{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T20:31:05Z","timestamp":1790368265642,"version":"4.1.0"},"reference-count":72,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,5,24]],"date-time":"2018-05-24T00:00:00Z","timestamp":1527120000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2018.01106","type":"journal-article","created":{"date-parts":[[2018,5,24]],"date-time":"2018-05-24T00:28:17Z","timestamp":1527121697000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":72,"title":["Current Insights in Microbiome Shifts in Sjogren\u2019s Syndrome and Possible Therapeutic Interventions"],"prefix":"10.3389","volume":"9","author":[{"given":"Christina","family":"Tsigalou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisavet","family":"Stavropoulou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenia","family":"Bezirtzoglou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,5,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1006\/clin.1994.1123","article-title":"Sj\u00f6gren\u2019s syndrome: autoimmune epithelitis","volume":"72","author":"Moutsopoulos","year":"1994","journal-title":"Clin Immunol Immunopathol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1016\/j.autrev.2015.03.008","article-title":"Google-driven search for big data in autoimmune geoepidemiology: analysis of 394,827 patients with systemic autoimmune diseases","volume":"14","author":"Ramos-Casals","year":"2015","journal-title":"Autoimmun Rev"},{"key":"B3","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1006\/clin.1993.1137","article-title":"Characterization of antinuclear autoantibodies present in the serum from nonobese diabetic (NOD) mice","volume":"68","author":"Humphreys-Beher","year":"1993","journal-title":"Clin Immunol Immunopathol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1007\/978-1-4615-2417-5_105","article-title":"Utilization of the non-obese diabetic (NOD) mouse as an animal model for the study of secondary Sjogren\u2019s syndrome","volume":"350","author":"Humphreys-Beher","year":"1994","journal-title":"Adv Exp Med Biol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1006\/clin.1996.0050","article-title":"Genetically programmed development of salivary gland abnormalities in the NOD (nonobese diabetic)-scid mouse in the absence of detectable lymphocytic infiltration: a potential trigger for sialoadenitis of NOD mice","volume":"79","author":"Robinson","year":"1996","journal-title":"Clin Immunol Immunopathol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"23561","DOI":"10.1038\/srep23561","article-title":"Altered mucosal microbiome diversity and disease severity in Sj\u00f6gren syndrome","volume":"6","author":"de Paiva","year":"2016","journal-title":"Sci Rep"},{"key":"B7","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1111\/j.1365-2249.2006.03311.x","article-title":"Expression of functional toll-like receptors by salivary gland epithelial cells: increased mRNA expression in cells derived from patients with primary Sjogren\u2019s syndrome","volume":"147","author":"Spachidou","year":"2007","journal-title":"Clin Exp Immunol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1016\/j.arcmed.2006.08.002","article-title":"Pathophysiology of Sjogren\u2019s syndrome","volume":"37","author":"Garcia-Carrasco","year":"2006","journal-title":"Arch Med Res"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1134","DOI":"10.1002\/art.22458","article-title":"Aberrant expression of BAFF by B lymphocytes infiltrating the salivary glands of patients with primary Sj\u00f6gren\u2019s syndrome","volume":"56","author":"Daridon","year":"2007","journal-title":"Arthritis Rheum"},{"key":"B10","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1172\/JCI0214121","article-title":"Association of BAFF\/BLyS overexpression and altered B cell differentiation with Sjogren\u2019s syndrome","volume":"109","author":"Groom","year":"2002","journal-title":"J Clin Invest"},{"key":"B11","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.clim.2016.10.015","article-title":"Increased frequency of the PTPN22W* variant in primary Sjogren\u2019s Syndrome: association with low type I IFN scores","volume":"173","author":"Vlachogiannis","year":"2016","journal-title":"Clin Immunol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1111\/sji.12405","article-title":"Low