{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:01:13Z","timestamp":1791644473632,"version":"4.3.4"},"reference-count":101,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,6,12]],"date-time":"2018-06-12T00:00:00Z","timestamp":1528761600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2018.01351","type":"journal-article","created":{"date-parts":[[2018,6,12]],"date-time":"2018-06-12T04:52:08Z","timestamp":1528779128000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":143,"title":["Dissociation of C-Reactive Protein Localizes and Amplifies Inflammation: Evidence for a Direct Biological Role of C-Reactive Protein and Its Conformational Changes"],"prefix":"10.3389","volume":"9","author":[{"given":"James D.","family":"McFadyen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jurij","family":"Kiefer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Braig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Loseff-Silver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence A.","family":"Potempa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen Ulrich","family":"Eisenhardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karlheinz","family":"Peter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,6,12]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1084\/jem.52.4.561","article-title":"Serological reactions in pneumonia with a non-protein somatic fraction of pneumococcus","volume":"52","author":"Tillett","year":"1930","journal-title":"J Exp Med"},{"key":"B2","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1084\/jem.73.2.173","article-title":"The occurrence during acute infections of a protein not normally present in the blood: I. Distribution of the reactive protein in patients\u2019 sera and the effect of calcium on the flocculation reaction with C polysaccharide of pneumococcus","volume":"73","author":"Abernethy","year":"1941","journal-title":"J Exp Med"},{"key":"B3","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1084\/jem.73.2.183","article-title":"The occurrence during acute infections of a protein not normally present in the blood: III. Immunological properties of the C-reactive protein and its differentiation from normal blood proteins","volume":"73","author":"Macleod","year":"1941","journal-title":"J Exp Med"},{"key":"B4","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1084\/jem.85.5.491","article-title":"The occurrence during acute infections of a protein not normally present in the blood: IV. Crystallization of the C-reactive protein","volume":"85","author":"McCarty","year":"1947","journal-title":"J Exp Med"},{"key":"B5","doi-asserted-by":"crossref","first-page":"9","DOI":"10.4049\/jimmunol.113.1.9","article-title":"Interaction of C-reactive protein complexes with the complement system. II. Consumption of guinea pig complement by CRP complexes: requirement for human C1q","volume":"113","author":"Volanakis","year":"1974","journal-title":"J Immunol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1172\/JCI116336","article-title":"Metabolic and scintigraphic studies of radioiodinated human C-reactive protein in health and disease","volume":"91","author":"Vigushin","year":"1993","journal-title":"J Clin Invest"},{"key":"B7","doi-asserted-by":"publisher","first-page":"2195","DOI":"10.1056\/NEJMoa0807646","article-title":"Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein","volume":"359","author":"Ridker","year":"2008","journal-title":"N Engl J Med"},{"key":"B8","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/S0140-6736(17)32814-3","article-title":"Relationship of C-reactive protein reduction to cardiovascular event reduction following treatment with canakinumab: a secondary analysis from the CANTOS randomised controlled trial","volume":"391","author":"Ridker","year":"2018","journal-title":"Lancet"},{"key":"B9","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1373\/clinchem.2008.119214","article-title":"C-reactive protein: eighty years from discovery to emergence as a major risk marker for cardiovascular disease","volume":"55","author":"Ridker","year":"2009","journal-title":"Clin Chem"},{"key":"B10","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1038\/nsb0496-346","article-title":"Three dimensional structure of human C-reactive protein","volume":"3","author":"Shrive","year":"1996","journal-title":"Nat Struct Biol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1073\/pnas.74.2.739","article-title":"Characterization of