{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T12:26:52Z","timestamp":1784204812564,"version":"3.55.0"},"reference-count":46,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,6,4]],"date-time":"2018-06-04T00:00:00Z","timestamp":1528070400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2018.01258","type":"journal-article","created":{"date-parts":[[2018,6,4]],"date-time":"2018-06-04T07:52:41Z","timestamp":1528098761000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Chronic Granulomatous Disease First Diagnosed in Adulthood Presenting With Spinal Cord Infection"],"prefix":"10.3389","volume":"9","author":[{"given":"Philipp","family":"Schwenkenbecher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Neyazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Donnerstag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix C.","family":"Ringshausen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Jacobs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Stoll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Kirschner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian Peter","family":"L\u00e4nger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emil","family":"Valizada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Gingele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Wegner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurt-Wolfram","family":"S\u00fchs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Stangel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Skripuletz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,6,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1176","DOI":"10.1093\/cid\/ciu1154","article-title":"Common severe infections in chronic granulomatous disease","volume":"60","author":"Marciano","year":"2015","journal-title":"Clin Infect Dis"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.1016\/j.jaci.2013.05.031","article-title":"Clinical outcome in children with chronic granulomatous disease managed conservatively or with hematopoietic stem cell transplantation","volume":"132","author":"Cole","year":"2013","journal-title":"J Allergy Clin Immunol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1097\/00005792-200005000-00003","article-title":"Chronic granulomatous disease. Report on a national registry of 368 patients","volume":"79","author":"Winkelstein","year":"2000","journal-title":"Medicine (Baltimore)"},{"key":"B4","doi-asserted-by":"publisher","first-page":"e5234","DOI":"10.1371\/journal.pone.0005234","article-title":"Chronic granulomatous disease: the European experience","volume":"4","author":"van den Berg","year":"2009","journal-title":"PLoS One"},{"key":"B5","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.clim.2007.09.008","article-title":"Clinical features, long-term follow-up and outcome of a large cohort of patients with Chronic granulomatous disease: an Italian multicenter study","volume":"126","author":"Martire","year":"2008","journal-title":"Clin Immunol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1067\/mpd.2000.109112","article-title":"Long-term follow-up and outcome of 39 patients with chronic granulomatous disease","volume":"137","author":"Liese","year":"2000","journal-title":"J Pediatr"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.1007\/s00431-008-0680-7","article-title":"Clinical features and prognoses of 23 patients with chronic granulomatous disease followed for 21 years by a single hospital in Japan","volume":"167","author":"Kobayashi","year":"2008","journal-title":"Eur J Pediatr"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1110","DOI":"10.1097\/INF.0000000000000840","article-title":"Chronic granulomatous disease: a large, single-center US experience","volume":"34","author":"Bortoletto","year":"2015","journal-title":"Pediatr Infect Dis J"},{"key":"B9","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1586\/1744666X.5.1.45","article-title":"Chronic granulomatous disease: complications and management","volume":"5","author":"Rosenzweig","year":"2009","journal-title":"Expert Rev Clin Immunol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1007\/s00281-008-0119-2","article-title":"Hyperinflammation in chronic granulomatous disease and anti-inflammatory role of the phagocyte NADPH oxidase","volume":"30","author":"Schappi","year":"2008","journal-title":"Semin Immunopathol"},{"key":"B11","first-page":"86","article-title":"[The clinical response to interferon-gamma in a patient with chronic granulomatous disease and brain abscesses due to Aspergillus fumigatus]","volume":"17","author":"Touza Rey","year":"2000","journal-title":"An Med Interna"},{"key":"B12","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1093\/bmb\/ldw009","article-title":"Chronic granulomatous disease","volume":"118","author":"Roos","year":"2016","journal-title":"Br Med Bull"},{"key":"B13","doi-asserted-by":"publisher","first-page":"e8","DOI":"10.1016\/j.jaci.2014.04.014","article-title":"Inflammatory