{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:27:38Z","timestamp":1793147258784,"version":"4.5.0"},"reference-count":68,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,6,12]],"date-time":"2018-06-12T00:00:00Z","timestamp":1528761600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["DE025020, DE025383, DE023584"],"award-info":[{"award-number":["DE025020, DE025383, DE023584"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2018.01300","type":"journal-article","created":{"date-parts":[[2018,6,12]],"date-time":"2018-06-12T04:24:35Z","timestamp":1528777475000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":64,"title":["Resolvin E1 Promotes Bone Preservation Under Inflammatory Conditions"],"prefix":"10.3389","volume":"9","author":[{"given":"Karim","family":"El Kholy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo","family":"Freire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsute","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas E.","family":"Van Dyke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,6,12]]},"reference":[{"key":"B1","doi-asserted-by":"crossref","first-page":"775","DOI":"10.4049\/jimmunol.138.3.775","article-title":"Tumor necrosis factors alpha and beta induce osteoblastic cells to stimulate osteoclastic bone resorption","volume":"138","author":"Thomson","year":"1987","journal-title":"J Immunol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1084\/jem.164.1.104","article-title":"Osteoblasts mediate interleukin 1 stimulation of bone resorption by rat osteoclasts","volume":"164","author":"Thomson","year":"1986","journal-title":"J Exp Med"},{"key":"B3","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.cytogfr.2003.10.005","article-title":"IL-6, RANKL, TNF-alpha\/IL-1: interrelations in bone resorption pathophysiology","volume":"15","author":"Kwan Tat","year":"2004","journal-title":"Cytokine Growth Factor Rev"},{"key":"B4","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1034\/j.1600-0765.2003.00615.x","article-title":"Receptor activator NF kappaB ligand (RANKL) and osteoprotegerin (OPG) protein expression in periodontitis","volume":"38","author":"Crotti","year":"2003","journal-title":"J Periodontal Res"},{"key":"B5","doi-asserted-by":"publisher","first-page":"ii11","DOI":"10.1093\/rheumatology\/keg327","article-title":"Pathogenesis of bone and cartilage destruction in rheumatoid arthritis","volume":"42","author":"Goldring","year":"2003","journal-title":"Rheumatology"},{"key":"B6","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1002\/1529-0131(200002)43:2<250::AID-ANR3>3.0.CO;2-P","article-title":"Synovial tissue in rheumatoid arthritis is a source of osteoclast differentiation factor","volume":"43","author":"Gravallese","year":"2000","journal-title":"Arthritis Rheum"},{"key":"B7","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/S0140-6736(94)91049-9","article-title":"Generalised bone loss in patients with early rheumatoid arthritis","volume":"344","author":"Gough","year":"1994","journal-title":"Lancet"},{"key":"B8","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1902\/jop.1999.70.4.457","article-title":"The pathogenesis of periodontal diseases","volume":"70","year":"1999","journal-title":"J Periodontol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1406","DOI":"10.1902\/jop.2005.76.8.1406","article-title":"Position paper: epidemiology of periodontal diseases","volume":"76","author":"Burt","year":"2005","journal-title":"J Periodontol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1902\/jop.1978.49.5.225","article-title":"A long-term survey of tooth loss in 600 treated periodontal patients","volume":"49","author":"Hirschfeld","year":"1978","journal-title":"J Periodontol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1902\/jop.1982.53.9.539","article-title":"Tooth loss in 100 treated patients with periodontal disease. A long-term study","volume":"53","author":"McFall","year":"1982","journal-title":"J Periodontol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"e90633","DOI":"10.1371\/journal.pone.0090633","article-title":"The burden of musculoskeletal conditions","volume":"9","author":"Palazzo","year":"2014","journal-title":"PLoS