{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:35:52Z","timestamp":1790645752227,"version":"4.1.0"},"reference-count":97,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,5,28]],"date-time":"2018-05-28T00:00:00Z","timestamp":1527465600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010414","name":"Health Research Board","doi-asserted-by":"publisher","award":["HRA-POR-2014-582"],"award-info":[{"award-number":["HRA-POR-2014-582"]}],"id":[{"id":"10.13039\/100010414","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2018.01145","type":"journal-article","created":{"date-parts":[[2018,5,28]],"date-time":"2018-05-28T12:28:16Z","timestamp":1527510496000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":28,"title":["Disease-Associated Particulates and Joint Inflammation; Mechanistic Insights and Potential Therapeutic Targets"],"prefix":"10.3389","volume":"9","author":[{"given":"Olwyn R.","family":"Mahon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aisling","family":"Dunne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,5,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"103","DOI":"10.3389\/fimmu.2018.00103","article-title":"Macrophage recognition of crystals and nanoparticles","volume":"9","author":"Nakayama","year":"2018","journal-title":"Front Immunol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/rheumatology\/key002","article-title":"Gout: state of the art after a decade of developments","author":"Pascart","year":"2018","journal-title":"Rheumatology"},{"key":"B3","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/s11926-018-0721-9","article-title":"Calcium-containing crystals and osteoarthritis: an unhealthy alliance","volume":"20","author":"Conway","year":"2018","journal-title":"Curr Rheumatol Rep"},{"key":"B4","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1038\/nrrheum.2011.165","article-title":"Osteoarthritis: crystal-gazing into the pathogenesis of osteoarthritis","volume":"7","author":"So","year":"2011","journal-title":"Nat Rev Rheumatol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"2575","DOI":"10.1056\/NEJMra1511117","article-title":"Calcium pyrophosphate deposition disease","volume":"374","author":"Rosenthal","year":"2016","journal-title":"N Engl J Med"},{"key":"B6","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1002\/jor.21554","article-title":"Review of periprosthetic osteolysis in total joint arthroplasty: an emphasis on host factors and future directions","volume":"30","author":"Beck","year":"2012","journal-title":"J Orthop Res"},{"key":"B7","doi-asserted-by":"publisher","first-page":"241","DOI":"10.2174\/1874325001610010241","article-title":"Particle disease: a current review of the biological mechanisms in periprosthetic osteolysis after hip arthroplasty","volume":"10","author":"Sukur","year":"2016","journal-title":"Open Orthop J"},{"key":"B8","doi-asserted-by":"publisher","first-page":"2039","DOI":"10.1016\/S0140-6736(16)00346-9","article-title":"Gout","volume":"388","author":"Dalbeth","year":"2016","journal-title":"Lancet"},{"key":"B9","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1038\/nrrheum.2015.91","article-title":"Global epidemiology of gout: prevalence, incidence and risk factors","volume":"11","author":"Kuo","year":"2015","journal-title":"Nat Rev Rheumatol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1549","DOI":"10.1002\/art.27356","article-title":"Cellular characterization of the gouty tophus: a quantitative analysis","volume":"62","author":"Dalbeth","year":"2010","journal-title":"Arthritis Rheum"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1290","DOI":"10.1136\/ard.2008.094201","article-title":"Mechanisms of bone erosion in gout: a quantitative analysis using plain radiography and computed tomography","volume":"68","author":"Dalbeth","year":"2009","journal-title":"Ann Rheum Dis"},{"key":"B12","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1016\/j.jare.2017.04.008","article-title":"Gout: an old disease in new perspective \u2013 a review","volume":"8","author":"Ragab","year":"2017","journal-title":"J Adv Res"},{"key":"B13","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1002\/art.11486","article-title":"Proline-rich