manifestations in a single-center cohort of patients with chronic granulomatous disease","volume":"134","author":"Magnani","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1097\/00005792-200005000-00004","article-title":"Genetic, biochemical, and clinical features of chronic granulomatous disease","volume":"79","author":"Segal","year":"2000","journal-title":"Medicine (Baltimore)"},{"key":"B15","doi-asserted-by":"publisher","first-page":"321","DOI":"10.3855\/jidc.132","article-title":"First case of extensive spinal cord infection with Aspergillus nidulans in a child with chronic granulomatous disease","volume":"3","author":"Bukhari","year":"2009","journal-title":"J Infect Dev Ctries"},{"key":"B16","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1136\/adc.68.3.412","article-title":"Cerebral aspergilloma in a child with autosomal recessive chronic granulomatous disease","volume":"68","author":"Dean","year":"1993","journal-title":"Arch Dis Child"},{"key":"B17","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1093\/clinids\/14.1.235","article-title":"Successful treatment of systemic Exophiala dermatitidis infection in a patient with chronic granulomatous disease","volume":"14","author":"Kenney","year":"1992","journal-title":"Clin Infect Dis"},{"key":"B18","first-page":"282","article-title":"Brain abscess caused by Salmonella enterica subspecies houtenae in a patient with chronic granulomatous disease","volume":"36","author":"Ma","year":"2003","journal-title":"J Microbiol Immunol Infect"},{"key":"B19","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1007\/s004310051231","article-title":"Streptococcus intermedius-brain abscess in chronic granulomatous disease","volume":"158","author":"Nagatomo","year":"1999","journal-title":"Eur J Pediatr"},{"key":"B20","doi-asserted-by":"publisher","first-page":"132","DOI":"10.3171\/jns.1987.67.1.0132","article-title":"Chronic granulomatous disease with cranial fungal osteomyelitis and epidural abscess. Case report","volume":"67","author":"Pollack","year":"1987","journal-title":"J Neurosurg"},{"key":"B21","doi-asserted-by":"publisher","first-page":"E137","DOI":"10.1086\/320158","article-title":"Successful treatment of aspergillus brain abscess with itraconazole and interferon-gamma in a patient with chronic granulomatous disease","volume":"32","author":"Saulsbury","year":"2001","journal-title":"Clin Infect Dis"},{"key":"B22","first-page":"210","article-title":"[Chronic septic granulomatosis in a young girl manifesting as invasive pulmonary aspergillosis and flaccid paraplegia]","volume":"78","author":"Mazigh M\u2019Rad","year":"2000","journal-title":"Tunis Med"},{"key":"B23","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1542\/peds.114.2.462","article-title":"Gastrointestinal involvement in chronic granulomatous disease","volume":"114","author":"Marciano","year":"2004","journal-title":"Pediatrics"},{"key":"B24","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1056\/NEJM198909143211102","article-title":"Urinary tract disorders in patients with chronic granulomatous disease","volume":"321","author":"Aliabadi","year":"1989","journal-title":"N Engl J Med"},{"key":"B25","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1093\/clinchem\/48.5.780","article-title":"Unusual late onset of X-linked chronic granulomatous disease in an adult woman after unsuspicious childhood","volume":"48","author":"Lun","year":"2002","journal-title":"Clin Chem"},{"key":"B26","first-page":"118","article-title":"Chronic granulomatous disease: a case report","volume":"33","author":"Ma","year":"2000","journal-title":"J Microbiol Immunol Infect"},{"key":"B27","doi-asserted-by":"publisher","first-page":"1521","DOI":"10.1183\/09031936.00020215","article-title":"Primary immunodeficiencies: not just paediatric diseases","volume":"45","author":"Gennery","year":"2015","journal-title":"Eur Respir J"},{"key":"B28","doi-asserted-by":"publisher","first-page":"S123","DOI":"10.1016\/j.bbmt.2010.09.008","article-title":"Chronic granulomatous disease: lessons from a rare disorder","volume":"17","author":"Segal","year":"2011","journal-title":"Biol Blood Marrow Transplant"},{"key":"B29","doi-asserted-by":"publisher","first-page":"1662","DOI":"10.1016\/j.bbadis.2013.05.001","article-title":"Different unequal cross-over events between NCF1 and its pseudogenes in autosomal p47(phox)-deficient chronic granulomatous disease","volume":"1832","author":"Hayrapetyan","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"B30","doi-asserted-by":"publisher","first-page":"217","DOI":"10.3858\/emm.2009.41.4.058","article-title":"p47phox, the phagocyte NADPH oxidase\/NOX2 organizer: structure, phosphorylation and implication in diseases","volume":"41","author":"El-Benna","year":"2009","journal-title":"Exp Mol Med"},{"key":"B31","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1111\/cei.12202","article-title":"Molecular diagnosis