One"},{"key":"B13","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1038\/nature13479","article-title":"Pro-resolving lipid mediators are leads for resolution physiology","volume":"510","author":"Serhan","year":"2014","journal-title":"Nature"},{"key":"B14","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1084\/jem.20020760","article-title":"Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals","volume":"196","author":"Serhan","year":"2002","journal-title":"J Exp Med"},{"key":"B15","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1084\/jem.192.8.1197","article-title":"Novel functional sets of lipid-derived mediators with antiinflammatory actions generated from omega-3 fatty acids via cyclooxygenase 2-nonsteroidal antiinflammatory drugs and transcellular processing","volume":"192","author":"Serhan","year":"2000","journal-title":"J Exp Med"},{"key":"B16","doi-asserted-by":"publisher","first-page":"14677","DOI":"10.1074\/jbc.M300218200","article-title":"Novel docosatrienes and 17S-resolvins generated from docosahexaenoic acid in murine brain, human blood, and glial cells. Autacoids in anti-inflammation","volume":"278","author":"Hong","year":"2003","journal-title":"J Biol Chem"},{"key":"B17","doi-asserted-by":"publisher","first-page":"4345","DOI":"10.4049\/jimmunol.174.9.5884c","article-title":"Molecular circuits of resolution: formation and actions of resolvins and protectins","volume":"174","author":"Bannenberg","year":"2005","journal-title":"J Immunol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"298","DOI":"10.3389\/fimmu.2012.00298","article-title":"Pro-resolving lipid mediators (SPMs) and their actions in regulating miRNA in novel resolution circuits in inflammation","volume":"3","author":"Recchiuti","year":"2012","journal-title":"Front Immunol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1038\/89759","article-title":"Lipid mediator class switching during acute inflammation: signals in resolution","volume":"2","author":"Levy","year":"2001","journal-title":"Nat Immunol"},{"key":"B20","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1146\/annurev.immunol.25.022106.141647","article-title":"Resolution phase of inflammation: novel endogenous anti-inflammatory and proresolving lipid mediators and pathways","volume":"25","author":"Serhan","year":"2007","journal-title":"Annu Rev Immunol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"38","DOI":"10.3389\/fimmu.2018.00038","article-title":"Bioactive lipids and chronic inflammation: managing the fire within","volume":"9","author":"Chiurchi\u00f9","year":"2018","journal-title":"Front Immunol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"7021","DOI":"10.4049\/jimmunol.179.10.7021","article-title":"Resolvin E1 regulates inflammation at the cellular and tissue level and restores tissue homeostasis in vivo","volume":"179","author":"Hasturk","year":"2007","journal-title":"J Immunol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"1848","DOI":"10.4049\/jimmunol.176.3.1848","article-title":"Anti-inflammatory actions of neuroprotectin D1\/protectin D1 and its natural stereoisomers: assignments of dihydroxy-containing docosatrienes","volume":"176","author":"Serhan","year":"2006","journal-title":"J Immunol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1146\/annurev-physiol-021113-170408","article-title":"Resolution of acute inflammation in the lung","volume":"76","author":"Levy","year":"2014","journal-title":"Annu Rev Physiol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1146\/annurev.pathmechdis.3.121806.151409","article-title":"Anti-inflammatory and proresolving lipid mediators","volume":"3","author":"Serhan","year":"2008","journal-title":"Annu Rev Pathol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1016\/j.coph.2013.05.012","article-title":"Resolution phase lipid mediators of inflammation: agonists of resolution","volume":"13","author":"Serhan","year":"2013","journal-title":"Curr Opin Pharmacol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"1970","DOI":"10.1161\/ATVBAHA.112.249508","article-title":"Resolvin D1 limits polymorphonuclear leukocyte recruitment to inflammatory loci: receptor-dependent