{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T10:59:31Z","timestamp":1779879571349,"version":"3.53.1"},"reference-count":48,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,5,17]],"date-time":"2018-05-17T00:00:00Z","timestamp":1526515200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2018.01052","type":"journal-article","created":{"date-parts":[[2018,5,17]],"date-time":"2018-05-17T00:16:29Z","timestamp":1526516189000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Critical Contribution of NK Group 2 Member D Expressed on Invariant Natural Killer T Cells in Concanavalin A-Induced Liver Hepatitis in Mice"],"prefix":"10.3389","volume":"9","author":[{"given":"Dina","family":"Al Dulaimi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihene","family":"Klibi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Olivo Pimentel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronique","family":"Parietti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthieu","family":"Allez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Toubert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamel","family":"Benlagha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,5,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1172\/JCI115836","article-title":"A T cell-dependent experimental liver injury in mice inducible by concanavalin A","volume":"90","author":"Tiegs","year":"1992","journal-title":"J Clin Invest"},{"key":"B2","doi-asserted-by":"publisher","first-page":"5498","DOI":"10.1073\/pnas.040566697","article-title":"Critical contribution of liver natural killer T cells to a murine model of hepatitis","volume":"97","author":"Takeda","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1146","DOI":"10.1038\/ni.2731","article-title":"Steady-state production of IL-4 modulates immunity in mouse strains and is determined by lineage diversity of iNKT cells","volume":"14","author":"Lee","year":"2013","journal-title":"Nat Immunol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"2091","DOI":"10.1084\/jem.182.6.2091","article-title":"Positive selection of mouse NK1+ T cells by CD1-expressing cortical thymocytes","volume":"182","author":"Bendelac","year":"1995","journal-title":"J Exp Med"},{"key":"B5","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1146\/annurev.immunol.25.022106.141711","article-title":"The biology of NKT cells","volume":"25","author":"Bendelac","year":"2007","journal-title":"Annu Rev Immunol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"4020","DOI":"10.4049\/jimmunol.171.8.4020","article-title":"Glycolipid antigen drives rapid expansion and sustained cytokine production by NK T cells","volume":"171","author":"Crowe","year":"2003","journal-title":"J Immunol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1126\/science.1069017","article-title":"A thymic precursor to the NK T cell lineage","volume":"296","author":"Benlagha","year":"2002","journal-title":"Science"},{"key":"B8","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1016\/S1471-4906(03)00162-5","article-title":"Liver NKT cells: an account of heterogeneity","volume":"24","author":"Emoto","year":"2003","journal-title":"Trends Immunol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1038\/nri3369","article-title":"Invariant natural killer T cells: an innate activation scheme linked to diverse effector functions","volume":"13","author":"Brennan","year":"2013","journal-title":"Nat Rev Immunol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1038\/nri2116","article-title":"Control points in NKT-cell development","volume":"7","author":"Godfrey","year":"2007","journal-title":"Nat Rev Immunol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1002\/hep.510300517","article-title":"Concanavalin A hepatotoxicity in mice: tumor necrosis factor-mediated organ failure independent of caspase-3-like protease activation","volume":"30","author":"Kunstle","year":"1999","journal-title":"Hepatology"},{"key":"B12","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1053\/gast.1996.v111.pm8690213","article-title":"Interferon gamma plays a critical role in T cell-dependent liver injury in mice initiated by concanavalin A","volume":"111","author":"Kusters","year":"1996","journal-title":"Gastroenterology"},{"key":"B13","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1084\/jem.191.1.105","article-title":"Augmentation of Valpha14 NKT cell-mediated cytotoxicity by interleukin 4 in an autocrine mechanism resulting in the development of concanavalin A-induced hepatitis","volume":"191","author":"Kaneko","year":"2000","journal-title":"J Exp Med"},{"key":"B14","doi-asserted-by":"publisher","first-page":"1142","DOI":"10.1038\/ni858","article-title":"Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D","volume":"3","author":"Diefenbach","year":"2002","journal-title":"Nat Immunol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/S1074-7613(02)00333-3","article-title":"The role of the NKG2D immunoreceptor