{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T12:30:22Z","timestamp":1781008222078,"version":"3.54.1"},"reference-count":62,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,5,7]],"date-time":"2018-05-07T00:00:00Z","timestamp":1525651200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003074","name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["PICT 2013-0162 and 2014-1925"],"award-info":[{"award-number":["PICT 2013-0162 and 2014-1925"]}],"id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002923","name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","doi-asserted-by":"publisher","award":["PIP 0373"],"award-info":[{"award-number":["PIP 0373"]}],"id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005363","name":"Universidad de Buenos Aires","doi-asserted-by":"publisher","award":["20020130200030, 20020120100128"],"award-info":[{"award-number":["20020130200030, 20020120100128"]}],"id":[{"id":"10.13039\/501100005363","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006449","name":"Fundaci\u00f3n Alberto J. Roemmers","doi-asserted-by":"publisher","award":["2015\u20132017"],"award-info":[{"award-number":["2015\u20132017"]}],"id":[{"id":"10.13039\/501100006449","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2018.01000","type":"journal-article","created":{"date-parts":[[2018,5,7]],"date-time":"2018-05-07T08:48:39Z","timestamp":1525682919000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":18,"title":["Platelets Promote Brucella abortus Monocyte Invasion by Establishing Complexes With Monocytes"],"prefix":"10.3389","volume":"9","author":[{"given":"Aldana","family":"Trotta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lis N.","family":"Vel\u00e1squez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Ayel\u00e9n","family":"Milillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Victoria","family":"Delpino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana M.","family":"Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ver\u00f3nica I.","family":"Landoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo H.","family":"Giambartolomei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto G.","family":"Pozner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Barrionuevo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,5,7]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1093\/clinids\/5.5.821","article-title":"Human brucellosis","volume":"5","author":"Young","year":"1983","journal-title":"Rev Infect Dis"},{"key":"B2","volume-title":"Enfermedades Infecciosas: Brucelosis","author":"Moral","year":"2013"},{"key":"B3","doi-asserted-by":"publisher","first-page":"18","DOI":"10.2174\/1574891X11308010005","article-title":"Immunopathology of Brucella infection","volume":"8","author":"Baldi","year":"2013","journal-title":"Recent Pat Antiinfect Drug Discov"},{"key":"B4","first-page":"290","article-title":"Thrombocytopenia in brucellosis: case report and literature review","volume":"97","author":"Sevinc","year":"2005","journal-title":"J Natl Med Assoc"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1093\/clinids\/20.5.1241","article-title":"Characteristics of and risk factors for relapse of brucellosis in humans","volume":"20","author":"Ariza","year":"1995","journal-title":"Clin Infect Dis"},{"key":"B6","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1002\/ajh.21098","article-title":"A multicenter retrospective study defining the clinical and hematological manifestations of brucellosis and pancytopenia in a large series: hematological malignancies, the unusual cause of pancytopenia in patients with brucellosis","volume":"83","author":"Sari","year":"2008","journal-title":"Am J Hematol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1016\/S1473-3099(07)70286-4","article-title":"Human brucellosis","volume":"7","author":"Franco","year":"2007","journal-title":"Lancet Infect Dis"},{"key":"B8","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1128\/IAI.63.2.720-723.1995","article-title":"Differential induction of macrophage-derived cytokines by live and dead intracellular bacteria in vitro","volume":"63","author":"Zhan","year":"1995","journal-title":"Infect Immun"},{"key":"B9","doi-asserted-by":"crossref","first-page":"4899","DOI":"10.1128\/IAI.61.11.4899-4901.1993","article-title":"Endogenous gamma interferon mediates resistance to Brucella abortus infection","volume":"61","author":"Zhan","year":"1993","journal-title":"Infect Immun"},{"key":"B10","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1128\/IAI.63.4.1387-1390.1995","article-title":"Endogenous interleukin-12 is involved in resistance to Brucella abortus infection","volume":"63","author":"Zhan","year":"1995","journal-title":"Infect Immun"},{"key":"B11","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/S0378-1135(02)00223-7","article-title":"The innate immune response against Brucella in humans","volume":"90","author":"Dornand","year":"2002","journal-title":"Vet Microbiol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1016\/j.micinf.2013.05.003","article-title":"Platelets