C-reactive protein and the complement subcomponent C1t as homologous proteins displaying cyclic pentameric symmetry (pentraxins)","volume":"74","author":"Osmand","year":"1977","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B12","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/S0969-2126(99)80023-9","article-title":"The physiological structure of human C-reactive protein and its complex with phosphocholine","volume":"7","author":"Thompson","year":"1999","journal-title":"Structure"},{"key":"B13","doi-asserted-by":"publisher","first-page":"46974","DOI":"10.1074\/jbc.M307764200","article-title":"The crystal structure of the globular head of complement protein C1q provides a basis for its versatile recognition properties","volume":"278","author":"Gaboriaud","year":"2003","journal-title":"J Biol Chem"},{"key":"B14","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1016\/0161-5890(83)90140-2","article-title":"Antigenic, electrophoretic and binding alterations of human C-reactive protein modified selectively in the absence of calcium","volume":"20","author":"Potempa","year":"1983","journal-title":"Mol Immunol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1016\/S1357-2725(98)00078-8","article-title":"Conversion of native oligomeric to a modified monomeric form of human C-reactive protein","volume":"30","author":"Kresl","year":"1998","journal-title":"Int J Biochem Cell Biol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1096\/fj.06-6722com","article-title":"Cell membranes and liposomes dissociate C-reactive protein (CRP) to form a new, biologically active structural intermediate: mCRP(m)","volume":"21","author":"Ji","year":"2007","journal-title":"FASEB J"},{"key":"B17","doi-asserted-by":"publisher","first-page":"14188","DOI":"10.1038\/ncomms14188","article-title":"Transitional changes in the CRP structure lead to the exposure of proinflammatory binding sites","volume":"8","author":"Braig","year":"2017","journal-title":"Nat Commun"},{"key":"B18","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1038\/281155a0","article-title":"Interaction of C-reactive protein with artificial phosphatidylcholine bilayers","volume":"281","author":"Volanakis","year":"1979","journal-title":"Nature"},{"key":"B19","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1161\/CIRCRESAHA.108.190611","article-title":"Dissociation of pentameric to monomeric C-reactive protein on activated platelets localizes inflammation to atherosclerotic plaques","volume":"105","author":"Eisenhardt","year":"2009","journal-title":"Circ Res"},{"key":"B20","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1161\/CIRCULATIONAHA.113.007124","article-title":"Dissociation of pentameric to monomeric C-reactive protein localizes and aggravates inflammation: in vivo proof of a powerful proinflammatory mechanism and a new anti-inflammatory strategy","volume":"130","author":"Thiele","year":"2014","journal-title":"Circulation"},{"key":"B21","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1093\/cvr\/cvs237","article-title":"Circulating microparticles generate and transport monomeric C-reactive protein in patients with myocardial infarction","volume":"96","author":"Habersberger","year":"2012","journal-title":"Cardiovasc Res"},{"key":"B22","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1084\/jem.123.2.365","article-title":"The liver as the site of C-reactive protein formation","volume":"123","author":"Hurlimann","year":"1966","journal-title":"J Exp Med"},{"key":"B23","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1084\/jem.164.1.321","article-title":"C-reactive protein is produced by a small number of normal human peripheral blood lymphocytes","volume":"164","author":"Kuta","year":"1986","journal-title":"J Exp Med"},{"key":"B24","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.1016\/j.jacc.2005.06.017","article-title":"Release of C-reactive protein in response to inflammatory cytokines by human adipocytes: linking obesity to vascular inflammation","volume":"46","author":"Calabro","year":"2005","journal-title":"J Am Coll Cardiol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/S0006-8993(00)02970-X","article-title":"Human neurons generate C-reactive protein and amyloid P: upregulation in Alzheimer\u2019s disease","volume":"887","author":"Yasojima","year":"2000","journal-title":"Brain Res"},{"key":"B26","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1002\/immu.200390018","article-title":"The kidney as a