{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:42:43Z","timestamp":1792172563888,"version":"4.4.0"},"reference-count":67,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,5,8]],"date-time":"2018-05-08T00:00:00Z","timestamp":1525737600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI097403, AI057229"],"award-info":[{"award-number":["AI097403, AI057229"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005567","name":"H. Lee Moffitt Cancer Center and Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005567","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000890","name":"National Multiple Sclerosis Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000890","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2018.00976","type":"journal-article","created":{"date-parts":[[2018,5,8]],"date-time":"2018-05-08T12:52:16Z","timestamp":1525783936000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":75,"title":["VDJServer: A Cloud-Based Analysis Portal and Data Commons for Immune Repertoire Sequences and Rearrangements"],"prefix":"10.3389","volume":"9","author":[{"given":"Scott","family":"Christley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Scarborough","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eddie","family":"Salinas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William H.","family":"Rounds","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inimary T.","family":"Toby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Fonner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikhail K.","family":"Levin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen A.","family":"Mock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Jordan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jared","family":"Ostmeyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Buntzman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Rubelt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco L.","family":"Davila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy L.","family":"Monson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard H.","family":"Scheuermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay G.","family":"Cowell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,5,8]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1038\/302575a0","article-title":"Somatic generation of antibody diversity","volume":"302","author":"Tonegawa","year":"1983","journal-title":"Nature"},{"key":"B2","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1111\/j.1600-065X.1988.tb00763.x","article-title":"The dynamic nature of the antibody repertoire","volume":"105","author":"Berek","year":"1988","journal-title":"Immunol Rev"},{"key":"B3","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.jtbi.2015.10.016","article-title":"How many TCR clonotypes does a body maintain?","volume":"389","author":"Lythe","year":"2016","journal-title":"J Theor Biol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1101\/gr.115428.110","article-title":"Exhaustive T-cell repertoire sequencing of human peripheral blood samples reveals signatures of antigen selection and a directly measured repertoire size of at least 1 million clonotypes","volume":"21","author":"Warren","year":"2011","journal-title":"Genome Res"},{"key":"B5","first-page":"xiii","article-title":"The clonal selection theory of acquired immunity","volume-title":"The Abraham Flexner lectures, 1958","author":"Burnet","year":"1959"},{"key":"B6","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/j.coi.2010.06.011","article-title":"Immune memory and aging: an infinite or finite resource?","volume":"22","author":"Nikolich-Zugich","year":"2010","journal-title":"Curr Opin Immunol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"2689","DOI":"10.4049\/jimmunol.1302064","article-title":"Age-related decrease in TCR repertoire diversity measured with deep and normalized sequence profiling","volume":"192","author":"Britanova","year":"2014","journal-title":"J Immunol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1038\/ni.3328","article-title":"Adjuvanted influenza-H1N1 vaccination reveals lymphoid signatures of age-dependent early responses and of clinical adverse events","volume":"17","author":"Sobolev","year":"2016","journal-title":"Nat Immunol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"E4088","DOI":"10.1073\/pnas.1306262110","article-title":"De novo identification of VRC01 