{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T22:04:50Z","timestamp":1792101890161,"version":"4.4.0"},"reference-count":76,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,4,30]],"date-time":"2018-04-30T00:00:00Z","timestamp":1525046400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL102076, R21 AI121644, R33 AI121644 and R01 GM111313"],"award-info":[{"award-number":["R01 HL102076, R21 AI121644, R33 AI121644 and R01 GM111313"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2018.00924","type":"journal-article","created":{"date-parts":[[2018,4,30]],"date-time":"2018-04-30T04:15:36Z","timestamp":1525061736000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":88,"title":["Extracellular Vesicle: An Emerging Mediator of Intercellular Crosstalk in Lung Inflammation and Injury"],"prefix":"10.3389","volume":"9","author":[{"given":"Heedoo","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Abston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish","family":"Rai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,4,30]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1038\/nm0397-272","article-title":"Cytokines and the acute respiratory distress syndrome (ARDS): a question of balance","volume":"3","author":"Martin","year":"1997","journal-title":"Nat Med"},{"key":"B2","doi-asserted-by":"publisher","first-page":"2731","DOI":"10.1172\/JCI60331","article-title":"The acute respiratory distress syndrome","volume":"122","author":"Matthay","year":"2012","journal-title":"J Clin Invest"},{"key":"B3","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/S0140-6736(67)90168-7","article-title":"Acute respiratory distress in adults","volume":"2","author":"Ashbaugh","year":"1967","journal-title":"Lancet"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1671","DOI":"10.1056\/NEJMoa051693","article-title":"Efficacy and safety of corticosteroids for persistent acute respiratory distress syndrome","volume":"354","author":"Steinberg","year":"2006","journal-title":"N Engl J Med"},{"key":"B5","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1016\/S0140-6736(07)61383-X","article-title":"From COPD to chronic systemic inflammatory syndrome?","volume":"370","author":"Fabbri","year":"2007","journal-title":"Lancet"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1334","DOI":"10.1183\/09031936.00018908","article-title":"Multifaceted mechanisms in COPD: inflammation, immunity, and tissue repair and destruction","volume":"31","author":"Chung","year":"2008","journal-title":"Eur Respir J"},{"key":"B7","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1046\/j.1440-1711.2001.01020.x","article-title":"Macrophage-neutrophil interaction: a paradigm for chronic inflammation revisited","volume":"79","author":"Lefkowitz","year":"2001","journal-title":"Immunol Cell Biol"},{"key":"B8","first-page":"1743","article-title":"Macrophage-lymphocyte interaction and antigen recognition","volume":"34","author":"Rosenthal","year":"1975","journal-title":"Fed Proc"},{"key":"B9","doi-asserted-by":"publisher","first-page":"91","DOI":"10.5114\/wo.2017.68616","article-title":"Crosstalk between mesenchymal stem cells and macrophages in inflammatory bowel disease and associated colorectal cancer","volume":"21","author":"Mao","year":"2017","journal-title":"Contemp Oncol (Pozn)"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1249288","DOI":"10.1126\/science.1249288","article-title":"Microbiota-dependent crosstalk between macrophages and ILC3 promotes intestinal homeostasis","volume":"343","author":"Mortha","year":"2014","journal-title":"Science"},{"key":"B11","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1038\/ni.3045","article-title":"Respiratory epithelial cells orchestrate pulmonary innate immunity","volume":"16","author":"Whitsett","year":"2015","journal-title":"Nat Immunol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1038\/ni.1944","article-title":"IL-37 is a fundamental inhibitor of innate immunity","volume":"11","author":"Nold","year":"2010","journal-title":"Nat Immunol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1007\/978-1-62703-125-7_10","article-title":"Isolation and culture of alveolar epithelial type I and type II cells from rat lungs","volume":"945","author":"Gonzalez","year":"2013","journal-title":"Methods Mol Biol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1016\/0041-008X(88)90051-8","article-title":"The alveolar type II epithelial cell: a multifunctional