{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T03:48:51Z","timestamp":1791517731531,"version":"4.3.4"},"reference-count":57,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,4,25]],"date-time":"2018-04-25T00:00:00Z","timestamp":1524614400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006221","name":"United States - Israel Binational Science Foundation","doi-asserted-by":"publisher","award":["2011465"],"award-info":[{"award-number":["2011465"]}],"id":[{"id":"10.13039\/100006221","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["DE025020, DE025383"],"award-info":[{"award-number":["DE025020, DE025383"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2018.00785","type":"journal-article","created":{"date-parts":[[2018,4,25]],"date-time":"2018-04-25T04:16:31Z","timestamp":1524629791000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":73,"title":["Resolvin D2 Restrains Th1 Immunity and Prevents Alveolar Bone Loss in Murine Periodontitis"],"prefix":"10.3389","volume":"9","author":[{"given":"Gabriel","family":"Mizraji","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oded","family":"Heyman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas E.","family":"Van Dyke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asaf","family":"Wilensky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,4,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1902\/jop.2008.080279","article-title":"Inflammation and periodontal diseases: a reappraisal","volume":"79","author":"Van Dyke","year":"2008","journal-title":"J Periodontol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/j.chom.2011.10.006","article-title":"Low-abundance biofilm species orchestrates inflammatory periodontal disease through the commensal microbiota and complement","volume":"10","author":"Hajishengallis","year":"2011","journal-title":"Cell Host Microbe"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1809","DOI":"10.1016\/S0140-6736(05)67728-8","article-title":"Periodontal diseases","volume":"366","author":"Pihlstrom","year":"2005","journal-title":"Lancet"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.1046\/j.0303-6979.2003.00425.x","article-title":"Relationship between clinical parameters and cytokine profiles in inflamed gingival tissue and serum samples from patients with chronic periodontitis","volume":"30","author":"Gorska","year":"2003","journal-title":"J Clin Periodontol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/j.celrep.2016.12.047","article-title":"Porphyromonas gingivalis promotes unrestrained type I interferon production by dysregulating TAM signaling via MYD88 degradation","volume":"18","author":"Mizraji","year":"2017","journal-title":"Cell Rep"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1600-051X.2010.01628.x","article-title":"Activation of the neutrophil respiratory burst by plasma from periodontitis patients is mediated by pro-inflammatory cytokines","volume":"38","author":"Dias","year":"2011","journal-title":"J Clin Periodontol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"5775","DOI":"10.4049\/jimmunol.181.8.5775","article-title":"Periodontitis associates with a type 1 IFN signature in peripheral blood neutrophils","volume":"181","author":"Wright","year":"2008","journal-title":"J Immunol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/S0092-8674(00)81569-X","article-title":"Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation","volume":"93","author":"Lacey","year":"1998","journal-title":"Cell"},{"key":"B9","doi-asserted-by":"publisher","first-page":"3597","DOI":"10.1073\/pnas.95.7.3597","article-title":"Osteoclast differentiation factor is a ligand for osteoprotegerin\/osteoclastogenesis-inhibitory factor and is identical to TRANCE\/RANKL","volume":"95","author":"Yasuda","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B10","doi-asserted-by":"publisher","first-page":"2087","DOI":"10.1016\/j.biomaterials.2006.12.028","article-title":"The enhancement of osteogenesis by nano-fibrous scaffolds incorporating rhBMP-7 nanospheres","volume":"28","author":"Wei","year":"2007","journal-title":"Biomaterials"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.1016\/j.micinf.2008.08.007","article-title":"Porphyromonas gingivalis regulates the RANKL-OPG system in bone marrow stromal cells","volume":"10","author":"Reddi","year":"2008","journal-title":"Microbes Infect"},{"key":"B12","doi-asserted-by":"publisher","first-page":"R59","DOI":"10.1172\/JCI10763","article-title":"Functional