{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:44:23Z","timestamp":1790811863233,"version":"4.1.0"},"reference-count":22,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,4,19]],"date-time":"2018-04-19T00:00:00Z","timestamp":1524096000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI117408, R01HL125749, R01AI072176, R01AR064369"],"award-info":[{"award-number":["R01AI117408, R01HL125749, R01AI072176, R01AR064369"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["CA16086 and P30CA06086"],"award-info":[{"award-number":["CA16086 and P30CA06086"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2018.00844","type":"journal-article","created":{"date-parts":[[2018,4,19]],"date-time":"2018-04-19T04:12:02Z","timestamp":1524111122000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":33,"title":["Efficient Capsid Antigen Presentation From Adeno-Associated Virus Empty Virions In Vivo"],"prefix":"10.3389","volume":"9","author":[{"given":"Xiaolei","family":"Pei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauriel Freya","family":"Earley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikita Elexa","family":"Hall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard Jude","family":"Samulski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengwen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,4,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1038\/nm1358","article-title":"Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response","volume":"12","author":"Manno","year":"2006","journal-title":"Nat Med"},{"key":"B2","doi-asserted-by":"publisher","first-page":"2357","DOI":"10.1056\/NEJMoa1108046","article-title":"Adenovirus-associated virus vector-mediated gene transfer in hemophilia B","volume":"365","author":"Nathwani","year":"2011","journal-title":"N Engl J Med"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1994","DOI":"10.1056\/NEJMoa1407309","article-title":"Long-term safety and efficacy of factor IX gene therapy in hemophilia B","volume":"371","author":"Nathwani","year":"2014","journal-title":"N Engl J Med"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1089\/hum.2017.167","article-title":"Advances in gene therapy for haemophilia","volume":"28","author":"Nathwani","year":"2017","journal-title":"Hum Gene Ther"},{"key":"B5","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1532\/IJH97.04200","article-title":"Antigen recognition and presentation by dendritic cells","volume":"81","author":"Inaba","year":"2005","journal-title":"Int J Hematol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1390","DOI":"10.1172\/JCI66611","article-title":"Adeno-associated virus capsid antigen presentation is dependent on endosomal escape","volume":"123","author":"Li","year":"2013","journal-title":"J Clin Invest"},{"key":"B7","doi-asserted-by":"publisher","first-page":"2079","DOI":"10.1089\/104303400750001390","article-title":"Purification of recombinant adeno-associated virus vectors by column chromatography and its performance in vivo","volume":"11","author":"Gao","year":"2000","journal-title":"Hum Gene Ther"},{"key":"B8","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1089\/hgtb.2011.217","article-title":"Analysis of particle content of recombinant adeno-associated virus serotype 8 vectors by ion-exchange chromatography","volume":"23","author":"Lock","year":"2012","journal-title":"Hum Gene Ther Methods"},{"key":"B9","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.jviromet.2006.11.019","article-title":"Separation of adeno-associated virus type 2 empty particles from genome containing vectors by anion-exchange column chromatography","volume":"140","author":"Qu","year":"2007","journal-title":"J Virol Methods"},{"key":"B10","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1016\/j.ymthe.2006.08.1217","article-title":"Removal of empty capsids from type 1 adeno-associated virus vector stocks by anion-exchange chromatography potentiates transgene expression","volume":"13","author":"Urabe","year":"2006","journal-title":"Mol Ther"},{"key":"B11","doi-asserted-by":"publisher","first-page":"8888","DOI":"10.1128\/JVI.00687-10","article-title":"Mutagenesis of adeno-associated virus type 2 capsid protein VP1 uncovers new roles for basic amino acids in trafficking and cell-specific transduction","volume":"84","author":"Johnson","year":"2010","journal-title":"J Virol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"194ra192","DOI":"10.1126\/scitranslmed.3005795","article-title":"Overcoming preexisting humoral immunity to AAV using capsid decoys","volume":"5","author":"Mingozzi","year":"2013","journal-title":"Sci Transl Med"},{"key":"B13","doi-asserted-by":"publisher","first-page":"20139","DOI":"10.1038\/mtm.2013.9","article-title":"Empty virions in AAV8 vector preparations reduce transduction efficiency and may cause total viral particle dose-limiting side effects","volume":"1","author":"Gao","year":"2014","journal-title":"Mol Ther Methods Clin Dev"},{"key":"B14","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1128\/JVI.72.3.2224-2232.1998","article-title":"Production of high-titer recombinant adeno-associated virus vectors in the absence of helper adenovirus","volume":"72","author":"Xiao","year":"1998","journal-title":"J Virol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"14258","DOI":"10.1073\/pnas.1109522108","article-title":"Combination therapy utilizing shRNA knockdown and an optimized resistant transgene for rescue of diseases caused by misfolded proteins","volume":"108","author":"Li","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B16","doi-asserted-by":"publisher","first-page":"2396","DOI":"10.4049\/jimmunol.178.4.2396","article-title":"Rapid clonal expansion and prolonged maintenance of memory CD8+ T cells of the effector (CD44highCD62Llow) and central (CD44highCD62Lhigh) phenotype by an archaeosome adjuvant independent of TLR2","volume":"178","author":"Krishnan","year":"2007","journal-title":"J Immunol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"6817","DOI":"10.1128\/JVI.00278-09","article-title":"Cytotoxic-T-lymphocyte-mediated elimination of target cells transduced with engineered adeno-associated virus type 2 vector in vivo","volume":"83","author":"Li","year":"2009","journal-title":"J Virol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1089\/hum.2013.065","article-title":"Kinetics of adeno-associated virus serotype 2 (AAV2) and AAV8 capsid antigen presentation in vivo are identical","volume":"24","author":"He","year":"2013","journal-title":"Hum Gene Ther"},{"key":"B19","doi-asserted-by":"publisher","first-page":"2632","DOI":"10.1128\/JVI.02309-08","article-title":"Enhancement of adeno-associated virus infection by mobilizing capsids into and out of the nucleolus","volume":"83","author":"Johnson","year":"2009","journal-title":"J Virol"},{"key":"B20","doi-asserted-by":"publisher","first-page":"5199","DOI":"10.1128\/JVI.02723-05","article-title":"Separate basic region motifs within the adeno-associated virus capsid proteins are essential for infectivity and assembly","volume":"80","author":"Grieger","year":"2006","journal-title":"J Virol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1099\/0022-1317-83-5-973","article-title":"The VP1 capsid protein of adeno-associated virus type 2 is carrying a phospholipase A2 domain required for virus infectivity","volume":"83","author":"Girod","year":"2002","journal-title":"J Gen Virol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"5296","DOI":"10.1128\/JVI.79.9.5296-5303.2005","article-title":"A conformational change in the adeno-associated virus type 2 capsid leads to the exposure of hidden VP1 N termini","volume":"79","author":"Kronenberg","year":"2005","journal-title":"J Virol"}],"updated-by":[{"DOI":"10.3389\/fimmu.2019.03076","type":"corrigendum","label":"Corrigendum","source":"publisher","updated":{"date-parts":[[2020,2,4]],"date-time":"2020-02-04T00:00:00Z","timestamp":1580774400000}}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2018.00844\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,3]],"date-time":"2020-02-03T15:00:35Z","timestamp":1580742035000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2018.00844\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,19]]},"references-count":22,"alternative-id":["10.3389\/fimmu.2018.00844"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2018.00844","relation":{"corrigendum":[{"id-type":"doi","id":"10.3389\/fimmu.2019.03076","asserted-by":"object"}]},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,19]]},"article-number":"844"}}