{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T03:51:01Z","timestamp":1778644261348,"version":"3.51.4"},"reference-count":90,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,6,22]],"date-time":"2018-06-22T00:00:00Z","timestamp":1529625600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003074","name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["PICT 2014-1362, PICT 2015-2559 and PICTO 2012-0083B"],"award-info":[{"award-number":["PICT 2014-1362, PICT 2015-2559 and PICTO 2012-0083B"]}],"id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2018.01441","type":"journal-article","created":{"date-parts":[[2018,6,22]],"date-time":"2018-06-22T04:14:24Z","timestamp":1529640864000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":27,"title":["Prostaglandin E2 Antagonizes TGF-\u03b2 Actions During the Differentiation of Monocytes Into Dendritic Cells"],"prefix":"10.3389","volume":"9","author":[{"given":"Federico","family":"Remes Lenicov","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Luz","family":"Paletta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melina","family":"Gonzalez Prinz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Augusto","family":"Varese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clara E.","family":"Pavillet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1lvaro","family":"Lopez Malizia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Sabatt\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge Raul","family":"Geffner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Ceballos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2018,6,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/978-1-4939-3606-9_1","article-title":"Review of mouse and human dendritic cell subsets","volume":"1423","author":"Segura","year":"2016","journal-title":"Methods Mol Biol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"5306","DOI":"10.1073\/pnas.0900655106","article-title":"TNF\/iNOS-producing dendritic cells are the necessary evil of lethal influenza virus infection","volume":"106","author":"Aldridge","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B3","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1126\/science.1151869","article-title":"Dendritic cell-induced memory T cell activation in nonlymphoid tissues","volume":"319","author":"Wakim","year":"2008","journal-title":"Science"},{"key":"B4","doi-asserted-by":"publisher","first-page":"2097","DOI":"10.1084\/jem.20101563","article-title":"Inflammatory dendritic cells \u2013 not basophils \u2013 are necessary and sufficient for induction of Th2 immunity to inhaled house dust mite allergen","volume":"207","author":"Hammad","year":"2010","journal-title":"J Exp Med"},{"key":"B5","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1016\/j.immuni.2012.10.018","article-title":"Human inflammatory dendritic cells induce Th17\u2009cell differentiation","volume":"38","author":"Segura","year":"2013","journal-title":"Immunity"},{"key":"B6","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1038\/nm.3189","article-title":"Inflammatory monocytes regulate pathologic responses to commensals during acute gastrointestinal infection","volume":"19","author":"Grainger","year":"2013","journal-title":"Nat Med"},{"key":"B7","doi-asserted-by":"publisher","first-page":"eaai7677","DOI":"10.1126\/sciimmunol.aai7677","article-title":"Human lymphoid organ dendritic cell identity is predominantly dictated by ontogeny, not tissue microenvironment","volume":"1","author":"Heidkamp","year":"2016","journal-title":"Sci Immunol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1016\/j.cell.2008.07.025","article-title":"TGF-beta: a master of all T cell trades","volume":"134","author":"Li","year":"2008","journal-title":"Cell"},{"key":"B9","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1146\/annurev-immunol-032713-120257","article-title":"TGF-beta activation and function in immunity","volume":"32","author":"Travis","year":"2014","journal-title":"Annu Rev Immunol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"2071","DOI":"10.4049\/jimmunol.174.4.2071","article-title":"Distinct effects of TGF-beta 1 on CD4+ and CD8+ T cell survival, division, and IL-2 production: a role for T cell intrinsic Smad3","volume":"174","author":"McKarns","year":"2005","journal-title":"J Immunol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"a022236","DOI":"10.1101\/cshperspect.a022236","article-title":"Regulation of the immune response by TGF-beta: from conception to autoimmunity and infection","volume":"9","author":"Sanjabi","year":"2017","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"10865","DOI":"10.1073\/pnas.0805058105","article-title":"TGF-beta