actions","volume":"32","author":"Norling","year":"2012","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"B28","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.cmet.2013.10.006","article-title":"Resolvins, specialized proresolving lipid mediators, and their potential roles in metabolic diseases","volume":"19","author":"Spite","year":"2014","journal-title":"Cell Metab"},{"key":"B29","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1016\/j.coph.2013.02.003","article-title":"The role of omega-3 derived resolvins in arthritis","volume":"13","author":"Norling","year":"2013","journal-title":"Curr Opin Pharmacol"},{"key":"B30","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1084\/jem.20042031","article-title":"Stereochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1","volume":"201","author":"Arita","year":"2005","journal-title":"J Exp Med"},{"key":"B31","doi-asserted-by":"publisher","first-page":"9323","DOI":"10.1074\/jbc.M609212200","article-title":"Resolvin D1 and its aspirin-triggered 17R epimer. Stereochemical assignments, anti-inflammatory properties, and enzymatic inactivation","volume":"282","author":"Sun","year":"2007","journal-title":"J Biol Chem"},{"key":"B32","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/j.bbrc.2008.01.012","article-title":"Resolvin E1 dampens airway inflammation and hyperresponsiveness in a murine model of asthma","volume":"367","author":"Aoki","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"B33","doi-asserted-by":"publisher","first-page":"7063","DOI":"10.4049\/jimmunol.169.12.7063","article-title":"An aspirin-triggered lipoxin A4 stable analog displays a unique topical anti-inflammatory profile","volume":"169","author":"Schottelius","year":"2002","journal-title":"J Immunol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1111\/j.1365-2133.2012.11177.x","article-title":"Efficacy and safety of 15(R\/S)-methyl-lipoxin A(4) in topical treatment of infantile eczema","volume":"168","author":"Wu","year":"2013","journal-title":"Br J Dermatol"},{"key":"B35","doi-asserted-by":"publisher","first-page":"2399","DOI":"10.1096\/fj.10-178657","article-title":"Resolvin D1 decreases adipose tissue macrophage accumulation and improves insulin sensitivity in obese-diabetic mice","volume":"25","author":"Hellmann","year":"2011","journal-title":"FASEB J"},{"key":"B36","doi-asserted-by":"publisher","first-page":"618","DOI":"10.2337\/db12-0684","article-title":"Proresolution therapy for the treatment of delayed healing of diabetic wounds","volume":"62","author":"Tang","year":"2013","journal-title":"Diabetes"},{"key":"B37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.nut.2012.02.003","article-title":"Lipoxins, resolvins, and protectins in the prevention and treatment of diabetic macular edema and retinopathy","volume":"29","author":"Das","year":"2013","journal-title":"Nutrition"},{"key":"B38","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1016\/j.exger.2009.09.002","article-title":"NF-kappaB signaling as a putative target for omega-3 metabolites in the prevention of age-related macular degeneration (AMD)","volume":"44","author":"Kaarniranta","year":"2009","journal-title":"Exp Gerontol"},{"key":"B39","doi-asserted-by":"publisher","first-page":"626","DOI":"10.3389\/fphar.2017.00626","article-title":"Nardosinone suppresses RANKL-induced osteoclastogenesis and attenuates lipopolysaccharide-induced alveolar bone resorption","volume":"8","author":"Niu","year":"2017","journal-title":"Front Pharmacol"},{"key":"B40","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1038\/252713a0","article-title":"Separation of parathyroid hormone and calcitonin-sensitive cells from non-responsive bone cells","volume":"252","author":"Wong","year":"1974","journal-title":"Nature"},{"key":"B41","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1002\/jbmr.5650030406","article-title":"Further biochemical and molecular characterization of primary rat parietal bone cell cultures","volume":"3","author":"McCarthy","year":"1988","journal-title":"J Bone Miner Res"},{"key":"B42","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1111\/j.1364-3703.2009.00552.x","article-title":"Isolation of RNA from laser-capture-microdissected giant cells at early differentiation stages suitable for differential transcriptome