{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:24:22Z","timestamp":1792628662684,"version":"4.5.0"},"reference-count":70,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,4,24]],"date-time":"2018-04-24T00:00:00Z","timestamp":1524528000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2018.00787","type":"journal-article","created":{"date-parts":[[2018,4,24]],"date-time":"2018-04-24T04:43:54Z","timestamp":1524545034000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["SYK Inhibition Induces Apoptosis in Germinal Center-Like B Cells by Modulating the Antiapoptotic Protein Myeloid Cell Leukemia-1, Affecting B-Cell Activation and Antibody Production"],"prefix":"10.3389","volume":"9","author":[{"given":"Nathalie","family":"Roders","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Herr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gorbatchev","family":"Ambroise","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Thaunat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Portier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aim\u00e9","family":"Vazquez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Durrbach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,4,24]]},"reference":[{"key":"B1","first-page":"698","article-title":"Effects of plasmapheresis in renal transplant rejection. A controlled study","volume":"31","author":"Bonomini","year":"1985","journal-title":"Trans Am Soc Artif Intern Organs"},{"key":"B2","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1111\/j.1744-9987.2009.00664.x","article-title":"Plasmapheresis and intravenous immunoglobulin in early antibody-mediated rejection of the renal allograft: a single-center experience","volume":"13","author":"Slatinska","year":"2009","journal-title":"Ther Apher Dial"},{"key":"B3","first-page":"199","article-title":"Desensitization therapy with intravenous gammaglobulin (IVIG): applications in solid organ transplantation","volume":"117","author":"Jordan","year":"2006","journal-title":"Trans Am Clin Climatol Assoc"},{"key":"B4","doi-asserted-by":"publisher","first-page":"e91","DOI":"10.1097\/TXD.0000000000000604","article-title":"Rituximab in combination with bortezomib, plasmapheresis, and high-dose IVIG to treat antibody-mediated renal allograft rejection","volume":"2","author":"Waiser","year":"2016","journal-title":"Transplant Direct"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1097\/01.tp.0000261113.30757.d1","article-title":"Rituximab therapy for acute humoral rejection after kidney transplan-tation","volume":"83","author":"Faguer","year":"2007","journal-title":"Transplantation"},{"key":"B6","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1097\/TP.0b013e31819389cc","article-title":"A single low-fixed dose of rituximab to salvage renal transplants from refractory antibody-mediated rejection","volume":"87","author":"Mulley","year":"2009","journal-title":"Transplantation"},{"key":"B7","doi-asserted-by":"publisher","first-page":"e12873","DOI":"10.1111\/petr.12873","article-title":"Bortezomib in the treatment of antibody-mediated rejection in pediatric kidney transplant recipients: A Multicenter Midwest Pediatric Nephrology Consortium study","volume":"21","author":"Kizilbash","year":"2017","journal-title":"Pediatr Transplant"},{"key":"B8","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1097\/TP.0000000000000298","article-title":"Eculizumab and splenectomy as salvage therapy for severe antibody-mediated rejection after HLA-incompatible kidney transplantation","volume":"98","author":"Orandi","year":"2014","journal-title":"Transplantation"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1754","DOI":"10.1016\/j.transproceed.2015.06.029","article-title":"Eculizumab for treatment of refractory antibody-mediated rejection in kidney transplant patients: a single-center experience","volume":"47","author":"Yelken","year":"2015","journal-title":"Transplant Proc"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1713","DOI":"10.1073\/pnas.97.4.1713","article-title":"Role of Syk in B-cell development and antigen-receptor signaling","volume":"97","author":"Cornall","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B11","doi-asserted-by":"publisher","first-page":"32650","DOI":"10.1074\/jbc.M806340200","article-title":"Molecular