{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T19:57:12Z","timestamp":1789156632557,"version":"build-2803163510"},"reference-count":35,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,6,27]],"date-time":"2018-06-27T00:00:00Z","timestamp":1530057600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2018.01488","type":"journal-article","created":{"date-parts":[[2018,6,27]],"date-time":"2018-06-27T00:17:32Z","timestamp":1530058652000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":19,"title":["CLA+ T Cell Response to Microbes in Psoriasis"],"prefix":"10.3389","volume":"9","author":[{"given":"Carmen","family":"De Jes\u00fas-Gil","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ester","family":"Ruiz-Romeu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Ferran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anca","family":"Chiriac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Deza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e9ter","family":"H\u00f3llo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Celada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramon M.","family":"Pujol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis F.","family":"Santamaria-Bab\u00ed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,6,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1016\/j.jaci.2017.07.004","article-title":"Psoriasis pathogenesis and the development of novel targeted immune therapies","volume":"140","author":"Hawkes","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1016\/j.clindermatol.2007.08.015","article-title":"Triggering psoriasis: the role of infections and medications","volume":"25","author":"Fry","year":"2007","journal-title":"Clin Dermatol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1016\/S0190-9622(85)70188-0","article-title":"Psoriasis of early and late onset: characterization of two types of psoriasis vulgaris","volume":"13","author":"Henseler","year":"1985","journal-title":"J Am Acad Dermatol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1111\/j.0022-202X.2004.23611.x","article-title":"Psoriasis phenotype at disease onset: clinical characterization of 400 adult cases","volume":"124","author":"Mallbris","year":"2005","journal-title":"J Invest Dermatol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/1471-5945-9-5","article-title":"HLA-Cw*0602 associates with a twofold higher prevalence of positive streptococcal throat swab at the onset of psoriasis: a case control study","volume":"9","author":"Mallbris","year":"2009","journal-title":"BMC Dermatol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.1111\/bjd.14886","article-title":"Early- and late-onset psoriasis: a cross-sectional clinical and immunocytochemical investigation","volume":"175","author":"Theodorakopoulou","year":"2016","journal-title":"Br J Dermatol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"135","DOI":"10.3109\/03009745509164855","article-title":"The significance of infections in the origination of psoriasis","volume":"1","author":"Norrlind","year":"1955","journal-title":"Acta Rheumatol Scand"},{"key":"B8","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1159\/000252565","article-title":"A study of the incidence of haemolytic streptococci in the throat in patients with psoriasis vulgaris, with reference to their role in the pathogenesis of this disease","volume":"140","author":"Tervaert","year":"1970","journal-title":"Dermatologica"},{"key":"B9","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1046\/j.1365-2273.1998.00084.x","article-title":"Tonsillitis and chronic psoriasis","volume":"23","author":"Wardrop","year":"1998","journal-title":"Clin Otolaryngol Allied Sci"},{"key":"B10","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1046\/j.1365-2133.2003.05552.x","article-title":"Streptococcal throat infections and exacerbation of chronic plaque psoriasis: a prospective study","volume":"149","author":"Gudjonsson","year":"2003","journal-title":"Br J Dermatol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1007\/s00403-010-1065-0","article-title":"Evidence for the presence of bacteria in the blood of psoriasis patients","volume":"302","author":"Munz","year":"2010","journal-title":"Arch Dermatol Res"},{"key":"B12","doi-asserted-by":"publisher","first-page":"340","DOI":"10.2340\/00015555-2562","article-title":"Patient-reported outcomes and clinical response in patients with moderate-to-severe plaque psoriasis treated with tonsillectomy: a randomized controlled trial","volume":"97","author":"Thorleifsdottir","year":"2017","journal-title":"Acta Derm Venereol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1111\/cei.12153","article-title":"The association of sore throat and psoriasis might be explained by histologically distinctive tonsils and increased expression of skin-homing molecules by tonsil T cells","volume":"174","author":"Sigurdardottir","year":"2013","journal-title":"Clin Exp Immunol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1016\/j.it.2009.07.008","article-title":"Psoriasis \u2013 as an autoimmune disease caused by molecular mimicry","volume":"30","author":"Valdimarsson","year":"2009","journal-title":"Trends Immunol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1084\/jem.20050500","article-title":"Plasmacytoid predendritic cells initiate psoriasis through interferon-alpha production","volume":"202","author":"Nestle","year":"2005","journal-title":"J Exp Med"},{"key":"B16","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/j.jaad.2009.05.042","article-title":"A randomized, double-blind, placebo-controlled, phase I study of MEDI-545, an anti-interferon-alfa monoclonal antibody, in subjects with chronic psoriasis","volume":"62","author":"Bissonnette","year":"2010","journal-title":"J Am Acad Dermatol"},{"key":"B17","first-page":"1053","article-title":"A