signaling in dendritic cells is a prerequisite for the control of autoimmune encephalomyelitis","volume":"105","author":"Laouar","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B13","doi-asserted-by":"publisher","first-page":"3878","DOI":"10.4049\/jimmunol.1201029","article-title":"Dendritic cell-specific disruption of TGF-beta receptor II leads to altered regulatory T cell phenotype and spontaneous multiorgan autoimmunity","volume":"189","author":"Ramalingam","year":"2012","journal-title":"J Immunol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1038\/ni1197","article-title":"Transforming growth factor-beta controls T helper type 1 cell development through regulation of natural killer cell interferon-gamma","volume":"6","author":"Laouar","year":"2005","journal-title":"Nat Immunol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"5788","DOI":"10.1073\/pnas.84.16.5788","article-title":"Transforming growth factor type beta induces monocyte chemotaxis and growth factor production","volume":"84","author":"Wahl","year":"1987","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B16","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1016\/S1286-4579(99)00257-9","article-title":"Bidirectional regulation of macrophage function by TGF-beta","volume":"1","author":"Ashcroft","year":"1999","journal-title":"Microbes Infect"},{"key":"B17","doi-asserted-by":"crossref","first-page":"4567","DOI":"10.4049\/jimmunol.162.8.4567","article-title":"TGF-beta 1 prevents the noncognate maturation of human dendritic Langerhans cells","volume":"162","author":"Geissmann","year":"1999","journal-title":"J Immunol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1111\/j.1365-2567.2010.03356.x","article-title":"Differences in T-helper polarizing capability between human monocyte-derived dendritic cells and monocyte-derived Langerhans\u2019-like cells","volume":"132","author":"Rajkovic","year":"2011","journal-title":"Immunology"},{"key":"B19","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1111\/j.1476-5381.1983.tb10530.x","article-title":"The source of thromboxane and prostaglandins in experimental inflammation","volume":"79","author":"Higgs","year":"1983","journal-title":"Br J Pharmacol"},{"key":"B20","doi-asserted-by":"publisher","first-page":"21599","DOI":"10.1074\/jbc.M109.003822","article-title":"Lipidomic analysis of dynamic eicosanoid responses during the induction and resolution of Lyme arthritis","volume":"284","author":"Blaho","year":"2009","journal-title":"J Biol Chem"},{"key":"B21","doi-asserted-by":"publisher","first-page":"21","DOI":"10.4049\/jimmunol.1101029","article-title":"Regulation of immune responses by prostaglandin E2","volume":"188","author":"Kalinski","year":"2012","journal-title":"J Immunol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"5033","DOI":"10.4049\/jimmunol.174.8.5033","article-title":"Cyclooxygenase 2 plays a pivotal role in the resolution of acute lung injury","volume":"174","author":"Fukunaga","year":"2005","journal-title":"J Immunol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1038\/9550","article-title":"Inducible cyclooxygenase may have anti-inflammatory properties","volume":"5","author":"Gilroy","year":"1999","journal-title":"Nat Med"},{"key":"B24","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1100\/tsw.2006.122","article-title":"COX-2: a pivotal enzyme in mucosal protection and resolution of inflammation","volume":"6","author":"Wallace","year":"2006","journal-title":"ScientificWorldJournal"},{"key":"B25","doi-asserted-by":"publisher","first-page":"5498","DOI":"10.1182\/blood-2011-07-365825","article-title":"Positive feedback between PGE2 and COX2 redirects the differentiation of human dendritic cells toward stable myeloid-derived suppressor cells","volume":"118","author":"Obermajer","year":"2011","journal-title":"Blood"},{"key":"B26","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1002\/(SICI)1097-4644(19981101)71:2<254::AID-JCB10>3.0.CO;2-L","article-title":"Role of EP2 receptors and cAMP in prostaglandin E2 regulated expression of type I collagen alpha1, lysyl oxidase, and cyclooxygenase-1 genes in human embryo lung fibroblasts","volume":"71","author":"Choung","year":"1998","journal-title":"J Cell Biochem"},{"key":"B27","doi-asserted-by":"publisher","first-page":"2227","DOI":"10.1093\/carcin\/bgn202","article-title":"Cox-2 inactivates Smad signaling and enhances EMT stimulated by TGF-beta through a PGE2-dependent mechanisms","volume":"29","author":"Neil","year":"2008","journal-title":"Carcinogenesis"},{"key":"B28","doi-asserted-by":"publisher","first-page":"17151","DOI":"10.1074\/jbc.M114.558130","article-title":"Prostaglandin E2 inhibits alpha-smooth muscle actin transcription