protein A20 in minor salivary glands is associated with lymphoma in primary Sj\u00f6gren\u2019s Syndrome","volume":"83","author":"Johnsen","year":"2016","journal-title":"Scand J Immunol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1186\/s13075-016-0987-0","article-title":"Sj\u00f6gren\u2019s syndrome-associated microRNAs in CD14+ monocytes unveils targeted TGF\u03b2 signaling","volume":"18","author":"Williams","year":"2016","journal-title":"Arthritis Res Ther"},{"key":"B14","doi-asserted-by":"publisher","first-page":"2936","DOI":"10.1002\/art.39792","article-title":"Epigenetic signatures of salivary gland inflammation in Sj\u00f6gren\u2019s syndrome","volume":"68","author":"Cole","year":"2016","journal-title":"Arthritis Rheumatol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1007\/s12026-015-8715-4","article-title":"Upregulation of long noncoding RNA TMEVPG1 enhances T helper type 1 cell response in patients with Sj\u00f6gren syndrome","volume":"64","author":"Wang","year":"2016","journal-title":"Immunol Res"},{"key":"B16","doi-asserted-by":"publisher","first-page":"e584","DOI":"10.4317\/jced.53605","article-title":"Sjogren\u2019s syndrome: review of the aetiology, pathophysiology & potential therapeutic interventions","volume":"9","author":"Nair","year":"2017","journal-title":"J Clin Exp Dent"},{"key":"B17","first-page":"179","article-title":"One year in review 2017: primary Sj\u00f6gren\u2019s syndrome","volume":"35","author":"Ferro","year":"2017","journal-title":"Clin Exp Rheumatol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"e3766","DOI":"10.1097\/MD.0000000000003766","article-title":"Predicting the risk for lymphoma development in Sjogren syndrome: an easy tool for clinical use","volume":"95","author":"Fragkioudaki","year":"2016","journal-title":"Medicine (Baltimore)"},{"key":"B19","first-page":"98","article-title":"Sj\u00f6gren\u2019s syndrome: managed care data from a large United States population highlight real-world health care burden and lack of treatment options","volume":"35","author":"Birt","year":"2017","journal-title":"Clin Exp Rheumatol"},{"key":"B20","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1038\/ni0901-764","article-title":"Systemic lupus erythematosus: an autoimmune disease of B cell hyperactivity","volume":"2","author":"Lipsky","year":"2001","journal-title":"Nat Immunol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"R109","DOI":"10.1186\/ar2506","article-title":"Biologic activity and safety of belimumab, a neutralizing anti-B-lymphocyte stimulator (BLyS) monoclonal antibody: a phase I trial in patients with systemic lupus erythematosus","volume":"10","author":"Furie","year":"2008","journal-title":"Arthritis Res Ther"},{"key":"B22","doi-asserted-by":"publisher","first-page":"4142","DOI":"10.1002\/art.23047","article-title":"Reduced B lymphocyte and immunoglobulin levels after atacicept treatment in patients with systemic lupus erythematosus: results of a multicenter, phase Ib, double-blind, placebo-controlled, dose-escalating trial","volume":"56","author":"Dall\u2019Era","year":"2007","journal-title":"Arthritis Rheum"},{"key":"B23","doi-asserted-by":"publisher","first-page":"476","DOI":"10.2353\/ajpath.2006.050600","article-title":"A soluble BAFF antagonist, BR3-Fc, decreases peripheral blood B cells and lymphoid tissue marginal zone and follicular B cells in cynomolgus monkeys","volume":"168","author":"Vugmeyster","year":"2006","journal-title":"Am J Pathol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"2740","DOI":"10.1002\/art.21260","article-title":"Rituximab treatment in patients with primary Sjogren\u2019s syndrome: an open-label phase II study","volume":"52","author":"Pijpe","year":"2005","journal-title":"Arthritis Rheum"},{"key":"B25","first-page":"555","article-title":"Methotrexate in primary Sjogren\u2019s syndrome","volume":"14","author":"Skopouli","year":"1996","journal-title":"Clin Exp Rheumatol"},{"key":"B26","unstructured":"National Library of Medicine (US); Identifier NCT01782235, Efficacy of Tocilizumab (ETAP)2017"},{"key":"B27","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1111\/j.1601-0825.2011.01851.x","article-title":"The oral microbiome in health and disease and the potential impact on personalized dental