tyrosine kinase 2 and Src kinase signaling transduce monosodium urate crystal-induced nitric oxide production and matrix metalloproteinase 3 expression in chondrocytes","volume":"50","author":"Liu","year":"2004","journal-title":"Arthritis Rheum"},{"key":"B14","doi-asserted-by":"publisher","first-page":"R23","DOI":"10.1186\/ar2930","article-title":"High-density lipoproteins downregulate CCL2 production in human fibroblast-like synoviocytes stimulated by urate crystals","volume":"12","author":"Scanu","year":"2010","journal-title":"Arthritis Res Ther"},{"key":"B15","doi-asserted-by":"publisher","first-page":"2273","DOI":"10.1002\/art.20317","article-title":"Macrophage release of transforming growth factor beta1 during resolution of monosodium urate monohydrate crystal-induced inflammation","volume":"50","author":"Yagnik","year":"2004","journal-title":"Arthritis Rheum"},{"key":"B16","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1002\/art.24185","article-title":"Resident macrophages initiating and driving inflammation in a monosodium urate monohydrate crystal-induced murine peritoneal model of acute gout","volume":"60","author":"Martin","year":"2009","journal-title":"Arthritis Rheum"},{"key":"B17","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1002\/art.1780340716","article-title":"Monocyte-derived neutrophil chemotactic factor\/interleukin-8 is a potential mediator of crystal-induced inflammation","volume":"34","author":"Terkeltaub","year":"1991","journal-title":"Arthritis Rheum"},{"key":"B18","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1038\/nature04516","article-title":"Gout-associated uric acid crystals activate the NALP3 inflammasome","volume":"440","author":"Martinon","year":"2006","journal-title":"Nature"},{"key":"B19","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.coi.2017.10.011","article-title":"Recent advances in inflammasome biology","volume":"50","author":"Place","year":"2018","journal-title":"Curr Opin Immunol"},{"key":"B20","doi-asserted-by":"publisher","first-page":"3955","DOI":"10.1242\/jcs.207365","article-title":"Inflammasome activation and assembly at a glance","volume":"130","author":"Malik","year":"2017","journal-title":"J Cell Sci"},{"key":"B21","doi-asserted-by":"publisher","first-page":"13273","DOI":"10.1074\/jbc.271.22.13273","article-title":"Activation of the native 45-kDa precursor form of interleukin-1-converting enzyme","volume":"271","author":"Yamin","year":"1996","journal-title":"J Biol Chem"},{"key":"B22","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1038\/356768a0","article-title":"A novel heterodimeric cysteine protease is required for interleukin-1\u03b2processing in monocytes","volume":"356","author":"Thornberry","year":"1992","journal-title":"Nature"},{"key":"B23","doi-asserted-by":"publisher","first-page":"3237","DOI":"10.1002\/art.27667","article-title":"Engagement of fatty acids with toll-like receptor 2 drives interleukin-1\u03b2 production via the ASC\/caspase 1 pathway in monosodium urate monohydrate crystal-induced gouty arthritis","volume":"62","author":"Joosten","year":"2010","journal-title":"Arthritis Rheum"},{"key":"B24","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.it.2018.01.009","article-title":"Orchestration of NLRP3 inflammasome activation by ion fluxes","volume":"39","author":"Gong","year":"2018","journal-title":"Trends Immunol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1074\/jbc.M110.139048","article-title":"Sodium overload and water influx activate the NALP3 inflammasome","volume":"286","author":"Schorn","year":"2011","journal-title":"J Biol Chem"},{"key":"B26","doi-asserted-by":"publisher","first-page":"2077","DOI":"10.1016\/j.celrep.2017.02.004","article-title":"\u03b2-Hydroxybutyrate deactivates neutrophil NLRP3 inflammasome to relieve gout flares","volume":"18","author":"Goldberg","year":"2017","journal-title":"Cell Rep"},{"key":"B27","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1093\/rheumatology\/kex499","article-title":"Suppression of NLRP3 inflammasome by oral treatment with sulforaphane alleviates acute gouty inflammation","volume":"57","author":"Yang","year":"2018","journal-title":"Rheumatology"},{"key":"B28","doi-asserted-by":"publisher","first-page":"38622","DOI":"10.1038\/srep38622","article-title":"Targeting