pneumocyte","volume":"93","author":"Castranova","year":"1988","journal-title":"Toxicol Appl Pharmacol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"2450","DOI":"10.4049\/jimmunol.1200634","article-title":"Type I alveolar epithelial cells mount innate immune responses during pneumococcal pneumonia","volume":"189","author":"Yamamoto","year":"2012","journal-title":"J Immunol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.taap.2011.09.007","article-title":"The innate and adaptive immune response induced by alveolar macrophages exposed to ambient particulate matter","volume":"257","author":"Miyata","year":"2011","journal-title":"Toxicol Appl Pharmacol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"491","DOI":"10.3389\/fimmu.2014.00491","article-title":"Macrophage cytokines: involvement in immunity and infectious diseases","volume":"5","author":"Arango Duque","year":"2014","journal-title":"Front Immunol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"435","DOI":"10.3389\/fimmu.2014.00435","article-title":"Role of alveolar macrophages in chronic obstructive pulmonary disease","volume":"5","author":"Vlahos","year":"2014","journal-title":"Front Immunol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/1471-2466-4-6","article-title":"The clinical significance of serum and bronchoalveolar lavage inflammatory cytokines in patients at risk for acute respiratory distress syndrome","volume":"4","author":"Bouros","year":"2004","journal-title":"BMC Pulm Med"},{"key":"B20","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1111\/cei.12157","article-title":"Macrophages promote epithelial repair through hepatocyte growth factor secretion","volume":"174","author":"D\u2019Angelo","year":"2013","journal-title":"Clin Exp Immunol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1165\/ajrcmb.26.4.4749","article-title":"Lung macrophage-epithelial cell interactions amplify particle-mediated cytokine release","volume":"26","author":"Tao","year":"2002","journal-title":"Am J Respir Cell Mol Biol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1566","DOI":"10.1172\/JCI83931","article-title":"Macrophage-epithelial paracrine crosstalk inhibits lung edema clearance during influenza infection","volume":"126","author":"Peteranderl","year":"2016","journal-title":"J Clin Invest"},{"key":"B23","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1126\/science.313.5789.901a","article-title":"Clinical research. Lessons from a failed drug trial","volume":"313","author":"Marshall","year":"2006","journal-title":"Science"},{"key":"B24","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0021-9258(17)34997-9","article-title":"The biological significance of the thromboplastic protein of blood","volume":"166","author":"Chargaff","year":"1946","journal-title":"J Biol Chem"},{"key":"B25","doi-asserted-by":"publisher","first-page":"27066","DOI":"10.3402\/jev.v4.27066","article-title":"Biological properties of extracellular vesicles and their physiological functions","volume":"4","author":"Yanez-Mo","year":"2015","journal-title":"J Extracell Vesicles"},{"key":"B26","doi-asserted-by":"publisher","first-page":"20677","DOI":"10.3402\/jev.v2i0.20677","article-title":"Distinct RNA profiles in subpopulations of extracellular vesicles: apoptotic bodies, microvesicles and exosomes","volume":"2","author":"Crescitelli","year":"2013","journal-title":"J Extracell Vesicles"},{"key":"B27","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1016\/j.devcel.2011.08.019","article-title":"The tetraspanin CD63 regulates ESCRT-independent and -dependent endosomal sorting during melanogenesis","volume":"21","author":"van Niel","year":"2011","journal-title":"Dev Cell"},{"key":"B28","doi-asserted-by":"publisher","first-page":"5553","DOI":"10.1242\/jcs.128868","article-title":"Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles","volume":"126","author":"Colombo","year":"2013","journal-title":"J Cell Sci"},{"key":"B29","doi-asserted-by":"publisher","first-page":"442","DOI":"10.3389\/fimmu.2014.00442","article-title":"Tetraspanins in extracellular vesicle formation and function","volume":"5","author":"Andreu","year":"2014","journal-title":"Front Immunol"},{"key":"B30","doi-asserted-by":"publisher","first-page":"C237","DOI":"10.1152\/ajpcell.00091.2003","article-title":"What is the role of SNARE proteins in membrane fusion?","volume":"285","author":"Duman","year":"2003","journal-title":"Am J Physiol Cell Physiol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1146\/annurev.cellbio.23.090506.123319","article-title":"Biogenesis