promote bacterial dissemination in a mouse model of streptococcal sepsis","volume":"15","author":"Kahn","year":"2013","journal-title":"Microbes Infect"},{"key":"B13","doi-asserted-by":"publisher","first-page":"4059","DOI":"10.4049\/jimmunol.1201103","article-title":"Activated platelets enhance IL-10 secretion and reduce TNF-alpha secretion by monocytes","volume":"191","author":"Gudbrandsdottir","year":"2013","journal-title":"J Immunol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1111\/jth.12795","article-title":"A novel conditional platelet depletion mouse model reveals the importance of platelets in protection against Staphylococcus aureus bacteremia","volume":"13","author":"Wuescher","year":"2015","journal-title":"J Thromb Haemost"},{"key":"B15","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.2217\/fmb.13.104","article-title":"Platelets as immune cells in infectious diseases","volume":"8","author":"Speth","year":"2013","journal-title":"Future Microbiol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1038\/nri2956","article-title":"Platelets and the immune continuum","volume":"11","author":"Semple","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1182\/blood-2005-06-2202","article-title":"Platelet toll-like receptor expression modulates lipopolysaccharide-induced thrombocytopenia and tumor necrosis factor-alpha production in vivo","volume":"107","author":"Aslam","year":"2006","journal-title":"Blood"},{"key":"B18","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1111\/j.1440-1711.2005.01314.x","article-title":"Evidence of toll-like receptor molecules on human platelets","volume":"83","author":"Cognasse","year":"2005","journal-title":"Immunol Cell Biol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1038\/nrmicro1425","article-title":"The interaction of bacterial pathogens with platelets","volume":"4","author":"Fitzgerald","year":"2006","journal-title":"Nat Rev Microbiol"},{"key":"B20","doi-asserted-by":"publisher","first-page":"2757","DOI":"10.1111\/j.1538-7836.2010.04093.x","article-title":"Invasive Streptococcus pneumoniae trigger platelet activation via toll-like receptor 2","volume":"8","author":"Keane","year":"2010","journal-title":"J Thromb Haemost"},{"key":"B21","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.thromres.2013.11.028","article-title":"Regulation of platelet responses triggered by toll-like receptor 2 and 4 ligands is another non-genomic role of nuclear factor-kappaB","volume":"133","author":"Rivadeneyra","year":"2014","journal-title":"Thromb Res"},{"key":"B22","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.blre.2009.04.001","article-title":"Platelet alpha-granules: basic biology and clinical correlates","volume":"23","author":"Blair","year":"2009","journal-title":"Blood Rev"},{"key":"B23","doi-asserted-by":"publisher","first-page":"1920","DOI":"10.1161\/ATVBAHA.108.169417","article-title":"Platelet chemokines in vascular disease","volume":"28","author":"Gleissner","year":"2008","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"e1002355","DOI":"10.1371\/journal.ppat.1002355","article-title":"Novel anti-bacterial activities of beta-defensin 1 in human platelets: suppression of pathogen growth and signaling of neutrophil extracellular trap formation","volume":"7","author":"Kraemer","year":"2011","journal-title":"PLoS Pathog"},{"key":"B25","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1172\/JCI562","article-title":"Platelet microbicidal proteins and neutrophil defensin disrupt the Staphylococcus aureus cytoplasmic membrane by distinct mechanisms of action","volume":"101","author":"Yeaman","year":"1998","journal-title":"J Clin Invest"},{"key":"B26","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1128\/IAI.65.3.1023-1031.1997","article-title":"Purification and in vitro activities of rabbit platelet microbicidal proteins","volume":"65","author":"Yeaman","year":"1997","journal-title":"Infect Immun"},{"key":"B27","doi-asserted-by":"publisher","first-page":"623","DOI":"10.4049\/jimmunol.167.2.623","article-title":"Cutting edge: IFN-inducible ELR-CXC chemokines display defensin-like antimicrobial activity","volume":"167","author":"Cole","year":"2001","journal-title":"J Immunol"},{"key":"B28","doi-asserted-by":"publisher","first-page":"384685","DOI":"10.1155\/2012\/384685","article-title":"Crosstalk between platelets and the immune system: old systems with new discoveries","volume":"2012","author":"Li","year":"2012","journal-title":"Adv Hematol"},{"key":"B29","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1084\/jem.20112322","article-title":"Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo","volume":"209","author":"von Bruhl","year":"2012","journal-title":"J Exp Med"},{"key":"B30","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.thromres.2012.11.028","article-title":"Platelet-leukocyte crosstalk: linking proinflammatory responses to procoagulant state","volume":"131","author":"Ghasemzadeh","year":"2013","journal-title":"Thromb Res"},{"key":"B31","doi-asserted-by":"publisher","first-page":"830","DOI":"10.2741\/1840","article-title":"Platelet-leukocyte