during myofibroblast differentiation via distinct mechanisms of modulation of serum response factor and myocardin-related transcription factor-A","volume":"289","author":"Penke","year":"2014","journal-title":"J Biol Chem"},{"key":"B29","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/j.jhep.2004.04.033","article-title":"Prostaglandin E2 inhibits transforming growth factor beta 1-mediated induction of collagen alpha 1(I) in hepatic stellate cells","volume":"41","author":"Hui","year":"2004","journal-title":"J Hepatol"},{"key":"B30","doi-asserted-by":"publisher","first-page":"e76346","DOI":"10.1371\/journal.pone.0076346","article-title":"TGF-beta1 downregulates COX-2 expression leading to decrease of PGE2 production in human lung cancer A549 cells, which is involved in fibrotic response to TGF-beta1","volume":"8","author":"Takai","year":"2013","journal-title":"PLoS One"},{"key":"B31","doi-asserted-by":"publisher","first-page":"20992","DOI":"10.1038\/srep20992","article-title":"Macrophages programmed by apoptotic cells inhibit epithelial-mesenchymal transition in lung alveolar epithelial cells via PGE2, PGD2, and HGF","volume":"6","author":"Yoon","year":"2016","journal-title":"Sci Rep"},{"key":"B32","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.4049\/jimmunol.175.3.1483","article-title":"Prostaglandin E2 induces FOXP3 gene expression and T regulatory cell function in human CD4+ T cells","volume":"175","author":"Baratelli","year":"2005","journal-title":"J Immunol"},{"key":"B33","first-page":"356","article-title":"PGE(2) contributes to TGF-beta induced T regulatory cell function in human non-small cell lung cancer","volume":"2","author":"Baratelli","year":"2010","journal-title":"Am J Transl Res"},{"key":"B34","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1111\/j.1365-2567.2009.03134.x","article-title":"Tumour-derived prostaglandin E and transforming growth factor-beta synergize to inhibit plasmacytoid dendritic cell-derived interferon-alpha","volume":"128","author":"Bekeredjian-Ding","year":"2009","journal-title":"Immunology"},{"key":"B35","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1530\/jrf.0.0520147","article-title":"Prostaglandin concentrations in the semen of fertile men","volume":"52","author":"Templeton","year":"1978","journal-title":"J Reprod Fertil"},{"key":"B36","doi-asserted-by":"publisher","first-page":"2183","DOI":"10.1093\/humrep\/dew185","article-title":"Seminal plasma transforming growth factor-beta, activin A and follistatin fluctuate within men over time","volume":"31","author":"Sharkey","year":"2016","journal-title":"Hum Reprod"},{"key":"B37","doi-asserted-by":"publisher","first-page":"4777","DOI":"10.4049\/jimmunol.1202089","article-title":"Semen promotes the differentiation of tolerogenic dendritic cells","volume":"189","author":"Remes Lenicov","year":"2012","journal-title":"J Immunol"},{"key":"B38","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1074\/jbc.M109.038620","article-title":"Increased cAMP levels modulate transforming growth factor-beta\/Smad-induced expression of extracellular matrix components and other key fibroblast effector functions","volume":"285","author":"Schiller","year":"2010","journal-title":"J Biol Chem"},{"key":"B39","doi-asserted-by":"publisher","first-page":"2717","DOI":"10.1084\/jem.20091579","article-title":"Spermatozoa capture HIV-1 through heparan sulfate and efficiently transmit the virus to dendritic cells","volume":"206","author":"Ceballos","year":"2009","journal-title":"J Exp Med"},{"key":"B40","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"B41","doi-asserted-by":"crossref","first-page":"28","DOI":"10.4049\/jimmunol.159.1.28","article-title":"IL-12-deficient dendritic cells, generated in the presence of prostaglandin E2, promote type 2 cytokine production in maturing human naive T helper cells","volume":"159","author":"Kali\u0144ski","year":"1997","journal-title":"J Immunol"},{"key":"B42","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1080\/003655202753416939","article-title":"Transforming growth factor-beta 1, activin and follistatin in patients with hepatocellular carcinoma and patients with alcoholic cirrhosis","volume":"37","author":"Yuen","year":"2002","journal-title":"Scand J Gastroenterol"},{"key":"B43","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1046\/j.1440-1843.2003.00474.x","article-title":"Transforming growth factor beta-1 level in pleural effusion","volume":"8","author":"Ceyhan","year":"2003","journal-title":"Respirology"},{"key":"B44","doi-asserted-by":"publisher","first-page":"1374","DOI":"10.1016\/j.joca.2012.07.006","article-title":"Shearing of synovial fluid activates latent