human T-cell immunity and osteoprotegerin ligand control alveolar bone destruction in periodontal infection","volume":"106","author":"Teng","year":"2000","journal-title":"J Clin Invest"},{"key":"B13","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1084\/jem.20020760","article-title":"Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals","volume":"196","author":"Serhan","year":"2002","journal-title":"J Exp Med"},{"key":"B14","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/j.immuni.2014.02.009","article-title":"Proresolving lipid mediators and mechanisms in the resolution of acute inflammation","volume":"40","author":"Buckley","year":"2014","journal-title":"Immunity"},{"key":"B15","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1038\/nature13479","article-title":"Pro-resolving lipid mediators are leads for resolution physiology","volume":"510","author":"Serhan","year":"2014","journal-title":"Nature"},{"key":"B16","doi-asserted-by":"publisher","first-page":"38","DOI":"10.3389\/fimmu.2018.00038","article-title":"Bioactive lipids and chronic inflammation: managing the fire within","volume":"9","author":"Chiurchiu","year":"2018","journal-title":"Front Immunol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1038\/nri2294","article-title":"Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators","volume":"8","author":"Serhan","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"353ra111","DOI":"10.1126\/scitranslmed.aaf7483","article-title":"Proresolving lipid mediators resolvin D1, resolvin D2, and maresin 1 are critical in modulating T cell responses","volume":"8","author":"Chiurchiu","year":"2016","journal-title":"Sci Transl Med"},{"key":"B19","doi-asserted-by":"publisher","first-page":"842","DOI":"10.4049\/jimmunol.1601650","article-title":"Novel resolvin D2 receptor axis in infectious inflammation","volume":"198","author":"Chiang","year":"2017","journal-title":"J Immunol"},{"key":"B20","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1096\/fj.05-4724fje","article-title":"RvE1 protects from local inflammation and osteoclast-mediated bone destruction in periodontitis","volume":"20","author":"Hasturk","year":"2006","journal-title":"FASEB J"},{"key":"B21","doi-asserted-by":"publisher","first-page":"7021","DOI":"10.4049\/jimmunol.179.10.7021","article-title":"Resolvin E1 regulates inflammation at the cellular and tissue level and restores tissue homeostasis in vivo","volume":"179","author":"Hasturk","year":"2007","journal-title":"J Immunol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"2796","DOI":"10.4049\/jimmunol.1600859","article-title":"Resolvin E1 reverses experimental periodontitis and dysbiosis","volume":"197","author":"Lee","year":"2016","journal-title":"J Immunol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"689","DOI":"10.4049\/jimmunol.1103688","article-title":"Resolvin E1 and chemokine-like receptor 1 mediate bone preservation","volume":"190","author":"Gao","year":"2013","journal-title":"J Immunol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1111\/j.1524-475X.2012.00853.x","article-title":"Resolvin D2 prevents secondary thrombosis and necrosis in a mouse burn wound model","volume":"21","author":"Bohr","year":"2013","journal-title":"Wound Repair Regen"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.1161\/CIRCRESAHA.116.309492","article-title":"Resolving lipid mediators maresin 1 and resolvin D2 prevent atheroprogression in mice","volume":"119","author":"Viola","year":"2016","journal-title":"Circ Res"},{"key":"B26","doi-asserted-by":"publisher","first-page":"476","DOI":"10.3390\/ijms18030476","article-title":"Pro-resolving molecules-new approaches to treat sepsis?","volume":"18","author":"Buechler","year":"2017","journal-title":"Int J Mol Sci"},{"key":"B27","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1111\/jcpe.12139","article-title":"The role of RgpA in the pathogenicity of Porphyromonas gingivalis in the murine periodontitis model","volume":"40","author":"Wilensky","year":"2013","journal-title":"J Clin Periodontol"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1359\/jbmr.1999.14.7.1167","article-title":"Direct three-dimensional morphometric analysis of human cancellous bone: microstructural data from spine, femur, iliac crest, and calcaneus","volume":"14","author":"Hildebrand","year":"1999","journal-title":"J Bone Miner