aggregates and derived microparticles in inflammation, vascular remodelling and thrombosis","volume":"11","author":"McGregor","year":"2006","journal-title":"Front Biosci"},{"key":"B32","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/j.chom.2012.06.011","article-title":"Intravascular neutrophil extracellular traps capture bacteria from the bloodstream during sepsis","volume":"12","author":"McDonald","year":"2012","journal-title":"Cell Host Microbe"},{"key":"B33","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1160\/TH11-01-0020","article-title":"Platelets regulate CD4(+) T-cell differentiation via multiple chemokines in humans","volume":"106","author":"Gerdes","year":"2011","journal-title":"Thromb Haemost"},{"key":"B34","doi-asserted-by":"publisher","first-page":"e9435","DOI":"10.1371\/journal.pone.0009435","article-title":"An atypical riboflavin pathway is essential for Brucella abortus virulence","volume":"5","author":"Bonomi","year":"2010","journal-title":"PLoS One"},{"key":"B35","doi-asserted-by":"publisher","first-page":"4635","DOI":"10.4049\/jimmunol.173.7.4635","article-title":"Lipoproteins, not lipopolysaccharide, are the key mediators of the proinflammatory response elicited by heat-killed Brucella abortus","volume":"173","author":"Giambartolomei","year":"2004","journal-title":"J Immunol"},{"key":"B36","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1111\/j.1538-7836.2011.04264.x","article-title":"Platelets and the innate immune system: mechanisms of bacterial-induced platelet activation","volume":"9","author":"Cox","year":"2011","journal-title":"J Thromb Haemost"},{"key":"B37","doi-asserted-by":"crossref","first-page":"4082","DOI":"10.4049\/jimmunol.144.11.4082","article-title":"Role of ICAM-1 in antigen presentation demonstrated by ICAM-1 defective mutants","volume":"144","author":"Dang","year":"1990","journal-title":"J Immunol"},{"key":"B38","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1182\/blood.V92.4.1259","article-title":"Thrombin-activated human endothelial cells support monocyte adhesion in vitro following expression of intercellular adhesion molecule-1 (ICAM-1; CD54) and vascular cell adhesion molecule-1 (VCAM-1; CD106)","volume":"92","author":"Kaplanski","year":"1998","journal-title":"Blood"},{"key":"B39","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1084\/jem.178.2.669","article-title":"CD40 expression by human monocytes: regulation by cytokines and activation of monocytes by the ligand for CD40","volume":"178","author":"Alderson","year":"1993","journal-title":"J Exp Med"},{"key":"B40","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1002\/eji.1830210406","article-title":"Platelet-induced expression of Fc gamma RIII (CD16) on human monocytes","volume":"21","author":"Phillips","year":"1991","journal-title":"Eur J Immunol"},{"key":"B41","doi-asserted-by":"publisher","first-page":"4674","DOI":"10.4049\/jimmunol.1302318","article-title":"Characterization of platelet-monocyte complexes in HIV-1-infected individuals: possible role in HIV-associated neuroinflammation","volume":"192","author":"Singh","year":"2014","journal-title":"J Immunol"},{"key":"B42","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1186\/1742-2094-10-144","article-title":"Targeting platelet-derived soluble CD40 ligand: a new treatment strategy for HIV-associated neuroinflammation?","volume":"10","author":"Davidson","year":"2013","journal-title":"J Neuroinflammation"},{"key":"B43","doi-asserted-by":"publisher","first-page":"4021","DOI":"10.1182\/blood-2001-12-0191","article-title":"Host defense role of platelets: engulfment of HIV and Staphylococcus aureus occurs in a specific subcellular compartment and is enhanced by platelet activation","volume":"99","author":"Youssefian","year":"2002","journal-title":"Blood"},{"key":"B44","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1128\/CVI.00296-10","article-title":"Internalization of IgG-coated targets results in activation and secretion of soluble CD40 ligand and RANTES by human platelets","volume":"18","author":"Antczak","year":"2011","journal-title":"Clin Vaccine Immunol"},{"key":"B45","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.clim.2012.09.004","article-title":"Human platelets can discriminate between various bacterial LPS isoforms via TLR4 signaling and differential cytokine secretion","volume":"145","author":"Berthet","year":"2012","journal-title":"Clin Immunol"},{"key":"B46","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1111\/j.1574-695X.2012.00945.x","article-title":"Human platelets efficiently kill IgG-opsonized E. coli","volume":"65","author":"Riaz","year":"2012","journal-title":"FEMS Immunol Med Microbiol"},{"key":"B47","doi-asserted-by":"publisher","first-page":"1525","DOI":"10.1172\/JCI118575","article-title":"Activated platelets signal chemokine synthesis by human monocytes","volume":"97","author":"Weyrich","year":"1996","journal-title":"J Clin Invest"},{"key":"B48","doi-asserted-by":"publisher","first-page":"1491","DOI":"10.1161\/ATVBAHA.108.167601","article-title":"Monocyte