mechanism of the Syk activation switch","volume":"283","author":"Tsang","year":"2008","journal-title":"J Biol Chem"},{"key":"B12","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1016\/j.molimm.2004.04.008","article-title":"B cell antigen receptor signaling 101","volume":"41","author":"Dal Porto","year":"2004","journal-title":"Mol Immunol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1038\/354389a0","article-title":"Intraclonal generation of antibody mutants in germinal centres","volume":"354","author":"Jacob","year":"1991","journal-title":"Nature"},{"key":"B14","doi-asserted-by":"publisher","first-page":"14723","DOI":"10.1073\/pnas.0507223102","article-title":"Lymphoid neogenesis in chronic rejection: evidence for a local humoral alloimmune response","volume":"102","author":"Thaunat","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B15","doi-asserted-by":"publisher","first-page":"646","DOI":"10.3389\/fimmu.2016.00646","article-title":"Lymphoid neogenesis and tertiary lymphoid organs in transplanted organs","volume":"7","author":"Koenig","year":"2016","journal-title":"Front Immunol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1016\/0092-8674(91)90289-B","article-title":"Maturation of the immune response in germinal centers","volume":"67","author":"Berek","year":"1991","journal-title":"Cell"},{"key":"B17","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1084\/jem.173.5.1165","article-title":"In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. I. The architecture and dynamics of responding cell populations","volume":"173","author":"Jacob","year":"1991","journal-title":"J Exp Med"},{"key":"B18","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1016\/S0092-8674(00)00078-7","article-title":"Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme","volume":"102","author":"Muramatsu","year":"2000","journal-title":"Cell"},{"key":"B19","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1038\/342929a0","article-title":"Mechanism of antigen-driven selection in germinal centres","volume":"342","author":"Liu","year":"1989","journal-title":"Nature"},{"key":"B20","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1016\/S0167-5699(00)01687-X","article-title":"Dissecting affinity maturation: a model explaining selection of antibody-forming cells and memory B cells in the germinal centre","volume":"21","author":"Tarlinton","year":"2000","journal-title":"Immunol Today"},{"key":"B21","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1093\/imammb\/dql012","article-title":"An analysis of B cell selection mechanisms in germinal centers","volume":"23","author":"Meyer-Hermann","year":"2006","journal-title":"Math Med Biol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1002\/eji.1830270210","article-title":"Antigen receptor-induced apoptosis of human germinal center B cells is targeted to a centrocytic subset","volume":"27","author":"Billian","year":"1997","journal-title":"Eur J Immunol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"3978","DOI":"10.1182\/blood-2007-05-091306","article-title":"Proapoptotic BH3-only protein Bim is essential for developmentally pro-grammed death of germinal center-derived memory B cells and antibody-forming cells","volume":"110","author":"Fischer","year":"2007","journal-title":"Blood"},{"key":"B24","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1038\/nrm2308","article-title":"The BCL-2 protein family: opposing activities that mediate cell death","volume":"9","author":"Youle","year":"2008","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"a008714","DOI":"10.1101\/cshperspect.a008714","article-title":"Mechanisms of action of Bcl-2 family proteins","volume":"5","author":"Shamas-Din","year":"2013","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1007\/s00204-014-1448-7","article-title":"The mystery of BCL2 family: Bcl-2 proteins and apoptosis: an update","volume":"89","author":"Siddiqui","year":"2015","journal-title":"Arch Toxicol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1126\/science.1191793","article-title":"Mcl-1 is essential for germinal center formation and B cell