{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:25:38Z","timestamp":1787318738166,"version":"build-2736575974"},"reference-count":98,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,6,13]],"date-time":"2018-06-13T00:00:00Z","timestamp":1528848000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI-83222 and HL-069031"],"award-info":[{"award-number":["AI-83222 and HL-069031"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2018.01368","type":"journal-article","created":{"date-parts":[[2018,6,13]],"date-time":"2018-06-13T04:22:31Z","timestamp":1528863751000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":45,"title":["The Role and Molecular Mechanism of Action of Surfactant Protein D in Innate Host Defense Against Influenza A Virus"],"prefix":"10.3389","volume":"9","author":[{"given":"I-Ni","family":"Hsieh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"De Luna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell R.","family":"White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevan L.","family":"Hartshorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,6,13]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1177\/1753425913508992","article-title":"The amazing innate immune response to influenza A virus infection","volume":"21","author":"Tripathi","year":"2013","journal-title":"Innate Immun"},{"key":"B2","doi-asserted-by":"publisher","first-page":"10211","DOI":"10.1128\/JVI.00323-12","article-title":"The NS1 protein of influenza A virus blocks RIG-I-mediated activation of the noncanonical NF-kappaB pathway and p52\/RelB-dependent gene expression in lung epithelial cells","volume":"86","author":"Ruckle","year":"2012","journal-title":"J Virol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"22015","DOI":"10.1074\/jbc.M111.319996","article-title":"Influenza virus partially counteracts restriction imposed by tetherin\/BST-2","volume":"287","author":"Mangeat","year":"2012","journal-title":"J Biol Chem"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1942","DOI":"10.1128\/JVI.06362-11","article-title":"Identification of RNA helicase A as a cellular factor that interacts with influenza A virus NS1 protein and its role in the virus life cycle","volume":"86","author":"Lin","year":"2012","journal-title":"J Virol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"2359","DOI":"10.1099\/vir.0.2008\/004606-0","article-title":"The multifunctional NS1 protein of influenza A viruses","volume":"89","author":"Hale","year":"2008","journal-title":"J Gen Virol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"2605","DOI":"10.1056\/NEJMoa0903810","article-title":"Emergence of a novel swine-origin influenza A (H1N1) virus in humans","volume":"360","author":"Dawood","year":"2009","journal-title":"N Engl J Med"},{"key":"B7","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1001\/jama.289.2.227","article-title":"Influenza-related mortality: considerations for practice and public health","volume":"289","author":"Morens","year":"2003","journal-title":"JAMA"},{"key":"B8","doi-asserted-by":"publisher","first-page":"169","DOI":"10.15585\/mmwr.mm6706a1","article-title":"Update: influenza activity \u2013 United States, October 1, 2017\u2013February 3, 2018","volume":"67","author":"Budd","year":"2018","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"B9","doi-asserted-by":"publisher","first-page":"24ra21","DOI":"10.1126\/scitranslmed.3000799","article-title":"Cross-neutralization of 1918 and 2009 influenza viruses: role of glycans in viral evolution and vaccine design","volume":"2","author":"Wei","year":"2010","journal-title":"Sci Transl Med"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1487","DOI":"10.1086\/652441","article-title":"Recipients of vaccine against the 1976 \u201cswine flu\u201d have enhanced neutralization responses to the 2009 novel H1N1 influenza virus","volume":"50","author":"McCullers","year":"2010","journal-title":"Clin Infect Dis"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1016\/j.ajpath.2013.06.020","article-title":"Why does pandemic influenza virus kill?","volume":"183","author":"Hartshorn","year":"2013","journal-title":"Am J Pathol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"3764","DOI":"10.1128\/IAI.00298-15","article-title":"Influenza and bacterial superinfection: illuminating the immunologic mechanisms of