in immune cell activation and natural killing","volume":"17","author":"Jamieson","year":"2002","journal-title":"Immunity"},{"key":"B16","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1038\/nri1199","article-title":"Roles of the NKG2D immunoreceptor and its ligands","volume":"3","author":"Raulet","year":"2003","journal-title":"Nat Rev Immunol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"4079","DOI":"10.4049\/jimmunol.169.8.4079","article-title":"Cutting edge: murine UL16-binding protein-like transcript 1: a newly described transcript encoding a high-affinity ligand for murine NKG2D","volume":"169","author":"Carayannopoulos","year":"2002","journal-title":"J Immunol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1016\/S1074-7613(00)80222-8","article-title":"Retinoic acid early inducible genes define a ligand family for the activating NKG2D receptor in mice","volume":"12","author":"Cerwenka","year":"2000","journal-title":"Immunity"},{"key":"B19","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1038\/77793","article-title":"Ligands for the murine NKG2D receptor: expression by tumor cells and activation of NK cells and macrophages","volume":"1","author":"Diefenbach","year":"2000","journal-title":"Nat Immunol"},{"key":"B20","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1034\/j.1600-065X.2001.1810113.x","article-title":"Ligands for natural killer cell receptors: redundancy or specificity","volume":"181","author":"Cerwenka","year":"2001","journal-title":"Immunol Rev"},{"key":"B21","doi-asserted-by":"publisher","first-page":"1186","DOI":"10.1038\/nature03884","article-title":"The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor","volume":"436","author":"Gasser","year":"2005","journal-title":"Nature"},{"key":"B22","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1146\/annurev-immunol-032712-095951","article-title":"Regulation of ligands for the NKG2D activating receptor","volume":"31","author":"Raulet","year":"2013","journal-title":"Annu Rev Immunol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"9452","DOI":"10.1073\/pnas.1632807100","article-title":"Stimulation of T cell autoreactivity by anomalous expression of NKG2D and its MIC ligands in rheumatoid arthritis","volume":"100","author":"Groh","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B24","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/j.immuni.2004.06.018","article-title":"A direct role for NKG2D\/MICA interaction in villous atrophy during celiac disease","volume":"21","author":"Hue","year":"2004","journal-title":"Immunity"},{"key":"B25","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1016\/j.immuni.2004.05.008","article-title":"NKG2D blockade prevents autoimmune diabetes in NOD mice","volume":"20","author":"Ogasawara","year":"2004","journal-title":"Immunity"},{"key":"B26","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1016\/j.immuni.2008.02.016","article-title":"NKG2D-deficient mice are defective in tumor surveillance in models of spontaneous malignancy","volume":"28","author":"Guerra","year":"2008","journal-title":"Immunity"},{"key":"B27","doi-asserted-by":"publisher","first-page":"1623","DOI":"10.1126\/science.278.5343.1623","article-title":"Requirement for Valpha14 NKT cells in IL-12-mediated rejection of tumors","volume":"278","author":"Cui","year":"1997","journal-title":"Science"},{"key":"B28","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/S1074-7613(00)80290-3","article-title":"CD1d1 mutant mice are deficient in natural T cells that promptly produce IL-4","volume":"6","author":"Mendiratta","year":"1997","journal-title":"Immunity"},{"key":"B29","doi-asserted-by":"publisher","first-page":"1895","DOI":"10.1084\/jem.191.11.1895","article-title":"In vivo identification of glycolipid antigen-specific T cells using fluorescent CD1d tetramers","volume":"191","author":"Benlagha","year":"2000","journal-title":"J Exp Med"},{"key":"B30","doi-asserted-by":"publisher","first-page":"e28323","DOI":"10.1371\/journal.pone.0028323","article-title":"Concanavalin A\/IFN-gamma triggers autophagy-related necrotic hepatocyte death through IRGM1-mediated lysosomal membrane disruption","volume":"6","author":"Chang","year":"2011","journal-title":"PLoS One"},{"key":"B31","doi-asserted-by":"publisher","first-page":"2142","DOI":"10.4049\/jimmunol.0901059","article-title":"Skin and peripheral lymph node invariant NKT cells are mainly retinoic acid receptor-related orphan receptor (gamma)t+ and respond preferentially under inflammatory conditions","volume":"183","author":"Doisne","year":"2009","journal-title":"J Immunol"},{"key":"B32","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1038\/ni.1841","article-title":"Raising the NKT cell family","volume":"11","author":"Godfrey","year":"2010","journal-title":"Nat Immunol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"1468","DOI":"10.1182\/blood-2005-04-1579","article-title":"Regulation of ITAM-positive receptors: role