class HIV-1-neutralizing antibodies by next-generation sequencing of B-cell transcripts","volume":"110","author":"Zhu","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B10","doi-asserted-by":"publisher","first-page":"20842","DOI":"10.1038\/srep20842","article-title":"IGHV1-69 polymorphism modulates anti-influenza antibody repertoires, correlates with IGHV utilization shifts and varies by ethnicity","volume":"6","author":"Avnir","year":"2016","journal-title":"Sci Rep"},{"key":"B11","doi-asserted-by":"publisher","first-page":"13926","DOI":"10.1038\/srep13926","article-title":"Facile discovery of a diverse panel of anti-Ebola virus antibodies by immune repertoire mining","volume":"5","author":"Wang","year":"2015","journal-title":"Sci Rep"},{"key":"B12","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1186\/s13073-016-0314-z","article-title":"Statistical inference of a convergent antibody repertoire response to influenza vaccine","volume":"8","author":"Strauli","year":"2016","journal-title":"Genome Med"},{"key":"B13","doi-asserted-by":"publisher","first-page":"26556","DOI":"10.1038\/srep26556","article-title":"Network signatures of IgG immune repertoires in hepatitis B associated chronic infection and vaccination responses","volume":"6","author":"Chang","year":"2016","journal-title":"Sci Rep"},{"key":"B14","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.gene.2015.07.011","article-title":"MSPrecise: a molecular diagnostic test for multiple sclerosis using next generation sequencing","volume":"572","author":"Rounds","year":"2015","journal-title":"Gene"},{"key":"B15","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/j.clim.2015.06.001","article-title":"Intrathecal BCR transcriptome in multiple sclerosis versus other neuroinflammation: equally diverse and compartmentalized, but more mutated, biased and overlapping with the proteome","volume":"160","author":"Johansen","year":"2015","journal-title":"Clin Immunol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"3439","DOI":"10.1002\/eji.201444662","article-title":"High-throughput sequencing of TCR repertoires in multiple sclerosis reveals intrathecal enrichment of EBV-reactive CD8+ T cells","volume":"44","author":"Lossius","year":"2014","journal-title":"Eur J Immunol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"R135","DOI":"10.1186\/ar2553","article-title":"Collagen-specific T-cell repertoire in blood and synovial fluid varies with disease activity in early rheumatoid arthritis","volume":"10","author":"Ria","year":"2008","journal-title":"Arthritis Res Ther"},{"key":"B18","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1186\/s13075-015-0655-9","article-title":"Longitudinal analysis of peripheral blood T cell receptor diversity in patients with systemic lupus erythematosus by next-generation sequencing","volume":"17","author":"Thapa","year":"2015","journal-title":"Arthritis Res Ther"},{"key":"B19","doi-asserted-by":"publisher","first-page":"21194","DOI":"10.1073\/pnas.1118357109","article-title":"High-throughput VDJ sequencing for quantification of minimal residual disease in chronic lymphocytic leukemia and immune reconstitution assessment","volume":"108","author":"Logan","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B20","doi-asserted-by":"publisher","first-page":"e0134833","DOI":"10.1371\/journal.pone.0134833","article-title":"High throughput sequencing analysis of the immunoglobulin heavy chain gene from flow-sorted B cell sub-populations define the dynamics of follicular lymphoma clonal evolution","volume":"10","author":"Carlotti","year":"2015","journal-title":"PLoS One"},{"key":"B21","doi-asserted-by":"publisher","first-page":"308ra158","DOI":"10.1126\/scitranslmed.aaa9122","article-title":"TCR sequencing facilitates diagnosis and identifies mature T cells as the cell of origin in CTCL","volume":"7","author":"Kirsch","year":"2015","journal-title":"Sci Transl Med"},{"key":"B22","doi-asserted-by":"publisher","first-page":"3073","DOI":"10.1182\/blood-2014-01-550020","article-title":"Prognostic value of deep sequencing method for minimal residual disease detection in multiple myeloma","volume":"123","author":"Martinez-Lopez","year":"2014","journal-title":"Blood"},{"key":"B23","doi-asserted-by":"publisher","first-page":"3679","DOI":"10.1182\/blood-2015-03-635169","article-title":"Noninvasive monitoring of diffuse large B-cell lymphoma by immunoglobulin high-throughput