Res"},{"key":"B29","doi-asserted-by":"publisher","first-page":"1282","DOI":"10.1902\/jop.2005.76.8.1282","article-title":"Three-dimensional quantification of alveolar bone loss in Porphyromonas gingivalis-infected mice using micro-computed tomography","volume":"76","author":"Wilensky","year":"2005","journal-title":"J Periodontol"},{"key":"B30","doi-asserted-by":"publisher","first-page":"e50388","DOI":"10.3791\/50388","article-title":"Isolation, processing and analysis of murine gingival cells","author":"Mizraji","year":"2013","journal-title":"J Vis Exp"},{"key":"B31","doi-asserted-by":"crossref","first-page":"2804","DOI":"10.1128\/IAI.67.6.2804-2809.1999","article-title":"CD4(+) T cells and the proinflammatory cytokines gamma interferon and interleukin-6 contribute to alveolar bone loss in mice","volume":"67","author":"Baker","year":"1999","journal-title":"Infect Immun"},{"key":"B32","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1080\/00016350152509247","article-title":"T-cell contributions to alveolar bone loss in response to oral infection with Porphyromonas gingivalis","volume":"59","author":"Baker","year":"2001","journal-title":"Acta Odontol Scand"},{"key":"B33","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1111\/j.1574-695X.2002.tb00601.x","article-title":"T cell knockout mice have diminished alveolar bone loss after oral infection with Porphyromonas gingivalis","volume":"34","author":"Baker","year":"2002","journal-title":"FEMS Immunol Med Microbiol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"7043","DOI":"10.1073\/pnas.1116770109","article-title":"Langerhans cells down-regulate inflammation-driven alveolar bone loss","volume":"109","author":"Arizon","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B35","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1111\/j.1600-051X.2010.01586.x","article-title":"Regulatory T cells attenuate experimental periodontitis progression in mice","volume":"37","author":"Garlet","year":"2010","journal-title":"J Clin Periodontol"},{"key":"B36","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1038\/ni.1920","article-title":"The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection","volume":"11","author":"Satoh","year":"2010","journal-title":"Nat Immunol"},{"key":"B37","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1038\/ni.1990","article-title":"IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses","volume":"12","author":"Krausgruber","year":"2011","journal-title":"Nat Immunol"},{"key":"B38","doi-asserted-by":"publisher","first-page":"1663","DOI":"10.4049\/jimmunol.164.4.1663","article-title":"Cutting edge: lipoxins rapidly stimulate nonphlogistic phagocytosis of apoptotic neutrophils by monocyte-derived macrophages","volume":"164","author":"Godson","year":"2000","journal-title":"J Immunol"},{"key":"B39","doi-asserted-by":"publisher","first-page":"615486","DOI":"10.1155\/2015\/615486","article-title":"Mechanisms of bone resorption in periodontitis","volume":"2015","author":"Hienz","year":"2015","journal-title":"J Immunol Res"},{"key":"B40","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1111\/j.0906-6713.2004.003557.x","article-title":"Immunoregulatory control of Th1\/Th2 cytokine profiles in periodontal disease","volume":"35","author":"Gemmell","year":"2004","journal-title":"Periodontol 2000"},{"key":"B41","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1111\/j.1600-0757.2007.00227.x","article-title":"T-cell phenotype as a risk factor for periodontal disease","volume":"45","author":"Houri-Haddad","year":"2007","journal-title":"Periodontol 2000"},{"key":"B42","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1111\/j.1755-148X.2010.00781.x","article-title":"Quantitative expression profiling of G-protein-coupled receptors (GPCRs) in metastatic melanoma: the constitutively active orphan GPCR GPR18 as novel drug target","volume":"24","author":"Qin","year":"2011","journal-title":"Pigment Cell Melanoma Res"},{"key":"B43","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1097\/FJC.0000000000000438","article-title":"The effect of chronic activation of the novel endocannabinoid receptor GPR18 on myocardial function and blood pressure in conscious rats","volume":"69","author":"Matouk","year":"2017","journal-title":"J Cardiovasc Pharmacol"},{"key":"B44","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/rr195","article-title":"Signaling and regulation of G protein-coupled receptors in airway smooth