disease","volume":"83","author":"Rynda-Apple","year":"2015","journal-title":"Infect Immun"},{"key":"B13","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1001\/jamacardio.2016.0433","article-title":"Seasonal influenza infections and cardiovascular disease mortality","volume":"1","author":"Nguyen","year":"2016","journal-title":"JAMA Cardiol"},{"key":"B14","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1201\/b20120-6","volume-title":"Glycobiology and Human Diseases","author":"Hartshorn","year":"2016"},{"key":"B15","doi-asserted-by":"publisher","first-page":"L563","DOI":"10.1152\/ajplung.00280.2001","article-title":"Absence of SP-A modulates innate and adaptive defense responses to pulmonary influenza infection","volume":"282","author":"LeVine","year":"2002","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"5868","DOI":"10.4049\/jimmunol.167.10.5868","article-title":"Surfactant protein D enhances clearance of influenza A virus from the lung in vivo","volume":"167","author":"LeVine","year":"2001","journal-title":"J Immunol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"e25333","DOI":"10.1371\/journal.pone.0025333","article-title":"Antiviral activity and increased host defense against influenza infection elicited by the human cathelicidin LL-37","volume":"6","author":"Barlow","year":"2011","journal-title":"PLoS One"},{"key":"B18","doi-asserted-by":"publisher","first-page":"6211","DOI":"10.4049\/jimmunol.180.9.6211","article-title":"Leukotriene B4 induces release of antimicrobial peptides in lungs of virally infected mice","volume":"180","author":"Gaudreault","year":"2008","journal-title":"J Immunol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"2478","DOI":"10.4049\/jimmunol.1103786","article-title":"Human H-ficolin inhibits replication of seasonal and pandemic influenza A viruses","volume":"189","author":"Verma","year":"2012","journal-title":"J Immunol"},{"key":"B20","doi-asserted-by":"crossref","first-page":"4358","DOI":"10.1128\/JVI.66.7.4358-4363.1992","article-title":"Two distinct serum mannose-binding lectins function as beta inhibitors of influenza virus: identification of bovine serum beta inhibitor as conglutinin","volume":"66","author":"Hartley","year":"1992","journal-title":"J Virol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"4485","DOI":"10.1073\/pnas.87.12.4485","article-title":"Bovine and mouse serum beta inhibitors of influenza A viruses are mannose-binding lectins","volume":"87","author":"Anders","year":"1990","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B22","doi-asserted-by":"crossref","first-page":"8204","DOI":"10.1128\/JVI.71.11.8204-8212.1997","article-title":"Collectin-mediated antiviral host defense of the lung: evidence from influenza virus infection of mice","volume":"71","author":"Reading","year":"1997","journal-title":"J Virol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1172\/JCI117323","article-title":"Evidence for a protective role of pulmonary surfactant protein D (SP-D) against influenza A viruses","volume":"94","author":"Hartshorn","year":"1994","journal-title":"J Clin Invest"},{"key":"B24","first-page":"A146","article-title":"Surfactant protein A (SP-A) prevents infection of cells by influenza A virus","volume":"148","author":"Iwaarden","year":"1993","journal-title":"Am Rev Resp Dis"},{"key":"B25","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1042\/BJ20050695","article-title":"Salivary agglutinin and lung scavenger receptor cysteine-rich glycoprotein 340 have broad anti-influenza activities and interactions with surfactant protein D that vary according to donor source and sialylation","volume":"393","author":"Hartshorn","year":"2006","journal-title":"Biochem J"},{"key":"B26","doi-asserted-by":"publisher","first-page":"L1066","DOI":"10.1152\/ajplung.00057.2003","article-title":"Lung and salivary scavenger receptor glycoprotein-340 contribute to the host defense against influenza A viruses","volume":"285","author":"Hartshorn","year":"2003","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"e59623","DOI":"10.1371\/journal.pone.0059623","article-title":"Serum amyloid P is a sialylated glycoprotein inhibitor of influenza A viruses","volume":"8","author":"Job","year":"2013","journal-title":"PLoS One"},{"key":"B28","doi-asserted-by":"publisher","first-page":"3391","DOI":"10.4049\/jimmunol.180.5.3391","article-title":"Antiviral activity of the long