ASC in NLRP3 inflammasome by caffeic acid phenethyl ester: a novel strategy to treat acute gout","volume":"6","author":"Lee","year":"2016","journal-title":"Sci Rep"},{"key":"B29","doi-asserted-by":"publisher","first-page":"e1000661","DOI":"10.1371\/journal.ppat.1000661","article-title":"IL-1\u03b2 processing in host defense: beyond the inflammasomes","volume":"6","author":"Netea","year":"2010","journal-title":"PLoS Pathog"},{"key":"B30","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1096\/fasebj.12.2.209","article-title":"Crystal-induced neutrophil activation VI. Involvement of Fc{gamma}RIIIB (CD16) and CD11b in response to inflammatory microcrystals","volume":"12","author":"Barabe","year":"1998","journal-title":"FASEB J"},{"key":"B31","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1189\/jlb.70.4.659","article-title":"Crystal-induced neutrophil activation. VII. Involvement of Syk in the responses to monosodium urate crystals","volume":"70","author":"Desaulniers","year":"2001","journal-title":"J Leukoc Biol"},{"key":"B32","doi-asserted-by":"publisher","first-page":"2104","DOI":"10.4049\/jimmunol.0900906","article-title":"Crystal-induced neutrophil activation: XI. Implication and novel roles of classical protein kinase C","volume":"183","author":"Popa-Nita","year":"2009","journal-title":"J Immunol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1189\/jlb.0307174","article-title":"Crystal-induced neutrophil activation. IX. Syk-dependent activation of class Ia phosphatidylinositol 3-kinase","volume":"82","author":"Popa-Nita","year":"2007","journal-title":"J Leukoc Biol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1016\/j.immuni.2008.09.013","article-title":"Receptor-independent, direct membrane binding leads to cell-surface lipid sorting and Syk kinase activation in dendritic cells","volume":"29","author":"Ng","year":"2008","journal-title":"Immunity"},{"key":"B35","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1111\/j.0105-2896.2009.00851.x","article-title":"Monosodium urate crystals in inflammation and immunity","volume":"233","author":"Shi","year":"2010","journal-title":"Immunol Rev"},{"key":"B36","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1189\/jlb.3HI0814-371RR","article-title":"Syk is involved in NLRP3 inflammasome-mediated caspase-1 activation through adaptor ASC phosphorylation and enhanced oligomerization","volume":"97","author":"Lin","year":"2015","journal-title":"J Leukoc Biol"},{"key":"B37","doi-asserted-by":"publisher","first-page":"e0185704","DOI":"10.1371\/journal.pone.0185704","article-title":"The tyrosine kinase inhibitor imatinib mesylate suppresses uric acid crystal-induced acute gouty arthritis in mice","volume":"12","author":"Reber","year":"2017","journal-title":"PLoS One"},{"key":"B38","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1002\/eji.201545605","article-title":"PMA and crystal-induced neutrophil extracellular trap formation involves RIPK1-RIPK3-MLKL signaling","volume":"46","author":"Desai","year":"2016","journal-title":"Eur J Immunol"},{"key":"B39","doi-asserted-by":"publisher","first-page":"2211","DOI":"10.1007\/s00018-016-2195-0","article-title":"Matters of life and death. How neutrophils die or survive along NET release and is \u201cNETosis\u201d = necroptosis?","volume":"73","author":"Desai","year":"2016","journal-title":"Cell Mol Life Sci"},{"key":"B40","doi-asserted-by":"publisher","first-page":"588","DOI":"10.3389\/fimmu.2015.00588","article-title":"Molecular and translational classifications of DAMPs in immunogenic cell death","volume":"6","author":"Garg","year":"2015","journal-title":"Front Immunol"},{"key":"B41","doi-asserted-by":"publisher","first-page":"461","DOI":"10.3389\/fimmu.2016.00461","article-title":"A critical reappraisal of neutrophil extracellular traps and NETosis mimics based on differential requirements for protein citrullination","volume":"7","author":"Konig","year":"2016","journal-title":"Front Immunol"},{"key":"B42","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1038\/nm.3547","article-title":"Aggregated neutrophil extracellular traps limit