analysis","volume":"10","author":"Portillo","year":"2009","journal-title":"Mol Plant Pathol"},{"key":"B43","doi-asserted-by":"publisher","first-page":"1537","DOI":"10.1101\/gr.6202607","article-title":"A systems biology approach for pathway level analysis","volume":"17","author":"Draghici","year":"2007","journal-title":"Genome Res"},{"key":"B44","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1093\/bioinformatics\/btn577","article-title":"A novel signaling pathway impact analysis","volume":"25","author":"Tarca","year":"2009","journal-title":"Bioinformatics"},{"key":"B45","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1902\/jop.2010.100263","article-title":"Development of an animal model for Aggregatibacter actinomycetemcomitans biofilm-mediated oral osteolytic infection: a preliminary study","volume":"82","author":"Freire","year":"2011","journal-title":"J Periodontol"},{"key":"B46","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1111\/j.1600-051X.2011.01810.x","article-title":"The RANKL-OPG system in clinical periodontology","volume":"39","author":"Belibasakis","year":"2012","journal-title":"J Clin Periodontol"},{"key":"B47","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.cyto.2011.03.009","article-title":"The RANKL-OPG system is differentially regulated by supragingival and subgingival biofilm supernatants","volume":"55","author":"Belibasakis","year":"2011","journal-title":"Cytokine"},{"key":"B48","doi-asserted-by":"publisher","first-page":"4367","DOI":"10.1210\/endo.140.9.7131","article-title":"Estrogen stimulates gene expression and protein production of osteoprotegerin in human osteoblastic cells","volume":"140","author":"Hofbauer","year":"1999","journal-title":"Endocrinology"},{"key":"B49","doi-asserted-by":"publisher","first-page":"3353","DOI":"10.4049\/jimmunol.169.6.3353","article-title":"IL-6, leukemia inhibitory factor, and oncostatin M stimulate bone resorption and regulate the expression of receptor activator of NF-kappa B ligand, osteoprotegerin, and receptor activator of NF-kappa B in mouse calvariae","volume":"169","author":"Palmqvist","year":"2002","journal-title":"J Immunol"},{"key":"B50","doi-asserted-by":"publisher","first-page":"1991","DOI":"10.1210\/en.2004-1167","article-title":"Cross-talk between the interleukin-6 and prostaglandin E(2) signaling systems results in enhancement of osteoclastogenesis through effects on the osteoprotegerin\/receptor activator of nuclear factor-{kappa}B (RANK) ligand\/RANK system","volume":"146","author":"Liu","year":"2005","journal-title":"Endocrinology"},{"key":"B51","doi-asserted-by":"publisher","first-page":"727063","DOI":"10.1155\/2011\/727063","article-title":"In vivo imaging of particle-induced inflammation and osteolysis in the calvariae of NFkappaB\/luciferase transgenic mice","volume":"2011","author":"Takahashi","year":"2011","journal-title":"J Biomed Biotechnol"},{"key":"B52","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1359\/jbmr.091106","article-title":"Role of chemerin\/CMKLR1 signaling in adipogenesis and osteoblastogenesis of bone marrow stem cells","volume":"25","author":"Muruganandan","year":"2010","journal-title":"J Bone Miner Res"},{"key":"B53","doi-asserted-by":"publisher","first-page":"689","DOI":"10.4049\/jimmunol.1103688","article-title":"Resolvin E1 and chemokine-like receptor 1 mediate bone preservation","volume":"190","author":"Gao","year":"2013","journal-title":"J Immunol"},{"key":"B54","doi-asserted-by":"publisher","first-page":"1214","DOI":"10.1038\/bjp.2008.367","article-title":"An endogenous regulator of inflammation, resolvin E1, modulates osteoclast differentiation and bone resorption","volume":"155","author":"Herrera","year":"2008","journal-title":"Br J Pharmacol"},{"key":"B55","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/S0952-3278(03)00060-7","article-title":"Protective role of n-3 lipids and soy protein in osteoporosis","volume":"68","author":"Fernandes","year":"2003","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"B56","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1093\/ajcn\/85.3.803","article-title":"n-3 Fatty acids are positively associated with peak bone mineral density and bone accrual in healthy men: the NO2 