chain pentraxin PTX3 against influenza viruses","volume":"180","author":"Reading","year":"2008","journal-title":"J Immunol"},{"key":"B29","doi-asserted-by":"publisher","first-page":"L831","DOI":"10.1152\/ajplung.00365.2004","article-title":"Cooperative anti-influenza activities of respiratory innate immune proteins and neuraminidase inhibitor","volume":"288","author":"White","year":"2005","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"B30","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1111\/j.1399-302X.2008.00468.x","article-title":"Multiple components contribute to ability of saliva to inhibit influenza viruses","volume":"24","author":"White","year":"2009","journal-title":"Oral Microbiol Immunol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1099\/vir.0.045013-0","article-title":"The human cathelicidin LL-37 inhibits influenza A viruses through a mechanism distinct from that of surfactant protein D or defensins","volume":"94","author":"Tripathi","year":"2013","journal-title":"J Gen Virol"},{"key":"B32","doi-asserted-by":"publisher","first-page":"8593","DOI":"10.1128\/JVI.00769-07","article-title":"N-linked glycosylation attenuates H3N2 influenza viruses","volume":"81","author":"Vigerust","year":"2007","journal-title":"J Virol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"8565","DOI":"10.1128\/JVI.78.16.8565-8572.2004","article-title":"Pulmonary collectins modulate strain-specific influenza a virus infection and host responses","volume":"78","author":"Hawgood","year":"2004","journal-title":"J Virol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1165\/ajrcmb.26.3.4584","article-title":"Surfactant protein-A \u2013 deficient mice display an exaggerated early inflammatory response to a beta-resistant strain of influenza A virus","volume":"26","author":"Li","year":"2002","journal-title":"Am J Respir Cell Mol Biol"},{"key":"B35","doi-asserted-by":"publisher","first-page":"L1293","DOI":"10.1152\/ajplung.00266.2007","article-title":"Impact of neutrophils on antiviral activity of human bronchoalveolar lavage fluid","volume":"293","author":"White","year":"2007","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"B36","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1016\/j.virol.2011.01.029","article-title":"The ability of pandemic influenza virus hemagglutinins to induce lower respiratory pathology is associated with decreased surfactant protein D binding","volume":"412","author":"Qi","year":"2011","journal-title":"Virology"},{"key":"B37","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.virol.2011.01.036","article-title":"Glycosylation of the hemagglutinin modulates the sensitivity of H3N2 influenza viruses to innate proteins in airway secretions and virulence in mice","volume":"413","author":"Tate","year":"2011","journal-title":"Virology"},{"key":"B38","doi-asserted-by":"publisher","first-page":"4284","DOI":"10.4049\/jimmunol.1001613","article-title":"Pandemic H1N1 influenza A viruses are resistant to the antiviral activities of innate immune proteins of the collectin and pentraxin superfamilies","volume":"185","author":"Job","year":"2010","journal-title":"J Immunol"},{"key":"B39","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1186\/1465-9921-9-65","article-title":"Role of viral hemagglutinin glycosylation in anti-influenza activities of recombinant surfactant protein D","volume":"9","author":"Hartshorn","year":"2008","journal-title":"Respir Res"},{"key":"B40","doi-asserted-by":"publisher","first-page":"1414","DOI":"10.1172\/JCI116345","article-title":"Human mannose-binding protein functions as an opsonin for influenza A viruses","volume":"91","author":"Hartshorn","year":"1993","journal-title":"J Clin Invest"},{"key":"B41","doi-asserted-by":"publisher","first-page":"e02116","DOI":"10.1128\/mBio.02116-14","article-title":"Contemporary avian influenza a virus subtype h1, h6, h7, h10, and h15 hemagglutinin genes encode a mammalian virulence factor similar to the 1918 pandemic virus h1 hemagglutinin","volume":"5","author":"Qi","year":"2014","journal-title":"MBio"},{"key":"B42","doi-asserted-by":"crossref","first-page":"6884","DOI":"10.1128\/JVI.72.8.6884-6887.1998","article-title":"Increased susceptibility of diabetic mice to influenza virus infection: compromise of collectin-mediated host defense of the lung by glucose","volume":"72","author":"Reading","year":"1998","journal-title":"J