inflammation by degrading cytokines and chemokines","volume":"20","author":"Schauer","year":"2014","journal-title":"Nat Med"},{"key":"B43","doi-asserted-by":"publisher","first-page":"1802","DOI":"10.4049\/jimmunol.1701382","article-title":"Monosodium urate crystals generate nuclease-resistant neutrophil extracellular traps via a distinct molecular pathway","volume":"200","author":"Chatfield","year":"2018","journal-title":"J Immunol"},{"key":"B44","doi-asserted-by":"publisher","first-page":"6529","DOI":"10.1038\/s41598-017-06901-w","article-title":"Differential signalling and kinetics of neutrophil extracellular trap release revealed by quantitative live imaging","volume":"7","author":"Van Der Linden","year":"2017","journal-title":"Sci Rep"},{"key":"B45","doi-asserted-by":"publisher","first-page":"2809","DOI":"10.1016\/j.celrep.2018.02.062","article-title":"Extracellular neutrophil proteases are efficient regulators of IL-1, IL-33, and IL-36 cytokine activity but poor effectors of microbial killing","volume":"22","author":"Clancy","year":"2018","journal-title":"Cell Rep"},{"key":"B46","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1002\/art.27761","article-title":"Articular cartilage calcification in osteoarthritis: insights into crystal-induced stress","volume":"63","author":"Ea","year":"2011","journal-title":"Arthritis Rheum"},{"key":"B47","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1097\/BOR.0000000000000245","article-title":"Basic calcium phosphate crystals and osteoarthritis pathogenesis: novel pathways and potential targets","volume":"28","author":"Stack","year":"2016","journal-title":"Curr Opin Rheumatol"},{"key":"B48","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1186\/ar3117","article-title":"Hypertrophic differentiation of chondrocytes in osteoarthritis: the developmental aspect of degenerative joint disorders","volume":"12","author":"Dreier","year":"2010","journal-title":"Arthritis Res Ther"},{"key":"B49","doi-asserted-by":"publisher","first-page":"35161","DOI":"10.1074\/jbc.273.52.35161","article-title":"Molecular mechanism of basic calcium phosphate crystal-induced activation of human fibroblasts: role of nuclear factor \u03baB, activator protein 1, and protein kinase C","volume":"273","author":"McCarthy","year":"1998","journal-title":"J Biol Chem"},{"key":"B50","doi-asserted-by":"publisher","first-page":"15190","DOI":"10.1074\/jbc.M200278200","article-title":"Molecular mechanism of the induction of metalloproteinases 1 and 3 in human fibroblasts by basic calcium phosphate crystals","volume":"277","author":"Reuben","year":"2002","journal-title":"J Biol Chem"},{"key":"B51","doi-asserted-by":"publisher","first-page":"1372","DOI":"10.1136\/annrheumdis-2015-207487","article-title":"Interleukin-6 and chondrocyte mineralisation act in tandem to promote experimental osteoarthritis","volume":"75","author":"Nasi","year":"2016","journal-title":"Ann Rheum Dis"},{"key":"B52","doi-asserted-by":"publisher","first-page":"2495","DOI":"10.4049\/jimmunol.1001284","article-title":"Basic calcium phosphate crystals induce monocyte\/macrophage IL-1 secretion through the NLRP3 inflammasome in vitro","volume":"186","author":"Pazar","year":"2011","journal-title":"J Immunol"},{"key":"B53","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s13075-017-1225-0","article-title":"Osteoarthritis-associated basic calcium phosphate crystals activate membrane proximal kinases in human innate immune cells","volume":"19","author":"Corr","year":"2017","journal-title":"Arthritis Res Ther"},{"key":"B54","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.clim.2012.06.007","article-title":"Osteoarthritis-associated basic calcium phosphate crystals induce pro-inflammatory cytokines and damage-associated molecules via activation of Syk and PI3 kinase","volume":"144","author":"Cunningham","year":"2012","journal-title":"Clin Immunol"},{"key":"B55","doi-asserted-by":"publisher","first-page":"14867","DOI":"10.1073\/pnas.1111101108","article-title":"NLRP3 inflammasome plays a critical role in the pathogenesis of hydroxyapatite-associated arthropathy","volume":"108","author":"Jin","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B56","doi-asserted-by":"publisher","first-page":"e57352","DOI":"10.1371\/journal.pone.0057352","article-title":"Pathogenic