study","volume":"85","author":"H\u00f6gstr\u00f6m","year":"2007","journal-title":"Am J Clin Nutr"},{"key":"B57","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1054\/plef.1999.0116","article-title":"Oestrogen and essential fatty acid supplementation corrects bone loss due to ovariectomy in the female Sprague Dawley rat","volume":"61","author":"Schlemmer","year":"1999","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"B58","doi-asserted-by":"publisher","first-page":"1206","DOI":"10.1359\/jbmr.2003.18.7.1206","article-title":"Dietary n-3 fatty acids decrease osteoclastogenesis and loss of bone mass in ovariectomized mice","volume":"18","author":"Sun","year":"2003","journal-title":"J Bone Miner Res"},{"key":"B59","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1002\/ajh.21170","article-title":"Identification of inflammatory and proresolving lipid mediators in bone marrow and their lipidomic profiles with ovariectomy and omega-3 intake","volume":"83","author":"Poulsen","year":"2008","journal-title":"Am J Hematol"},{"key":"B60","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1038\/nri2852","article-title":"The impact of the extracellular matrix on inflammation","volume":"10","author":"Sorokin","year":"2010","journal-title":"Nat Rev Immunol"},{"key":"B61","doi-asserted-by":"publisher","first-page":"3451","DOI":"10.1074\/jbc.M109.044131","article-title":"Resolvin E1 receptor activation signals phosphorylation and phagocytosis","volume":"285","author":"Ohira","year":"2010","journal-title":"J Biol Chem"},{"key":"B62","doi-asserted-by":"publisher","first-page":"R228","DOI":"10.1186\/ar3215","article-title":"Human articular chondrocytes express ChemR23 and chemerin; ChemR23 promotes inflammatory signalling upon binding the ligand chemerin(21-157)","volume":"12","author":"Berg","year":"2010","journal-title":"Arthritis Res Ther"},{"key":"B63","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1189\/jlb.0909610","article-title":"TNF-alpha, IL-6, and IL-1 expression is inhibited by GAS6 in monocytes\/macrophages","volume":"87","author":"Alciato","year":"2010","journal-title":"J Leukoc Biol"},{"key":"B64","doi-asserted-by":"publisher","first-page":"22847","DOI":"10.1074\/jbc.M603766200","article-title":"Metabolic inactivation of resolvin E1 and stabilization of its anti-inflammatory actions","volume":"281","author":"Arita","year":"2006","journal-title":"J Biol Chem"},{"key":"B65","doi-asserted-by":"publisher","first-page":"1689","DOI":"10.1002\/(SICI)1521-4141(199805)28:05<1689::AID-IMMU1689>3.0.CO;2-I","article-title":"ChemR23, a putative chemoattractant receptor, is expressed in monocyte-derived dendritic cells and macrophages and is a coreceptor for SIV and some primary HIV-1 strains","volume":"28","author":"Samson","year":"1998","journal-title":"Eur J Immunol"},{"key":"B66","doi-asserted-by":"publisher","first-page":"3912","DOI":"10.4049\/jimmunol.178.6.3912","article-title":"Resolvin E1 selectively interacts with leukotriene B4 receptor BLT1 and ChemR23 to regulate inflammation","volume":"178","author":"Arita","year":"2007","journal-title":"J Immunol"},{"key":"B67","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1084\/jem.20030382","article-title":"Specific recruitment of antigen-presenting cells by chemerin, a novel processed ligand from human inflammatory fluids","volume":"198","author":"Wittamer","year":"2003","journal-title":"J Exp Med"},{"key":"B68","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1006\/bbrc.1997.6455","article-title":"A novel G protein-coupled receptor with homology to neuropeptide and chemoattractant receptors expressed during bone development","volume":"233","author":"Methner","year":"1997","journal-title":"Biochem Biophys Res Commun"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2018.01300\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T04:11:11Z","timestamp":1693714271000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2018.01300\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,12]]},"references-count":68,"alternative-id":["10.3389\/fimmu.2018.01300"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2018.01300","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,12]]},"article-number":"1300"}}