{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:55:38Z","timestamp":1753890938315,"version":"3.41.2"},"reference-count":41,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,6,25]],"date-time":"2018-06-25T00:00:00Z","timestamp":1529884800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2018.01424","type":"journal-article","created":{"date-parts":[[2018,6,25]],"date-time":"2018-06-25T00:34:46Z","timestamp":1529886886000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["An Interferon Signature Discriminates Pneumococcal From Staphylococcal Pneumonia"],"prefix":"10.3389","volume":"9","author":[{"given":"Anja","family":"Strehlitz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver","family":"Goldmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina C.","family":"Pils","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Pessler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Medina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2018,6,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1016\/S0140-6736(15)60733-4","article-title":"Community-acquired pneumonia","volume":"386","author":"Prina","year":"2015","journal-title":"Lancet"},{"key":"B2","doi-asserted-by":"publisher","first-page":"S27","DOI":"10.1086\/511159","article-title":"Infectious Diseases Society of America\/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults","volume":"44","author":"Mandell","year":"2007","journal-title":"Clin Infect Dis"},{"key":"B3","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1111\/j.1469-0691.2007.01915.x","article-title":"Factors impacting on length of stay and mortality of community-acquired pneumonia","volume":"14","author":"Garau","year":"2008","journal-title":"Clin Microbiol Infect"},{"key":"B4","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.jinf.2013.03.003","article-title":"Can an etiologic agent be identified in adults who are hospitalized for community-acquired pneumonia: results of a one-year study","volume":"67","author":"Musher","year":"2013","journal-title":"J Infect"},{"key":"B5","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1007\/s10096-012-1778-4","article-title":"The role of Streptococcus pneumoniae in community-acquired pneumonia among adults in Europe: a meta-analysis","volume":"32","author":"Rozenbaum","year":"2013","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1264","DOI":"10.1016\/S0140-6736(10)61459-6","article-title":"Viral pneumonia","volume":"377","author":"Ruuskanen","year":"2011","journal-title":"Lancet"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1736","DOI":"10.1093\/cid\/cix549","article-title":"Evolving understanding of the causes of pneumonia in adults, with special attention to the role of pneumococcus","volume":"65","author":"Musher","year":"2017","journal-title":"Clin Infect Dis"},{"key":"B8","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1016\/S1473-3099(09)70133-1","article-title":"Emergence of community-acquired meticillin-resistant Staphylococcus aureus strain USA300 as a cause of necrotising community-onset pneumonia","volume":"9","author":"Hidron","year":"2009","journal-title":"Lancet Infect Dis"},{"key":"B9","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1128\/CMR.00081-09","article-title":"Community-associated methicillin-resistant Staphylococcus aureus: epidemiology and clinical consequences of an emerging epidemic","volume":"23","author":"David","year":"2010","journal-title":"Clin Microbiol Rev"},{"key":"B10","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1136\/thoraxjnl-2013-203384","article-title":"Multidrug-resistant pathogens in hospitalised patients coming from the community with pneumonia: a European perspective","volume":"68","author":"Aliberti","year":"2013","journal-title":"Thorax"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.1093\/cid\/cis022","article-title":"Prevalence of methicillin-resistant Staphylococcus aureus as an etiology of community-acquired pneumonia","volume":"54","author":"Moran","year":"2012","journal-title":"Clin Infect Dis"},{"key":"B12","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1093\/cid\/ciw300","article-title":"Staphylococcus aureus community-acquired pneumonia: prevalence, clinical characteristics, and outcomes","volume":"63","author":"Self","year":"2016","journal-title":"Clin Infect Dis"},{"key":"B13","doi-asserted-by":"publisher","first-page":"936.e11","DOI":"10.1016\/j.cmi.2015.06.015","article-title":"De-escalation therapy among bacteraemic