and function of multivesicular bodies","volume":"23","author":"Piper","year":"2007","journal-title":"Annu Rev Cell Dev Biol"},{"key":"B32","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.1016\/j.bbamem.2008.03.007","article-title":"How lipid flippases can modulate membrane structure","volume":"1778","author":"Devaux","year":"2008","journal-title":"Biochim Biophys Acta"},{"key":"B33","doi-asserted-by":"publisher","first-page":"R988","DOI":"10.1016\/j.cub.2011.11.009","article-title":"Extracellular vesicles: budding regulated by a phosphatidylethanolamine translocase","volume":"21","author":"Tuck","year":"2011","journal-title":"Curr Biol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"1519","DOI":"10.4049\/jimmunol.181.2.1519","article-title":"Exosomes from bronchoalveolar fluid of tolerized mice prevent allergic reaction","volume":"181","author":"Prado","year":"2008","journal-title":"J Immunol"},{"key":"B35","doi-asserted-by":"publisher","first-page":"16070","DOI":"10.18632\/oncotarget.7445","article-title":"Podoplanin is a component of extracellular vesicles that reprograms cell-derived exosomal proteins and modulates lymphatic vessel formation","volume":"7","author":"Carrasco-Ramirez","year":"2016","journal-title":"Oncotarget"},{"key":"B36","doi-asserted-by":"publisher","first-page":"26166","DOI":"10.3402\/jev.v4.26166","article-title":"Lung-derived exosome uptake into and epigenetic modulation of marrow progenitor\/stem and differentiated cells","volume":"4","author":"Aliotta","year":"2015","journal-title":"J Extracell Vesicles"},{"key":"B37","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.4049\/jimmunol.1700165","article-title":"Lung epithelial cell-derived microvesicles regulate macrophage migration via MicroRNA-17\/221-induced integrin beta1 recycling","volume":"199","author":"Lee","year":"2017","journal-title":"J Immunol"},{"key":"B38","doi-asserted-by":"publisher","first-page":"1875","DOI":"10.1016\/j.cub.2009.09.059","article-title":"ARF6-regulated shedding of tumor cell-derived plasma membrane microvesicles","volume":"19","author":"Muralidharan-Chari","year":"2009","journal-title":"Curr Biol"},{"key":"B39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11060-013-1084-8","article-title":"Biogenesis of extracellular vesicles (EV): exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies","volume":"113","author":"Akers","year":"2013","journal-title":"J Neurooncol"},{"key":"B40","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1016\/j.jmb.2015.09.019","article-title":"ExoCarta: a web-based compendium of exosomal cargo","volume":"428","author":"Keerthikumar","year":"2016","journal-title":"J Mol Biol"},{"key":"B41","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1038\/nrm3335","article-title":"Intercellular communication: diverse structures for exchange of genetic information","volume":"13","author":"Mittelbrunn","year":"2012","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B42","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1177\/1947601913499020","article-title":"Extracellular vesicle-mediated transfer of a novel long noncoding RNA TUC339: a mechanism of intercellular signaling in human hepatocellular cancer","volume":"4","author":"Kogure","year":"2013","journal-title":"Genes Cancer"},{"key":"B43","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/1745-6150-8-12","article-title":"Exosomes secreted by human cells transport largely mRNA fragments that are enriched in the 3\u2019-untranslated regions","volume":"8","author":"Batagov","year":"2013","journal-title":"Biol Direct"},{"key":"B44","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1101\/gr.089367.108","article-title":"New class of microRNA targets containing simultaneous 5\u2019-UTR and 3\u2019-UTR interaction sites","volume":"19","author":"Lee","year":"2009","journal-title":"Genome Res"},{"key":"B45","doi-asserted-by":"publisher","first-page":"14888","DOI":"10.1073\/pnas.1408301111","article-title":"Quantitative and stoichiometric analysis of the microRNA content of exosomes","volume":"111","author":"Chevillet","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B46","doi-asserted-by":"publisher","first-page":"1712","DOI":"10.1093\/infdis\/jiu676","article-title":"Association of cytokines with exosomes in the plasma of HIV-1-seropositive individuals","volume":"211","author":"Konadu","year":"2015","journal-title":"J Infect