memory","volume":"330","author":"Vikstrom","year":"2010","journal-title":"Science"},{"key":"B28","doi-asserted-by":"publisher","first-page":"4120","DOI":"10.1182\/blood-2011-04-347096","article-title":"Regulation of memory B-cell survival by the BH3-only protein Puma","volume":"118","author":"Clybouw","year":"2011","journal-title":"Blood"},{"key":"B29","doi-asserted-by":"publisher","first-page":"3845","DOI":"10.1128\/MCB.00279-09","article-title":"Mcl-1 integrates the opposing actions of signaling pathways that mediate survival and apoptosis","volume":"29","author":"Morel","year":"2009","journal-title":"Mol Cell Biol"},{"key":"B30","doi-asserted-by":"publisher","first-page":"550","DOI":"10.3791\/550","article-title":"Production of replication-defective retrovirus by transient transfection of 293T cells","volume":"10","author":"Gavrilescu","year":"2007","journal-title":"J Vis Exp"},{"key":"B31","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1084\/jem.180.1.329","article-title":"Analysis of somatic mutation in five B cell subsets of human tonsil","volume":"180","author":"Pascual","year":"1994","journal-title":"J Exp Med"},{"key":"B32","doi-asserted-by":"publisher","first-page":"1520","DOI":"10.1056\/NEJM199911113412007","article-title":"Cellular origin of human B-cell lymphomas","volume":"341","author":"K\u00fcppers","year":"1999","journal-title":"N Engl J Med"},{"key":"B33","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1124\/jpet.103.052316","article-title":"The orally available spleen tyrosine kinase inhibitor 2-[7-(3,4-dimethoxyphenyl)-imidazo[1,2-c]pyrimidin-5-ylamino]nicotinamide dihydrochloride (BAY 61-3606) blocks antigen-induced airway inflammation in rodents","volume":"306","author":"Yamamoto","year":"2003","journal-title":"J Pharmacol Exp Ther"},{"key":"B34","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.ymeth.2007.12.001","article-title":"Apoptosis and necrosis: detection, discrimination and phagocytosis","volume":"44","author":"Krysko","year":"2008","journal-title":"Methods"},{"key":"B35","doi-asserted-by":"publisher","first-page":"4818","DOI":"10.1038\/sj.onc.1207648","article-title":"Mcl-1 is required for Akata6 B-lymphoma cell survival and is converted to a cell death molecule by efficient caspase-mediated cleavage","volume":"23","author":"Michels","year":"2004","journal-title":"Oncogene"},{"key":"B36","doi-asserted-by":"publisher","first-page":"3255","DOI":"10.1182\/blood-2004-10-3984","article-title":"Evidence for a protective role of Mcl-1 in proteasome inhibitor-induced apoptosis","volume":"105","author":"Nencioni","year":"2005","journal-title":"Blood"},{"key":"B37","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1042\/BJ20050465","article-title":"STAT3-mediated transcription of Bcl-2, Mcl-1 and c-IAP2 prevents apoptosis in polyamine-depleted cells","volume":"392","author":"Bhattacharya","year":"2005","journal-title":"Biochem J"},{"key":"B38","doi-asserted-by":"publisher","first-page":"2981","DOI":"10.1016\/j.febslet.2010.05.061","article-title":"Mcl-1; the molecular regulation of protein function","volume":"584","author":"Thomas","year":"2010","journal-title":"FEBS Lett"},{"key":"B39","doi-asserted-by":"publisher","first-page":"1635","DOI":"10.1084\/jem.182.6.1635","article-title":"In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. IV. Affinity-dependent, antigen-driven B cell apoptosis in germinal centers as a mechanism for maintaining self-tolerance","volume":"182","author":"Han","year":"1995","journal-title":"J Exp Med"},{"key":"B40","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1038\/375334a0","article-title":"Antigen-induced B-cell death and elimination during germinal-centre immune responses","volume":"375","author":"Shokat","year":"1995","journal-title":"Nature"},{"key":"B41","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1182\/blood.V83.7.1856.1856","article-title":"Inverse expression of bcl-2 protein and Fas antigen in lymphoblasts in peripheral lymph nodes and activated peripheral blood T and B lymphocytes","volume":"83","author":"Yoshino","year":"1994","journal-title":"Blood"},{"key":"B42","doi-asserted-by":"publisher","first-page":"5536","DOI":"10.1182\/blood-2008-12-193037","article-title":"The BCL6 transcriptional program features