sequencing","volume":"125","author":"Kurtz","year":"2015","journal-title":"Blood"},{"key":"B24","doi-asserted-by":"publisher","first-page":"214ra169","DOI":"10.1126\/scitranslmed.3007247","article-title":"Digital genomic quantification of tumor-infiltrating lymphocytes","volume":"5","author":"Robins","year":"2013","journal-title":"Sci Transl Med"},{"key":"B25","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s40425-015-0070-4","article-title":"Peripheral T cell receptor diversity is associated with clinical outcomes following ipilimumab treatment in metastatic melanoma","volume":"3","author":"Postow","year":"2015","journal-title":"J Immunother Cancer"},{"key":"B26","doi-asserted-by":"publisher","first-page":"e1001230","DOI":"10.1080\/2162402X.2014.1001230","article-title":"Diversity index of mucosal resident T lymphocyte repertoire predicts clinical prognosis in gastric cancer","volume":"4","author":"Jia","year":"2015","journal-title":"Oncoimmunology"},{"key":"B27","doi-asserted-by":"publisher","first-page":"3818","DOI":"10.1158\/1078-0432.CCR-13-3368","article-title":"Prognostic B-cell signatures using mRNA-seq in patients with subtype-specific breast and ovarian cancer","volume":"20","author":"Iglesia","year":"2014","journal-title":"Clin Cancer Res"},{"key":"B28","doi-asserted-by":"publisher","first-page":"e1021537","DOI":"10.1080\/2162402X.2015.1021537","article-title":"Identification of characteristic TRB V usage in HBV-associated HCC by using differential expression profiling analysis","volume":"4","author":"Han","year":"2015","journal-title":"Oncoimmunology"},{"key":"B29","doi-asserted-by":"publisher","first-page":"2424","DOI":"10.1158\/1078-0432.CCR-13-2648","article-title":"CTLA4 blockade broadens the peripheral T-cell receptor repertoire","volume":"20","author":"Robert","year":"2014","journal-title":"Clin Cancer Res"},{"key":"B30","doi-asserted-by":"publisher","first-page":"e26615","DOI":"10.4161\/onci.26615","article-title":"BRAF inhibition is associated with increased clonality in tumor-infiltrating lymphocytes","volume":"2","author":"Cooper","year":"2013","journal-title":"Oncoimmunology"},{"key":"B31","doi-asserted-by":"publisher","first-page":"4955","DOI":"10.1182\/blood-2013-03-489757","article-title":"A distinct evolution of the T-cell repertoire categorizes treatment refractory gastrointestinal acute graft-versus-host disease","volume":"121","author":"Meyer","year":"2013","journal-title":"Blood"},{"key":"B32","doi-asserted-by":"publisher","first-page":"272ra10","DOI":"10.1126\/scitranslmed.3010760","article-title":"Tracking donor-reactive T cells: evidence for clonal deletion in tolerant kidney transplant patients","volume":"7","author":"Morris","year":"2015","journal-title":"Sci Transl Med"},{"key":"B33","doi-asserted-by":"publisher","first-page":"e1001890","DOI":"10.1371\/journal.pmed.1001890","article-title":"Monitoring pharmacologically induced immunosuppression by immune repertoire sequencing to detect acute allograft rejection in heart transplant patients: a proof-of-concept diagnostic accuracy study","volume":"12","author":"Vollmers","year":"2015","journal-title":"PLoS Med"},{"key":"B34","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1186\/s13073-015-0169-8","article-title":"A bioinformatic framework for immune repertoire diversity profiling enables detection of immunological status","volume":"7","author":"Greiff","year":"2015","journal-title":"Genome Med"},{"key":"B35","doi-asserted-by":"publisher","first-page":"4099","DOI":"10.1182\/blood-2009-04-217604","article-title":"Comprehensive assessment of T-cell receptor beta-chain diversity in alphabeta T cells","volume":"114","author":"Robins","year":"2009","journal-title":"Blood"},{"key":"B36","doi-asserted-by":"publisher","first-page":"20216","DOI":"10.1073\/pnas.0909775106","article-title":"Precise determination of the diversity of a combinatorial antibody library gives insight into the human immunoglobulin repertoire","volume":"106","author":"Glanville","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B37","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1126\/science.1170020","article-title":"High-throughput sequencing of the zebrafish antibody repertoire","volume":"324","author":"Weinstein","year":"2009","journal-title":"Science"},{"key":"B38","doi-asserted-by":"publisher","first-page":"1817","DOI":"10.1101\/gr.092924.109","article-title":"Profiling the T-cell receptor beta-chain repertoire by