unique phenotype of skin-associated lymphocytes in humans. Preferential expression of the HECA-452 epitope by benign and malignant T cells at cutaneous sites","volume":"136","author":"Picker","year":"1990","journal-title":"Am J Pathol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1111\/exd.12154","article-title":"Circulating CLA+ T lymphocytes as peripheral cell biomarkers in T-cell-mediated skin diseases","volume":"22","author":"Ferran","year":"2013","journal-title":"Exp Dermatol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1111\/all.13080","article-title":"Circulating CLA(+) T cells in atopic dermatitis and their possible role as peripheral biomarkers","volume":"72","author":"Czarnowicki","year":"2017","journal-title":"Allergy"},{"key":"B20","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1038\/jid.2012.418","article-title":"Streptococcus induces circulating CLA(+) memory T-cell-dependent epidermal cell activation in psoriasis","volume":"133","author":"Ferran","year":"2013","journal-title":"J Invest Dermatol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/j.jaci.2016.02.008","article-title":"Streptococcus pyogenes-induced cutaneous lymphocyte antigen-positive T cell-dependent epidermal cell activation triggers TH17 responses in patients with guttate psoriasis","volume":"138","author":"Ruiz-Romeu","year":"2016","journal-title":"J Allergy Clin Immunol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"219ra8","DOI":"10.1126\/scitranslmed.3007828","article-title":"Human TH9 cells are skin-tropic and have autocrine and paracrine proinflammatory capacity","volume":"6","author":"Schlapbach","year":"2014","journal-title":"Sci Transl Med"},{"key":"B23","doi-asserted-by":"publisher","first-page":"e51752","DOI":"10.1371\/journal.pone.0051752","article-title":"Involvement of IL-9 in Th17-associated inflammation and angiogenesis of psoriasis","volume":"8","author":"Singh","year":"2013","journal-title":"PLoS One"},{"key":"B24","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1016\/j.jid.2017.08.048","article-title":"Microbe-dependent induction of IL-9 by CLA(+) T cells in psoriasis and relationship with IL-17A","volume":"138","author":"Ruiz-Romeu","year":"2018","journal-title":"J Invest Dermatol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1337","DOI":"10.1038\/sj.jid.5700744","article-title":"Increased blood levels of IgG reactive with secreted Streptococcus pyogenes proteins in chronic plaque psoriasi","volume":"127","author":"El-Rachkidy","year":"2007","journal-title":"J Invest Dermatol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/s00403-011-1189-x","article-title":"Comparison of bacterial microbiota in skin biopsies from normal and psoriatic skin","volume":"304","author":"Fahlen","year":"2012","journal-title":"Arch Dermatol Res"},{"key":"B27","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1016\/j.it.2016.04.007","article-title":"Skin immunity to Candida albicans","volume":"37","author":"Kashem","year":"2016","journal-title":"Trends Immunol"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.1084\/jem.20080321","article-title":"Mutations in STAT3 and IL12RB1 impair the development of human IL-17-producing T cells","volume":"205","author":"de Beaucoudrey","year":"2008","journal-title":"J Exp Med"},{"key":"B29","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1126\/science.1260668","article-title":"T cell immunity. Functional heterogeneity of human memory CD4(+) T cell clones primed by pathogens or vaccines","volume":"347","author":"Becattini","year":"2015","journal-title":"Science"},{"key":"B30","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1111\/1523-1747.ep12468941","article-title":"A potential role for superantigens in the pathogenesis of psoriasis","volume":"100","author":"Leung","year":"1993","journal-title":"J Invest Dermatol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/0923-1811(95)00473-4","article-title":"Candida albicans induces selective expansion of human T lymphocytes expressing the T-cell receptor variable region V beta 5.1","volume":"12","author":"Walsh","year":"1996","journal-title":"J Dermatol Sci"},{"key":"B32","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1146\/annurev-med-042915-103905","article-title":"Highly effective new treatments for psoriasis target the IL-23\/type 17 T cell autoimmune axis","volume":"68","author":"Kim","year":"2017","journal-title":"Annu Rev Med"},{"key":"B33","doi-asserted-by":"publisher","first-page":"5953","DOI":"10.4049\/jimmunol.1403066","article-title":"Candida albicans stimulates IL-23 release by human dendritic cells and downstream IL-17 secretion by Vdelta1 T cells","volume":"194","author":"Maher","year":"2015","journal-title":"J Immunol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"e2719","DOI":"10.1371\/journal.pone.0002719","article-title":"Substantial alterations of the cutaneous bacterial biota in psoriatic lesions","volume":"3","author":"Gao","year":"2008","journal-title":"PLoS One"},{"key":"B35","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1111\/bjd.16081","article-title":"The role of the microbiome in psoriasis: moving from disease description to treatment selection?","volume":"178","author":"Langan","year":"2018","journal-title":"Br J Dermatol"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2018.01488\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,6,27]],"date-time":"2018-06-27T00:17:36Z","timestamp":1530058656000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2018.01488\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,27]]},"references-count":35,"alternative-id":["10.3389\/fimmu.2018.01488"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2018.01488","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,27]]},"article-number":"1488"}}