patients with community-acquired pneumonia","volume":"21","author":"Carugati","year":"2015","journal-title":"Clin Microbiol Infect"},{"key":"B14","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1093\/jac\/dkw441","article-title":"Impact of antibiotic de-escalation on clinical outcomes in community-acquired pneumococcal pneumonia","volume":"72","author":"Viasus","year":"2017","journal-title":"J Antimicrob Chemother"},{"key":"B15","doi-asserted-by":"publisher","first-page":"1618","DOI":"10.1056\/NEJM199512143332408","article-title":"Community-acquired pneumonia","volume":"333","author":"Bartlett","year":"1995","journal-title":"N Engl J Med"},{"key":"B16","doi-asserted-by":"publisher","first-page":"2120","DOI":"10.3390\/ijms17122120","article-title":"Microbial etiology of pneumonia: epidemiology, diagnosis and resistance patterns","volume":"17","author":"Cilloniz","year":"2016","journal-title":"Int J Mol Sci"},{"key":"B17","doi-asserted-by":"publisher","first-page":"1748","DOI":"10.1016\/S0012-3692(15)36397-2","article-title":"Urinary antigen test for pneumococcal pneumonia","volume":"120","author":"Dominguez","year":"2001","journal-title":"Chest"},{"key":"B18","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.mimet.2017.07.005","article-title":"Evaluation of Sofia fluorescent immunoassay analyzer for pneumococcal urinary antigen detection in hospitalized patients with community-acquired pneumonia","volume":"141","author":"Vicente","year":"2017","journal-title":"J Microbiol Methods"},{"key":"B19","doi-asserted-by":"publisher","first-page":"2460","DOI":"10.1128\/JCM.02498-06","article-title":"Evaluation and improvement of real-time PCR assays targeting lytA, ply, and psaA genes for detection of pneumococcal DNA","volume":"45","author":"Carvalho Mda","year":"2007","journal-title":"J Clin Microbiol"},{"key":"B20","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1016\/j.prrv.2011.12.001","article-title":"Streptococcus pneumoniae \u2013 a review of carriage, infection, serotype replacement and vaccination","volume":"13","author":"Mehr","year":"2012","journal-title":"Paediatr Respir Rev"},{"key":"B21","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.idc.2012.11.003","article-title":"Biomarkers: what is their benefit in the identification of infection, severity assessment, and management of community-acquired pneumonia?","volume":"27","author":"Upadhyay","year":"2013","journal-title":"Infect Dis Clin North Am"},{"key":"B22","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1093\/jpids\/pis074","article-title":"The pediatric infectious diseases society annual awards, 2012","volume":"1","author":"Downes","year":"2012","journal-title":"J Pediatric Infect Dis Soc"},{"key":"B23","doi-asserted-by":"publisher","first-page":"e0160278","DOI":"10.1371\/journal.pone.0160278","article-title":"Host biomarkers for distinguishing bacterial from non-bacterial causes of acute febrile illness: a comprehensive review","volume":"11","author":"Kapasi","year":"2016","journal-title":"PLoS One"},{"key":"B24","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1097\/MCC.0000000000000442","article-title":"The current status of biomarkers for the diagnosis of nosocomial pneumonias","volume":"23","author":"Salluh","year":"2017","journal-title":"Curr Opin Crit Care"},{"key":"B25","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.jiac.2016.11.002","article-title":"New possible biomarkers for diagnosis of infections and diagnostic distinction between bacterial and viral infections in children","volume":"23","author":"Yusa","year":"2017","journal-title":"J Infect Chemother"},{"key":"B26","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1126\/science.1061217","article-title":"Complete genome sequence of a virulent isolate of Streptococcus pneumoniae","volume":"293","author":"Tettelin","year":"2001","journal-title":"Science"},{"key":"B27","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1016\/S0140-6736(06)68231-7","article-title":"Complete genome sequence of USA300, an epidemic clone of community-acquired meticillin-resistant Staphylococcus aureus","volume":"367","author":"Diep","year":"2006","journal-title":"Lancet"},{"key":"B28","doi-asserted-by":"publisher","first-page":"3229","DOI":"10.4049\/jimmunol.0804277","article-title":"Novel reporter mouse reveals constitutive and inflammatory expression of IFN-beta in vivo","volume":"183","author":"Lienenklaus","year":"2009","journal-title":"J