Virol"},{"key":"B43","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1183\/09031936.00156508","article-title":"Serum surfactant protein D is steroid sensitive and associated with exacerbations of COPD","volume":"34","author":"Lomas","year":"2009","journal-title":"Eur Respir J"},{"key":"B44","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/1465-9921-9-13","article-title":"Chronic obstructive pulmonary disease and inhaled steroids alter surfactant protein D (SP-D) levels: a cross-sectional study","volume":"9","author":"Sims","year":"2008","journal-title":"Respir Res"},{"key":"B45","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1378\/chest.109.4.1006","article-title":"Decreased contents of surfactant proteins A and D in BAL fluids of healthy smokers","volume":"109","author":"Honda","year":"1996","journal-title":"Chest"},{"key":"B46","doi-asserted-by":"publisher","first-page":"1532","DOI":"10.4049\/jimmunol.174.3.1532","article-title":"A common polymorphism in the SFTPD gene influences assembly, function, and concentration of surfactant protein D","volume":"174","author":"Leth-Larsen","year":"2005","journal-title":"J Immunol"},{"key":"B47","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1203\/PDR.0b013e3181a1d768","article-title":"Transmission of surfactant protein variants and haplotypes in children hospitalized with respiratory syncytial virus","volume":"66","author":"Thomas","year":"2009","journal-title":"Pediatr Res"},{"key":"B48","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1007\/s00430-007-0051-4","article-title":"Inhibition of hemagglutination activity of influenza A viruses by SP-A1 and SP-A2 variants expressed in CHO cells","volume":"197","author":"Mikerov","year":"2008","journal-title":"Med Microbiol Immunol"},{"key":"B49","doi-asserted-by":"publisher","first-page":"R127","DOI":"10.1186\/cc13934","article-title":"Surfactant protein A genetic variants associate with severe respiratory insufficiency in pandemic influenza A virus infection","volume":"18","author":"Herrera-Ramos","year":"2014","journal-title":"Crit Care"},{"key":"B50","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1111\/apm.12111","article-title":"Lower mannose-binding lectin contributes to deleterious H1N1 2009 infection in children","volume":"122","author":"Gao","year":"2013","journal-title":"APMIS"},{"key":"B51","doi-asserted-by":"crossref","first-page":"15808","DOI":"10.1016\/S0021-9258(17)40752-6","article-title":"Recombinant pulmonary surfactant protein D","volume":"269","author":"Crouch","year":"1994","journal-title":"J Biol Chem"},{"key":"B52","doi-asserted-by":"publisher","first-page":"13724","DOI":"10.1074\/jbc.271.23.13724","article-title":"Site directed mutagenesis of Cys15 and Cys20 of pulmonary surfactant protein D: expression of a trimeric protein with altered anti-viral properties","volume":"271","author":"Brown-Augsburger","year":"1996","journal-title":"J Biol Chem"},{"key":"B53","first-page":"L753","article-title":"Interactions of recombinant human pulmonary surfactant protein D and SP-D multimers with influenza A","volume":"271","author":"Hartshorn","year":"1996","journal-title":"Am J Physiol"},{"key":"B54","first-page":"L958","article-title":"Pulmonary surfactant proteins A and D enhance neutrophil uptake of bacteria","volume":"274","author":"Hartshorn","year":"1998","journal-title":"Am J Physiol"},{"key":"B55","doi-asserted-by":"publisher","first-page":"6129","DOI":"10.1128\/IAI.70.11.6129-6139.2002","article-title":"Contributions of the N- and C-terminal domains of surfactant protein d to the binding, aggregation, and phagocytic uptake of bacteria","volume":"70","author":"Hartshorn","year":"2002","journal-title":"Infect Immun"},{"key":"B56","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1177\/1753425916678470","article-title":"Collectins, H-ficolin and LL-37 reduce influence viral replication in human monocytes and modulate virus-induced cytokine production","volume":"23","author":"White","year":"2017","journal-title":"Innate Immun"},{"key":"B57","doi-asserted-by":"publisher","first-page":"7936","DOI":"10.4049\/jimmunol.181.11.7936","article-title":"Multimerization of surfactant protein D, but not its collagen domain, is required for antiviral and opsonic activities related to influenza virus","volume":"181","author":"White","year":"2008","journal-title":"J