{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T08:41:40Z","timestamp":1790757700823,"version":"4.1.0"},"reference-count":34,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,5,24]],"date-time":"2018-05-24T00:00:00Z","timestamp":1527120000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2018.01152","type":"journal-article","created":{"date-parts":[[2018,5,24]],"date-time":"2018-05-24T04:20:12Z","timestamp":1527135612000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["Functional Invariant Natural Killer T Cells Secreting Cytokines Are Associated With Non-Progressive Human Immunodeficiency Virus-1 Infection but Not With Suppressive Anti-Retroviral Treatment"],"prefix":"10.3389","volume":"9","author":[{"given":"Dharmendra","family":"Singh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manisha","family":"Ghate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheela","family":"Godbole","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Smita","family":"Kulkarni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhuri","family":"Thakar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,5,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1230","DOI":"10.1038\/ni1002","article-title":"Mechanism of CD1d-restricted natural killer T cell activation during microbial infection","volume":"4","author":"Brigl","year":"2003","journal-title":"Nat Immunol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1038\/nature03408","article-title":"Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections","volume":"434","author":"Mattner","year":"2005","journal-title":"Nature"},{"key":"B3","doi-asserted-by":"publisher","first-page":"5663","DOI":"10.4049\/jimmunol.0903730","article-title":"Secretion of IFN-gamma but not IL-17 by CD1d-restricted NKT cells enhances rejection of skin grafts expressing epithelial cell-derived antigen","volume":"184","author":"Mattarollo","year":"2010","journal-title":"J Immunol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1038\/ni.1841","article-title":"Raising the NKT cell family","volume":"11","author":"Godfrey","year":"2010","journal-title":"Nat Immunol"},{"key":"B5","doi-asserted-by":"crossref","first-page":"4647","DOI":"10.4049\/jimmunol.163.9.4647","article-title":"Cutting edge: cross-talk between cells of the innate immune system: NKT cells rapidly activate NK cells","volume":"163","author":"Carnaud","year":"1999","journal-title":"J Immunol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"5140","DOI":"10.4049\/jimmunol.171.10.5140","article-title":"NKT cells enhance CD4+ and CD8+ T cell responses to soluble antigen in vivo through direct interaction with dendritic cells","volume":"171","author":"Hermans","year":"2003","journal-title":"J Immunol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1089\/aid.2007.0119","article-title":"Association of cells with natural killer (NK) and NKT immunophenotype with incident cancers in HIV-infected women","volume":"24","author":"Nowicki","year":"2008","journal-title":"AIDS Res Hum Retroviruses"},{"key":"B8","doi-asserted-by":"publisher","first-page":"3627","DOI":"10.4049\/jimmunol.180.6.3627","article-title":"NKT cells in tumor immunity: opposing subsets define a new immunoregulatory axis","volume":"180","author":"Berzofsky","year":"2008","journal-title":"J Immunol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"3114","DOI":"10.4049\/jimmunol.167.6.3114","article-title":"Human NKT cells mediate antitumor cytotoxicity directly by recognizing target cell CD1d with bound ligand or indirectly by producing IL-2 to activate NK cells","volume":"167","author":"Metelitsa","year":"2001","journal-title":"J Immunol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"4","DOI":"10.2174\/156652409787314534","article-title":"Natural killer T cells and autoimmune disease","volume":"9","author":"Wu","year":"2009","journal-title":"Curr Mol Med"},{"key":"B11","doi-asserted-by":"publisher","first-page":"4827","DOI":"10.2741\/3042","article-title":"Immune regulation by invariant NKT cells in autoimmunity","volume":"13","author":"Ronchi","year":"2008","journal-title":"Front Biosci"},{"key":"B12","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1038\/icb.2014.25","article-title":"NKT cell depletion in humans during early HIV infection","volume":"92","author":"Fernandez","year":"2014","journal-title":"Immunol Cell Biol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.smim.2009.11.001","article-title":"A double-edged sword: the role of NKT cells in malaria and HIV infection and immunity","volume":"22","author":"Vasan","year":"2010","journal-title":"Semin Immunol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"1965","DOI":"10.1097\/QAD.0b013e32832b5134","article-title":"Lower cytokine secretion ex vivo by natural killer T cells in HIV-infected individuals is associated with higher CD161 expression","volume":"23","author":"Snyder-Cappione","year":"2009","journal-title":"AIDS"},{"key":"B15","doi-asserted-by":"publisher","first-page":"3283","DOI":"10.1002\/eji.200939800","article-title":"NKT cells: friend or foe during viral infections?","volume":"39","author":"Diana","year":"2009","journal-title":"Eur J Immunol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"312","DOI":"10.3389\/fimmu.2015.00312","article-title":"CD1d expression and invariant NKT cell responses in herpesvirus infections","volume":"6","author":"Chung","year":"2015","journal-title":"Front Immunol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1084\/jem.20011712","article-title":"CD1d-restricted human natural killer T cells are highly susceptible to human immunodeficiency virus 1 