role of basic calcium phosphate crystals in destructive arthropathies","volume":"8","author":"Ea","year":"2013","journal-title":"PLoS One"},{"key":"B57","doi-asserted-by":"publisher","first-page":"282","DOI":"10.3389\/fphar.2017.00282","article-title":"Revisiting the role of interleukin-1 pathway in osteoarthritis: interleukin-1\u03b1 and -1\u03b2, and NLRP3 inflammasome are not involved in the pathological features of the murine menisectomy model of osteoarthritis","volume":"8","author":"Nasi","year":"2017","journal-title":"Front Pharmacol"},{"key":"B58","doi-asserted-by":"publisher","first-page":"2141","DOI":"10.1016\/j.joca.2016.07.001","article-title":"Intra-articular basic calcium phosphate and monosodium urate crystals inhibit anti-osteoclastogenic cytokine signalling","volume":"24","author":"Cunningham","year":"2016","journal-title":"Osteoarthritis Cartilage"},{"key":"B59","doi-asserted-by":"publisher","first-page":"e0158196","DOI":"10.1371\/journal.pone.0158196","article-title":"Sodium thiosulfate prevents chondrocyte mineralization and reduces the severity of murine osteoarthritis","volume":"11","author":"Nasi","year":"2016","journal-title":"PLoS One"},{"key":"B60","doi-asserted-by":"publisher","first-page":"6488","DOI":"10.4049\/jimmunol.1203215","article-title":"Pseudogout-associated inflammatory calcium pyrophosphate dihydrate microcrystals induce formation of neutrophil extracellular traps","volume":"190","author":"Pang","year":"2013","journal-title":"J Immunol"},{"key":"B61","doi-asserted-by":"publisher","first-page":"65","DOI":"10.3899\/jrheum.111476","article-title":"Upregulation of ANK protein expression in joint tissue in calcium pyrophosphate dihydrate crystal deposition disease","volume":"41","author":"Uzuki","year":"2014","journal-title":"J Rheumatol"},{"key":"B62","doi-asserted-by":"publisher","first-page":"3033","DOI":"10.1002\/jbm.a.34599","article-title":"Macrophages \u2013 key cells in the response to wear debris from joint replacements","volume":"101","author":"Nich","year":"2013","journal-title":"J Biomed Mater Res A"},{"key":"B63","doi-asserted-by":"publisher","first-page":"849","DOI":"10.2106\/00004623-199274060-00006","article-title":"Periprosthetic bone loss in total hip arthroplasty. Polyethylene wear debris and the concept of the effective joint space","volume":"74","author":"Schmalzried","year":"1992","journal-title":"J Bone Joint Surg Am"},{"key":"B64","doi-asserted-by":"publisher","first-page":"2739","DOI":"10.1016\/S0142-9612(03)00089-9","article-title":"Importance of hydroxyapatite particles characteristics on cytokines production by human monocytes in vitro","volume":"24","author":"Laquerriere","year":"2003","journal-title":"Biomaterials"},{"key":"B65","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1007\/s10787-013-0192-6","article-title":"Periprosthetic osteolysis after total hip replacement: molecular pathology and clinical management","volume":"21","author":"Howie","year":"2013","journal-title":"Inflammopharmacology"},{"key":"B66","doi-asserted-by":"publisher","first-page":"172","DOI":"10.5312\/wjo.v6.i2.172","article-title":"Biological response to prosthetic debris","volume":"6","author":"Bitar","year":"2015","journal-title":"World J Orthop"},{"key":"B67","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1007\/s11420-006-9003-6","article-title":"The central role of wear debris in periprosthetic osteolysis","volume":"2","author":"Purdue","year":"2006","journal-title":"HSS J"},{"key":"B68","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1503\/cjs.003711","article-title":"Periprosthetic osteolysis: genetics, mechanisms and potential therapeutic interventions","volume":"55","author":"Noordin","year":"2012","journal-title":"Can J Surg"},{"key":"B69","doi-asserted-by":"publisher","first-page":"6974","DOI":"10.1039\/c3nr06047k","article-title":"Extracellular entrapment and degradation of single-walled carbon nanotubes","volume":"6","author":"Farrera","year":"2014","journal-title":"Nanoscale"},{"key":"B70","doi-asserted-by":"publisher","first-page":"e0121359","DOI":"10.1371\/journal.pone.0121359","article-title":"The