medicine","volume":"18","author":"Zarco","year":"2012","journal-title":"Oral Dis"},{"key":"B28","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1038\/nature11209","article-title":"A framework for human microbiome research","volume":"486","year":"2012","journal-title":"Nature"},{"key":"B29","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1038\/nature11234","article-title":"Structure, function and diversity of the healthy human microbiome","volume":"486","year":"2012","journal-title":"Nature"},{"key":"B30","doi-asserted-by":"publisher","first-page":"1605","DOI":"10.1136\/gut.2007.133603","article-title":"High-throughput diversity and functionality analysis of the gastrointestinal tract microbiota","volume":"57","author":"Zoetendal","year":"2008","journal-title":"Gut"},{"key":"B31","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1038\/nature09944","article-title":"Enterotypes of the human gut microbiome","volume":"473","author":"Arumugam","year":"2011","journal-title":"Nature"},{"key":"B32","doi-asserted-by":"publisher","first-page":"R42","DOI":"10.1186\/gb-2012-13-6-r42","article-title":"Composition of the adult digestive tract bacterial microbiome based on seven mouth surfaces, tonsils, throat and stool samples","volume":"13","author":"Segata","year":"2012","journal-title":"Genome Biol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/j.anaerobe.2011.03.010","article-title":"Immunology and probiotic impact of the newborn and young children intestinal microflora","volume":"17","author":"Bezirtzoglou","year":"2011","journal-title":"Anaerobe"},{"key":"B34","doi-asserted-by":"publisher","first-page":"e1002863","DOI":"10.1371\/journal.pcbi.1002863","article-title":"A guide to enterotypes across the human body: meta-analysis of microbial community structures in human microbiome datasets","volume":"9","author":"Koren","year":"2013","journal-title":"PLoS Comput Biol"},{"key":"B35","doi-asserted-by":"publisher","first-page":"400","DOI":"10.3389\/fimmu.2017.00400","article-title":"Clinical evidence for the microbiome in inflammatory diseases","volume":"8","author":"Slingerland","year":"2017","journal-title":"Front Immunol"},{"key":"B36","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.3389\/fmicb.2015.01050","article-title":"Human microbiomes and their roles in dysbiosis, common diseases, and novel therapeutic approaches","volume":"6","author":"Beliz\u00e1rio","year":"2015","journal-title":"Front Microbiol"},{"key":"B37","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1038\/ni.1801","article-title":"Influence of microbial environment on autoimmunity","volume":"11","author":"Chervonsky","year":"2010","journal-title":"Nat Immunol"},{"key":"B38","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1016\/j.chom.2015.04.010","article-title":"Microbiota and autoimmunity: exploring new avenues","volume":"17","author":"Yurkovetskiy","year":"2015","journal-title":"Cell Host Microbe"},{"key":"B39","first-page":"1221","article-title":"Maternal EFA composition affects the pathogenesis of type 1 diabetes in NOD mouse offspring","volume":"23","author":"Kagohashi","year":"2006","journal-title":"Zool Sci"},{"key":"B40","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1126\/science.1233521","article-title":"Sex differences in the gut microbiome drive hormone-dependent regulation of autoimmunity","volume":"339","author":"Markle","year":"2013","journal-title":"Science"},{"key":"B41","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1016\/j.immuni.2013.08.013","article-title":"Gender bias in autoimmunity is influenced by microbiota","volume":"39","author":"Yurkovetskiy","year":"2013","journal-title":"Immunity"},{"key":"B42","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1111\/odi.12472","article-title":"The microbiome-systemic diseases connection","volume":"22","author":"Van der Meulen","year":"2016","journal-title":"Oral Dis"},{"key":"B43","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1038\/nature18848","article-title":"The microbiota in adaptive immune homeostasis and disease","volume":"535","author":"Honda","year":"2016","journal-title":"Nature"},{"key":"B44","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1016\/j.cell.2009.09.033","article-title":"Induction of intestinal Th17\u2009cells by