repression of multiple oncogenes in primary B cells and is deregulated in DLBCL","volume":"113","author":"Ci","year":"2009","journal-title":"Blood"},{"key":"B43","doi-asserted-by":"publisher","first-page":"11294","DOI":"10.1073\/pnas.0903854106","article-title":"BCL6 suppression of BCL2 via Miz1 and its disruption in diffuse large B cell lymphoma","volume":"106","author":"Saito","year":"2009","journal-title":"Proc Nat Acad Sci U S A"},{"key":"B44","doi-asserted-by":"publisher","first-page":"1461","DOI":"10.1084\/jem.183.4.1461","article-title":"Chronic inflammation caused by lymphotoxin is lymphoid neogenesis","volume":"183","author":"Kratz","year":"1996","journal-title":"J Exp Med"},{"key":"B45","doi-asserted-by":"publisher","first-page":"4710","DOI":"10.4049\/jimmunol.167.8.4710","article-title":"T cell activation in rheumatoid synovium is B-cell dependent","volume":"167","author":"Takemura","year":"2001","journal-title":"J Immunol"},{"key":"B46","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1097\/01.ASN.0000113316.52371.2E","article-title":"Lymphatic neoangiogenesis in human kidney transplants is associated with immunologically active lymphocytic infiltrates","volume":"15","author":"Kerjaschki","year":"2004","journal-title":"J Am Soc Nephrol"},{"key":"B47","doi-asserted-by":"publisher","first-page":"717","DOI":"10.4049\/jimmunol.0903589","article-title":"Chronic rejection triggers the development of an aggressive intragraft immune response through recapitulation of lymphoid organogenesis","volume":"185","author":"Thaunat","year":"2010","journal-title":"J Immunol"},{"key":"B48","doi-asserted-by":"publisher","first-page":"5560","DOI":"10.1073\/pnas.1101148108","article-title":"Ectopic B-cell clusters that infiltrate transplanted human kidneys are clonal","volume":"108","author":"Cheng","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B49","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1038\/nrneph.2009.233","article-title":"Advances in immunosuppression for renal transplantation","volume":"6","author":"Durrbach","year":"2010","journal-title":"Nat Rev Nephrol"},{"key":"B50","doi-asserted-by":"publisher","first-page":"1226","DOI":"10.1111\/j.1600-6143.2011.03539.x","article-title":"Solid organ allograft survival improvement in the United States: the long-term does not mirror the dramatic short-term success","volume":"11","author":"Lodhi","year":"2011","journal-title":"Am J Transplant"},{"key":"B51","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1038\/nrneph.2012.81","article-title":"The impact of donor-specific anti-HLA antibodies on late kidney allograft failure","volume":"8","author":"Loupy","year":"2012","journal-title":"Nat Rev Nephrol"},{"key":"B52","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1097\/BOR.0b013e328277ef3b","article-title":"Regulation of autoreactive antibodies","volume":"19","author":"Yurasov","year":"2007","journal-title":"Curr Opin Rheumatol"},{"key":"B53","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1111\/j.1600-065X.2010.00936.x","article-title":"Molecular underpinning of B-cell anergy","volume":"237","author":"Yarkoni","year":"2010","journal-title":"Immunol Rev"},{"key":"B54","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1007\/PL00000728","article-title":"Functional analysis of the human MCL-1 gene","volume":"57","author":"Akgul","year":"2000","journal-title":"Cell Mol Life Sci"},{"key":"B55","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1182\/blood-2005-07-2871","article-title":"Critical role for Stat3 in T-dependent terminal differentiation of IgG B cells","volume":"107","author":"Fornek","year":"2006","journal-title":"Blood"},{"key":"B56","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1084\/jem.20091706","article-title":"B cell\u2013intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans","volume":"207","author":"Avery","year":"2010","journal-title":"J Exp Med"},{"key":"B57","doi-asserted-by":"publisher","first-page":"4477","DOI":"10.4049\/jimmunol.1502043","article-title":"STAT3 signaling in B cells is critical for germinal center maintenance and contributes to the pathogenesis of murine models of lupus","volume":"196","author":"Ding","year":"2016","journal-title":"J