TGF-beta","volume":"20","author":"Albro","year":"2012","journal-title":"Osteoarthritis Cartilage"},{"key":"B45","doi-asserted-by":"publisher","first-page":"51008","DOI":"10.18632\/oncotarget.16846","article-title":"Ascites promotes cell migration through the repression of miR-125b in ovarian cancer","volume":"8","author":"Yang","year":"2017","journal-title":"Oncotarget"},{"key":"B46","doi-asserted-by":"publisher","first-page":"26793","DOI":"10.1074\/jbc.M212187200","article-title":"Transforming growth factor-beta1 produced by ovarian cancer cell line HRA stimulates attachment and invasion through an up-regulation of plasminogen activator inhibitor type-1 in human peritoneal mesothelial cells","volume":"278","author":"Hirashima","year":"2003","journal-title":"J Biol Chem"},{"key":"B47","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1111\/j.1365-2567.2008.02919.x","article-title":"TGF-beta1 dampens the susceptibility of dendritic cells to environmental stimulation, leading to the requirement for danger signals for activation","volume":"126","author":"Ohtani","year":"2009","journal-title":"Immunology"},{"key":"B48","doi-asserted-by":"publisher","first-page":"23","DOI":"10.3389\/fimmu.2013.00023","article-title":"Toward a refined definition of monocyte subsets","volume":"4","author":"Ziegler-Heitbrock","year":"2013","journal-title":"Front Immunol"},{"key":"B49","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.cellimm.2010.03.010","article-title":"Prostaglandin E2 suppresses beta1-integrin expression via E-prostanoid receptor in human monocytes\/macrophages","volume":"263","author":"Hasegawa","year":"2010","journal-title":"Cell Immunol"},{"key":"B50","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.celrep.2017.09.018","article-title":"Prostaglandin E2 leads to the acquisition of DNMT3A-dependent tolerogenic functions in human myeloid-derived suppressor cells","volume":"21","author":"Rodr\u00edguez-Ubreva","year":"2017","journal-title":"Cell Rep"},{"key":"B51","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1038\/nri3712","article-title":"Dendritic cells, monocytes and macrophages: a unified nomenclature based on ontogeny","volume":"14","author":"Guilliams","year":"2014","journal-title":"Nat Rev Immunol"},{"key":"B52","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/j.immuni.2007.01.017","article-title":"Monocyte-derived dendritic cells formed at the infection site control the induction of protective T helper 1 responses against Leishmania","volume":"26","author":"Leon","year":"2007","journal-title":"Immunity"},{"key":"B53","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1073\/pnas.1005201108","article-title":"Recruited inflammatory monocytes stimulate antiviral Th1 immunity in infected tissue","volume":"108","author":"Iijima","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B54","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1016\/j.immuni.2012.10.016","article-title":"Conventional and monocyte-derived CD11b(+) dendritic cells initiate and maintain T helper 2 cell-mediated immunity to house dust mite allergen","volume":"38","author":"Plantinga","year":"2013","journal-title":"Immunity"},{"key":"B55","doi-asserted-by":"publisher","first-page":"1210","DOI":"10.1016\/j.jaci.2007.03.006","article-title":"Major differences in inflammatory dendritic cells and their products distinguish atopic dermatitis from psoriasis","volume":"119","author":"Guttman-Yassky","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"B56","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1038\/jid.2008.194","article-title":"Psoriasis is characterized by accumulation of immunostimulatory and Th1\/Th17\u2009cell-polarizing myeloid dendritic cells","volume":"129","author":"Zaba","year":"2009","journal-title":"J Invest Dermatol"},{"key":"B57","doi-asserted-by":"publisher","first-page":"eaah4573","DOI":"10.1126\/science.aah4573","article-title":"Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors","volume":"356","author":"Villani","year":"2017","journal-title":"Science"},{"key":"B58","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1016\/j.immuni.2017.08.016","article-title":"Aryl hydrocarbon receptor controls monocyte differentiation into dendritic cells versus macrophages","volume":"47","author":"Goudot","year":"2017","journal-title":"Immunity"},{"key":"B59","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.cytogfr.2009.11.008","article-title":"Transforming growth factor beta (TGF-beta) and inflammation in cancer","volume":"21","author":"Bierie","year":"2010","journal-title":"Cytokine Growth Factor Rev"},{"key":"B60","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1007\/s00281-012-0342-8","article-title":"Multifaceted roles of PGE2 in