second site of human C-reactive protein formation in vivo","volume":"33","author":"Jabs","year":"2003","journal-title":"Eur J Immunol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1080\/08958370490464599","article-title":"Expression of C-reactive protein in human lung epithelial cells and upregulation by cytokines and carbon particles","volume":"16","author":"Ramage","year":"2004","journal-title":"Inhal Toxicol"},{"key":"B28","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/S0065-2776(08)60379-X","article-title":"Acute phase proteins with special reference to C-reactive protein and related proteins (pentaxins) and serum amyloid A protein","volume":"34","author":"Pepys","year":"1983","journal-title":"Adv Immunol"},{"key":"B29","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1007\/BF02031616","article-title":"C-reactive protein levels in patients with rheumatoid arthritis: the impact of therapy","volume":"4","author":"Tishler","year":"1985","journal-title":"Clin Rheumatol"},{"key":"B30","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1007\/s00134-002-1209-6","article-title":"C-reactive protein: a valuable marker of sepsis","volume":"28","author":"Povoa","year":"2002","journal-title":"Intensive Care Med"},{"key":"B31","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1213\/ANE.0000000000000263","article-title":"C-reactive protein kinetics after major surgery","volume":"119","author":"Santonocito","year":"2014","journal-title":"Anesth Analg"},{"key":"B32","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1161\/01.CIR.0000079173.84669.4F","article-title":"C-reactive protein and lesion morphology in patients with acute myocardial infarction","volume":"108","author":"Sano","year":"2003","journal-title":"Circulation"},{"key":"B33","doi-asserted-by":"publisher","first-page":"9503","DOI":"10.1074\/jbc.271.16.9503","article-title":"STAT3 participates in transcriptional activation of the C-reactive protein gene by interleukin-6","volume":"271","author":"Zhang","year":"1996","journal-title":"J Biol Chem"},{"key":"B34","doi-asserted-by":"publisher","first-page":"3755","DOI":"10.1002\/art.25042","article-title":"Interferon-alpha mediates suppression of C-reactive protein: explanation for muted C-reactive protein response in lupus flares?","volume":"60","author":"Enocsson","year":"2009","journal-title":"Arthritis Rheum"},{"key":"B35","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1001\/jama.286.1.64","article-title":"Effect of statin therapy on C-reactive protein levels: the pravastatin inflammation\/CRP evaluation (PRINCE): a randomized trial and cohort study","volume":"286","author":"Albert","year":"2001","journal-title":"JAMA"},{"key":"B36","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1016\/j.molimm.2005.06.045","article-title":"Statins and nitric oxide reduce C-reactive protein production while inflammatory conditions persist","volume":"43","author":"Voleti","year":"2006","journal-title":"Mol Immunol"},{"key":"B37","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1046\/j.1365-2567.2003.01608.x","article-title":"Overexpressed nuclear factor-kappaB can participate in endogenous C-reactive protein induction, and enhances the effects of C\/EBPbeta and signal transducer and activator of transcription-3","volume":"108","author":"Agrawal","year":"2003","journal-title":"Immunology"},{"key":"B38","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/S0161-5890(03)00148-2","article-title":"Transcription factor c-Rel enhances C-reactive protein expression by facilitating the binding of C\/EBPbeta to the promoter","volume":"40","author":"Agrawal","year":"2003","journal-title":"Mol Immunol"},{"key":"B39","doi-asserted-by":"publisher","first-page":"25095","DOI":"10.1074\/jbc.M504782200","article-title":"Analysis of binding sites in human C-reactive protein for Fc{gamma}RI, Fc{gamma}RIIA, and C1q by site-directed mutagenesis","volume":"280","author":"Bang","year":"2005","journal-title":"J Biol Chem"},{"key":"B40","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1038\/nature07468","article-title":"Structural recognition and functional activation of FcgammaR by innate pentraxins","volume":"456","author":"Lu","year":"2008","journal-title":"Nature"},{"key":"B41","doi-asserted-by":"publisher","first-page":"1806","DOI":"10.1096\/fj.08-116962","article-title":"Monomeric C-reactive protein activates endothelial cells via interaction with lipid raft