Immunol"},{"key":"B58","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1042\/BJ20071663","article-title":"Critical role for cross-linking of trimeric lectin domains of surfactant protein D in antiviral activity against influenza A virus","volume":"412","author":"Tecle","year":"2008","journal-title":"Biochem J"},{"key":"B59","doi-asserted-by":"publisher","first-page":"24496","DOI":"10.1074\/jbc.M600651200","article-title":"Correction of pulmonary abnormalities in Sftpd-\/- mice requires the collagenous domain of surfactant protein D","volume":"281","author":"Kingma","year":"2006","journal-title":"J Biol Chem"},{"key":"B60","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1159\/000272313","article-title":"Enhancement of antiviral activity of collectin trimers through cross-linking and mutagenesis of the carbohydrate recognition domain","volume":"2","author":"White","year":"2010","journal-title":"J Innate Immun"},{"key":"B61","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1111\/j.1365-3083.2010.02409.x","article-title":"Increasing antiviral activity of surfactant protein d trimers by introducing residues from bovine serum collectins: dissociation of mannan-binding and antiviral activity","volume":"72","author":"Hartshorn","year":"2010","journal-title":"Scand J Immunol"},{"key":"B62","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/1465-9921-8-9","article-title":"Reduced influenza viral neutralizing activity of natural human trimers of surfactant protein D","volume":"8","author":"Hartshorn","year":"2007","journal-title":"Respir Res"},{"key":"B63","doi-asserted-by":"publisher","first-page":"5726","DOI":"10.4049\/jimmunol.169.10.5726","article-title":"CL-46, a novel collectin highly expressed in bovine thymus and liver","volume":"169","author":"Hansen","year":"2002","journal-title":"J Immunol"},{"key":"B64","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1111\/j.1432-1033.1997.t01-1-00630.x","article-title":"Structural characterization of bovine collectin-43","volume":"243","author":"Rothmann","year":"1997","journal-title":"Eur J Biochem"},{"key":"B65","doi-asserted-by":"publisher","first-page":"17046","DOI":"10.1074\/jbc.M413932200","article-title":"Ligand specificity of human surfactant protein D: expression of a mutant trimeric collectin that shows enhanced interactions with influenza A virus","volume":"280","author":"Crouch","year":"2005","journal-title":"J Biol Chem"},{"key":"B66","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1042\/bj20011868","article-title":"Distinctive anti-influenza properties of recombinant collectin 43","volume":"366","author":"Hartshorn","year":"2002","journal-title":"Biochem J"},{"key":"B67","doi-asserted-by":"publisher","first-page":"22453","DOI":"10.1074\/jbc.M201632200","article-title":"Complementation of pulmonary abnormalities in SP-D(-\/-) mice with an SP-D\/conglutinin fusion protein","volume":"277","author":"Zhang","year":"2002","journal-title":"J Biol Chem"},{"key":"B68","doi-asserted-by":"publisher","first-page":"2108","DOI":"10.4049\/jimmunol.165.4.2108","article-title":"Enhanced antiviral and opsonic activity of a human mannose-binding lectin and surfactant protein D chimera","volume":"165","author":"White","year":"2000","journal-title":"J Immunol"},{"key":"B69","doi-asserted-by":"publisher","first-page":"L90","DOI":"10.1152\/ajplung.2000.278.1.L90","article-title":"Enhanced anti-influenza activity of a surfactant protein D and serum conglutinin fusion protein","volume":"278","author":"Hartshorn","year":"2000","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"B70","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1006\/bbrc.2001.5373","article-title":"Increased antiviral and opsonic activity of a highly multimerized collectin chimera","volume":"286","author":"White","year":"2001","journal-title":"Biochem Biophys Res Commun"},{"key":"B71","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1165\/ajrcmb.26.6.4520","article-title":"Porcine surfactant protein D is N-glycosylated in its carbohydrate recognition domain and is assembled into differently charged oligomers","volume":"26","author":"van Eijk","year":"2002","journal-title":"Am J Respir Cell Mol Biol"},{"key":"B72","doi-asserted-by":"crossref","first-page":"1012010125","DOI":"10.1016\/S0021-9258(18)82180-9","article-title":"Purification and characterization of a bovine