inflammation and cancer","volume":"35","author":"Nakanishi","year":"2013","journal-title":"Semin Immunopathol"},{"key":"B61","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1084\/jem.179.4.1109","article-title":"Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte\/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha","volume":"179","author":"Sallusto","year":"1994","journal-title":"J Exp Med"},{"key":"B62","doi-asserted-by":"publisher","first-page":"635","DOI":"10.3109\/08820139.2012.695417","article-title":"PGE(2)-driven induction and maintenance of cancer-associated myeloid-derived suppressor cells","volume":"41","author":"Obermajer","year":"2012","journal-title":"Immunol Invest"},{"key":"B63","doi-asserted-by":"publisher","first-page":"4345","DOI":"10.4049\/jimmunol.174.9.5884c","article-title":"Molecular circuits of resolution: formation and actions of resolvins and protectins","volume":"174","author":"Bannenberg","year":"2005","journal-title":"J Immunol"},{"key":"B64","doi-asserted-by":"publisher","first-page":"2445","DOI":"10.4049\/jimmunol.1102736","article-title":"Seminal fluid induces leukocyte recruitment and cytokine and chemokine mRNA expression in the human cervix after coitus","volume":"188","author":"Sharkey","year":"2012","journal-title":"J Immunol"},{"key":"B65","doi-asserted-by":"publisher","first-page":"2928","DOI":"10.1093\/humrep\/dem281","article-title":"Concentrations and significance of cytokines and other immunologic factors in semen of healthy fertile men","volume":"22","author":"Politch","year":"2007","journal-title":"Hum Reprod"},{"key":"B66","doi-asserted-by":"publisher","first-page":"8080","DOI":"10.4049\/jimmunol.0804018","article-title":"Cross-presentation of male seminal fluid antigens elicits T cell activation to initiate the female immune response to pregnancy","volume":"182","author":"Moldenhauer","year":"2009","journal-title":"J Immunol"},{"key":"B67","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1111\/j.1600-0897.2011.01039.x","article-title":"Peri-conceptual cytokines \u2013 setting the trajectory for embryo implantation, pregnancy and beyond","volume":"66","author":"Robertson","year":"2011","journal-title":"Am J Reprod Immunol"},{"key":"B68","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.4049\/jimmunol.1200005","article-title":"TGF-beta mediates proinflammatory seminal fluid signaling in human cervical epithelial cells","volume":"189","author":"Sharkey","year":"2012","journal-title":"J Immunol"},{"key":"B69","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1038\/360258a0","article-title":"GM-CSF and TNF-alpha cooperate in the generation of dendritic Langerhans cells","volume":"360","author":"Caux","year":"1992","journal-title":"Nature"},{"key":"B70","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.4049\/jimmunol.157.4.1499","article-title":"TGF-beta 1 promotes in vitro development of dendritic cells from CD34+ hemopoietic progenitors","volume":"157","author":"Strobl","year":"1996","journal-title":"J Immunol"},{"key":"B71","doi-asserted-by":"publisher","first-page":"2411","DOI":"10.1182\/blood-2014-04-568311","article-title":"Human blood BDCA-1 dendritic cells differentiate into Langerhans-like cells with thymic stromal lymphopoietin and TGF-beta","volume":"124","author":"Martinez-Cingolani","year":"2014","journal-title":"Blood"},{"key":"B72","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1038\/ni1307","article-title":"Langerhans cells arise from monocytes in vivo","volume":"7","author":"Ginhoux","year":"2006","journal-title":"Nat Immunol"},{"key":"B73","doi-asserted-by":"publisher","first-page":"2545","DOI":"10.1084\/jem.20071401","article-title":"Autocrine\/paracrine TGFbeta1 is required for the development of epidermal Langerhans cells","volume":"204","author":"Kaplan","year":"2007","journal-title":"J Exp Med"},{"key":"B74","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1084\/jem.187.6.961","article-title":"Transforming growth factor beta1, in the presence of granulocyte\/macrophage colony-stimulating factor and interleukin 4, induces differentiation of human peripheral blood monocytes into dendritic Langerhans cells","volume":"187","author":"Geissmann","year":"1998","journal-title":"J Exp Med"},{"key":"B75","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1002\/jlb.66.5.781","article-title":"Respective involvement of TGF-beta and IL-4 in the development of Langerhans cells and non-Langerhans dendritic cells from CD34+ progenitors","volume":"66","author":"Caux","year":"1999","journal-title":"J Leukoc Biol"},{"key":"B76","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1111\/imm.12363","article-title":"Inflammatory conditions distinctively