microdomains","volume":"23","author":"Ji","year":"2009","journal-title":"FASEB J"},{"key":"B42","doi-asserted-by":"publisher","first-page":"5355","DOI":"10.4049\/jimmunol.167.9.5355","article-title":"Loss of pentameric symmetry of C-reactive protein is associated with promotion of neutrophil-endothelial cell adhesion","volume":"167","author":"Zouki","year":"2001","journal-title":"J Immunol"},{"key":"B43","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1161\/01.RES.0000183881.11739.CB","article-title":"Loss of pentameric symmetry in C-reactive protein induces interleukin-8 secretion through peroxynitrite signaling in human neutrophils","volume":"97","author":"Khreiss","year":"2005","journal-title":"Circ Res"},{"key":"B44","doi-asserted-by":"publisher","first-page":"2016","DOI":"10.1161\/01.CIR.0000125527.41598.68","article-title":"Conformational rearrangement in C-reactive protein is required for proinflammatory actions on human endothelial cells","volume":"109","author":"Khreiss","year":"2004","journal-title":"Circulation"},{"key":"B45","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/0092-8674(94)90337-9","article-title":"Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm","volume":"76","author":"Springer","year":"1994","journal-title":"Cell"},{"key":"B46","doi-asserted-by":"crossref","first-page":"3829","DOI":"10.1182\/blood.V94.11.3829","article-title":"Fibrinogen deposition at the postischemic vessel wall promotes platelet adhesion during ischemia-reperfusion in vivo","volume":"94","author":"Massberg","year":"1999","journal-title":"Blood"},{"key":"B47","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1016\/0092-8674(90)90661-W","article-title":"VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4\/fibronectin binding site","volume":"60","author":"Elices","year":"1990","journal-title":"Cell"},{"key":"B48","doi-asserted-by":"publisher","first-page":"14283","DOI":"10.1074\/jbc.M114.555318","article-title":"Topological localization of monomeric C-reactive protein determines proinflammatory endothelial cell responses","volume":"289","author":"Li","year":"2014","journal-title":"J Biol Chem"},{"key":"B49","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1038\/nri2956","article-title":"Platelets and the immune continuum","volume":"11","author":"Semple","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"B50","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1093\/cvr\/cvr226","article-title":"Monomeric C-reactive protein is prothrombotic and dissociates from circulating pentameric C-reactive protein on adhered activated platelets under flow","volume":"92","author":"Molins","year":"2011","journal-title":"Cardiovasc Res"},{"key":"B51","doi-asserted-by":"publisher","first-page":"2048","DOI":"10.1111\/jth.12415","article-title":"Monomerization of C-reactive protein requires glycoprotein IIb-IIIa activation: pentraxins and platelet deposition","volume":"11","author":"de la Torre","year":"2013","journal-title":"J Thromb Haemost"},{"key":"B52","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1161\/01.ATV.0000206211.21895.73","article-title":"Effect of modified C-reactive protein on complement activation: a possible complement regulatory role of modified or monomeric C-reactive protein in atherosclerotic lesions","volume":"26","author":"Ji","year":"2006","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"B53","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1084\/jem.114.6.961","article-title":"Studies of acute phase protein. I. An immunohistochemical method for the localization of Cx-reactive protein in rabbits. Association with necrosis in local inflammatory lesions","volume":"114","author":"Kushner","year":"1961","journal-title":"J Exp Med"},{"key":"B54","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1084\/jem.192.9.1353","article-title":"C-reactive protein binds to apoptotic cells, protects the cells from assembly of the terminal complement components, and sustains an antiinflammatory innate immune response: implications for systemic autoimmunity","volume":"192","author":"Gershov","year":"2000","journal-title":"J Exp Med"},{"key":"B55","doi-asserted-by":"publisher","first-page":"1630","DOI":"10.1038\/cdd.2009.103","article-title":"Monomeric CRP contributes to complement control in fluid phase and on cellular surfaces and increases phagocytosis by recruiting factor H","volume":"16","author":"Mihlan","year":"2009","journal-title":"Cell Death