of IL-12 and IL-18","volume":"107","author":"Ortaldo","year":"2006","journal-title":"Blood"},{"key":"B34","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1111\/j.0105-2896.2010.00893.x","article-title":"Effect of NKG2D ligand expression on host immune responses","volume":"235","author":"Champsaur","year":"2010","journal-title":"Immunol Rev"},{"key":"B35","doi-asserted-by":"publisher","first-page":"22","DOI":"10.2174\/157339509787314369","article-title":"Beyond stressed self: evidence for NKG2D ligand expression on healthy cells","volume":"5","author":"Eagle","year":"2009","journal-title":"Curr Immunol Rev"},{"key":"B36","doi-asserted-by":"publisher","first-page":"250","DOI":"10.4049\/jimmunol.182.1.250","article-title":"NKG2A inhibits invariant NKT cell activation in hepatic injury","volume":"182","author":"Kawamura","year":"2009","journal-title":"J Immunol"},{"key":"B37","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1182\/blood-2004-11-4257","article-title":"IFN-gamma-mediated negative feedback regulation of NKT-cell function by CD94\/NKG2","volume":"106","author":"Ota","year":"2005","journal-title":"Blood"},{"key":"B38","doi-asserted-by":"publisher","first-page":"3519","DOI":"10.1007\/s00018-011-0797-0","article-title":"Regulation of immune cell function and differentiation by the NKG2D receptor","volume":"68","author":"Zafirova","year":"2011","journal-title":"Cell Mol Life Sci"},{"key":"B39","doi-asserted-by":"publisher","first-page":"3472","DOI":"10.4049\/jimmunol.179.6.3472","article-title":"Engagement of TLR3, TLR7, and NKG2D regulate IFN-gamma secretion but not NKG2D-mediated cytotoxicity by human NK cells stimulated with suboptimal doses of IL-12","volume":"179","author":"Girart","year":"2007","journal-title":"J Immunol"},{"key":"B40","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1002\/hep.21872","article-title":"Increased susceptibility to liver injury in hepatitis B virus transgenic mice involves NKG2D-ligand interaction and natural killer cells","volume":"46","author":"Chen","year":"2007","journal-title":"Hepatology"},{"key":"B41","doi-asserted-by":"publisher","first-page":"18187","DOI":"10.1073\/pnas.0708968104","article-title":"Blockade of NKG2D on NKT cells prevents hepatitis and the acute immune response to hepatitis B virus","volume":"104","author":"Vilarinho","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B42","doi-asserted-by":"publisher","first-page":"2933","DOI":"10.1161\/CIRCULATIONAHA.111.034850","article-title":"Immune activation resulting from NKG2D\/ligand interaction promotes atherosclerosis","volume":"124","author":"Xia","year":"2011","journal-title":"Circulation"},{"key":"B43","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.4049\/jimmunol.1300670","article-title":"NKG2D induces Mcl-1 expression and mediates survival of CD8 memory T cell precursors via phosphatidylinositol 3-kinase","volume":"191","author":"Wensveen","year":"2013","journal-title":"J Immunol"},{"key":"B44","doi-asserted-by":"publisher","first-page":"1529","DOI":"10.1084\/jem.179.5.1529","article-title":"T cell activation-associated hepatic injury: mediation by tumor necrosis factors and protection by interleukin 6","volume":"179","author":"Mizuhara","year":"1994","journal-title":"J Exp Med"},{"key":"B45","doi-asserted-by":"publisher","first-page":"2222","DOI":"10.1172\/JCI91075","article-title":"TNF superfamily receptor OX40 triggers invariant NKT cell pyroptosis and liver injury","volume":"127","author":"Lan","year":"2017","journal-title":"J Clin Invest"},{"key":"B46","doi-asserted-by":"publisher","first-page":"2027","DOI":"10.1002\/hep.27392","article-title":"IL-30 (IL27p28) attenuates liver fibrosis through inducing NKG2D-rae1 interaction between NKT and activated hepatic stellate cells in mice","volume":"60","author":"Mitra","year":"2014","journal-title":"Hepatology"},{"key":"B47","doi-asserted-by":"publisher","first-page":"13930","DOI":"10.1038\/ncomms13930","article-title":"The immunoreceptor NKG2D promotes tumour growth in a model of hepatocellular carcinoma","volume":"8","author":"Sheppard","year":"2017","journal-title":"Nat Commun"},{"key":"B48","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1002\/hep.25959","article-title":"Simultaneous knockdown of multiple ligands of innate receptor NKG2D prevents natural killer cell-mediated fulminant hepatitis in mice","volume":"57","author":"Huang","year":"2013","journal-title":"Hepatology"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2018.01052\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,5,17]],"date-time":"2018-05-17T00:16:34Z","timestamp":1526516194000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2018.01052\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,17]]},"references-count":48,"alternative-id":["10.3389\/fimmu.2018.01052"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2018.01052","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,17]]},"article-number":"1052"}}