alter immunological functions of Langerhans-like cells and dendritic cells in vitro","volume":"144","author":"Said","year":"2015","journal-title":"Immunology"},{"key":"B77","doi-asserted-by":"publisher","first-page":"1924","DOI":"10.1016\/j.intimp.2007.07.003","article-title":"Physiological concentrations of transforming growth factor beta1 selectively inhibit human dendritic cell function","volume":"7","author":"Fogel-Petrovic","year":"2007","journal-title":"Int Immunopharmacol"},{"key":"B78","doi-asserted-by":"publisher","first-page":"1794","DOI":"10.1016\/j.bpj.2013.02.052","article-title":"Accumulation of exogenous activated TGF-beta in the superficial zone of articular cartilage","volume":"104","author":"Albro","year":"2013","journal-title":"Biophys J"},{"key":"B79","doi-asserted-by":"publisher","first-page":"a021907","DOI":"10.1101\/cshperspect.a021907","article-title":"Regulation of the bioavailability of TGF-beta and TGF-beta-related proteins","volume":"8","author":"Robertson","year":"2016","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"B80","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1096\/fj.09-141341","article-title":"PGE2 receptor EP2 mediates the antagonistic effect of COX-2 on TGF-beta signaling during mammary tumorigenesis","volume":"24","author":"Tian","year":"2010","journal-title":"FASEB J"},{"key":"B81","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1248\/bpb.b15-00840","article-title":"The roles of EP4 prostanoid receptors in cancer malignancy signaling","volume":"39","author":"Fujino","year":"2016","journal-title":"Biol Pharm Bull"},{"key":"B82","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.1084\/jem.20070109","article-title":"CREB\/ATF-dependent T cell receptor-induced FoxP3 gene expression: a role for DNA methylation","volume":"204","author":"Kim","year":"2007","journal-title":"J Exp Med"},{"key":"B83","doi-asserted-by":"publisher","first-page":"6413","DOI":"10.4049\/jimmunol.1001829","article-title":"The role of the transcription factor CREB in immune function","volume":"185","author":"Wen","year":"2010","journal-title":"J Immunol"},{"key":"B84","doi-asserted-by":"publisher","first-page":"475","DOI":"10.4049\/jimmunol.1301892","article-title":"TGF-beta-mediated Foxp3 gene expression is cooperatively regulated by Stat5, Creb, and AP-1 through CNS2","volume":"192","author":"Ogawa","year":"2014","journal-title":"J Immunol"},{"key":"B85","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1096\/fj.13-241646","article-title":"Adenosine 2A receptor promotes collagen production by human fibroblasts via pathways involving cyclic AMP and AKT but independent of Smad2\/3","volume":"28","author":"Perez-Aso","year":"2014","journal-title":"FASEB J"},{"key":"B86","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1016\/j.ccell.2014.09.007","article-title":"Dissecting the tumor myeloid compartment reveals rare activating antigen-presenting cells critical for T cell immunity","volume":"26","author":"Broz","year":"2014","journal-title":"Cancer Cell"},{"key":"B87","doi-asserted-by":"publisher","first-page":"13720","DOI":"10.1038\/ncomms13720","article-title":"The tumour microenvironment harbours ontogenically distinct dendritic cell populations with opposing effects on tumour immunity","volume":"7","author":"Laoui","year":"2016","journal-title":"Nat Commun"},{"key":"B88","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1016\/j.it.2004.03.002","article-title":"CD1a in human cancers: a new role for an old molecule","volume":"25","author":"Coventry","year":"2004","journal-title":"Trends Immunol"},{"key":"B89","doi-asserted-by":"publisher","first-page":"4333","DOI":"10.4049\/jimmunol.168.9.4333","article-title":"Prostanoids play a major role in the primary tumor-induced inhibition of dendritic cell differentiation","volume":"168","author":"Sombroek","year":"2002","journal-title":"J Immunol"},{"key":"B90","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.4049\/jimmunol.1100889","article-title":"M2 macrophages induced by prostaglandin E2 and IL-6 from cervical carcinoma are switched to activated M1 macrophages by CD4+ Th1\u2009cells","volume":"187","author":"Heusinkveld","year":"2011","journal-title":"J Immunol"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2018.01441\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T08:55:51Z","timestamp":1693731351000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2018.01441\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,22]]},"references-count":90,"alternative-id":["10.3389\/fimmu.2018.01441"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2018.01441","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,22]]},"article-number":"1441"}}