Differ"},{"key":"B56","doi-asserted-by":"publisher","first-page":"F1308","DOI":"10.1152\/ajprenal.00645.2014","article-title":"Monomeric C-reactive protein inhibits renal cell-directed complement activation mediated by properdin","volume":"310","author":"O\u2019Flynn","year":"2016","journal-title":"Am J Physiol Renal Physiol"},{"key":"B57","doi-asserted-by":"publisher","first-page":"4198","DOI":"10.1096\/fj.11-186460","article-title":"Monomeric C-reactive protein modulates classic complement activation on necrotic cells","volume":"25","author":"Mihlan","year":"2011","journal-title":"FASEB J"},{"key":"B58","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.1038\/nm.2507","article-title":"Ischemia and reperfusion \u2013 from mechanism to translation","volume":"17","author":"Eltzschig","year":"2011","journal-title":"Nat Med"},{"key":"B59","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1172\/JCI62874","article-title":"Myocardial ischemia-reperfusion injury: a neglected therapeutic target","volume":"123","author":"Hausenloy","year":"2013","journal-title":"J Clin Invest"},{"key":"B60","doi-asserted-by":"publisher","first-page":"1733","DOI":"10.1084\/jem.190.12.1733","article-title":"C-reactive protein and complement are important mediators of tissue damage in acute myocardial infarction","volume":"190","author":"Griselli","year":"1999","journal-title":"J Exp Med"},{"key":"B61","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1161\/01.CIR.95.1.97","article-title":"C-reactive protein colocalizes with complement in human hearts during acute myocardial infarction","volume":"95","author":"Lagrand","year":"1997","journal-title":"Circulation"},{"key":"B62","doi-asserted-by":"publisher","first-page":"F1358","DOI":"10.1152\/ajprenal.00476.2012","article-title":"C-reactive protein exacerbates renal ischemia-reperfusion injury","volume":"304","author":"Pegues","year":"2013","journal-title":"Am J Physiol Renal Physiol"},{"key":"B63","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1097\/BCR.0b013e318198a252","article-title":"Acute inflammation is persistent locally in burn wounds: a pivotal role for complement and C-reactive protein","volume":"30","author":"van de Goot","year":"2009","journal-title":"J Burn Care Res"},{"key":"B64","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1093\/intimm\/dxu056","article-title":"A conformational change of C-reactive protein in burn wounds unmasks its proinflammatory properties","volume":"26","author":"Braig","year":"2014","journal-title":"Int Immunol"},{"key":"B65","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1111\/ajt.14557","article-title":"OPTN\/SRTR 2016 annual data report: kidney","volume":"18","author":"Hart","year":"2018","journal-title":"Am J Transplant"},{"key":"B66","first-page":"1263","article-title":"Early rejection: determining the fate of renal transplants","volume":"23","author":"Cecka","year":"1991","journal-title":"Transplant Proc"},{"key":"B67","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1097\/00007890-199202010-00013","article-title":"The incidence and impact of early rejection episodes on graft outcome in recipients of first cadaver kidney transplants","volume":"53","author":"Gulanikar","year":"1992","journal-title":"Transplantation"},{"key":"B68","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1097\/00007890-199403270-00015","article-title":"The impact of an acute rejection episode on long-term renal allograft survival (t1\/2)","volume":"57","author":"Matas","year":"1994","journal-title":"Transplantation"},{"key":"B69","doi-asserted-by":"publisher","first-page":"3579","DOI":"10.1172\/JCI74370","article-title":"Non-self recognition by monocytes initiates allograft rejection","volume":"124","author":"Oberbarnscheidt","year":"2014","journal-title":"J Clin Invest"},{"key":"B70","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/S0041-1345(96)00015-2","article-title":"The \u201cinjury response\u201d: a concept linking nonspecific injury, acute rejection, and long-term transplant outcomes","volume":"29","author":"Halloran","year":"1997","journal-title":"Transplant Proc"},{"key":"B71","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1111\/j.1523-1755.2004.00416.x","article-title":"Cold ischemia and the reduced long-term survival of cadaveric renal allografts","volume":"65","author":"Salahudeen","year":"2004","journal-title":"Kidney Int"},{"key":"B72","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1016\/j.healun.2010.08.008","article-title":"The registry