Dis"},{"key":"B47","doi-asserted-by":"publisher","first-page":"23743","DOI":"10.3402\/jev.v3.23743","article-title":"Exosomes provide a protective and enriched source of miRNA for biomarker profiling compared to intracellular and cell-free blood","volume":"3","author":"Cheng","year":"2014","journal-title":"J Extracell Vesicles"},{"key":"B48","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.ijpharm.2017.02.038","article-title":"Exosomes as novel bio-carriers for gene and drug delivery","volume":"521","author":"Jiang","year":"2017","journal-title":"Int J Pharm"},{"key":"B49","doi-asserted-by":"publisher","first-page":"1699","DOI":"10.1002\/bit.25307","article-title":"Co-opting biology to deliver drugs","volume":"111","author":"Yousefpour","year":"2014","journal-title":"Biotechnol Bioeng"},{"key":"B50","doi-asserted-by":"publisher","first-page":"3354","DOI":"10.1002\/pmic.201300282","article-title":"Comparative proteomics evaluation of plasma exosome isolation techniques and assessment of the stability of exosomes in normal human blood plasma","volume":"13","author":"Kalra","year":"2013","journal-title":"Proteomics"},{"key":"B51","doi-asserted-by":"publisher","first-page":"657086","DOI":"10.1155\/2015\/657086","article-title":"Exosomes: novel biomarkers for clinical diagnosis","volume":"2015","author":"Lin","year":"2015","journal-title":"ScientificWorldJournal"},{"key":"B52","doi-asserted-by":"publisher","first-page":"769","DOI":"10.2217\/bmm.13.63","article-title":"Exosomes: the future of biomarkers in medicine","volume":"7","author":"Properzi","year":"2013","journal-title":"Biomark Med"},{"key":"B53","doi-asserted-by":"publisher","first-page":"6","DOI":"10.3389\/fimmu.2015.00006","article-title":"Urinary extracellular vesicles as source of biomarkers in kidney diseases","volume":"6","author":"Gamez-Valero","year":"2015","journal-title":"Front Immunol"},{"key":"B54","doi-asserted-by":"publisher","first-page":"267","DOI":"10.3389\/fonc.2014.00267","article-title":"Extracellular vesicles as shuttles of tumor biomarkers and anti-tumor drugs","volume":"4","author":"Zocco","year":"2014","journal-title":"Front Oncol"},{"key":"B55","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/1471-2121-14-23","article-title":"Circulating microparticles: square the circle","volume":"14","author":"Barteneva","year":"2013","journal-title":"BMC Cell Biol"},{"key":"B56","doi-asserted-by":"publisher","first-page":"527","DOI":"10.2147\/COPD.S99547","article-title":"Microparticles in sputum of COPD patients: a potential biomarker of the disease?","volume":"11","author":"Lacedonia","year":"2016","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"key":"B57","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1111\/vox.12092","article-title":"The effect of platelet-derived microparticles in stored apheresis platelet concentrates on polymorphonuclear leucocyte respiratory burst","volume":"106","author":"Xie","year":"2014","journal-title":"Vox Sang"},{"key":"B58","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1016\/j.jamcollsurg.2011.12.032","article-title":"Microparticles from stored red blood cells activate neutrophils and cause lung injury after hemorrhage and resuscitation","volume":"214","author":"Belizaire","year":"2012","journal-title":"J Am Coll Surg"},{"key":"B59","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1111\/trf.12952","article-title":"Platelet-derived microparticles induce polymorphonuclear leukocyte-mediated damage of human pulmonary microvascular endothelial cells","volume":"55","author":"Xie","year":"2015","journal-title":"Transfusion"},{"key":"B60","doi-asserted-by":"publisher","first-page":"1494","DOI":"10.1183\/09031936.00023310","article-title":"Role of NF-kappaB and PPAR-gamma in lung inflammation induced by monocyte-derived microparticles","volume":"37","author":"Neri","year":"2011","journal-title":"Eur Respir J"},{"key":"B61","doi-asserted-by":"publisher","first-page":"L1035","DOI":"10.1152\/ajplung.00214.2009","article-title":"Procoagulant alveolar microparticles in the lungs of patients with acute respiratory distress syndrome","volume":"297","author":"Bastarache","year":"2009","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"B62","doi-asserted-by":"publisher","first-page":"e2016","DOI":"10.1038\/cddis.2015.282","article-title":"Lung epithelial cell-derived extracellular vesicles activate macrophage-mediated inflammatory responses via ROCK1 pathway","volume":"6","author":"Moon","year":"2015","journal-title":"Cell Death