of chronic granulomatous disease","volume":"175","author":"Roos","year":"2014","journal-title":"Clin Exp Immunol"},{"key":"B32","doi-asserted-by":"publisher","first-page":"1613","DOI":"10.1183\/09031936.00118414","article-title":"Pulmonary manifestations in adult patients with chronic granulomatous disease","volume":"45","author":"Salvator","year":"2015","journal-title":"Eur Respir J"},{"key":"B33","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1002\/art.1780370524","article-title":"Polyarthritis resembling juvenile rheumatoid arthritis in a girl with chronic granulomatous disease","volume":"37","author":"Lee","year":"1994","journal-title":"Arthritis Rheum"},{"key":"B34","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1002\/art.1780340116","article-title":"Systemic lupus erythematosus in a boy with chronic granulomatous disease: case report and review of the literature","volume":"34","author":"Manzi","year":"1991","journal-title":"Arthritis Rheum"},{"key":"B35","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1182\/blood.V95.6.2150","article-title":"Recombination events between the p47-phox gene and its highly homologous pseudogenes are the main cause of autosomal recessive chronic granulomatous disease","volume":"95","author":"Roesler","year":"2000","journal-title":"Blood"},{"key":"B36","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1111\/j.1365-2249.2007.03321.x","article-title":"Cutaneous and other lupus-like symptoms in carriers of X-linked chronic granulomatous disease: incidence and autoimmune serology","volume":"148","author":"Cale","year":"2007","journal-title":"Clin Exp Immunol"},{"key":"B37","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1111\/j.1365-2133.1986.tb02805.x","article-title":"Discoid lupus erythematosus-like lesions in an autosomal form of chronic granulomatous disease","volume":"114","author":"Stalder","year":"1986","journal-title":"Br J Dermatol"},{"key":"B38","first-page":"334","article-title":"Chronic granulomatous disease: recent advances in pathophysiology and treatment","volume":"68","author":"Seger","year":"2010","journal-title":"Neth J Med"},{"key":"B39","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/S0022-3476(87)80452-3","article-title":"Corticosteroids in treatment of obstructive lesions of chronic granulomatous disease","volume":"111","author":"Chin","year":"1987","journal-title":"J Pediatr"},{"key":"B40","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/S0022-3476(06)80138-1","article-title":"Outpatient management with oral corticosteroid therapy for obstructive conditions in chronic granulomatous disease","volume":"122","author":"Danziger","year":"1993","journal-title":"J Pediatr"},{"key":"B41","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1093\/cid\/cir896","article-title":"Corticosteroid therapy for liver abscess in chronic granulomatous disease","volume":"54","author":"Leiding","year":"2012","journal-title":"Clin Infect Dis"},{"key":"B42","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1086\/520985","article-title":"Fulminant mulch pneumonitis: an emergency presentation of chronic granulomatous disease","volume":"45","author":"Siddiqui","year":"2007","journal-title":"Clin Infect Dis"},{"key":"B43","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/S1081-1206(10)60023-3","article-title":"Corticosteroid therapy for refractory infections in chronic granulomatous disease: case reports and review of the literature","volume":"97","author":"Yamazaki-Nakashimada","year":"2006","journal-title":"Ann Allergy Asthma Immunol"},{"key":"B44","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1086\/422993","article-title":"Long-term interferon-gamma therapy for patients with chronic granulomatous disease","volume":"39","author":"Marciano","year":"2004","journal-title":"Clin Infect Dis"},{"key":"B45","doi-asserted-by":"publisher","first-page":"e778","DOI":"10.1542\/peds.2008-0123","article-title":"First successful bone marrow transplantation for X-linked chronic granulomatous disease by using preimplantation female gender typing and HLA matching","volume":"122","author":"Reichenbach","year":"2008","journal-title":"Pediatrics"},{"key":"B46","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1111\/j.1365-2141.2007.06880.x","article-title":"Modern management of chronic granulomatous disease","volume":"140","author":"Seger","year":"2008","journal-title":"Br J Haematol"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2018.01258\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,3]],"date-time":"2020-11-03T02:17:59Z","timestamp":1604369879000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2018.01258\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,4]]},"references-count":46,"alternative-id":["10.3389\/fimmu.2018.01258"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2018.01258","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,4]]},"article-number":"1258"}}