initial inflammatory response to bioactive implants is characterized by NETosis","volume":"10","author":"Vitkov","year":"2015","journal-title":"PLoS One"},{"key":"B71","doi-asserted-by":"publisher","first-page":"e0137550","DOI":"10.1371\/journal.pone.0137550","article-title":"Neutrophil responses to sterile implant materials","volume":"10","author":"Jhunjhunwala","year":"2015","journal-title":"PLoS One"},{"key":"B72","doi-asserted-by":"publisher","first-page":"E5856","DOI":"10.1073\/pnas.1602230113","article-title":"Nanoparticles size-dependently initiate self-limiting NETosis-driven inflammation","volume":"113","author":"Mu\u00f1oz","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B73","doi-asserted-by":"publisher","first-page":"557","DOI":"10.3389\/fimmu.2016.00557","article-title":"Oxidative burst-dependent NETosis is implicated in the resolution of necrosis-associated sterile inflammation","volume":"7","author":"Biermann","year":"2016","journal-title":"Front Immunol"},{"key":"B74","doi-asserted-by":"publisher","first-page":"S6","DOI":"10.1186\/ar2170","article-title":"Aseptic loosening of total joint replacements: mechanisms underlying osteolysis and potential therapies","volume":"9","author":"Abu-Amer","year":"2007","journal-title":"Arthritis Res Ther"},{"key":"B75","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1080\/08916930701694626","article-title":"Alternative macrophage activation in periprosthetic osteolysis","volume":"41","author":"Purdue","year":"2008","journal-title":"Autoimmunity"},{"key":"B76","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1016\/S0142-9612(01)00134-X","article-title":"Inflammatory responses to orthopaedic biomaterials in the murine air pouch","volume":"23","author":"Wooley","year":"2002","journal-title":"Biomaterials"},{"key":"B77","doi-asserted-by":"publisher","first-page":"1418","DOI":"10.1002\/jor.21149","article-title":"Periprosthetic osteolysis: characterizing the innate immune response to titanium wear-particles","volume":"28","author":"St Pierre","year":"2010","journal-title":"J Orthop Res"},{"key":"B78","doi-asserted-by":"publisher","first-page":"802","DOI":"10.2106\/00004623-199306000-00002","article-title":"Studies of the mechanism by which the mechanical failure of polymethylmethacrylate leads to bone resorption","volume":"75","author":"Horowitz","year":"1993","journal-title":"J Bone Joint Surg Am"},{"key":"B79","doi-asserted-by":"publisher","first-page":"596870","DOI":"10.1155\/2012\/596870","article-title":"The role of TLR and chemokine in wear particle-induced aseptic loosening","volume":"2012","author":"Gu","year":"2012","journal-title":"J Biomed Biotechnol"},{"key":"B80","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1006\/cyto.1999.0647","article-title":"Monocyte migration inhibitory factor synthesis and gene expression in particle-activated macrophages","volume":"12","author":"Lind","year":"2000","journal-title":"Cytokine"},{"key":"B81","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1002\/jbm.a.31467","article-title":"Human macrophage response to UHMWPE, TiAlV, CoCr, and alumina particles: analysis of multiple cytokines using protein arrays","volume":"84","author":"Kaufman","year":"2008","journal-title":"J Biomed Mater Res A"},{"key":"B82","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1302\/0301-620X.81B1.0810155","article-title":"Induction of macrophage C-C chemokine expression by titanium alloy and bone cement particles","volume":"81","author":"Nakashima","year":"1999","journal-title":"J Bone Joint Surg Br"},{"key":"B83","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1016\/S0736-0266(01)00003-1","article-title":"Fibroblast expression of C-C chemokines in response to orthopaedic biomaterial particle challenge in vitro","volume":"19","author":"Yaszay","year":"2001","journal-title":"J Orthop Res"},{"key":"B84","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1016\/j.actbio.2017.10.041","article-title":"Orthopaedic implant materials drive M1 macrophage polarization in a spleen tyrosine kinase- and mitogen-activated protein kinase-dependent manner","volume":"65","author":"Mahon","year":"2018","journal-title":"Acta