muscle","volume":"4","author":"Billington","year":"2003","journal-title":"Respir Res"},{"key":"B45","first-page":"235","article-title":"Pathogenesis of inflammatory periodontal disease. A summary of current work","volume":"34","author":"Page","year":"1976","journal-title":"Lab Invest"},{"key":"B46","doi-asserted-by":"publisher","first-page":"36S","DOI":"10.14219\/jada.archive.2009.0356","article-title":"The biology, prevention, diagnosis and treatment of periodontal diseases: scientific advances in the United States","volume":"140","author":"Armitage","year":"2009","journal-title":"J Am Dent Assoc"},{"key":"B47","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1902\/jop.2003.74.1.66","article-title":"Neutrophil-mediated tissue injury in periodontal disease pathogenesis: findings from localized aggressive periodontitis","volume":"74","author":"Kantarci","year":"2003","journal-title":"J Periodontol"},{"key":"B48","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1084\/jem.20150225","article-title":"Identification of resolvin D2 receptor mediating resolution of infections and organ protection","volume":"212","author":"Chiang","year":"2015","journal-title":"J Exp Med"},{"key":"B49","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1084\/jem.192.8.1197","article-title":"Novel functional sets of lipid-derived mediators with antiinflammatory actions generated from omega-3 fatty acids via cyclooxygenase 2-nonsteroidal antiinflammatory drugs and transcellular processing","volume":"192","author":"Serhan","year":"2000","journal-title":"J Exp Med"},{"key":"B50","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1016\/j.imbio.2010.05.031","article-title":"Interleukin-4 induced interferon regulatory factor (Irf) 4 participates in the regulation of alternative macrophage priming","volume":"215","author":"El Chartouni","year":"2010","journal-title":"Immunobiology"},{"key":"B51","doi-asserted-by":"publisher","first-page":"4192","DOI":"10.1096\/fj.201600144RR","article-title":"D-series resolvins inhibit murine abdominal aortic aneurysm formation and increase M2 macrophage polarization","volume":"30","author":"Pope","year":"2016","journal-title":"FASEB J"},{"key":"B52","doi-asserted-by":"publisher","first-page":"5922","DOI":"10.1021\/cr100396c","article-title":"Resolvins and protectins in inflammation resolution","volume":"111","author":"Serhan","year":"2011","journal-title":"Chem Rev"},{"key":"B53","doi-asserted-by":"publisher","first-page":"5944","DOI":"10.1167\/iovs.14-14356","article-title":"The resolvin D1 analogue controls maturation of dendritic cells and suppresses alloimmunity in corneal transplantation","volume":"55","author":"Hua","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"B54","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1038\/cmi.2011.7","article-title":"Type I and II interferons enhance dendritic cell maturation and migration capacity by regulating CD38 and CD74 that have synergistic effects with TLR agonists","volume":"8","author":"Nguyen-Pham","year":"2011","journal-title":"Cell Mol Immunol"},{"key":"B55","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1089\/jir.1997.17.347","article-title":"Effects of interferons on the production of interleukin-6 and interleukin-8 in human keratinocytes","volume":"17","author":"Fujisawa","year":"1997","journal-title":"J Interferon Cytokine Res"},{"key":"B56","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.1210\/endo.139.3.5837","article-title":"Identity of osteoclastogenesis inhibitory factor (OCIF) and osteoprotegerin (OPG): a mechanism by which OPG\/OCIF inhibits osteoclastogenesis in vitro","volume":"139","author":"Yasuda","year":"1998","journal-title":"Endocrinology"},{"key":"B57","doi-asserted-by":"publisher","first-page":"1300","DOI":"10.1902\/jop.2007.070073","article-title":"RANKL inhibition through osteoprotegerin blocks bone loss in experimental periodontitis","volume":"78","author":"Jin","year":"2007","journal-title":"J Periodontol"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2018.00785\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T07:37:00Z","timestamp":1604216220000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2018.00785\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,25]]},"references-count":57,"alternative-id":["10.3389\/fimmu.2018.00785"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2018.00785","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,25]]},"article-number":"785"}}