functional responsiveness after PSGL-1-mediated platelet adhesion is dependent on platelet activation status","volume":"28","author":"Bournazos","year":"2008","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"B49","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.thromres.2003.08.017","article-title":"Platelet-monocyte complex formation: effect of blocking PSGL-1 alone, and in combination with alphaIIbbeta3 and alphaMbeta2, in coronary stenting","volume":"111","author":"Fernandes","year":"2003","journal-title":"Thromb Res"},{"key":"B50","doi-asserted-by":"publisher","first-page":"2297","DOI":"10.1172\/JCI117921","article-title":"Monocyte tethering by P-selectin regulates monocyte chemotactic protein-1 and tumor necrosis factor-alpha secretion. Signal integration and NF-kappa B translocation","volume":"95","author":"Weyrich","year":"1995","journal-title":"J Clin Invest"},{"key":"B51","doi-asserted-by":"publisher","first-page":"2702","DOI":"10.1161\/01.ATV.20.12.2702","article-title":"Platelet-leukocyte cross talk in whole blood","volume":"20","author":"Li","year":"2000","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"B52","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1038\/nm1565","article-title":"Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood","volume":"13","author":"Clark","year":"2007","journal-title":"Nat Med"},{"key":"B53","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1161\/01.CIR.0000154607.90506.45","article-title":"Dipyridamole selectively inhibits inflammatory gene expression in platelet-monocyte aggregates","volume":"111","author":"Weyrich","year":"2005","journal-title":"Circulation"},{"key":"B54","doi-asserted-by":"publisher","first-page":"2727","DOI":"10.1172\/JCI27209","article-title":"Expression of COX-2 in platelet-monocyte interactions occurs via combinatorial regulation involving adhesion and cytokine signaling","volume":"116","author":"Dixon","year":"2006","journal-title":"J Clin Invest"},{"key":"B55","doi-asserted-by":"publisher","first-page":"8767","DOI":"10.1073\/pnas.91.19.8767","article-title":"P-selectin induces the expression of tissue factor on monocytes","volume":"91","author":"Celi","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B56","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1189\/jlb.3A0415-161R","article-title":"Mediators and molecular pathways involved in the regulation of neutrophil extracellular trap formation mediated by activated platelets","volume":"99","author":"Carestia","year":"2016","journal-title":"J Leukoc Biol"},{"key":"B57","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1182\/blood.V95.4.1158.004k31_1158_1166","article-title":"The CXC-chemokine platelet factor 4 promotes monocyte survival and induces monocyte differentiation into macrophages","volume":"95","author":"Scheuerer","year":"2000","journal-title":"Blood"},{"key":"B58","doi-asserted-by":"publisher","first-page":"2060","DOI":"10.4049\/jimmunol.173.3.2060","article-title":"Platelet factor 4\/CXCL4 induces phagocytosis and the generation of reactive oxygen metabolites in mononuclear phagocytes independently of Gi protein activation or intracellular calcium transients","volume":"173","author":"Pervushina","year":"2004","journal-title":"J Immunol"},{"key":"B59","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1186\/s12866-016-0685-8","article-title":"Influence of platelet-activating factor receptor (PAFR) on Brucella abortus infection: implications for manipulating the phagocytic strategy of B. abortus","volume":"16","author":"Lee","year":"2016","journal-title":"BMC Microbiol"},{"key":"B60","doi-asserted-by":"publisher","first-page":"2657","DOI":"10.1038\/ncomms3657","article-title":"Platelets protect from septic shock by inhibiting macrophage-dependent inflammation via the cyclooxygenase 1 signalling pathway","volume":"4","author":"Xiang","year":"2013","journal-title":"Nat Commun"},{"key":"B61","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1038\/ni.2631","article-title":"Nucleation of platelets with blood-borne pathogens on Kupffer cells precedes other innate immunity and contributes to bacterial clearance","volume":"14","author":"Wong","year":"2013","journal-title":"Nat Immunol"},{"key":"B62","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1093\/infdis\/jit278","article-title":"Platelet activation and platelet-monocyte aggregate formation contribute to decreased platelet count during acute simian immunodeficiency virus infection in pig-tailed macaques","volume":"208","author":"Metcalf Pate","year":"2013","journal-title":"J Infect Dis"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2018.01000\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T13:20:19Z","timestamp":1693660819000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2018.01000\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,7]]},"references-count":62,"alternative-id":["10.3389\/fimmu.2018.01000"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2018.01000","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,7]]},"article-number":"1000"}}