Biomater"},{"key":"B85","doi-asserted-by":"publisher","first-page":"2815","DOI":"10.1016\/j.actbio.2012.03.042","article-title":"Acta biomaterialia revision joint replacement, wear particles, and macrophage polarization","volume":"8","author":"Rao","year":"2012","journal-title":"Acta Biomater"},{"key":"B86","doi-asserted-by":"publisher","first-page":"2255","DOI":"10.1002\/jbm.a.35759","article-title":"The effect of local IL-4 delivery or CCL2 blockade on implant fixation and bone structural properties in a mouse model of wear particle induced osteolysis","volume":"104","author":"Sato","year":"2016","journal-title":"J Biomed Mater Res A"},{"key":"B87","doi-asserted-by":"publisher","first-page":"55","DOI":"10.3109\/07853899708998743","article-title":"Bisphosphonates: preclinical aspects and use in osteoporosis","volume":"29","author":"Fleisch","year":"1997","journal-title":"Ann Med"},{"key":"B88","doi-asserted-by":"publisher","first-page":"61","DOI":"10.11138\/ccmbm\/2013.10.1.061","article-title":"Bisphosphonate treatment for osteolysis in total hip arthroplasty. A report of four cases","volume":"10","author":"Trevisan","year":"2013","journal-title":"Clin Cases Miner Bone Metab"},{"key":"B89","doi-asserted-by":"publisher","first-page":"e0139927","DOI":"10.1371\/journal.pone.0139927","article-title":"Bisphosphonate use and risk of implant revision after total hip\/knee arthroplasty: a meta-analysis of observational studies","volume":"10","author":"Teng","year":"2015","journal-title":"PLoS One"},{"key":"B90","doi-asserted-by":"publisher","first-page":"2609","DOI":"10.1056\/NEJMoa030288","article-title":"A phase 2 study of bortezomib in relapsed, refractory myeloma","volume":"348","author":"Richardson","year":"2003","journal-title":"N Engl J Med"},{"key":"B91","doi-asserted-by":"publisher","first-page":"3277","DOI":"10.1002\/art.27690","article-title":"The proteasome inhibitor bortezomib drastically affects inflammation and bone disease in adjuvant-induced arthritis in rats","volume":"62","author":"Yannaki","year":"2010","journal-title":"Arthritis Rheum"},{"key":"B92","doi-asserted-by":"publisher","first-page":"1761","DOI":"10.1136\/ard.2008.097709","article-title":"Bortezomib attenuates murine collagen-induced arthritis","volume":"68","author":"Lee","year":"2009","journal-title":"Ann Rheum Dis"},{"key":"B93","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1038\/nri.2016.100","article-title":"Crosstalk between autophagy and inflammatory signalling pathways: balancing defence and homeostasis","volume":"16","author":"Cadwell","year":"2016","journal-title":"Nat Rev Immunol"},{"key":"B94","doi-asserted-by":"publisher","first-page":"5485","DOI":"10.1073\/pnas.1620910114","article-title":"Uric acid priming in human monocytes is driven by the AKT-PRAS40 autophagy pathway","volume":"114","author":"Cri\u015fan","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B95","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/j.actbio.2016.11.020","article-title":"TiAl6V4particles promote osteoclast formation via autophagy-mediated downregulation of interferon-beta in osteocytes","volume":"48","author":"Wang","year":"2017","journal-title":"Acta Biomater"},{"key":"B96","doi-asserted-by":"publisher","first-page":"11545","DOI":"10.1074\/jbc.M113.523811","article-title":"Osteocytes produce interferon-beta as a negative regulator of osteoclastogenesis","volume":"289","author":"Hayashida","year":"2014","journal-title":"J Biol Chem"},{"key":"B97","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.ebiom.2016.10.034","article-title":"Therapeutic targeting of autophagy","volume":"14","author":"Towers","year":"2016","journal-title":"EBioMedicine"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2018.01145\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,5,28]],"date-time":"2018-05-28T12:28:22Z","timestamp":1527510502000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2018.01145\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,28]]},"references-count":97,"alternative-id":["10.3389\/fimmu.2018.01145"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2018.01145","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,28]]},"article-number":"1145"}}