Immunol"},{"key":"B58","doi-asserted-by":"publisher","first-page":"3945","DOI":"10.1002\/(SICI)1521-4141(199912)29:12<3945::AID-IMMU3945>3.0.CO;2-O","article-title":"IL-6 up-regulates mcl-1 in human myeloma cells through JAK\/STAT rather than ras\/MAP kinase pathway","volume":"29","author":"Puthier","year":"1999","journal-title":"Eur J Immunol"},{"key":"B59","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1172\/JCI9940","article-title":"Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression","volume":"107","author":"Epling-Burnette","year":"2001","journal-title":"J Clin Invest"},{"key":"B60","doi-asserted-by":"publisher","first-page":"6133","DOI":"10.1038\/sj.onc.1210436","article-title":"mir-29 regulates Mcl-1 protein expression and apoptosis","volume":"26","author":"Mott","year":"2007","journal-title":"Oncogene"},{"key":"B61","doi-asserted-by":"publisher","first-page":"2851","DOI":"10.1038\/sj.onc.1210092","article-title":"Engagement of the B-cell antigen receptor activates STAT through Lyn in a Jak-independent pathway","volume":"26","author":"Wang","year":"2006","journal-title":"Oncogene"},{"key":"B62","doi-asserted-by":"publisher","first-page":"2902","DOI":"10.1073\/pnas.0909086107","article-title":"STAT3 is a substrate of SYK tyrosine kinase in B-lineage leukemia\/lymphoma cells exposed to oxidative stress","volume":"107","author":"Uckun","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B63","doi-asserted-by":"publisher","first-page":"e2345","DOI":"10.1038\/cddis.2016.237","article-title":"MCL-1 is required throughout B-cell development and its loss sensitizes specific B-cell subsets to inhibition of BCL-2 or BCL-XL","volume":"7","author":"Vikstrom","year":"2016","journal-title":"Cell Death Dis"},{"key":"B64","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.jdermsci.2014.02.008","article-title":"Blockade of Syk ameliorates the development of murine sclerodermatous chronic graft-versus-host disease","volume":"74","author":"Le Huu","year":"2014","journal-title":"J Dermatol Sci"},{"key":"B65","doi-asserted-by":"publisher","first-page":"2108","DOI":"10.1182\/blood-2013-10-533562","article-title":"Increased BCR responsiveness in B cells from patients with chronic GVHD","volume":"123","author":"Allen","year":"2014","journal-title":"Blood"},{"key":"B66","doi-asserted-by":"publisher","first-page":"4085","DOI":"10.1182\/blood-2014-08-595470","article-title":"Targeting Syk-activated B cells in murine and human chronic graft-versus-host disease","volume":"125","author":"Flynn","year":"2015","journal-title":"Blood"},{"key":"B67","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.1097\/01.TP.0000031249.33030.FB","article-title":"All chronic rejection failures of kidney transplants were preceded by the development of HLA antibodies","volume":"74","author":"Lee","year":"2002","journal-title":"Transplantation"},{"key":"B68","doi-asserted-by":"publisher","first-page":"1541","DOI":"10.1002\/ajt.12212","article-title":"De novo donor-specific HLA antibodies decrease patient and graft survival in liver transplant recipients","volume":"13","author":"Kaneku","year":"2013","journal-title":"Am J Transplant"},{"key":"B69","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1111\/iji.12032","article-title":"16th IHIW: anti-HLA alloantibodies of the of IgA isotype in re-transplant candidates","volume":"40","author":"Arnold","year":"2013","journal-title":"Int J Immunogenet"},{"key":"B70","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1097\/01.TP.0000441362.11232.48","article-title":"Impact of IgM and IgG3 anti-HLA alloantibodies in primary renal allograft recipients","volume":"97","author":"Everly","year":"2014","journal-title":"Transplantation"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2018.00787\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,16]],"date-time":"2019-10-16T22:50:26Z","timestamp":1571266226000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2018.00787\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,24]]},"references-count":70,"alternative-id":["10.3389\/fimmu.2018.00787"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2018.00787","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,24]]},"article-number":"787"}}