serum lectin (CL-43) with structural homology to conglutinin and SP-D and carbohydrate specificity similar to mannan-binding protein","volume":"268","author":"Holmskov","year":"1993","journal-title":"J Biol Chem"},{"key":"B73","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/S0022-2836(03)00761-7","article-title":"High-resolution structural insights into ligand binding and immune cell recognition by human lung surfactant protein D","volume":"331","author":"Shrive","year":"2003","journal-title":"J Mol Biol"},{"key":"B74","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/S0969-2126(99)80036-7","article-title":"Crystal structure of the trimeric alpha helical coiled-coil and the three lectin domains of human lung surfactant protein D","volume":"24","author":"Hakansson","year":"1999","journal-title":"Structure"},{"key":"B75","doi-asserted-by":"publisher","first-page":"3335","DOI":"10.1021\/bi8022703","article-title":"Recognition of mannosylated ligands and influenza A virus by human surfactant protein D: contributions of an extended site and residue 343","volume":"48","author":"Crouch","year":"2009","journal-title":"Biochemistry"},{"key":"B76","doi-asserted-by":"publisher","first-page":"L1036","DOI":"10.1152\/ajplung.00035.2014","article-title":"Mutations flanking the carbohydrate binding site of surfactant protein D confer antiviral activity for pandemic influenza A viruses","volume":"306","author":"Nikolaidis","year":"2014","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"B77","doi-asserted-by":"publisher","first-page":"40681","DOI":"10.1074\/jbc.M111.300673","article-title":"Mutagenesis of surfactant protein D informed by evolution and X-ray crystallography enhances defenses against influenza A virus in vivo","volume":"286","author":"Crouch","year":"2011","journal-title":"J Biol Chem"},{"key":"B78","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1165\/rcmb.2005-0462OC","article-title":"Species differences in the carbohydrate binding preferences of surfactant protein D","volume":"35","author":"Crouch","year":"2006","journal-title":"Am J Respir Cell Mol Biol"},{"key":"B79","doi-asserted-by":"publisher","first-page":"8527","DOI":"10.1021\/bi4010683","article-title":"Molecular mechanisms of inhibition of influenza by surfactant protein D revealed by large-scale molecular dynamics simulation","volume":"52","author":"Goh","year":"2013","journal-title":"Biochemistry"},{"key":"B80","doi-asserted-by":"publisher","first-page":"L79","DOI":"10.1152\/ajplung.00223.2009","article-title":"Viral aggregating and opsonizing activity in collectin trimers","volume":"298","author":"Hartshorn","year":"2010","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"B81","doi-asserted-by":"publisher","first-page":"1895","DOI":"10.1074\/mcp.M116.058016","article-title":"Integrated omics and computational glycobiology reveal structural basis for influenza A virus glycan microheterogeneity and host interactions","volume":"15","author":"Khatri","year":"2016","journal-title":"Mol Cell Proteomics"},{"key":"B82","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/j.virusres.2012.08.003","article-title":"The number and position of N-linked glycosylation sites in the hemagglutinin determine differential recognition of seasonal and 2009 pandemic H1N1 influenza virus by porcine surfactant protein D","volume":"169","author":"Hillaire","year":"2012","journal-title":"Virus Res"},{"key":"B83","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.4049\/jimmunol.171.3.1431","article-title":"Porcine pulmonary collectins show distinct interactions with influenza A viruses: role of the N-linked oligosaccharides in the carbohydrate recognition domain","volume":"171","author":"van Eijk","year":"2003","journal-title":"J Immunol"},{"key":"B84","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.virusres.2014.08.019","article-title":"Assessment of the antiviral properties of recombinant surfactant protein D against influenza B virus in vitro","volume":"195","author":"Hillaire","year":"2015","journal-title":"Virus Res"},{"key":"B85","doi-asserted-by":"publisher","first-page":"20137","DOI":"10.1074\/jbc.M111.224469","article-title":"Introduction of N-linked glycans in the lectin domain of surfactant protein D: impact on interactions with influenza A viruses","volume":"286","author":"van Eijk","year":"2011","journal-title":"J Biol