segmented filamentous bacteria","volume":"139","author":"Ivanov","year":"2009","journal-title":"Cell"},{"key":"B45","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1016\/j.immuni.2010.06.001","article-title":"Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells","volume":"32","author":"Wu","year":"2010","journal-title":"Immunity"},{"key":"B46","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1126\/science.1200439","article-title":"Chronic mucocutaneous candidiasis in humans with inborn errors of interleukin-17 immunity","volume":"332","author":"Puel","year":"2011","journal-title":"Science"},{"key":"B47","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1126\/science.aaa4282","article-title":"Impairment of immunity to Candida and Mycobacterium in humans with bi-allelic RORC mutations","volume":"349","author":"Okada","year":"2015","journal-title":"Science"},{"key":"B48","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1038\/ni.1698","article-title":"The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo","volume":"10","author":"Mc Geachy","year":"2009","journal-title":"Nat Immunol"},{"key":"B49","doi-asserted-by":"publisher","first-page":"1595","DOI":"10.1084\/jem.20111453","article-title":"IL-1\u03b2 mediates chronic intestinal inflammation by promoting the accumulation of IL-17A secreting innate lymphoid cells and CD4+ Th17\u2009cells","volume":"209","author":"Coccia","year":"2012","journal-title":"J Exp Med"},{"key":"B50","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1038\/nature12331","article-title":"Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota","volume":"500","author":"Atarashi","year":"2013","journal-title":"Nature"},{"key":"B51","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1126\/science.1198469","article-title":"Induction of colonic regulatory T cells by indigenous Clostridium species","volume":"331","author":"Atarashi","year":"2011","journal-title":"Science"},{"key":"B52","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1126\/science.1219328","article-title":"Microbial exposure during early life has persistent effects on natural killer T cell function","volume":"336","author":"Olszak","year":"2012","journal-title":"Science"},{"key":"B53","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1016\/j.immuni.2015.10.016","article-title":"A wave of regulatory T cells into neonatal skin mediates tolerance to commensal microbes","volume":"43","author":"Scharschmidt","year":"2015","journal-title":"Immunity"},{"key":"B54","first-page":"11","article-title":"Genetics, genomics, and proteomics of Sj\u00f6gren\u2019s syndrome","volume-title":"Sj\u00f6gren\u2019s Syndrome \u2013 Diagnosis and Therapeutics","author":"Lessard","year":"2012"},{"key":"B55","doi-asserted-by":"publisher","first-page":"2545","DOI":"10.1002\/art.38726","article-title":"Implication of Epstein\u2013Barr virus infection in disease-specific autoreactive B cell activation in ectopic lymphoid structures of Sj\u00f6gren\u2019s syndrome","volume":"66","author":"Croia","year":"2014","journal-title":"Arthritis Rheumatol"},{"key":"B56","doi-asserted-by":"publisher","first-page":"2770","DOI":"10.1073\/pnas.0510837103","article-title":"Activation of IFN pathways and plasmacytoid dendritic cell recruitment in target organs of primary Sj\u00f6gren\u2019s syndrome","volume":"103","author":"Gottenberg","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B57","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1034\/j.1399-302X.2003.180101.x","article-title":"Oral microbiota associated with hyposalivation of different origins","volume":"18","author":"Almst\u00e5hl","year":"2003","journal-title":"Oral Microbiol Immunol"},{"key":"B58","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.clim.2014.02.004","article-title":"T cell epitope mimicry between Sj\u00f6gren\u2019s syndrome antigen A (SSA)\/Ro60 and oral, gut, skin and vaginal bacteria","volume":"152","author":"Szymula","year":"2014","journal-title":"Clin Immunol"},{"key":"B59","doi-asserted-by":"publisher","first-page":"1555","DOI":"10.1007\/s00296-014-3003-5","article-title":"Increased dental visits in patients prior to diagnosis of primary Sj\u00f6gren\u2019s syndrome: a population-based study in Taiwan","volume":"34","author":"Lu","year":"2014","journal-title":"Rheumatol