massively parallel sequencing","volume":"19","author":"Freeman","year":"2009","journal-title":"Genome Res"},{"key":"B39","doi-asserted-by":"publisher","first-page":"12ra23","DOI":"10.1126\/scitranslmed.3000540","article-title":"Measurement and clinical monitoring of human lymphocyte clonality by massively parallel VDJ pyrosequencing","volume":"1","author":"Boyd","year":"2009","journal-title":"Sci Transl Med"},{"key":"B40","doi-asserted-by":"publisher","first-page":"1418","DOI":"10.3389\/fimmu.2017.01418","article-title":"Reproducibility and reuse of adaptive immune receptor repertoire data","volume":"8","author":"Breden","year":"2017","journal-title":"Front Immunol"},{"key":"B41","doi-asserted-by":"publisher","first-page":"1274","DOI":"10.1038\/ni.3873","article-title":"Adaptive Immune Receptor Repertoire Community recommendations for sharing immune-repertoire sequencing data","volume":"18","author":"Rubelt","year":"2017","journal-title":"Nat Immunol"},{"key":"B42","doi-asserted-by":"publisher","first-page":"W34","DOI":"10.1093\/nar\/gkt382","article-title":"IgBLAST: an immunoglobulin variable domain sequence analysis tool","volume":"41","author":"Ye","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"B43","doi-asserted-by":"publisher","first-page":"2333","DOI":"10.1038\/ncomms3333","article-title":"IMGT\/HighV QUEST paradigm for T cell receptor IMGT clonotype diversity and next generation repertoire immunoprofiling","volume":"4","author":"Li","year":"2013","journal-title":"Nat Commun"},{"key":"B44","doi-asserted-by":"publisher","first-page":"26","DOI":"10.4172\/1745-7580.1000056","article-title":"IMGT\/HighV-QUEST: the IMGT web portal for immunoglobulin (Ig) or antibody and T cell receptor (TR) analysis from NGS high throughput and deep sequencing","volume":"8","author":"Alamyar","year":"2012","journal-title":"Immun Res"},{"key":"B45","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1101\/pdb.prot5633","article-title":"IMGT\/V-QUEST: IMGT standardized analysis of the immunoglobulin (IG) and T cell receptor (TR) nucleotide sequences","volume":"2011","author":"Giudicelli","year":"2011","journal-title":"Cold Spring Harb Protoc"},{"key":"B46","doi-asserted-by":"publisher","first-page":"i379","DOI":"10.1093\/bioinformatics\/bth945","article-title":"IMGT\/Junction Analysis: the first tool for the analysis of the immunoglobulin and T cell receptor complex V-J and V-D-J JUNCTIONs","volume":"20","author":"Yousfi Monod","year":"2004","journal-title":"Bioinformatics"},{"key":"B47","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1101\/pdb.prot5634","article-title":"IMGT\/JunctionAnalysis: IMGT standardized analysis of the V-J and V-D-J junctions of the rearranged immunoglobulins (IG) and T cell receptors (TR)","volume":"2011","author":"Giudicelli","year":"2011","journal-title":"Cold Spring Harb Protoc"},{"key":"B48","doi-asserted-by":"publisher","first-page":"e0166126","DOI":"10.1371\/journal.pone.0166126","article-title":"Vidjil: a web platform for analysis of high-throughput repertoire sequencing","volume":"11","author":"Duez","year":"2016","journal-title":"PLoS One"},{"key":"B49","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1093\/bioinformatics\/btt593","article-title":"PEAR: a fast and accurate Illumina Paired-End reAd mergeR","volume":"30","author":"Zhang","year":"2014","journal-title":"Bioinformatics"},{"key":"B50","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1038\/nmeth.3364","article-title":"MiXCR: software for comprehensive adaptive immunity profiling","volume":"12","author":"Bolotin","year":"2015","journal-title":"Nat Methods"},{"key":"B51","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1186\/s12865-014-0059-7","article-title":"ImmunoGlobulin galaxy (IGGalaxy) for simple determination and quantitation of immunoglobulin heavy chain rearrangements from NGS","volume":"15","author":"Moorhouse","year":"2014","journal-title":"BMC Immunol"},{"key":"B52","doi-asserted-by":"publisher","first-page":"4156","DOI":"10.4049\/jimmunol.1601921","article-title":"Antigen receptor galaxy: a user-friendly, web-based tool for analysis and visualization of T and B cell receptor repertoire data","volume":"198","author":"IJspeert","year":"2017","journal-title":"J Immunol"},{"key":"B53","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.1101\/gr.4086505","article-title":"Galaxy: a platform for interactive large-scale genome