of the International Society for Heart and Lung Transplantation: thirteenth official pediatric lung and heart-lung transplantation report \u2013 2010","volume":"29","author":"Aurora","year":"2010","journal-title":"J Heart Lung Transplant"},{"key":"B73","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1681\/ASN.V1171317","article-title":"Contribution of prolonged ischemia and donor age to chronic renal allograft dysfunction","volume":"11","author":"Tullius","year":"2000","journal-title":"J Am Soc Nephrol"},{"key":"B74","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1056\/NEJM199403243301203","article-title":"The influence of HLA compatibility on graft survival after heart transplantation. The Collaborative Transplant Study","volume":"330","author":"Opelz","year":"1994","journal-title":"N Engl J Med"},{"key":"B75","doi-asserted-by":"publisher","first-page":"2492","DOI":"10.1172\/JCI90597","article-title":"Antibody-mediated rejection across solid organ transplants: manifestations, mechanisms, and therapies","volume":"127","author":"Valenzuela","year":"2017","journal-title":"J Clin Invest"},{"key":"B76","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1038\/90609","article-title":"Toll-like receptors: critical proteins linking innate and acquired immunity","volume":"2","author":"Akira","year":"2001","journal-title":"Nat Immunol"},{"key":"B77","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1016\/j.cell.2006.02.015","article-title":"Pathogen recognition and innate immunity","volume":"124","author":"Akira","year":"2006","journal-title":"Cell"},{"key":"B78","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1056\/NEJM199901143400207","article-title":"Atherosclerosis \u2013 an inflammatory disease","volume":"340","author":"Ross","year":"1999","journal-title":"N Engl J Med"},{"key":"B79","doi-asserted-by":"publisher","first-page":"9S","DOI":"10.1016\/j.amjmed.2004.02.006","article-title":"Inflammation and atherosclerosis: role of C-reactive protein in risk assessment","volume":"116","author":"Libby","year":"2004","journal-title":"Am J Med"},{"key":"B80","doi-asserted-by":"publisher","first-page":"S19","DOI":"10.1016\/j.ahj.2004.04.028","article-title":"High-sensitivity C-reactive protein, inflammation, and cardiovascular risk: from concept to clinical practice to clinical benefit","volume":"148","author":"Ridker","year":"2004","journal-title":"Am Heart J"},{"key":"B81","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1161\/01.CIR.98.8.731","article-title":"Prospective study of C-reactive protein and the risk of future cardiovascular events among apparently healthy women","volume":"98","author":"Ridker","year":"1998","journal-title":"Circulation"},{"key":"B82","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1056\/NEJM199704033361401","article-title":"Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men","volume":"336","author":"Ridker","year":"1997","journal-title":"N Engl J Med"},{"key":"B83","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/j.jacc.2013.05.016","article-title":"High-sensitivity C-reactive protein and cardiovascular disease: a resolute belief or an elusive link?","volume":"62","author":"Yousuf","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"B84","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.jacc.2005.04.029","article-title":"Local release of C-reactive protein from vulnerable plaque or coronary arterial wall injured by stenting","volume":"46","author":"Inoue","year":"2005","journal-title":"J Am Coll Cardiol"},{"key":"B85","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1136\/jcp.2005.027235","article-title":"Colocalisation of intraplaque C reactive protein, complement, oxidised low density lipoprotein, and macrophages in stable and unstable angina and acute myocardial infarction","volume":"59","author":"Meuwissen","year":"2006","journal-title":"J Clin Pathol"},{"key":"B86","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1038\/nature04672","article-title":"Targeting C-reactive protein for the treatment of cardiovascular disease","volume":"440","author":"Pepys","year":"2006","journal-title":"Nature"},{"key":"B87","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/S0140-6736(15)01124-1","article-title":"Alzheimer\u2019s disease","volume":"388","author":"Scheltens","year":"2016","journal-title":"Lancet"},{"key":"B88","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1038\/nrneurol.2017.111","article-title":"A systemic view of Alzheimer disease \u2013 insights from amyloid-beta metabolism beyond the brain","volume":"13","author":"Wang","year":"2017","journal-title":"Nat Rev Neurol"},{"key":"B89","doi-asserted-by":"publisher","first-page":"15056","DOI":"10.1038\/nrdp.2015.56","article-title":"Alzheimer\u2019s disease","volume":"1","author":"Masters","year":"2015","journal-title":"Nat Rev Dis Primers."