Chem"},{"key":"B86","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1165\/rcmb.2003-0355OC","article-title":"Interactions of influenza A virus with sialic acids present on porcine surfactant protein D","volume":"30","author":"van Eijk","year":"2004","journal-title":"Am J Respir Cell Mol Biol"},{"key":"B87","doi-asserted-by":"publisher","first-page":"26666","DOI":"10.1074\/jbc.M112.368571","article-title":"A unique sugar-binding site mediates the distinct anti-influenza activity of pig surfactant protein D","volume":"287","author":"van Eijk","year":"2012","journal-title":"J Biol Chem"},{"key":"B88","doi-asserted-by":"publisher","first-page":"2169","DOI":"10.4049\/jimmunol.1202433","article-title":"Addition of glycosylation to influenza A virus hemagglutinin modulates antibody-mediated recognition of H1N1 2009 pandemic viruses","volume":"190","author":"Job","year":"2013","journal-title":"J Immunol"},{"key":"B89","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1164\/rccm.201007-1184OC","article-title":"Glycan shielding of the influenza virus hemagglutinin contributes to immunopathology in mice","volume":"183","author":"Wanzeck","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"key":"B90","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1099\/0022-1317-83-12-3067","article-title":"Effect of addition of new oligosaccharide chains to the globular head of influenza A\/H2N2 virus haemagglutinin on the intracellular transport and biological activities of the molecule","volume":"83","author":"Tsuchiya","year":"2002","journal-title":"J Gen Virol"},{"key":"B91","doi-asserted-by":"publisher","first-page":"2990","DOI":"10.1128\/JVI.01705-10","article-title":"N-linked glycosylation facilitates sialic acid-independent attachment and entry of influenza A viruses into cells expressing DC-SIGN or L-SIGN","volume":"85","author":"Londrigan","year":"2011","journal-title":"J Virol"},{"key":"B92","doi-asserted-by":"publisher","first-page":"10010","DOI":"10.1128\/JVI.00301-11","article-title":"Galectin-1 binds to influenza virus and ameliorates influenza virus pathogenesis","volume":"85","author":"Yang","year":"2011","journal-title":"J Virol"},{"key":"B93","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1046\/j.1365-2567.2003.01707.x","article-title":"Inhibition of DC-SIGN-mediated trans infection of T cells by mannose-binding lectin","volume":"110","author":"Spear","year":"2003","journal-title":"Immunology"},{"key":"B94","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/s00408-014-9669-3","article-title":"Serum surfactant protein D (SP-D) is a prognostic marker of poor outcome in patients with A\/H1N1 virus infection","volume":"193","author":"Delgado","year":"2015","journal-title":"Lung"},{"key":"B95","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1097\/JOM.0b013e318124a927","article-title":"Roles of serum clara cell protein 16 and surfactant protein-D in the early diagnosis and progression of silicosis","volume":"49","author":"Wang","year":"2007","journal-title":"J Occup Environ Med"},{"key":"B96","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/j.antiviral.2011.08.022","article-title":"GM-CSF modulates pulmonary resistance to influenza A infection","volume":"92","author":"Sever-Chroneos","year":"2011","journal-title":"Antiviral Res"},{"key":"B97","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1164\/rccm.201012-2036OC","article-title":"GM-CSF in the lung protects against lethal influenza infection","volume":"184","author":"Huang","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"key":"B98","doi-asserted-by":"publisher","first-page":"E6613","DOI":"10.1073\/pnas.1621172114","article-title":"Mitogenic stimulation accelerates influenza-induced mortality by increasing susceptibility of alveolar type II cells to infection","volume":"114","author":"Nikolaidis","year":"2017","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2018.01368\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,25]],"date-time":"2022-08-25T16:07:29Z","timestamp":1661443649000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2018.01368\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,13]]},"references-count":98,"alternative-id":["10.3389\/fimmu.2018.01368"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2018.01368","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,13]]},"article-number":"1368"}}