analysis","volume":"15","author":"Giardine","year":"2005","journal-title":"Genome Res"},{"key":"B54","doi-asserted-by":"publisher","first-page":"3356","DOI":"10.1093\/bioinformatics\/btv359","article-title":"Change-O: a toolkit for analyzing large-scale B cell immunoglobulin repertoire sequencing data","volume":"31","author":"Gupta","year":"2015","journal-title":"Bioinformatics"},{"key":"B55","doi-asserted-by":"publisher","first-page":"e134","DOI":"10.1093\/nar\/gks457","article-title":"Quantifying selection in high-throughput immunoglobulin sequencing data sets","volume":"40","author":"Yaari","year":"2012","journal-title":"Nucleic Acids Res"},{"key":"B56","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1093\/bioinformatics\/btw593","article-title":"ImmuneDB: a system for the analysis and exploration of high-throughput adaptive immune receptor sequencing data","volume":"33","author":"Rosenfeld","year":"2017","journal-title":"Bioinformatics"},{"key":"B57","doi-asserted-by":"publisher","first-page":"1930","DOI":"10.1093\/bioinformatics\/btu138","article-title":"pRESTO: a toolkit for processing high-throughput sequencing raw reads of lymphocyte receptor repertoires","volume":"30","author":"Vander Heiden","year":"2014","journal-title":"Bioinformatics"},{"key":"B58","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.jim.2015.10.009","article-title":"Discrimination of germline V genes at different sequencing lengths and mutational burdens: a new tool for identifying and evaluating the reliability of V gene assignment","volume":"427","author":"Zhang","year":"2015","journal-title":"J Immunol Methods"},{"key":"B59","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/s13742-016-0135-4","article-title":"Tools and techniques for computational reproducibility","volume":"5","author":"Piccolo","year":"2016","journal-title":"Gigascience"},{"key":"B60","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1038\/nrg3305","article-title":"Next-generation sequencing data interpretation: enhancing reproducibility and accessibility","volume":"13","author":"Nekrutenko","year":"2012","journal-title":"Nat Rev Genet"},{"key":"B61","article-title":"Software-as-a-service: the iPlant Foundation API","author":"Dooley","year":"2012"},{"key":"B62","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1186\/s12859-017-1853-z","article-title":"VDJPipe: a pipelined tool for pre-processing immune repertoire sequencing data","volume":"18","author":"Christley","year":"2017","journal-title":"BMC Bioinformatics"},{"key":"B63","doi-asserted-by":"publisher","first-page":"D413","DOI":"10.1093\/nar\/gku1056","article-title":"IMGT(R), the international ImMunoGeneTics information system(R) 25 years on","volume":"43","author":"Lefranc","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"B64","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1186\/s12859-016-1214-3","article-title":"VDJML: a file format with tools for capturing the results of inferring immune receptor rearrangements","volume":"17","author":"Toby","year":"2016","journal-title":"BMC Bioinformatics"},{"key":"B65","doi-asserted-by":"publisher","first-page":"160018","DOI":"10.1038\/sdata.2016.18","article-title":"The FAIR Guiding Principles for scientific data management and stewardship","volume":"3","author":"Wilkinson","year":"2016","journal-title":"Sci Data"},{"key":"B66","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1186\/s12859-017-1814-6","article-title":"Statistical classifiers for diagnosing disease from immune repertoires: a case study using multiple sclerosis","volume":"18","author":"Ostmeyer","year":"2017","journal-title":"BMC Bioinformatics"},{"key":"B67","doi-asserted-by":"publisher","first-page":"5009","DOI":"10.1073\/pnas.1100551108","article-title":"Prospective separation of normal and leukemic stem cells based on differential expression of TIM3, a human acute myeloid leukemia stem cell marker","volume":"108","author":"Jan","year":"2011","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2018.00976\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,5,8]],"date-time":"2018-05-08T12:52:24Z","timestamp":1525783944000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2018.00976\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,8]]},"references-count":67,"alternative-id":["10.3389\/fimmu.2018.00976"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2018.00976","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,8]]},"article-number":"976"}}