Int"},{"key":"B60","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.jaci.2014.11.012","article-title":"The gut microbiota and inflammatory noncommunicable diseases: associations and potentials for gut microbiota therapies","volume":"135","author":"West","year":"2015","journal-title":"J Allergy Clin Immunol"},{"key":"B61","article-title":"Guidelines for the evaluation of probiotics in food","volume-title":"Report of a Joint FAO\/WHO Working Group on Drafting Guidelines for the Evaluation of Probiotics in Food","year":"2002"},{"key":"B62","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/10408398.2017.1379469","article-title":"Human microbiota in aging and infection: a review","volume":"4","author":"Stavropoulou","year":"2017","journal-title":"Crit Rev Food Sci Nutr"},{"key":"B63","doi-asserted-by":"publisher","first-page":"1682S","DOI":"10.1093\/ajcn\/71.6.1682S","article-title":"Prebiotics and probiotics: are they functional foods?","volume":"71","author":"Roberfroid","year":"2000","journal-title":"Am J Clin Nutr"},{"key":"B64","doi-asserted-by":"publisher","first-page":"830S","DOI":"10.1093\/jn\/137.3.830S","article-title":"Prebiotics: the concept revisited","volume":"137","author":"Roberfroid","year":"2007","journal-title":"J Nutr"},{"key":"B65","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1017\/S000711451100064X","article-title":"Effect of the continuous intake of probiotic-fermented milk containing Lactobacillus casei strain Shirota on fever in a mass outbreak of norovirus gastroenteritis and the faecal microflora in a health service facility for the aged","volume":"106","author":"Nagata","year":"2011","journal-title":"Br J Nutr"},{"key":"B66","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/j.autrev.2016.01.002","article-title":"Induction of regulatory T cells: a role for probiotics and prebiotics to suppress autoimmunity","volume":"15","author":"Dwivedi","year":"2016","journal-title":"Autoimmun Rev"},{"key":"B67","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1016\/j.jaut.2010.07.006","article-title":"Characterization of regulatory T cells in patients with dermatomyositis","volume":"35","author":"Antiga","year":"2010","journal-title":"J Autoimmun"},{"key":"B68","doi-asserted-by":"publisher","first-page":"8392","DOI":"10.4049\/jimmunol.175.12.8392","article-title":"Global natural regulatory T cell depletion in active systemic lupus erythematosus","volume":"175","author":"Miyara","year":"2005","journal-title":"J Immunol"},{"key":"B69","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.autrev.2014.10.002","article-title":"Regulatory T cells in vitiligo: implications for pathogenesis and therapeutics","volume":"14","author":"Dwivedi","year":"2015","journal-title":"Autoimmun Rev"},{"key":"B70","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1136\/gutjnl-2011-300936","article-title":"Bifidobacterium infantis 35624 administration induces Foxp3 T regulatory cells in human peripheral blood: potential role for myeloid and plasmacytoid dendritic cells","volume":"61","author":"Konieczna","year":"2012","journal-title":"Gut"},{"key":"B71","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1093\/femsre\/fuw045","article-title":"Intestinal microbiome landscaping: insight in community assemblage and implications for microbial modulation strategies","volume":"41","author":"Shetty","year":"2017","journal-title":"FEMS Microbiol Rev"},{"key":"B72","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1111\/1756-185X.12888","article-title":"Clinical and metabolic response to probiotic supplementation in patients with rheumatoid arthritis: a randomized, double-blind, placebo-controlled trial","volume":"19","author":"Zamani","year":"2016","journal-title":"Int J Rheum Dis"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2018.01106\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,5,24]],"date-time":"2018-05-24T00:28:29Z","timestamp":1527121709000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2018.01106\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,24]]},"references-count":72,"alternative-id":["10.3389\/fimmu.2018.01106"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2018.01106","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,24]]},"article-number":"1106"}}