},{"key":"B90","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/0304-3940(94)90035-3","article-title":"Demonstration of CRP immunoreactivity in brains of Alzheimer\u2019s disease: immunohistochemical study using formic acid pretreatment of tissue sections","volume":"177","author":"Iwamoto","year":"1994","journal-title":"Neurosci Lett"},{"key":"B91","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/0006-8993(93)91327-O","article-title":"Cytokine indices in Alzheimer\u2019s temporal cortex: no changes in mature IL-1 beta or IL-1RA but increases in the associated acute phase proteins IL-6, alpha 2-macroglobulin and C-reactive protein","volume":"629","author":"Wood","year":"1993","journal-title":"Brain Res"},{"key":"B92","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1111\/j.1750-3639.2011.00539.x","article-title":"Amyloid plaques dissociate pentameric to monomeric C-reactive protein: a novel pathomechanism driving cortical inflammation in Alzheimer\u2019s disease?","volume":"22","author":"Strang","year":"2012","journal-title":"Brain Pathol"},{"key":"B93","doi-asserted-by":"publisher","first-page":"13281","DOI":"10.1038\/srep13281","article-title":"Monomeric C-reactive protein \u2013 a key molecule driving development of Alzheimer\u2019s disease associated with brain ischaemia?","volume":"5","author":"Slevin","year":"2015","journal-title":"Sci Rep"},{"key":"B94","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1001\/archopht.122.4.564","article-title":"Prevalence of age-related macular degeneration in the United States","volume":"122","author":"Friedman","year":"2004","journal-title":"Arch Ophthalmol"},{"key":"B95","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1001\/archopht.123.6.774","article-title":"Progression of age-related macular degeneration: prospective assessment of C-reactive protein, interleukin 6, and other cardiovascular biomarkers","volume":"123","author":"Seddon","year":"2005","journal-title":"Arch Ophthalmol"},{"key":"B96","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1002\/path.4766","article-title":"Monomeric C-reactive protein and inflammation in age-related macular degeneration","volume":"240","author":"Chirco","year":"2016","journal-title":"J Pathol"},{"key":"B97","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1126\/science.1110189","article-title":"Complement factor H polymorphism and age-related macular degeneration","volume":"308","author":"Edwards","year":"2005","journal-title":"Science"},{"key":"B98","doi-asserted-by":"publisher","first-page":"5336","DOI":"10.1167\/iovs.10-5322","article-title":"Complement component C5a activates ICAM-1 expression on human choroidal endothelial cells","volume":"51","author":"Skeie","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"B99","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1074\/mcp.M900523-MCP200","article-title":"Quantitative proteomics: comparison of the macular Bruch membrane\/choroid complex from age-related macular degeneration and normal eyes","volume":"9","author":"Yuan","year":"2010","journal-title":"Mol Cell Proteomics"},{"key":"B100","first-page":"55","article-title":"Isolation and characterization of C-reactive protein and serum amyloid P component in the rat","volume":"45","author":"de Beer","year":"1982","journal-title":"Immunology"},{"key":"B101","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1385\/IR:26:1-3:279","article-title":"Varied biologic functions of C-reactive protein: lessons learned from transgenic mice","volume":"26","author":"Szalai","year":"2002","journal-title":"Immunol Res"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2018.01351\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T04:11:42Z","timestamp":1693714302000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2018.01351\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,12]]},"references-count":101,"alternative-id":["10.3389\/fimmu.2018.01351"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2018.01351","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,12]]},"article-number":"1351"}}