Dis"},{"key":"B63","doi-asserted-by":"publisher","first-page":"35250","DOI":"10.1038\/srep35250","article-title":"Epithelial cell-derived microvesicles activate macrophages and promote inflammation via microvesicle-containing microRNAs","volume":"6","author":"Lee","year":"2016","journal-title":"Sci Rep"},{"key":"B64","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1136\/thoraxjnl-2015-208032","article-title":"Alveolar macrophage-derived microvesicles mediate acute lung injury","volume":"71","author":"Soni","year":"2016","journal-title":"Thorax"},{"key":"B65","doi-asserted-by":"publisher","first-page":"1286","DOI":"10.1038\/nm1494","article-title":"Hyperoxia causes angiopoietin 2-mediated acute lung injury and necrotic cell death","volume":"12","author":"Bhandari","year":"2006","journal-title":"Nat Med"},{"key":"B66","doi-asserted-by":"publisher","first-page":"1812","DOI":"10.1172\/JCI116056","article-title":"Inhibition of lung epithelial cell proliferation by hyperoxia. Posttranscriptional regulation of proliferation-related genes","volume":"90","author":"Clement","year":"1992","journal-title":"J Clin Invest"},{"key":"B67","doi-asserted-by":"publisher","first-page":"6098","DOI":"10.1073\/pnas.1031851100","article-title":"Inducible expression of keratinocyte growth factor (KGF) in mice inhibits lung epithelial cell death induced by hyperoxia","volume":"100","author":"Ray","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B68","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1172\/JCI9674","article-title":"IL-13 stimulates vascular endothelial cell growth factor and protects against hyperoxic acute lung injury","volume":"106","author":"Corne","year":"2000","journal-title":"J Clin Invest"},{"key":"B69","doi-asserted-by":"publisher","first-page":"L379","DOI":"10.1152\/ajplung.00010.2008","article-title":"Animal models of acute lung injury","volume":"295","author":"Matute-Bello","year":"2008","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"B70","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.1189\/jlb.3A1116-483R","article-title":"Macrophage-derived apoptotic bodies promote the proliferation of the recipient cells via shuttling microRNA-221\/222","volume":"101","author":"Zhu","year":"2017","journal-title":"J Leukoc Biol"},{"key":"B71","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1038\/ncomms1180","article-title":"Tumour microvesicles contain retrotransposon elements and amplified oncogene sequences","volume":"2","author":"Balaj","year":"2011","journal-title":"Nat Commun"},{"key":"B72","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1016\/j.jaci.2012.12.1565","article-title":"Proinflammatory role of epithelial cell-derived exosomes in allergic airway inflammation","volume":"131","author":"Kulshreshtha","year":"2013","journal-title":"J Allergy Clin Immunol"},{"key":"B73","doi-asserted-by":"publisher","first-page":"31596","DOI":"10.1038\/srep31596","article-title":"Structural and functional characterization of endothelial microparticles released by cigarette smoke","volume":"6","author":"Serban","year":"2016","journal-title":"Sci Rep"},{"key":"B74","doi-asserted-by":"publisher","first-page":"28388","DOI":"10.3402\/jev.v4.28388","article-title":"Suppression of autophagy by extracellular vesicles promotes myofibroblast differentiation in COPD pathogenesis","volume":"4","author":"Fujita","year":"2015","journal-title":"J Extracell Vesicles"},{"key":"B75","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1136\/thoraxjnl-2011-201395","article-title":"Increased circulating endothelial microparticles in COPD patients: a potential biomarker for COPD exacerbation susceptibility","volume":"67","author":"Takahashi","year":"2012","journal-title":"Thorax"},{"key":"B76","doi-asserted-by":"publisher","first-page":"1801","DOI":"10.3390\/ijms17111801","article-title":"Extracellular vesicles in chronic obstructive pulmonary disease","volume":"17","author":"Kadota","year":"2016","journal-title":"Int J Mol Sci"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2018.00924\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,21]],"date-time":"2022-08-21T10:00:37Z","timestamp":1661076037000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2018.00924\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,30]]},"references-count":76,"alternative-id":["10.3389\/fimmu.2018.00924"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2018.00924","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,30]]},"article-number":"924"}}