infection","volume":"195","author":"Motsinger","year":"2002","journal-title":"J Exp Med"},{"key":"B18","doi-asserted-by":"publisher","first-page":"7528","DOI":"10.1128\/JVI.76.15.7528-7534.2002","article-title":"Selective loss of innate CD4(+) V alpha 24 natural killer T cells in human immunodeficiency virus infection","volume":"76","author":"Sandberg","year":"2002","journal-title":"J Virol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"1490","DOI":"10.4049\/jimmunol.168.3.1490","article-title":"Selective decrease in circulating V alpha 24+V beta 11+ NKT cells during HIV type 1 infection","volume":"168","author":"van der Vliet","year":"2002","journal-title":"J Immunol"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1046\/j.1365-2567.2003.01580.x","article-title":"Natural killer T cells are targets for human immunodeficiency virus infection","volume":"108","author":"Crowe","year":"2003","journal-title":"Immunology"},{"key":"B21","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1038\/mi.2012.101","article-title":"Preferential depletion of gut CD4-expressing iNKT cells contributes to systemic immune activation in HIV-1 infection","volume":"6","author":"Ibarrondo","year":"2013","journal-title":"Mucosal Immunol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1843","DOI":"10.4049\/jimmunol.1600556","article-title":"Innate invariant NKT cell recognition of HIV-1-infected dendritic cells is an early detection mechanism targeted by viral immune evasion","volume":"197","author":"Paquin-Proulx","year":"2016","journal-title":"J Immunol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"5775","DOI":"10.4049\/jimmunol.177.9.5775","article-title":"Cutting edge: rapid recovery of NKT cells upon institution of highly active antiretroviral therapy for HIV-1 infection","volume":"177","author":"van der Vliet","year":"2006","journal-title":"J Immunol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1093\/intimm\/dxm055","article-title":"Function of NKT cells, potential anti-HIV effector cells, are improved by beginning HAART during acute HIV-1 infection","volume":"19","author":"Vasan","year":"2007","journal-title":"Int Immunol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1089\/aid.2006.0253","article-title":"Delayed reconstitution of CD4+ iNKT cells after effective HIV type 1 therapy","volume":"23","author":"Yang","year":"2007","journal-title":"AIDS Res Hum Retroviruses"},{"key":"B26","doi-asserted-by":"publisher","first-page":"e104","DOI":"10.1097\/QAI.0000000000001322","article-title":"CD1d-restricted natural killer T cells are preserved in Indian long-term nonprogressors","volume":"75","author":"Singh","year":"2017","journal-title":"J Acquir Immune Defic Syndr"},{"key":"B27","doi-asserted-by":"publisher","first-page":"3081","DOI":"10.1182\/blood-2005-09-3636","article-title":"Expansion of CD1d-restricted NKT cells in patients with primary HIV-1 infection treated with interleukin-2","volume":"107","author":"Moll","year":"2006","journal-title":"Blood"},{"key":"B28","doi-asserted-by":"publisher","first-page":"902","DOI":"10.1002\/eji.200838780","article-title":"Severe functional impairment and elevated PD-1 expression in CD1d-restricted NKT cells retained during chronic HIV-1 infection","volume":"39","author":"Moll","year":"2009","journal-title":"Eur J Immunol"},{"key":"B29","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1038\/mi.2016.34","article-title":"Bacteroides are associated with GALT iNKT cell function and reduction of microbial translocation in HIV-1 infection","volume":"10","author":"Paquin-Proulx","year":"2017","journal-title":"Mucosal Immunol"},{"key":"B30","doi-asserted-by":"publisher","first-page":"1713","DOI":"10.1097\/QAD.0000000000001147","article-title":"Elevated levels of invariant natural killer T-cell and natural killer cell activation correlate with disease progression in HIV-1 and HIV-2 infections","volume":"30","author":"Bachle","year":"2016","journal-title":"AIDS"},{"key":"B31","doi-asserted-by":"publisher","first-page":"e1002928","DOI":"10.1371\/journal.ppat.1002928","article-title":"Loss of effector and anti-inflammatory natural killer T lymphocyte function in pathogenic simian immunodeficiency virus infection","volume":"8","author":"Rout","year":"2012","journal-title":"PLoS Pathog"},{"key":"B32","doi-asserted-by":"publisher","first-page":"222","DOI":"10.3389\/fimmu.2014.00222","article-title":"Higher expression of activating receptors on cytotoxic NK cells is associated with early control on HIV-1C multiplication","volume":"5","author":"Kulkarni","year":"2014","journal-title":"Front Immunol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"3440","DOI":"10.1182\/blood-2016-11-751065","article-title":"Invariant NKT cells contribute to chronic lymphocytic leukemia surveillance and prognosis","volume":"129","author":"Gorini","year":"2017","journal-title":"Blood"},{"key":"B34","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1007\/s00262-010-0963-5","article-title":"Targeting NKT cells and PD-L1 pathway results in augmented anti-tumor responses in a melanoma model","volume":"60","author":"Durgan","year":"2011","journal-title":"Cancer Immunol Immunother"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2018.01152\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T19:54:13Z","timestamp":1693684453000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2018.01152\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,24]]},"references-count":34,"alternative-id":["10.3389\/fimmu.2018.01152"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2018.01152","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,24]]},"article-number":"1152"}}