186\/s12885-015-2006-2","article-title":"A randomized phase II study of radiation induced immune boost in operable non-small cell lung cancer (RadImmune trial)","volume":"15","author":"Safi","year":"2015","journal-title":"BMC Cancer"},{"key":"B101","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.clgc.2014.09.001","article-title":"Combining immunotherapy and radiation for prostate cancer","volume":"13","author":"Finkelstein","year":"2015","journal-title":"Clin Genitourin Cancer"},{"key":"B102","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1016\/j.ctrv.2015.03.011","article-title":"The abscopal effect of local radiotherapy: using immunotherapy to make a rare event clinically relevant","volume":"41","author":"Reynders","year":"2015","journal-title":"Cancer Treat Rev"},{"key":"B103","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1158\/0008-5472.CAN-14-2538","article-title":"Cancer immunotherapy and breaking immune tolerance: new approaches to an old challenge","volume":"75","author":"Makkouk","year":"2015","journal-title":"Cancer Res"},{"key":"B104","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.gdata.2014.06.025","article-title":"The HER2 amplicon includes several genes required for the growth and survival of HER2 positive breast cancer cells \u2013 a data description","volume":"2","author":"Hongisto","year":"2014","journal-title":"Genom Data"},{"key":"B105","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1016\/j.molonc.2012.10.012","article-title":"The HER2 amplicon includes several genes required for the growth and survival of HER2 positive breast cancer cells","volume":"7","author":"Sahlberg","year":"2013","journal-title":"Mol Oncol"},{"key":"B106","doi-asserted-by":"publisher","first-page":"2919","DOI":"10.1158\/1535-7163.MCT-06-0389","article-title":"C35 (C17orf37) is a novel tumor biomarker abundantly expressed in breast cancer","volume":"5","author":"Evans","year":"2006","journal-title":"Mol Cancer Ther"},{"key":"B107","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1038\/sj.bjc.6605763","article-title":"A gene on the HER2 amplicon, C35, is an oncogene in breast cancer whose actions are prevented by inhibition of Syk","volume":"103","author":"Katz","year":"2010","journal-title":"Br J Cancer"},{"key":"B108","doi-asserted-by":"publisher","first-page":"54913","DOI":"10.18632\/oncotarget.10798","article-title":"MIEN1 drives breast tumor cell migration by regulating cytoskeletal-focal adhesion dynamics","volume":"7","author":"Kpetemey","year":"2016","journal-title":"Oncotarget"},{"key":"B109","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1002\/humu.23006","article-title":"Rare noncoding mutations extend the mutational spectrum in the PGAP3 subtype of hyperphosphatasia with mental retardation syndrome","volume":"37","author":"Knaus","year":"2016","journal-title":"Hum Mutat"},{"key":"B110","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1016\/j.ajpath.2014.12.018","article-title":"Elevated levels of StAR-related lipid transfer protein 3 alter cholesterol balance and adhesiveness of breast cancer cells: potential mechanisms contributing to progression of HER2-positive breast cancers","volume":"185","author":"Vassilev","year":"2015","journal-title":"Am J Pathol"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2018.00776\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T16:49:09Z","timestamp":1693673349000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2018.00776\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,15]]},"references-count":110,"alternative-id":["10.3389\/fimmu.2018.00776"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2018.00776","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,15]]},"article-number":"776"}}