Immunol"},{"key":"B29","doi-asserted-by":"publisher","first-page":"e45","DOI":"10.1093\/nar\/29.9.e45","article-title":"A new mathematical model for relative quantification in real-time RT-PCR","volume":"29","author":"Pfaffl","year":"2001","journal-title":"Nucleic Acids Res"},{"key":"B30","doi-asserted-by":"publisher","first-page":"W251","DOI":"10.1093\/nar\/gkv380","article-title":"MetaboAnalyst 3.0 \u2013 making metabolomics more meaningful","volume":"43","author":"Xia","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"B31","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1016\/j.molmed.2007.08.003","article-title":"The peripheral-blood transcriptome: new insights into disease and risk assessment","volume":"13","author":"Mohr","year":"2007","journal-title":"Trends Mol Med"},{"key":"B32","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1165\/rcmb.2013-0316OC","article-title":"Mechanisms of interferon-gamma production by neutrophils and its function during Streptococcus pneumoniae pneumonia","volume":"52","author":"Gomez","year":"2015","journal-title":"Am J Respir Cell Mol Biol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1016\/j.micinf.2010.03.014","article-title":"Streptococcus pneumoniae induces expression of the antibacterial CXC chemokine MIG\/CXCL9 via MyD88-dependent signaling in a murine model of airway infection","volume":"12","author":"Eliasson","year":"2010","journal-title":"Microbes Infect"},{"key":"B34","doi-asserted-by":"publisher","first-page":"e00016","DOI":"10.1128\/mBio.00016-11","article-title":"Streptococcus pneumoniae DNA initiates type I interferon signaling in the respiratory tract","volume":"2","author":"Parker","year":"2011","journal-title":"MBio"},{"key":"B35","doi-asserted-by":"publisher","first-page":"4735","DOI":"10.1128\/IAI.00165-06","article-title":"Regulation of production of mucosal antibody to pneumococcal protein antigens by T-cell-derived gamma interferon and interleukin-10 in children","volume":"74","author":"Zhang","year":"2006","journal-title":"Infect Immun"},{"key":"B36","doi-asserted-by":"publisher","first-page":"811","DOI":"10.4049\/jimmunol.1004143","article-title":"Streptococcus pneumoniae stimulates a STING- and IFN regulatory factor 3-dependent type I IFN production in macrophages, which regulates RANTES production in macrophages, cocultured alveolar epithelial cells, and mouse lungs","volume":"188","author":"Koppe","year":"2012","journal-title":"J Immunol"},{"key":"B37","doi-asserted-by":"publisher","first-page":"4537","DOI":"10.4049\/jimmunol.1201111","article-title":"Failure to induce IFN-beta production during Staphylococcus aureus infection contributes to pathogenicity","volume":"189","author":"Kaplan","year":"2012","journal-title":"J Immunol"},{"key":"B38","doi-asserted-by":"publisher","first-page":"1931","DOI":"10.1172\/JCI35879","article-title":"Staphylococcus aureus activates type I IFN signaling in mice and humans through the Xr repeated sequences of protein A","volume":"119","author":"Martin","year":"2009","journal-title":"J Clin Invest"},{"key":"B39","doi-asserted-by":"publisher","first-page":"4040","DOI":"10.4049\/jimmunol.1201055","article-title":"Staphylococcus aureus induces type I IFN signaling in dendritic cells via TLR9","volume":"189","author":"Parker","year":"2012","journal-title":"J Immunol"},{"key":"B40","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1097\/00003246-200004000-00011","article-title":"Calcitonin precursors are reliable markers of sepsis in a medical intensive care unit","volume":"28","author":"Muller","year":"2000","journal-title":"Crit Care Med"},{"key":"B41","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1164\/rccm.200512-1922OC","article-title":"Procalcitonin guidance of antibiotic therapy in community-acquired pneumonia: a randomized trial","volume":"174","author":"Christ-Crain","year":"2006","journal-title":"Am J Respir Crit Care Med"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2018.01424\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,6,25]],"date-time":"2018-06-25T00:34:50Z","timestamp":1529886890000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2018.01424\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,25]]},"references-count":41,"alternative-id":["10.3389\/fimmu.2018.01424"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2018.01424","relation":{},"ISSN":["1664-3224"],"issn-type":[{"type":"electronic","value":"1664-3224"}],"subject":[],"published":{"date-parts":[[2018,6,25]]},"article-number":"1424"}}